[The link between obesity and cancer].

Abstract:

:While some genetic factors may explain the development of cancer, its main causes are related to environmental exposure to carcinogenic agents as well as to the effect of determined lifestyles and habits. Several epidemiological studies have shown a consistent relation between obesity and cancer. In non smokers, obesity is the most relevant risk factor in the development of malignant tumors. There is a clear association between obesity and endometrial cancer, breast cancer in postmenopausal women, pancreatic, esophageal and colon cancer. Sexual steroids, insulin like growth factor axis and adipokines are the three main models to explain the biological basis for the obesity-cancer relationship. However, these models do not explain all the biological mechanisms that link obesity to cancer. There are other factors in play such as chronic inflammation, hypoxia and oxidative stress. Obesity may hamper the screening, diagnosis and treatment of some tumors, increasing mortality rates. Obesity prevention and management, therefore, may be the most important modifiable factor in reducing both incidence and mortality in cancer. New studies are required to quantify the effect of intentional weight reduction on the incidence and relapse of cancer. Considering the efficacy of bariatric surgery for weight reduction, it is an attractive model to study this link.

journal_name

Rev Med Chil

journal_title

Revista medica de Chile

authors

Sánchez R C,Ibáñez C,Klaassen J

doi

10.4067/S0034-98872014000200010

subject

Has Abstract

pub_date

2014-02-01 00:00:00

pages

211-21

issue

2

eissn

0034-9887

issn

0717-6163

pii

S0034-98872014000200010

journal_volume

142

pub_type

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