[Results of acute myeloid leukemia treatment. Analysis of 63 patients between 2010-2014].

Abstract:

BACKGROUND:Acute myeloid leukemia (AML) is the most common acute leukemia in adults, emphasizing its high recurrence rate despite hematopoietic cell transplantation (HCT). AIM:To report the results of AML treatment at the Catholic University of Chile Clinical Hospital. PATIENTS AND METHODS:Review of medical records of patients with AML. RESULTS:63 patients, median age 55.4 years (range:16-89), treated between 2010 and 2014. Admission laboratory values showed (median values): leukocytes 45.989/mm³, hemoglobin 9.1 g/dl, platelets 75.548/mm³, peripheral blood blasts 38% and bone marrow blasts 74%. According to cytogenetic risk classification we observed the following groups: favorable 8% (n = 5), intermediate 51% (n = 32), unfavorable 13% (n = 8) and unknown 28% (n = 17). Seventy five percent of patients received induction chemotherapy and 25% palliative care. Median survival of treated and palliative care patients was 27.3 and 1 month respectively. Induction chemotherapy (IC) mortality (ICM) was 4.2%. Seventy percent (n = 33) of patients who received IC had complete response (CR) with a 3-year relapse free survival (RFS) of 25% and overall survival (OS) of 31%. Multivariate analysis demonstrated that achievement of CR, cytogenetic risk group and receiving consolidation chemotherapy were significantly associated with better RFS and OS. CONCLUSIONS:AML treatment with standard chemotherapy in our center achieves similar results to what has been described in international series regarding induction rates and ICM, however RFS and OS are still very low, especially in intermediate and high cytogenetic risk groups.

journal_name

Rev Med Chil

journal_title

Revista medica de Chile

authors

Fuentes M,Rojas P,Ernst D,Ocqueteau M,Bertin P,Sarmiento M,Ramírez P

doi

10.4067/S0034-98872015001000005

subject

Has Abstract

pub_date

2015-10-01 00:00:00

pages

1269-76

issue

10

eissn

0034-9887

issn

0717-6163

pii

S0034-98872015001000005

journal_volume

143

pub_type

杂志文章
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    doi:

    authors: Danhier A,Brieva J,Villegas G,Yates T,Pérez H,Boggiano G

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  • [Acquired hemophagocytic syndrome treated with HLH 94-04 chemotherapy protocol: Report of four cases].

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  • [Diethylpropion in magisterial formulations. Influence of cellulosis derivatives on in vitro stability and availability].

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    doi:

    authors: Gómez M,Alvarez A,Cid E

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  • [Integrons and resistance gene cassettes: structure and role against antimicrobials].

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    doi:

    authors: Sánchez G,Zulantay I,Gajardo M,Venegas J,Villanueva R,Pérez A,Liendo F,Apt W,Solari A

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  • [Psychosocial and familial variables associated with teenage pregnancy].

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    doi:

    authors: Burrows R,Rosales ME,Alayo M,Muzzo S

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  • [Hospital case management].

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  • [Prevention and treatment of obesity since childhood: strategy to decrease the non transmissible chronic diseases in adult].

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    journal_title:Revista medica de Chile

    pub_type: 杂志文章,评审

    doi:

    authors: Burrows R

    更新日期:2000-01-01 00:00:00

  • [Evolution of internal medicine and its specialties in the last decades: an outward view].

    abstract::The development of the subspecialties of internal medicine in the western world is reviewed from a historical perspective, focusing on the case of the United States of America. During the last decades, changes both in society and in medicine as a whole have prompted a great dispersion of medical practice styles, not a...

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    pub_type: 历史文章,杂志文章

    doi:

    authors: Rosselot E

    更新日期:1996-04-01 00:00:00

  • [Metabolic control of non insulin dependent diabetes mellitus in surgery].

    abstract::We followed 50 type II diabetic patients undergoing various types of surgical procedures. Control of blood sugar was evaluated as percent of tests within an acceptable limit defined as 160 mg/dl in the preoperative period, 80-240 mg/dl in the early postoperative period and 80-120 mg/dl thereafter. Adequate control was...

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    authors: Morales H,Maiz A,Arteaga A

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  • [Raúl B. Etcheverry, M.D. (1909-2014)].

    abstract::Professor Raúl B. Etcheverry, M.D., was a founder of Chilean Hematology back in the 1940's and a practicing physician and teacher until an advanced age. Being a superb clinician, he was admired by his ability to unveil from the most common to the most difficult diagnosis of blood disorders and neoplasms by examining b...

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    pub_type: 传,历史文章,杂志文章

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    authors: Reyes B H

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  • [Association between food addiction and nutritional status in Chilean college students].

    abstract:BACKGROUND:High calorie foods, especially high in sugar and sodium may have an addictive potential. Experimental rats are able to develop symptoms and neurochemical changes, comparable to those observed in drug abuse, when they are exposed intermittently to sucrose. AIM:To evaluate the association between nutritional ...

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  • [Transplacental alloimmunization against specific platelet antigens: prevalence and features in a Chilean population].

    abstract:BACKGROUND:Neonatal alloimmune thrombocytopenia (NAIT) is a result of fetomaternal incompatibility. Platelet destruction is caused by a maternal antibody directed against a fetal platelet antigen inherited from the father and lacking on the mother's platelets. The incidence and features of transplacental alloimmunizati...

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    doi:/S0034-98872008001000013

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  • [Wernicke's encephalopathy and dialysis: report of two cases].

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    authors: Toro J,Sacks C,Fuentes R

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  • [Bioethical challenges of stem cell tourism].

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  • [Bovine serum albumin (BSA) antibodies in children with recently diagnosed type 1 diabetes with breast feeding and milk exposition].

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    authors: Oyarzún A,Santos JL,Carrasco E,Albala C,Salinas A,Pérez F

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  • [Renal transplantation in patients with neurogenic bladder].

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    journal_title:Revista medica de Chile

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  • [Mitochondrial DNA heteroplasmy of the m.3243A>G mutation in maternally inherited diabetes and deafness].

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  • [Environmental risk factors in the development and evolution of inflammatory bowel disease].

    abstract::Environmental factors may influence the development of Inflammatory Bowel Disease and modify its natural history. The objective of this review is to evaluate current evidence about environmental factors associated with the disease. A better knowledge about the pathogenesis of the disease can lead to better treatment s...

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  • [Prolonged treatment with acyclovir in recurrent genital herpes. Clinical, virological, and immunological response].

    abstract::The effect of a prolonged course of oral acyclovir was evaluated in 55 pts with recurrent genital herpes (36 men and 19 women). The pts were voluntarily enrolled after an acute episode, with tissue culture viral isolation. All the pts received an initial course with 200 mg of acyclovir x 5 for 10 days. Then they were ...

    journal_title:Revista medica de Chile

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Velasco M,Saavedra T,Sepúlveda C,Suárez M

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  • [Cytogenetic study of acute and chronic leukemias].

    abstract::From 1983 to 1987 we studied 30 patients with leukemia searching for chromosomal alterations. Cytogenetic studies of bone marrow showed an abnormal karyotype in 19 (67%). Seven out of 14 cases of acute leukemia presented different chromosomic alterations. The Philadelphia chromosome was found in 11 patients with chron...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Conte G,Torrens M,Larraín C,Be C,Daher V,Youlton R

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  • [Use of hyperbaric oxygenation for wound management].

    abstract::Hyperbaric oxygenation consists in exposing patients to increased gas pressures while inhaling pure oxygen. It involves the use of hyperbaric chambers that can double or triple gas pressure inside them. Hyperbaric oxygenation may be useful in different clinical situations, but mostly for the treatment of decompression...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章,评审

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  • [Umbilical cord hematopoietic precursors transplantation. Report of five patients].

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    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:/S0034-98872009000800009

    authors: Burotto P M,Bertín C-M P,Galindo A H,Garrido S M,Melgoza P G,Nervi N B,Ramírez V P,Ocqueteau T M,Besa de C P,García V V,Jara A V,Alvarez J E,Betancur B M,Rivera L M,Alvarez Z M

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  • [Ethical problems in daily medical practice].

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    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Rosselot E

    更新日期:1994-01-01 00:00:00

  • [Epidemiological profile of liver cirrhosis in Chile 1970-1992].

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    pub_type: 杂志文章

    doi:

    authors: Serra I,Araneda J,Decinti E

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  • [Application of a system of serological surveillance of Chagas disease in a region of high chagasic endemia. I. Prevalence of Trypanosoma cruzi infection in Salamanca].

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    doi:

    authors: Lorca M,Reyes V,Muñoz P,Tassara R,Canales M,Mercado R,Atías A

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  • [Intensive chemotherapy for Burkitt lymphoma in HIV positive patients].

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