Abstract:
:Tumorogenesis is associated with several events by which a normal cell transforms itself into a tumour cell with an increased proliferation rate. One of the most important research initiatives in this area is the characterization of the molecular mechanisms involved in tumorogenesis and cancer. Oncogenes and tumour suppressor genes are directly involved in the cell cycle, differentiation, and apoptosis. The cellular oncogene MDM2 seems to be abnormally elevated in several human tumours, specially in sarcomas. The MDM2 gene product, mdm2 protein, pS3 and retinoblastoma (Rb) proteins, play crucial roles in the control of the cell cycle. The molecular interactions between mdm2, pS3 and Rb in cancer, are associated with a loss of control in the G1 phase of the cell cycle leading to uncontrolled cell proliferation. Studies by gene amplification appear to show an incomplete picture of mdm2 protein levels in tumour cells. The simultaneous determination of mdm2 protein and mRNA levels seems to give a more accurate interpretation of the abnormal function of the mdm2 protein. Thus, in addition to gene amplification, different mechanisms by which mdm2 is overexpressed in cancer cells also play an important role in tumorogenesis.
journal_name
Rev Med Chiljournal_title
Revista medica de Chileauthors
Flores C,Sobrevia Lsubject
Has Abstractpub_date
2000-05-01 00:00:00pages
539-46issue
5eissn
0034-9887issn
0717-6163journal_volume
128pub_type
杂志文章,评审abstract:BACKGROUND:New vaccination strategies are needed to control the increasing problem of pertussis in teenagers and adults. AIM:To determine the immunogenicity and reactogenicity of a diphtheria-tetanus-acellular pertussis (dTpa) vaccine with reduced antigen content. MATERIAL AND METHODS:A single dose of the dTpa vaccin...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2002-05-01 00:00:00
abstract:BACKGROUND:With the aim of contributing to he Healthy Goal 2010 of reducing significantly the prevalence of childhood obesity we developed and implemented during 2003 and 2004, a school-based obesity prevention intervention which included nutrition education and the promotion of physical activity. AIM:To report the re...
journal_title:Revista medica de Chile
pub_type: 杂志文章,多中心研究
doi:/S0034-98872008000100003
更新日期:2008-01-01 00:00:00
abstract::Gestational Diabetes is characterized by different degrees of glucose intolerance that produce a series of fetal and perinatal alterations. During many years, in those cases of gestational diabetes that did not respond to nutritional interventions, the use of insulin was a proven treatment to achieve metabolic control...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:/S0034-98872008000700015
更新日期:2008-07-01 00:00:00
abstract:BACKGROUND:Restless legs syndrome (RLS) affects 10% of the general population. AIM:To analyze a series of patients with a minimum follow-up period of four years, treated during an interval of 14 years. MATERIAL AND METHODS:Retrospective analysis of medical records of 200 patients assessed and followed by the authors ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872016001200007
更新日期:2016-12-01 00:00:00
abstract::Hemophagocytic syndrome is a severe condition of excessive immune activation that has a high mortality in the absence of treatment. The syndrome is classified as primary if associated with congenital or hereditary problems, or secondary/acquired if associated with infectious, autoimmune or oncology diseases. We report...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:10.4067/S0034-98872015000900010
更新日期:2015-09-01 00:00:00
abstract::Sixty-three patients with severe acute pancreatitis have been studied. Pancreatitis was associated with biliary tract disease in 23 patients (36.5%) and with alcoholism in 21 (33.3%). It occurred post-operatively in 9, and was associated with other conditions in 10. We evaluated the Ranson prognostic signs (RPS) with ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1991-06-01 00:00:00
abstract::We analyzed the infectious complications associated with the use of permanent central venous catheters (PVC) in pediatric and adult cancer patients. 62 patients used 74 PVC (54 external, 20 subcutaneous), which were in place for an average of 200 days with a total observation period of 14,876 days, 152 febrile episode...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1992-07-01 00:00:00
abstract::Struma ovarii is a teratoma composed of thyroid tissue and can be a rare cause of hyperthyroidism. We report a 35 years old woman with a left ovarian mass whose pathology revealed a Struma ovarii. This tumor was partially excised initially to avoid fertility problems and after a successful gestation, the tumor was com...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2003-07-01 00:00:00
abstract:BACKGROUND:Felodipine is a calcium channel inhibitor with high vascular selectivity. AIM:To study the effectiveness of felodipine in the treatment of essential hypertension in subjects older than 64 years old. PATIENTS AND OUTCOME:Fifty subjects were studied. After a washout period of four weeks, subjects received a ...
journal_title:Revista medica de Chile
pub_type: 临床试验,杂志文章
doi:
更新日期:1996-07-01 00:00:00
abstract:BACKGROUND:Laparoscopic esophagomyotomy is becoming a good alternative to pneumatic dilatation, injection of botulinic toxin or classical surgery in the treatment of achalasia. AIM:To report the results of laparoscopic esophagomyotomy in patients with achalasia. PATIENTS AND METHODS:Nineteen patients with achalasia, ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2001-10-01 00:00:00
abstract:BACKGROUND:Vildagliptin is a dipeptidyl peptidase IV inhibitor (DPP4i). Its efficacy and safety of DPP4i in Chilean real life type 2 diabetic (T2D) patients is not well known. AIM:To assess the safety profile and effectiveness of 12 weeks of treatment with Vildagliptin for glycemic control in T2D Chilean patients with...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872015000100008
更新日期:2015-01-01 00:00:00
abstract::Technology for diabetes care has undergone major development during recent decades. These technological advances include continuous subcutaneous insulin infusion (CSII), also known as insulin pumps, and real-time continuous glucose monitoring system (RT-CGMS). The integration of CSII and RT-CGMS into a single device h...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:10.4067/S0034-98872017000500011
更新日期:2017-05-01 00:00:00
abstract::Sickle cell anemia was a rare disease in Chile, especially in adults, however the recent immigration wave from Haiti is changing this scenario. We report a 29 year old black female from Haiti with a non-disclosed history of sickle cell anemia. She was transfused with two units of red blood cells, found unconscious and...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872018001101347
更新日期:2018-11-01 00:00:00
abstract::The new Chilean regulation about patients' rights and duties is generating a significant change in the information that health care professionals must provide to their patients. This issue will gravitate on medical liability. If this duty is accomplished incorrectly, professionals would fall into an illicit act and be...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872018000800909
更新日期:2018-08-01 00:00:00
abstract::Renal failure secondary to effort rhabdomyolysis is uncommon. We report three males age 28, 37 (military sportsmen) and 44 years (sedentary obese), with this condition. Episodes occurred after a training session to run a triathlon, during the course of a mini marathon and during a rescue attempt of a drowning person. ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872006000200012
更新日期:2006-02-01 00:00:00
abstract::We report a 16-year-old boy, who suffered a right vent ride penetrating injury caused by a sharp blade that evolved to cardiac tampon. He underwent surgery and was discharged four days later. Thirteen days later, a cardiac murmur was found. An echocardiography showed an aorta-right ventricular fistula. Surgical closur...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872010000200010
更新日期:2010-02-01 00:00:00
abstract::Background Patients discharged from general hospitals with a potentially disabling condition can benefit in their recovery with the aid of physical medicine and rehabilitation services. Aim To determine the proportion of patients discharged from a general hospital with a potentially disabling condition, who were deriv...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872017001201541
更新日期:2017-12-01 00:00:00
abstract::Spontaneous hemoperitoneum secondary to intraabdominal variceal rupture, is an uncommon and highly lethal complication of cirrhosis. We report a case of a 68 years old male submitted because of abdominal pain and fainting. The clinical and laboratory work up concluded that the patient had cirrhosis and hemoperitoneum....
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2002-04-01 00:00:00
abstract:BACKGROUND:Illicit drug abuse is a public health problem, generally starting in adolescence. Medical students are not an exception. AIM:To assess the consumption of illicit drugs among medical students of the Pontificia Universidad Católica de Chile. MATERIAL AND METHODS:A questionnaire used by the National Council f...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872009000400002
更新日期:2009-04-01 00:00:00
abstract::The model of epidemiological transition proposed by Omram explains the changes in disease patterns in communities. In societies with a high level of development this model has been complemented with the study of the post transition process. In this context, the emergence of allergic diseases, asthma and subsequently, ...
journal_title:Revista medica de Chile
pub_type: 社论
doi:10.4067/s0034-98872006000600001
更新日期:2006-06-01 00:00:00
abstract::The mortality of acute bacterial meningitis (BM) has remained stable in the last decades in spite of the use of new antibiotics, probably due to vascular complications. We report a 68-year-old woman with BM who had a malignant infarction of left middle cerebral artery territory 72 hours after admission to the hospital...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872004001000009
更新日期:2004-10-01 00:00:00
abstract:BACKGROUND:Valsartan is an angiotensin AT1 receptor antagonist. Clinical studies have shown that this is an effective and well tolerated drug. AIM:To compare valsartan with other commonly used antihypertensives in a National multicentric study. MATERIAL AND METHODS:Between 1997 and 1998, a pharmacological surveillanc...
journal_title:Revista medica de Chile
pub_type: 临床试验,杂志文章,多中心研究
doi:
更新日期:2000-05-01 00:00:00
abstract:BACKGROUND:Pharmacological treatment improves survival in patients with heart failure with reduced ejection fraction. The use of sacubutril/valsartan and ivabradine has been recently approved and incorporated in the latest guidelines. AIM:To identify candidates eligible for these therapies among patients treated in a ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872019000300330
更新日期:2019-03-01 00:00:00
abstract::Constrictive Pericarditis (CP) is an unusual disease. Its most common causes are idiopathic or secondary to cardiac surgery. Less frequently it is caused by connective tissue diseases. We report a 30 years old woman hospitalized due to progressive dyspnea, chest pain and signs of right sided heart failure. During her ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872014000800015
更新日期:2014-08-01 00:00:00
abstract::There is a close link between hypertension and atherosderosis. Hypertension causes atherosclerotic damage of several organs, called target organs and the risk factors for hypertension and atherosderosis are very similar. The risk of mortality associated to hypertension increases with blood pressure values below the cu...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:/S0034-98872010000300015
更新日期:2010-03-01 00:00:00
abstract::We analyzed 33 patients with recurring nodular goiter (from a population of 2,500 operated patients). Recurrence occurred 0.7 to 12 years after surgery. T4, T3, TSH, perchlorate and TRH tests were performed in 18. Results were similar to those in 13 operated patients without recurrence. Administration of thyroid hormo...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:Title revalidation of foreign medical graduates to practice medicine in Chile is a complex and expensive process. According to the legislation they are required to approve the Unique National Exam of Medical Knowledge (EUNACOM), which has a theoretical and a practical section. AIM:To demonstrate that a coll...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872018000200232
更新日期:2018-02-01 00:00:00
abstract::The aim of this study was to compare in vitro activity, measuring minimal inhibitory concentration, of amoxicillin or its combination with clavulanic acid against 109 strains of Acinetobacter baumanii, 104 strains of Hemophilus influenzae and 94 strains of Staphylococcus aureus. All these were obtained from different ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1993-08-01 00:00:00
abstract:BACKGROUND:Microbial invasion of amniotic cavity occurs in 30 to 50% of patients with premature membrane rupture. AIM:To determine the outcomes associated with microbial invasion of the amniotic cavity (MIAC) in patients with preterm premature rupture of membrane (pPROM). PATIENTS AND METHODS:One hundred thirty four ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872005000100007
更新日期:2005-01-01 00:00:00
abstract::This article analyzes important changes in medical practice, focusing in those most deeply perceived by a group of physiciansfrom the Metropolitan Region of Santiago, included in a joint research conducted by the Departments of Psychiatry and Mental Health (East) of the Medical Faculty at the University of Chile and P...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872004000600015
更新日期:2004-06-01 00:00:00