[Chronic kidney disease: classification, mechanisms of progression and strategies for renoprotection].

Abstract:

:Chronic kidney disease is a worldwide health problem. The incidence and prevalence of kidney failure is in constant increase, involving poor outcomes and high costs. The leading causes of kidney failure are type 2 diabetes and hypertension. The new initiative "Kidney Disease Improving Global Outcomes (KDIGO)" is a global public health approach to face this problem. A formal definition for chronic kidney disease and a staging of kidney diseases from kidney damage with preserved function to kidney failure, were proposed. We reviewed the main mechanisms involved in renal disease progression, with emphasis in the proteinuria and the intrarenal activation of renin angiotensin system. Moreover, the evidence in the literature of therapeutical interventions with proved efficacy in slowing the rate of reduction of renal function is discussed, particularly the optimal control of hypertension, reduction of proteinuria and renin angiotensin system blocking. Finally, we recommend a strategy for the clinical management of patients in the different stages of chronic kidney disease.

journal_name

Rev Med Chil

journal_title

Revista medica de Chile

authors

Mezzano S,Aros C

doi

10.4067/s0034-98872005000300011

subject

Has Abstract

pub_date

2005-03-01 00:00:00

pages

338-48

issue

3

eissn

0034-9887

issn

0717-6163

pii

S0034-98872005000300011

journal_volume

133

pub_type

杂志文章,评审
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  • [Prevalence of obesity among Chilean women in childbearing ages].

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    doi:

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    doi:

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  • [Prevalence of metabolic syndrome among Chilean adults].

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    abstract::The prevalence of obesity among children and teenagers is increasing by 1.5% per year, probably due to a higher consumption of highly caloric foods and to physical inactivity. Hypercholesterolemia, increased insulin levels and high blood pressure of childhood obesity, precede atherosclerosis, coronary artery disease, ...

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  • [Immunophenotype. Clinical and laboratory features of acute lymphoblastic leukemia in Chile. Study of 500 children and 131 adults].

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  • [HRP/WHO: special program of research, development and research training in human reproduction, of the World Health Organization].

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    pub_type: 历史文章,杂志文章

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  • [Hospital case management].

    abstract::Due to demographic changes, rising health expenditures, and the reimbursement mechanisms of insurers in the past 30 years, physicians and nurses have had to change the way services are delivered. Concepts such as cost effectiveness and patient safety have also led to the emergence of case management. Case management, ...

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  • [Equity in health and health technology assessment in Chile].

    abstract::Equity has been recognized as one of the driving principles of many health systems in the world. In Latin America, Chile has led the explicit inclusion of equity in their health policies, which is reflected in its recent health reform. On the other hand, Chile faces the challenge of defining and implementing a policy ...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章,评审

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  • [Hyperthyroxinemia and clinical euthyroidism. Report of one case].

    abstract::The association of hyperthyroxinemia and euthyroidism is frequent and characterized by high plasma thyroxin concentrations, normal TSH values and absence of clinical signs of hyperthyroidism. We report an asymptomatic 28 years old male presenting with a serum total plasma thyroxin of 18.5 micrograms/dl (N 6.1-12.5), a...

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    pub_type: 杂志文章

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    authors: López JM,Mosso L,Campino C

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  • [IgG4 associated nephritis and recurrent hemoptysis: Case report].

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    pub_type: 杂志文章

    doi:10.4067/S0034-98872017000100018

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