当前位置： SCI文献检索 > REVISTA MEDICA DE CHILE期刊下所有文献 > [Transplacental alloimmunization against specific platelet antigens: prevalence and features in a Chilean population].

[Transplacental alloimmunization against specific platelet antigens: prevalence and features in a Chilean population].

Abstract：

BACKGROUND:Neonatal alloimmune thrombocytopenia (NAIT) is a result of fetomaternal incompatibility. Platelet destruction is caused by a maternal antibody directed against a fetal platelet antigen inherited from the father and lacking on the mother's platelets. The incidence and features of transplacental alloimmunization depend on the frequency of expression of platelet specific antigens; which are highly variable among different populations. AIM:To determine the prevalence and characteristics of transplacental alloimmunization in a large group of pregnant women in Chile. MATERIAL AND METHODS:We studied 3,041 samples obtained during the third trimester of gestation. In all samples, anti platelet antibodies were screened by ELISA with platelet membranes fixed to a microtiter plate. Positive samples were further studied for antigenic specificity with the monoclonal antibody specific immobilization of platelet antigens (MAIPA) test. RESULTS:Anti platelet antibodies were found in 261 samples (8.5%). The MAIPA test identified 6 samples with antibodies directed against major platelet membrane glycoproteins, 2 anti GPIb, 2 anti GPIIb/IIIa and 2 anti GPIa/IIa. In four cases, anti HLA antibodies coexisted. Two cases corresponded to well defined platelet antigen systems: one anti HPA-1a and one anti HPA-5b. No clinical evidence of thrombocytopenia of the newborn was detected in all these cases with anti GP antibodies. CONCLUSIONS:A prevalence of platelet specific antibodies of 0.2% with only one anti HPA-1a was detected. These findings are in contrast with those of other populations but in accordance with the low frequency of the HPA-1 b/b phenotype in the Chilean population. The very low incidence of platelet specific antibodies and the lack of association with clinical thrombocytopenia in the newborn, do not support the recommendation of routine antenatal screening to all women in Chile.

journal_name

Rev Med Chil

journal_title

Revista medica de Chile

authors

Pereira J,Soto M,Hidalgo P,Amaya S,Mezzano D

subject

Has Abstract

pub_date

1997-12-01 00:00:00

pages

1449-56

issue

12

eissn

0034-9887

issn

0717-6163

journal_volume

125

pub_type

杂志文章

相关文献

REVISTA MEDICA DE CHILE文献大全
  • [A workshop to improve written communication skills of medical students].

    abstract：BACKGROUND:Despite being among the best academically prepared of the country, many medical students have difficulties to communicate in writing. In 2005, the School of Medicine at the Pontificia Universidad Católica de Chile introduced a writing workshop in the undergraduate curriculum, to enhance the students' writing...

    journal_title：Revista medica de Chile

    pub_type： 杂志文章

    doi：/S0034-98872009000500004

    authors： Bitran M,Zúñiga D,Flotts P,Padilla O,Moreno R

    更新日期：2009-05-01 00:00:00

  • [Long term results of mitral balloon valvuloplasty].

    abstract：BACKGROUND:Mitral balloon valvuloplasty (MBV) is the therapy of choice for the treatment of symptomatic mitral stenosis with suitable anatomy. Although its short and mid-term results are favorable, there is a paucity of information about long-term follow-up. AIM:To assess the late results of MBV. MATERIAL AND METHODS...

    journal_title：Revista medica de Chile

    pub_type： 杂志文章

    doi：10.4067/S0034-98872014001100001

    authors： Martínez R G,Fajuri N A,Córdova A S,Braun J S,Marchant D E,Guarda S E,Veas P N,Méndez L M,Lindefjeld C D,Pérez P O,Flores A,Valenzuela E,Martínez S A

    更新日期：2014-11-01 00:00:00

  • [Potential difference of the gastric mucosa in gastroduodenal disease. Relation with endoscopical and histologic findings].

    abstract：:Most studies of gastric transmucosal potential difference concern acute damage. We studied this phenomenon in 168 patients with different pathologic processes: erosive gastritis, duodenal and prepyloric ulcer, atrophic gastritis, gastric ulcer and normal controls. Ag-AgCl electrodes and Agar-KCl bridges were used to r...

    journal_title：Revista medica de Chile

    pub_type： 杂志文章

    doi：

    authors： Defilippi C,Morales A,Smok G,Angelo S

    更新日期：1989-04-01 00:00:00

  • [No association between insulin sensitivity and serum lipid levels in postmenopausal women].

    abstract：BACKGROUND:It is not clear if changes in serum lipid profile during menopause are related to changes in the distribution of fat or to insulin resistance. AIM:To look for an association between insulin resistance and changes in serum lipid levels in post menopausal women. PATIENTS AND METHODS:Cross-sectional study of ...

    journal_title：Revista medica de Chile

    pub_type： 杂志文章

    doi：10.4067/s0034-98872007000500009

    authors： Zavalza AB,Grover FP,Mora JM,Centeno M,Anaya RP

    更新日期：2007-05-01 00:00:00

  • [Impact of an educational manual on knowledge and attitudes of rheumatic patients and health care workers].

    abstract：BACKGROUND:Education may induce voluntary behavioral changes in patients that lead to an improvement in health status. AIM:To assess the impact of the educational manual "Aches and Pain" on knowledge and attitudes of patients with chronic rheumatism and paramedics, using an instrument with 40 asseverations extracted f...

    journal_title：Revista medica de Chile

    pub_type： 杂志文章

    doi：

    authors： Pacheco D,Berdichevsky R,Ballesteros F,Fuentealba C,Arinoviche R,Jérez J

    更新日期：1996-09-01 00:00:00

  • [Geographical distribution of mortality caused by stomach, trachea, bronchi and lung malignant tumors in Chile].

    abstract：BACKGROUND:Maps have played a critical role in public health since 1855, when John Snow associated a cholera outbreak with contaminated water source in London. After cardiovascular diseases, cancer is the second leading cause of death in Chile. Cancer was responsible for 22.7% of all deaths in 1997-2004 period. AIM:To...

    journal_title：Revista medica de Chile

    pub_type： 杂志文章

    doi：/S0034-98872007001100005

    authors： Icaza N MG,Núñez F ML,Torres A FJ,Díaz S NL,Várela G DE

    更新日期：2007-11-01 00:00:00

  • [Effectiveness of a case management intervention for high blood pressure and type II diabetes in primary health care].

    abstract：BACKGROUND:Adequate management of high blood pressure (HBP) and Type 2 Diabetes (DM2) is a challenge to the healthcare system in Chile. AIM:To evaluate the effectiveness of a case management (CM) approach to manage HBP and DMII at Primary Healthcare (PHC) level, headed by healthcare technicians with the supervision of...

    journal_title：Revista medica de Chile

    pub_type： 杂志文章,多中心研究

    doi：10.4067/S0034-98872018001101269

    authors： Poblete F,Barticevic N,Bastías G,Quevedo D,Vargas I

    更新日期：2018-11-01 00:00:00

  • [Obesity as a risk factor for complications during acute respiratory infections in children].

    abstract：:Obesity has a high prevalence among children. On the other hand, acute respiratory infections especially of viral origin, are an important cause of morbidity and mortality in this age group. During the recent pandemic of influenza A (H1N1) virus, obesity was identified as a novel independent risk factor for severity m...

    journal_title：Revista medica de Chile

    pub_type： 杂志文章,评审

    doi：10.4067/S0034-98872016000900012

    authors： Fuenzalida L,García-Díaz DF

    更新日期：2016-09-01 00:00:00

  • [Wernicke's encephalopathy and dialysis: report of two cases].

    abstract：:Wernicke encephalopathy is considered a complication of dialytic therapy, but there are few reports of this complication. We report a 57 years old man and a 45 years old woman, with grade IV renal failure, who after acute peritoneodialysis and chronic hemodialysis respectively, had a confusional syndrome that responde...

    journal_title：Revista medica de Chile

    pub_type： 杂志文章

    doi：

    authors： Toro J,Sacks C,Fuentes R

    更新日期：1997-05-01 00:00:00

  • [Mushroom poisoning in the IX region. Role of Amanita gemmata].

    abstract：:We report four episodes of mushroom poisoning that occurred between 1986 and 1990 in the province of Malleco. Twenty five of 36 individuals who ingested the mushroom became ill; they had an acute gastroenteritis that was followed in 7 by an acute hepatitis and in one by a massive upper gastrointestinal bleeding. Three...

    journal_title：Revista medica de Chile

    pub_type： 杂志文章

    doi：

    authors： Sierralta A,Jeria ME,Figueroa G,Pinto J,Araya JC,San Juan J,Grinbergs J,Valenzuela E

    更新日期：1994-07-01 00:00:00

  • [Evaluation of a program for management of metabolic syndrome in adults with overweight and obesity].

    abstract：BACKGROUND:The Chilean Ministry of Health developed a healthy lifestyles intervention directed to adults with overweight and cardiovascular risk factors, called "Program on Healthy Eating and Physical Activity" (PASAF). AIM:To evaluate the impact of PASAF on nutritional status and metabolic parameters. PATIENTS AND M...

    journal_title：Revista medica de Chile

    pub_type： 杂志文章

    doi：10.4067/S0034-98872014000700001

    authors： Henríquez S,Barrera G,Hirsch S,de la Maza MP,Jara N,Leiva L,Bunot D

    更新日期：2014-07-01 00:00:00

  • [Primary cholangiocarcinoma associated with Caroli disease].

    abstract：:A 68 years old male presented with right hypochondrium abdominal pain and jaundice with no other clinical finding. CAT Scan and Ultrasonography showed right lobe bile duct dilatation. Magnetic Resonance Cholangiopancreatography gave an outstanding vision of a restricted right lobe bile duct dilatation associated to ch...

    journal_title：Revista medica de Chile

    pub_type： 杂志文章

    doi：

    authors： Faría G,de Aretxabala X,Sierralta A,Flores P,Burgos L

    更新日期：2001-12-01 00:00:00

  • [Suprarenal inferior vena cava filters. Retrospective review of 30 cases].

    abstract：BACKGROUND:Inferior vena cava (IVC) filters are used to prevent massive pulmonary embolism in cases where anticoagulation is contraindicated or has failed. It is usually implanted below the renal veins. In a few cases it is necessary to deploy the filter above them, with theoretical risk of secondary renal failure. AI...

    journal_title：Revista medica de Chile

    pub_type： 杂志文章

    doi：/S0034-98872008001200005

    authors： Mariné L,Mertens R,Krämer Sch A,Valdés F,Bergoeing M,Arriagada I,Vergara J,Carvajal C

    更新日期：2008-12-01 00:00:00

  • [Perception of medical students about formative assessments during clinical courses].

    abstract：BACKGROUND:Formative evaluation is a range of formal assessment employed by professors during the teaching process in order to modify curriculum activities, to improve student attainment. For students, it is helpful to evaluate their learning process. Although recommended, it is seldom used. AIM:To evaluate the percep...

    journal_title：Revista medica de Chile

    pub_type： 杂志文章

    doi：10.4067/S0034-98872014000900014

    authors： Labarca J,Figueroa C,Huidobro B,Wright AC,Riquelme A,Moreno R

    更新日期：2014-09-01 00:00:00

  • [Delayed hypersensitivity to evoked antigens: normal values in Chilean young adults].

    abstract：:Delayed hypersensitivity skin test are widely accepted as in vivo measure of cellular immunity. Since genetic and environmental factors may affect these tests, each population must establish its own normal values. The aim of this work was to study delayed hypersensitivity in Chilean normal young adults. We studied the...

    journal_title：Revista medica de Chile

    pub_type： 杂志文章

    doi：

    authors： Jurlow E,Orvieto M,Guerrero J,Bezanilla CG,Cox P,Cartier E,Silva M

    更新日期：1996-01-01 00:00:00

  • [Familial association of epilepsy and cleft palate: an expression of predisposed common genetic factors or a teratogenic effect of the epilepsy genotype?].

    abstract：:The familial association of epilepsy and cleft lip with or without cleft palate (CL (P)) is analyzed assuming both entities share common genetic predisposing factors. The genealogical data stemming from 169 CL (P) probands and 168 epileptic probands yielded information on the prevalence rates of cleft and epileptic re...

    journal_title：Revista medica de Chile

    pub_type： 杂志文章

    doi：

    authors： Blanco R,Cifuentes L,Miranda M,Rameau MX,Muñoz MA,Jara L

    更新日期：1992-09-01 00:00:00

  • [Cutaneous infection by mycobacterium marinum: case report].

    abstract：:A 45 year old male who manipulated tropical fish ponds developed painless nodular plaques in both hands. Biopsy showed mononuclear infiltrate of the dermis with few granulomata. Repeated cultures revealed M. marinum (diagnosis confirmed at the WHO/PAHO Reference Center in Canada). Good initial results were obtained wi...

    journal_title：Revista medica de Chile

    pub_type： 杂志文章

    doi：

    authors： Guarda R,Gubelin W,Gajardo J,Rohmann I,Valenzuela MT

    更新日期：1992-09-01 00:00:00

  • [Comparison of Shigella susceptibility to commonly used antimicrobials in the Temuco Regional Hospital, Chile 1990 - 2001].

    abstract：BACKGROUND:The permanent surveillance of antimicrobial susceptibility of Shigella sp in the Temuco Regional Hospital, allowed us to define the empirical use of antimicrobials in dysenteric syndrome. AIM:To study antimicrobial susceptibility of Shigella strains collected from 1997 to May 2001 and compare the results wi...

    journal_title：Revista medica de Chile

    pub_type： 杂志文章

    doi：

    authors： Boehme C,Iglesias T,Loyola A,Soto L,Rodríguez G,Reydet P,Illesca V

    更新日期：2002-09-01 00:00:00

  • [Effects of smoking on plasma antimüllerian hormone concentrations among infertile women].

    abstract：BACKGROUND:Smoking may hamper female fertility, probably modifying ovarian reserve. Antimüllerian hormone (AMH) is an accurate marker for ovarian reserve. AIM:To look for an association between smoking status and plasma AMH concentration. PATIENTS AND METHODS:A cohort of 141 infertile women in a university setting in...

    journal_title：Revista medica de Chile

    pub_type： 杂志文章

    doi：10.4067/S0034-98872013000100003

    authors： Fuentes A,Escalona J,Céspedes P,Repetto V,Iñiguez G

    更新日期：2013-01-01 00:00:00

  • [Intestinal tuberculosis: analysis of clinical cases and autopsy].

    abstract：:Intestinal tuberculosis is rare compared to other forms of the disease. A review of the last 10 years in a General University hospital identified 21 cases diagnosed at autopsy and 8 during life. Most patients were males, older than 30 years of age, alcoholics and originating in southern Chile. Evidence of concomitant ...

    journal_title：Revista medica de Chile

    pub_type： 杂志文章

    doi：

    authors： Fica A,Belletti J,Cruzat C,Rojas D,Montalva M

    更新日期：1991-10-01 00:00:00

  • [Thyroid function tests in normal pregnant women (third trimester) and in pregnant women with pregnancy cholestasis or with acute hepatitis].

    abstract：BACKGROUND:Intrahepatic cholestasis of pregnancy (ICP) is a disease of unknown cause characterized by pruritus and biochemical cholestasis in the 3rd trimester of pregnancy. Its pathogenesis may be due to the interaction of abnormalities in the metabolism of estrogens and progesterone, while still unknown environmental...

    journal_title：Revista medica de Chile

    pub_type： 杂志文章

    doi：

    authors： Pineda G,Aguayo J,Ribalta J,González M,Reyes H

    更新日期：2000-01-01 00:00:00

  • [The training of specialists. The case of nephrologists].

    abstract：:Specialists must be trained in properly certified university centers. There are established applicant selection programs and mechanisms and faculties maintain a favorable learning environment. The careful selection of teachers must be based in their personal attributes, their interest and dedication to academic work a...

    journal_title：Revista medica de Chile

    pub_type： 杂志文章

    doi：

    authors： Vial S

    更新日期：1995-05-01 00:00:00

  • [The duty to inform in the Chilean legislation].

    abstract：:The new Chilean regulation about patients' rights and duties is generating a significant change in the information that health care professionals must provide to their patients. This issue will gravitate on medical liability. If this duty is accomplished incorrectly, professionals would fall into an illicit act and be...

    journal_title：Revista medica de Chile

    pub_type： 杂志文章

    doi：10.4067/s0034-98872018000800909

    authors： Pizarro W C

    更新日期：2018-08-01 00:00:00

  • [Rapidly progressing glomerulonephritis secondary to IgA nephropathy. A clinical case].

    abstract：:We report the case of a woman with rapidly progressive IgA nephropathy. She was treated with pulse methylprednisolone sodium succinate (1 g/d for three days), cyclophosphamide, dipyridamole and aspirin. The rapid progression of renal failure was apparently halted after 6 months. ...

    journal_title：Revista medica de Chile

    pub_type： 杂志文章

    doi：

    authors： Duclos J,Sánchez B,Espinosa R,Opazo H

    更新日期：1989-10-01 00:00:00

  • [CD44 (HCAM) expression in subserous gallbladder carcinoma].

    abstract：BACKGROUND:HCAM or CD44 is a multifunctional cell adhesion molecule, related to cell-cell, cell-extracellular matrix interactions and involved in tumor invasion. AIM:To study the importance of CD44 expression in subserous gallbladder carcinoma. MATERIAL AND METHODS:One hundred five samples (93 female) of subserous ga...

    journal_title：Revista medica de Chile

    pub_type： 杂志文章

    doi：

    authors： Roa I,Villaseca M,Araya J,Roa J,de Aretxabala X,Ibacache G,García M

    更新日期：2001-07-01 00:00:00

  • [Application of a system of serological surveillance of Chagas disease in a region of high chagasic endemia. I. Prevalence of Trypanosoma cruzi infection in Salamanca].

    abstract：:A serologic study for prevalence of Chagas infection was performed in Salamanca, Northern Chile. Indirect immunofluorescence and indirect hemagglutination reactions were used in samples from 1529 females and 698 males representing 10% of the population. A total of 499 positive results were obtained. The incidence of i...

    journal_title：Revista medica de Chile

    pub_type： 杂志文章

    doi：

    authors： Lorca M,Reyes V,Muñoz P,Tassara R,Canales M,Mercado R,Atías A

    更新日期：1991-04-01 00:00:00

  • [Dimensions of medical professionalism. Perspectives for the 21st. Century].

    abstract：:Medicine is progressively loosing its prestige and efficacy and needs to rebuild the moral values that maintain the tacit social contract subscribed between doctors and patients. This altruistic commitment to serve people has been devaluated by changes in health systems, by advances in knowledge and by social and econ...

    journal_title：Revista medica de Chile

    pub_type： 杂志文章

    doi：10.4067/s0034-98872006000500016

    authors： Rosselot J E

    更新日期：2006-05-01 00:00:00

  • [Measurement of maximal oxygen uptake in a Chilean population sample].

    abstract：BACKGROUND:Maximal oxygen uptake is considered by the International Biological Programme as the international standard of cardiorespiratory adequacy and physical condition. AIM:To measure maximal oxygen uptake in normal Chilean subjects, to establish normal reference values. SUBJECTS AND METHODS:Maximal oxygen uptake...

    journal_title：Revista medica de Chile

    pub_type： 杂志文章

    doi：

    authors： Donoso H,Osorio J

    更新日期：1997-09-01 00:00:00

  • [Neurology and HIV/AIDS infection: ethical problems].

    abstract：:Human immunodeficiency virus infection raises ethical issues in medical practice. This work presents several problems with ethical connotations related to HIV infections, observed by a neurologist during his medical practice. Patient-physician relationships, confidentiality, the request of patient consent to perform d...

    journal_title：Revista medica de Chile

    pub_type： 杂志文章

    doi：

    authors： Nogales-Gaete J

    更新日期：1994-10-01 00:00:00

  • Smoking promotes exacerbated inflammatory features in dendritic cells of Chilean rheumatoid arthritis patients.

    abstract：BACKGROUND:The dual potential to promote tolerance or inflammation when facing self-antigens makes dendritic cells (DCs) fundamental players in autoimmunity. There is an association between smoking and DCs maturation in patients with rheumatoid arthritis (RA). However, ethnicity is a key factor in autoimmune disorders....

    journal_title：Revista medica de Chile

    pub_type： 杂志文章

    doi：10.4067/s0034-98872018000200150

    authors： Prado C,Iruretagoyena M,Burgos PI,Pacheco R

    更新日期：2018-02-01 00:00:00