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[Restless legs syndrome: long-term follow-up of a series of patients].

Abstract：

BACKGROUND:Restless legs syndrome (RLS) affects 10% of the general population. AIM:To analyze a series of patients with a minimum follow-up period of four years, treated during an interval of 14 years. MATERIAL AND METHODS:Retrospective analysis of medical records of 200 patients assessed and followed by the authors at a private outpatient clinic. RESULTS:Fifty patients aged 25 to 90 years (34 females), who had a mean follow-up of 6,3 years (range 4-14 years), were selected. Sixty percent responded to therapy that initially consisted in dopamine agonists in 78% of cases. Thirty four percent remained symptomatic and 4% worsened. RLS severity scale improved from an initial score of 19,2 to 12,5 at the last follow-up visit (p < 0.05). Thirty-three patients (66%) experienced an overall worsening of symptoms beyond pretreatment levels during follow-up. The strategies to overcome this augmentation were the change to another agonist, use of ligands such as pregabalin and gabapentin, opioids and iron. Low ferritin was common in most of the patients in whom it was measured (24 of 45 results), mainly in those with augmentation (p < 0,05). Six percent of patients treated with dopamine agonist developed an impulse control disorder. CONCLUSIONS:RLS is a treatable condition during a long period of follow-up in most patients. We found a high rate of potentiation at presentation which can be explained by the inadequate use of high doses of dopaminergic agents.

journal_name

Rev Med Chil

journal_title

Revista medica de Chile

authors

Miranda C M,Hudson A L

doi

10.4067/S0034-98872016001200007

subject

Has Abstract

pub_date

2016-12-01 00:00:00

pages

1561-1566

issue

12

eissn

0034-9887

issn

0717-6163

pii

S0034-98872016001200007

journal_volume

144

pub_type

杂志文章

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