[Renal artery thrombosis after withdrawal from anticoagulation therapy in a kidney transplant recipient with thrombophilia: report of one case].

Abstract:

:Kidney graft loss because arterial thrombosis is not common and is related to risk factors such as recurrent vascular hemodialysis access thrombosis, collagen-vascular disease, repeated miscarriage, diabetes mellitus and thrombophilia. Patients having this last disorder have an increased risk of repeated thrombosis in successive transplants unless they receive anticoagulation therapy. We report a 51 year-old diabetic woman who had a history of recurrent vascular hemodialysis access thrombosis (both native and prosthetic) while on dialysis and received a cadaveric donor kidney. One month after transplantation she had axillary vein thrombosis complicated with pulmonary embolism and received anticoagulants for six months. Just days after stopping the anticoagulation, she became suddenly anuric due to renal artery thrombosis and complete graft infarction. The coagulation study showed moderate hyperhomocysteinemia and a significant protein C deficiency (39%). Days after nephrectomy she suffered a femoral vein thrombosis and anticoagulation was prescribed for life.

journal_name

Rev Med Chil

journal_title

Revista medica de Chile

authors

Vega S J,Goecke S H,Vásquez G A,Peña M A

doi

10.4067/s0034-98872007000100014

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

98-102

issue

1

eissn

0034-9887

issn

0717-6163

pii

S0034-98872007000100014

journal_volume

135

pub_type

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