[Lipids, lipoproteins and apolipoproteins in normal newborns].

Abstract:

BACKGROUND:In Chile, there is a high prevalence of cardiovascular diseases. Because atherosclerosis starts in childhood, it is important to assess serum lipid levels in children. AIM:To measure serum lipid levels in normal Chilean newborns. SUBJECTS AND METHODS:A sample of umbilical cord venous blood was obtained from 156 normal newborns (76 male) immediately after delivery. Total and HDL cholesterol, triglycerides, apoprotein A1, B and lipoprotein (a) were measured. RESULTS:Mean values for total cholesterol in males, females and in the total sample were 60.6, 67.8 and 64 mg/dl respectively. The figures for HDL cholesterol were 24.9, 29.3 and 27 mg/dl, for LDL cholesterol were 28.3, 32.4 and 30 mg/dl, for triglycerides were 37.5, 30.3 and 35 mg/dl, for apoprotein A1 were 69, 79 and 74 mg/dl, for apoB were 23, 25 and 24 mg/dl and for lipoprotein (a) were 1.58, 1.79 and 1.69 mg/dl. Total cholesterol, HDL cholesterol, triglycerides and apoprotein A1 were significantly different between sexes. Percentiles 5 and 95 for total cholesterol were 37 and 111, for HDL cholesterol were 14 and 40, for LDL cholesterol were 13 and 57, for triglycerides were 20 and 69, for apoprotein A1 were 53 and 101, for apoprotein B were 11 and 48 and for lipoprotein (a) were 1.3 and 2.1 mg/dl. Five percent of children had apoprotein B values over 48 mg/dl. CONCLUSIONS:The detection of high levels of apoprotein B in newborns, could allow the early identification of individuals with high cardiovascular risk.

journal_name

Rev Med Chil

journal_title

Revista medica de Chile

authors

Casanueva V,Cid X,Chiang MT,Molina M,Ferrada MC,Pérez R,Casanueva P

subject

Has Abstract

pub_date

1998-09-01 00:00:00

pages

1073-8

issue

9

eissn

0034-9887

issn

0717-6163

journal_volume

126

pub_type

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