[Pharmacokinetic comparison of Sinemet and Grifoparkin (levodopa/carbidopa 250/25 mg) in Parkinson s disease: a single dose study].

Abstract:

BACKGROUND:There are doubts wether generic medications have the same bioavailability and efficacy compared with the original drugs developed by pharmaceutical companies with research capabilities. AIM:To compare the pharmacokinetics and clinical (motor) responses of Sinemet and Grifoparkin (generic carbidopa/levodopa 250/25 mg) in patients with advanced Parkinson's disease. PATIENTS AND METHODS:Patients were randomly assigned to Sinemet (15 patients 62 +/- 12 years old; mean disease duration 11 +/- 7 years) or Grifoparkin (15 patients, 64 +/- 11 years old; mean disease duration 12 +/- 4 years) groups. Medication and food were withheld 12 h before the study. Fifteen blood samples were collected (starting 9 AM) immediately before (sample 1, t = 0 min) and after (samples 2-15, t = 20-360 min) oral administration of a single dose of Sinemet or Grifoparkin, and plasmatic L-DOPA was quantified using HPLC with electrochemical detection. Additionally, each patient was clinically evaluated every 20 minutes, using the tapping test and the unified Parkinson's disease scale Hoehn & Yarh. RESULTS:Tmax (time at which the maximal L-DOPA concentration was reached) were 69 +/- 12 min and 64 +/- 11 min for Sinemet and Grifoparkin respectively (NS). Cmax (maximal L-DOPA concentration reached) was 3161 +/- 345 ng/ml for Sinemet and 3274 +/- 520 ng/ml for Grifoparkin (NS). The t1/2 (half life time), CL (clearance) and volume of distribution (Vd) values calculated were 159 +/- 32 min, 51.7 +/- 5.1 1/h and 3.6 +/- 1.2 l/kg for Sinemet and 161 +/- 48 min, 58.7 +/- 8 l/h and 3.0 +/- 0.7 l/kg for Grifoparkin (NS). UPDRS-III value for the best "on state" and for the worst "off state" were 23 +/- 11 and 50 +/- 19 for Sinemet and 20 +/- 7 and 46 +/- 13 for Grifoparkin respectively (NS). CONCLUSION:The results obtained showed that both drugs are bioequivalent in patients with advanced Parkinson's disease.

journal_name

Rev Med Chil

journal_title

Revista medica de Chile

authors

Chaná P,Fierro A,Reyes-Parada M,Sáez-Briones P

subject

Has Abstract

pub_date

2003-06-01 00:00:00

pages

623-31

issue

6

eissn

0034-9887

issn

0717-6163

journal_volume

131

pub_type

临床试验,杂志文章,随机对照试验
  • [Neuropsychological assessment of patients with relapsing remitting multiple sclerosis prior to the use of immunomodulatory drugs].

    abstract:BACKGROUND:The detection of cognitive changes (CC) and psychiatric disorders in relapsing remitting multiple sclerosis (MS-RR) contributes to patient clinical monitoring. AIM:To assess the frequency and characteristics of CC and psychiatric disorders in Chilean patients with MS-RR, before starting immunomodulatory tre...

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    authors: Nogales-Gaete J,Aracena R,Díaz V,Zitko P,Eloiza C,Cepeda-Zumaeta S,Agurto P,González C

    更新日期:2012-11-01 00:00:00

  • [Pancreatic choristoma in the gallbladder: report of two cases].

    abstract::Pancreatic choristoma is the occurrence of normal pancreatic tissue in an abnormal location without any anatomic continuity with the main body of the gland. Although heterotopia is uncommon in the gallbladder and biliary tract, anecdotic cases of gastric mucosa, liver, adrenal gland and pancreas among other tissues ha...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:/S0034-98872007001000013

    authors: Beltrán MA,Barría C,Naquira C,Almonacid J,Cruces KS

    更新日期:2007-10-01 00:00:00

  • [Laugier-Hunziker syndrome in a patient with Sjögren’s syndrome: Report of one case].

    abstract::Laugier-Hunziker syndrome is a rare benign idiopathic condition characterized by acquired macular pigmentation of lips and buccal mucosa, often accompanied with melanonychia. The main concern with this condition is to rule out other differential diagnosis with systemic repercussions and similar hyperpigmentation patte...

    journal_title:Revista medica de Chile

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    authors: Fajre X,Aspillaga M,McNab M,Navarrete J,Sanhueza V,Benedetto J

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  • [Viral etiology of community acquired pneumonia among adults admitted to a general hospital].

    abstract:BACKGROUND:There is paucity of information about viral etiology of community acquired pneumonia in adults. AIM:To investigate the viral etiology of pneumonia among hospitalized patients. MATERIAL AND METHODS:All adults with pneumonia that were hospitalized were prospectively enrolled at Puerto Montt hospital. A micro...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:10.4067/S0034-98872012000800003

    authors: Rioseco Z ML,Riquelme O R,Riquelme O M,Inzunza P C,Oyarzún G P,Agüero O Y,Ferrés G M,Vial C P,Fasce P R,Torres M A

    更新日期:2012-08-01 00:00:00

  • [Perception of medical students about formative assessments during clinical courses].

    abstract:BACKGROUND:Formative evaluation is a range of formal assessment employed by professors during the teaching process in order to modify curriculum activities, to improve student attainment. For students, it is helpful to evaluate their learning process. Although recommended, it is seldom used. AIM:To evaluate the percep...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:10.4067/S0034-98872014000900014

    authors: Labarca J,Figueroa C,Huidobro B,Wright AC,Riquelme A,Moreno R

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  • [Work absenteeism in a mining company: trends in 1985-1988].

    abstract::The magnitude of medical and non medical absenteeism among male workers performing rotative shifts in a high altitude mining company was studied. There was a general rate of absenteeism of 8.8 absent days per 100 labor days, which means that 31.8% of the total labor force was absent every month. Absenteeism due to med...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Cantuarias J,Cornejo E

    更新日期:1993-07-01 00:00:00

  • [Sociodemographic/clinical characteristics and outcomes of patients admitted to the National Burn Center of Chile].

    abstract:BACKGROUND:Approximately 150 subjects per year suffer severe burns in Chile. AIM:To analyze sociodemographic/clinical features and outcomes of severely burned patients. MATERIAL AND METHODS:Retrospective cohort study of 936 patients aged 47 ± 20 years (66% males), admitted to the National Burn Center of Chile between...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

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    authors: Albornoz CR,Villegas J,Peña V,Whittle S

    更新日期:2013-02-01 00:00:00

  • [Outcome of microbial invasion of amniotic cavity in the preterm premature rupture of membranes].

    abstract:BACKGROUND:Microbial invasion of amniotic cavity occurs in 30 to 50% of patients with premature membrane rupture. AIM:To determine the outcomes associated with microbial invasion of the amniotic cavity (MIAC) in patients with preterm premature rupture of membrane (pPROM). PATIENTS AND METHODS:One hundred thirty four ...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:10.4067/s0034-98872005000100007

    authors: Ovalle S A,Gómez M R,Martínez T MA,Kakarieka W E,Fuentes G A,Aspillaga M C,Ferrand M P,Ramírez F C

    更新日期:2005-01-01 00:00:00

  • [Reference values of growth hormone binding protein (GHBP) for a normal pediatric population].

    abstract:UNLABELLED:Circulating concentrations of the high affinity growth hormone binding protein (GHBP) may be a marker of GH receptor density as well as GH sensitivity. GOAL:To determine values of GHBP for a normal Chilean pediatric population. METHODS:We determined GHBP levels in 73 males and 73 females between 4 to 15.5 ...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Salazar TE,Méricq MV,Espinoza M,Iñiguez G,de Carvallo P,Cassorla F

    更新日期:2001-04-01 00:00:00

  • [Cutaneous infection by mycobacterium marinum: case report].

    abstract::A 45 year old male who manipulated tropical fish ponds developed painless nodular plaques in both hands. Biopsy showed mononuclear infiltrate of the dermis with few granulomata. Repeated cultures revealed M. marinum (diagnosis confirmed at the WHO/PAHO Reference Center in Canada). Good initial results were obtained wi...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Guarda R,Gubelin W,Gajardo J,Rohmann I,Valenzuela MT

    更新日期:1992-09-01 00:00:00

  • [Sexual behavior and contraceptive practices among university students].

    abstract::The aim of this work was to study the knowledge, opinions and sexual behaviour of a sample of 464 students from the Universidad Austral de Chile. Results show that 78% of male and 41% of female students have had a sexual intercourse and that 78% of males and 72% of females with an active sexual life use contraceptive ...

    journal_title:Revista medica de Chile

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    doi:

    authors: Repossi A,Araneda JM,Bustos L,Puente C,Rojas C

    更新日期:1994-01-01 00:00:00

  • [Addisonian crisis caused by metastatic lung cancer. Report of one case].

    abstract::Addisonian crisis as a first manifestation of metastatic disease secondary to cancer is uncommon. We report a 63-year-old man with a history of one year of fatigue, weakness, weight loss and repeated symptomatic hypoglycemia. The cortisol stimulation test with ACTH confirmed primary adrenal insufficiency. While receiv...

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    authors: Utreras C,Díaz RE,Ascui R,Caro R,Véliz J,Wohllk N

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  • Nausea and vomiting of pregnancy: an evolutionary hypothesis.

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  • [Perceived work characteristics and coping strategies that predict distress among workers at primary health care centers].

    abstract:BACKGROUND:Demands on primary health care services in Chile are increasing. The staff perception of specific sources of tension at work is not known. This knowledge is necessary to avoid preventable health problems caused by distress. AIM:To identify specific work stressors in primary health care facilities and to exa...

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    pub_type: 杂志文章

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    authors: Guic S E,Mora O P,Rey C R,Robles G A

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  • [Masters of Chilean Internal Medicine].

    abstract::Master of internal Medicine is the highest award granted by the Chilean Society of Internal Medicine (Sociedad Médica de Santiago) to its members. This article outlines the sense and transcendence of this award and provides an abridged, certainly incomplete, data of the recipients since 1981 when this award was first ...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Rosselot E

    更新日期:2003-08-01 00:00:00

  • [Ectopic or migrating spleen and supernumerary spleens: detection and identification with 99mTc, 51Cr and 113In radioisotopes].

    abstract::Congenital malformations of the spleen are rare. We report a patient with an ectopic spleen located in the left iliac fossa, which was excised in order to prevent severe complications such as torsion of the pedicle, rupture or infection. A second patient with idiopathic thrombocytopenic purpura presented with an acces...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章,评审

    doi:

    authors: Etcheverry R,Allamand JP,Guzmán G,Robinson MI

    更新日期:1989-12-01 00:00:00

  • [Physical activity and cognitive reserve as protective factors for attentional functioning in older people].

    abstract:BACKGROUND:Attention is considered a central control mechanism in cognitive processing systems. Attention deficits contribute to the symptomatic profile of Alzheimer's disease (AD). Physical exercise and cognitive reserve, could delay cognitive impairment and constitute a protective factor against clinical manifestatio...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:10.4067/s0034-98872018000500570

    authors: Wikee G,Martella D

    更新日期:2018-05-01 00:00:00

  • [Undergraduate medical students' expectative of their desired profile as medical doctors].

    abstract:BACKGROUND:During the last few years, multiple new medical schools have emerged in Chile, associated to the constant preoccupation to provide a good quality medical care. This created the need to evaluate medical training programs and to open a discussion about the attributes that a good physician should have. AIM:To ...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:10.4067/s0034-98872006000800001

    authors: García-Huidobro D,Núñez F,Vargas P,Astudillo S,Hitschfeld M,Gennero R,Salvatierra L,Benavente A

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  • [Epidemiological profile of liver cirrhosis in Chile 1970-1992].

    abstract:BACKGROUND:Liver cirrhosis is an important public health problem in Chile. AIM:To review the main epidemiological features of liver cirrhosis in Chile in the last 22 years. METHODS:Review of yearbooks of mortality and causes of death of the Ministry of Health and Instituto Nacional de Estadísticas, review of hospital...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Serra I,Araneda J,Decinti E

    更新日期:1995-11-01 00:00:00

  • [Mirizzi syndrome: experience of 77 cases].

    abstract::Mirizzi syndrome is estimated to occur in about 1% of cases requiring urgent or elective biliary tract surgery. The key anatomic finding is extrinsic compression of the common duct by a stone located in the gallbladder or cystic duct. Among patients operated on in the last 12 years we have found 77 patients meeting cr...

    journal_title:Revista medica de Chile

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    doi:

    authors: Jiménez O,Palacios JM,Correa R,Rojas M,Lopez O

    更新日期:1989-05-01 00:00:00

  • [Markers of HIV infection in prostitutes: analysis of preventive and risk factors].

    abstract::We studied 501 prostitutes from the northern and eastern areas of Santiago in november and december, 1987. HIV infection was studied by the HIV antibody and also by HIV antigen. At that time no positive reactors were found. Prostitutes from the northern area were older, of a lower socioeconomic background and less pro...

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    pub_type: 杂志文章

    doi:

    authors: Quero MS,Suárez M,Uribe J,Cerda P,Espoz H,Arroyave R

    更新日期:1989-06-01 00:00:00

  • [Aseptic techniques for minor surgical procedures].

    abstract::Aseptic techniques are those practices designed to reduce the risk of surgical site infection (SSI), defined as such, all those that occur within the first 30 days of the procedure. While the patient’s risk of developing an SSI in dermatologic surgery is low since many of the procedures are considered sterile, there a...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章,评审

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  • [Cardiotoxicity of anticancer therapies. Towards the implementation of cardio-oncology units].

    abstract::Recently, we have witnessed major improvements in cancer treatment. Early diagnosis and development of new therapies have reduced cancer-related mortality. However, these new therapies, along with greater patient survival, are associated with an increase in untoward effects, particularly in the cardiovascular system. ...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章,评审

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    更新日期:2018-01-01 00:00:00

  • [Bone metastases of a gallbladder carcinoma detected by positron emission tomography/computed tomography: Case report].

    abstract::Signet ring gallbladder carcinoma is a rare aggressive variant of mucinous adenocarcinoma with poor prognosis. Positron emission tomography/computed tomography (PET/CT) with Fluor18 deoxyglucose (F18-FDG) is a useful tool in the staging of gallbladder cancer. We report a 68 years old man with a surgically resected acu...

    journal_title:Revista medica de Chile

    pub_type:

    doi:10.4067/S0034-98872017000400013

    authors: Humeres P,González P,González J,Prado E,Hiplan E

    更新日期:2017-04-01 00:00:00

  • [Urinary nickel in children exposed to petcoke pollution].

    abstract:BACKGROUND:Petcoke is a remnant of the oil refining process that contains Ni and other heavy metals. Undesired human exposure to these compounds may result from petcoke combustion in plants located in the vicinity of the cities. AIM:To compare levels of urinary Ni in schoolchildren residing in cities exposed and not e...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:/S0034-98872008000800013

    authors: Iglesias A V,Burgos D S,Marchetti P N,Silva Z C,Pino Z P

    更新日期:2008-08-01 00:00:00

  • [Systemic leptospirosis as a cause of multiple organ failure. Report of a case].

    abstract::Leptospirosis is a world-spread zoonosis that is incidentally acquired by humans. It causes a diphasic febrile illness in which the Weil syndrome is its severest form, with renal, hepatic, clotting and central nervous system involvement. We report a 73 years old male, that was admitted to an intensive care unit with m...

    journal_title:Revista medica de Chile

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    doi:

    authors: Garrido R,Castillo L,Hernández G,Abarca J,Montes JM,Monsalve V,Espinoza R,Valenzuela S,Pérez G

    更新日期:1996-03-01 00:00:00

  • [Dr. Alfonso María Thévenot. 2. In Chile and in France].

    abstract::This French physician was hired by the Chilean government in 1867. He was a brilliant surgeon who made significant contributions to Chilean medicine. He returned to France in 1873, where he had a successful career as a professor of obstetrics. ...

    journal_title:Revista medica de Chile

    pub_type: 传,历史文章,杂志文章

    doi:

    authors: Costa-Casaretto C

    更新日期:1990-11-01 00:00:00

  • [An analysis of authorship in articles published in Revista Médica de Chile].

    abstract:BACKGROUND:Multiauthorship and unjustified authorship have been documented in journals with wide international circulation but this has not been thoroughly studied in journals from developing countries. Revista Médica de Chile is published in Spanish and it contains about 40% of the clinical and biomedical manuscripts ...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Jacard M,Herskovic V,Hernández I,Reyes H

    更新日期:2002-12-01 00:00:00

  • [Systemic inflammatory response syndrome: is it comparable with severe sepsis?].

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    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Hernández G,Dougnac A,Castro J,Labarca E,Ojeda M,Bugedo G,Castillo L,Andresen M,Bruhn A,Huidobro LF,Huidobro R,Caballero MT,Hernández A

    更新日期:1999-11-01 00:00:00

  • [Ménétrier disease. Report of one case].

    abstract:BACKGROUND:Ménétrier disease is a rare disorder of the stomach, characterized by giant hypertrophic folds that usually involve the gastric body and fundus, associated to hypoalbuminemia due to serum protein loss across the gastric mucosa. We report a 55-years-old male presenting with abdominal pain, vomiting, weight lo...

    journal_title:Revista medica de Chile

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    authors: Gompertz M,Montenegro C,Bufadel ME,Defilippi C,Castillo J,Morales C

    更新日期:2012-09-01 00:00:00