Abstract:
BACKGROUND:New vaccination strategies are needed to control the increasing problem of pertussis in teenagers and adults. AIM:To determine the immunogenicity and reactogenicity of a diphtheria-tetanus-acellular pertussis (dTpa) vaccine with reduced antigen content. MATERIAL AND METHODS:A single dose of the dTpa vaccine was administered to 60 children 10 to 11 years old and 60 healthy adults. At the moment of vaccination and one month later, antibody levels were measured against 3 B pertussis antigens: anti-pertussis toxin (PT), anti-pertactin (PRN) and anti-filamentous hemagglutinin (FHA), as well as anti-tetanus and anti-diphtheria antibodies. Local and general symptoms were registered during 14 days following vaccine administration. RESULTS:Antibody response for PT, FHA and PRN was 98.3%, 100% and 100% in adults and 98.2%, 100% and 98.2% in children. Seropositivity for all pertussis antigens was 100% in adults and in children one month after vaccination. Geometric mean titers (GMT) significantly increased in adults and children. The seroprotection level achieved for tetanus and diphtheria antibodies one month after vaccination was 96.7% for adults and 100% for children, respectively. No serious adverse events were reported during the study. Among local symptoms pain was the most frequent (88-90%), but it was mostly mild or moderate. Solicited general symptoms observed for children and adults, respectively, included headache (37% and 53%), fatigue (18% and 35%) gastrointestinal symptoms (18% and 25%) and fever (8% and 3%). Only one vaccinee had fever above 39 degrees C. CONCLUSIONS:The dTpa vaccine showed an adequate safety profile and induced an intense immunological response to all antigens in adults and children aged 10-11.
journal_name
Rev Med Chiljournal_title
Revista medica de Chileauthors
Abarca K,Valdivieso F,Potin M,Ibáñez I,Vial Psubject
Has Abstractpub_date
2002-05-01 00:00:00pages
502-10issue
5eissn
0034-9887issn
0717-6163journal_volume
130pub_type
杂志文章abstract::On 17-19 May 2006, the World Health Organization (WHO) and the March of Dimes Birth Defects Foundation held a meeting in Geneva: The Management of Birth Defects and Haemoglobin Disorders. Meeting participants included 18 experts from developing and industrialized countries, including the author and nine staff from WHO...
journal_title:Revista medica de Chile
pub_type:
doi:10.4067/s0034-98872007000600018
更新日期:2007-06-01 00:00:00
abstract:BACKGROUND:Reproductive number (R0)-maps estimate risk zones of vector-borne diseases and geographical distribution changes under climate change. AIM:To map R0 aiming to estimate the epidemiological risk of Chagas disease in Chile, its distribution and possible changes due to the global climate change. MATERIAL AND M...
journal_title:Revista medica de Chile
pub_type: 杂志文章
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abstract:BACKGROUND:The ras gene family (H-ras, N-ras and K-ras) are oncogenes that mutate frequently in human cancer, specially in tumors of the biliary tract and pancreas. AIM:To determine the frequency of K-ras gene codon 12 mutation in pancreatic and biliary tumors. MATERIAL AND METHODS:Samples of 35 gallbladder, 15 ampul...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872005001200004
更新日期:2005-12-01 00:00:00
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journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:10.4067/S0034-98872016000900012
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abstract::In the context of a festschrift to commemorate the 125th anniversary of the Revista Médica de Chile, "radiography" of the journal has been depicted using several scientometric indicators. Among the mainstream journals in the category of Medicine, General & Internal and taking into account the wide editorial coverage a...
journal_title:Revista medica de Chile
pub_type: 历史文章,杂志文章
doi:
更新日期:1997-07-01 00:00:00
abstract:BACKGROUND:Type 2 diabetes etiology has a strong genetic component. More than 20 genetic variants have been associated with diabetes and other metabolic markers. However, the polymorphism rs7903146 of the TCF7L2 gene has shown the strongest association. AIM:To investigate the association of TCF7L2 (rs7903146) genotype...
journal_title:Revista medica de Chile
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doi:10.4067/S0034-98872019000800965
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journal_title:Revista medica de Chile
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doi:
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journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872015000400010
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journal_title:Revista medica de Chile
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journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872019000700828
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journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1989-07-01 00:00:00
abstract::We report preliminary results of treatment of Hodgkin disease according to the National Protocol on Antineoplastic Drugs. 37 males and 22 females with a median age of 34 years (range 16 to 76) were treated. Patients with stages I or II received radiotherapy alone or chemotherapy (C-MOPP) followed by radiotherapy. Pati...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
abstract::Approximately, 10% of cirrhotic patients with ascites become refractory to medical treatment, a condition that reduces overall survival. TIPS is a therapeutic alternative for the management of refractory ascites. It corrects sinusoidal portal hypertension, becoming a rational and relatively safe therapeutic approach. ...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:
更新日期:1999-10-01 00:00:00
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journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872008001100005
更新日期:2008-11-01 00:00:00
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journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872004000200003
更新日期:2004-02-01 00:00:00
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journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872007000700013
更新日期:2007-07-01 00:00:00
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journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872011000800005
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND:Approximately 150 subjects per year suffer severe burns in Chile. AIM:To analyze sociodemographic/clinical features and outcomes of severely burned patients. MATERIAL AND METHODS:Retrospective cohort study of 936 patients aged 47 ± 20 years (66% males), admitted to the National Burn Center of Chile between...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872013000200006
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journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872010000800011
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journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872015001000005
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journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
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abstract:BACKGROUND:Intestinal intussusception, a medical emergency, is more commonly idiopathic and ileocolic and occurs with higher frequency in children aged 6 months to 2 years. Barium enema confirms the diagnosis and allows its hydrostatic reduction, that is the treatment of choice of this condition. AIM:To report our exp...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract::Human immunodeficiency virus infection raises ethical issues in medical practice. This work presents several problems with ethical connotations related to HIV infections, observed by a neurologist during his medical practice. Patient-physician relationships, confidentiality, the request of patient consent to perform d...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1994-10-01 00:00:00
abstract::Two atypical cases of parvovirus B19 infection occurred consecutively within a family. A 14 year-old patient presented an extended papular-purpuric "gloves and socks" syndrome and two weeks later his mother developed a predominantly unilateral purpuric rash in the limbs with severe malaise. Specific IgM antibodies in ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872008000500011
更新日期:2008-05-01 00:00:00
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journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872010000300005
更新日期:2010-03-01 00:00:00
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journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:
更新日期:2001-06-01 00:00:00
abstract:BACKGROUND:Chronic obstructive pulmonary disease (COPD) has a relevant impact on health-related quality of life (HRQoL). Short Form 6 dimensions (SF-6D) quality of life tool allows researchers to calculate preference-based utilities using data from SF-12 or SF-36 questionnaires. AIM:To provide normative values of SF-6...
journal_title:Revista medica de Chile
pub_type: 杂志文章
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更新日期:2017-02-01 00:00:00
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journal_title:Revista medica de Chile
pub_type: 杂志文章
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更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:Uterine cervical cancer (UCC) is an important public health problem in Chile. Although HPV infection has been established as the main cause of UCC, little is known of its frequency and distribution in our population. AIM:To determine the presence and frequency of viral genotypes in uterine cervical specimen...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2003-12-01 00:00:00
abstract::Infections caused by Listeria monocytogenes are usually found in cattle and occasionally appear in humans, particularly pregnant women and immunocompromised individuals. Peritonitis by Listeria monocytogenes is a rare but dangerous condition that must be recognized early, since it requires a specific treatment. We rep...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872006000900013
更新日期:2006-09-01 00:00:00