Abstract:
BACKGROUND:Intrahepatic cholestasis of pregnancy (ICP) is a disease of unknown cause characterized by pruritus and biochemical cholestasis in the 3rd trimester of pregnancy. Its pathogenesis may be due to the interaction of abnormalities in the metabolism of estrogens and progesterone, while still unknown environmental factor (s) modulate the expressivity of a genetic predisposing trait. AIMS:To verify if thyroid function tests (TFT) are altered in ICP as in other hepatic diseases and whether a dietary iodine deficiency could be involved. MATERIAL AND METHODS:From 1983 to 1986, 13 normal pregnancies (3rd trimester), 26 ICP patients (with 30 pregnancies) and 4 patients with acute non-A non-B hepatitis in pregnancy, were studied. Serum T3, rT3, T4, fT4 and TSH (before and after TRH) were measured by RIA; in ICP patients, measurements were repeated in puerperium. Urinary 24 h iodine excretion was measured in normal pregnancies and in 6 ICP patients. RESULTS:In normal pregnancies, T3 (3.00 +/- 0.22 nmol/L) and rT3 (0.40 +/- 0.03 nmol/L) were higher than the values detected in non-pregnant women; other TFT were unchanged. Urinary iodine excretion was normal in all individuals tested. Patients with acute hepatitis in pregnancy or with ICP had lower T3 than normal pregnancies (1.82 +/- 0.19 nmol/L in hepatitis; 2.24 +/- 0.12 nmol/L in ICP; p < 0.01) and higher rT3 (0.80 +/- 0.25 nmol/L in hepatitis; 0.54 +/- 0.05 nmol/L in ICP; p < 0.05), while other TFT were unchanged. None of them had clinical signs of hypo or hyperthyroidism. A "euthyroid sick syndrome" was detected in 2 ICP patients and in 2 acute hepatitis in pregnancy. In puerperium of ICP patients, T3 and rT3 returned to levels in non-pregnant women. CONCLUSIONS:In ICP patients, TFT show similar trends than in more severe hepatic and non-hepatic diseases. Although thyroid binding-globulin was not measured in our patients, the pattern of TFT suggests that an impaired peripheral (hepatic?) deiodination of T4 is responsible for these changes. The influence of a dietary iodine deficiency can be ruled out.
journal_name
Rev Med Chiljournal_title
Revista medica de Chileauthors
Pineda G,Aguayo J,Ribalta J,González M,Reyes Hsubject
Has Abstractpub_date
2000-01-01 00:00:00pages
35-43issue
1eissn
0034-9887issn
0717-6163journal_volume
128pub_type
杂志文章abstract::We report the case of a woman with rapidly progressive IgA nephropathy. She was treated with pulse methylprednisolone sodium succinate (1 g/d for three days), cyclophosphamide, dipyridamole and aspirin. The rapid progression of renal failure was apparently halted after 6 months. ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1989-10-01 00:00:00
abstract::Antibacterial potency of cephalosporins depends on inhibition (acylation) of one or more penicillin-binding proteins (PBP). Recently, reduced affinity of PBP for cephalosporins and other B-lactam agents has been found in some cases. Mechanism for these changes in affinity are analyzed in this review. ...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:
更新日期:1989-09-01 00:00:00
abstract:BACKGROUND:Aging is the main risk factor to acquire breast cancer (BC). Nevertheless BC in elderly patients is sub-represented in clinical trials. AIM:To describe the clinical characteristics and long term treatment results of localized BC in older women. MATERIAL AND METHODS:Review of medical records of 65 women age...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872013001200006
更新日期:2013-12-01 00:00:00
abstract::This paper undertakes an analysis of the scientific criteria used in the diagnosis of death and underscores the importance of intellectual rigor in the definition of medical concepts, particularly regarding such a critical issue as the diagnosis of death. Under the cardiorespiratory criterion, death is defined as "the...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:10.4067/s0034-98872004000100015
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:Celiac disease (CD) is an immune-mediated enteropathy triggered by the ingestion of gluten in genetically susceptible individuals. Its prevalence in Europe and the USA is 0.5 to 1%. AIM:To analyze epidemiological aspects and degree of compliance with gluten-free diet (GFD) among Chilean individuals with CD....
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872011000700003
更新日期:2011-07-01 00:00:00
abstract::Pulmonary hypertension is a clinical condition with a low prevalence, but carries high morbidity and mortality. Important advances in the understanding of this disease and in its therapy have occurred. A particular scenario is pulmonary hypertension in patients undergoing non-cardiac as well as cardiac surgery. The ai...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:/S0034-98872010000400016
更新日期:2010-04-01 00:00:00
abstract::In 160 girls from low and middle socio-economic class of Santiago we correlated the age at menarque with genetic markers such as ABO blood group, Rh, MN, Xg, haptoglobins, Esterase D and Phosphoglucomutase. No significant association of these markers and age at menarque was found. ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1990-07-01 00:00:00
abstract::The development of the subspecialties of internal medicine in the western world is reviewed from a historical perspective, focusing on the case of the United States of America. During the last decades, changes both in society and in medicine as a whole have prompted a great dispersion of medical practice styles, not a...
journal_title:Revista medica de Chile
pub_type: 历史文章,杂志文章
doi:
更新日期:1996-04-01 00:00:00
abstract:BACKGROUND:The Latin American Study of Congenital Malformations (ECLAMC) has performed an epidemiological surveillance of congenital malformations since 1967. This allows to detect any unexpected change in the incidence of malformations, possibly caused by a new environmental teratogenic agent. AIM:To report a summary...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872011000100010
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Self-efficacy refers to people's expectations about personal resources available for goal achievement. Higher self-efficacy expectations are correlated with higher academic performance. AIM:To analyze the psychometric properties of the Academic Behavior Self-Efficacy Scale (ABSES) and to describe Self-effic...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872019000700914
更新日期:2019-07-01 00:00:00
abstract::High blood pressure of unknown etiology has been related to many pathogenetic factors, mainly dietary salt intake, mental stress, alcohol consumption, sedentary living and aging. Hypertension is more common in condition such as obesity and diabetes mellitus. Sustained elevation of arterial pressure is mediated by vaso...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:
更新日期:1992-06-01 00:00:00
abstract:BACKGROUND:Annually, acute bronchiolitis (AB) occurrence peaks during winter and is probably associated with air pollution. AIM:To relate the number of ambulatory consultations, emergency and hospital admission due to AB with climatic factors and air pollution. PATIENTS AND METHODS:Patients of less than 1 year old wi...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2003-10-01 00:00:00
abstract:BACKGROUND:In Chile, cerebrovascular diseases are the fifth cause of death among men and the third cause among women. AIM:To assess the clinical features and management of patients with cerebrovascular disease admitted to a public hospital during 1997. PATIENTS AND METHODS:A retrospective analysis of clinical records...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2000-11-01 00:00:00
abstract:BACKGROUND:Vildagliptin is a dipeptidyl peptidase IV inhibitor (DPP4i). Its efficacy and safety of DPP4i in Chilean real life type 2 diabetic (T2D) patients is not well known. AIM:To assess the safety profile and effectiveness of 12 weeks of treatment with Vildagliptin for glycemic control in T2D Chilean patients with...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872015000100008
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:The preferred treatment for ischemic mitral insufficiency is mitral valve repair with a prosthetic ring, because it does not deteriorate left ventricular function, allowing better immediate and long-term results. AIM:To assess long-term results of mitral annuloplasty with a prosthetic ring for ischemic mitr...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872011001200003
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:Human and animal trichinosis has been recorded in Chile since the late XIX century and is irregularly distributed along the country. From high rates of infection in the early 1900, the frequency of this parasitosis in man has progressively decreased. AIM:To describe and discuss the epidemiological situation...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2002-03-01 00:00:00
abstract:BACKGROUND:The few studies in Chile assessing the nutritional status of indigenous children show a high prevalence of stunting, excess weight and feeding problems. AIM:To compare anthropometric indices in children from indigenous and non indigenous ancestry. SUBJECTS AND METHODS:School children aged 6 to 8 years old,...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1999-08-01 00:00:00
abstract::Geographical inequalities arising in the death of children under 1 year are studied. Causes regarded as avoidable at the present moment and leading to death are determined and the 27 Regional Chilean Health Services are ranked from best to worse in levels of mortality using cluster analysis. Results show that: 1) t...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1982-04-01 00:00:00
abstract::Embryo cryopreservation improves efficiency and security of assisted reproduction techniques. Nonetheless, it can be questionable, so it must be justified from technical, legal and ethical points of view. This article analyses these perspectives. Embryo cryopreservation maximizes the probability of pregnancy, avoids n...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872014000700011
更新日期:2014-07-01 00:00:00
abstract::Heterozygous familial hypercholesterolemia affects one every 400 individuals, is caused by mutations in the LDL receptor gene and is associated with premature coronary artery disease. Nowadays, LDL cholesterol can be efficiently reduced with the new therapies to reduce blood lipids. We report a female patient who cons...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872007000200011
更新日期:2007-02-01 00:00:00
abstract::A 54 years old female patient with a mitral valve prolapse and a rheumatoid arthritis treated with steroids was admitted with dyspnea and hypotension, that started 30 min after taking a pill containing enapril and hydrochlorothiazide. Hemodynamic monitoring with a Swan-Ganz catheter showed a pulmonary capillary pressu...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1996-06-01 00:00:00
abstract:AIM:To compare the efficacy of imipenem/cilastatine and ceftazidime-amikacin in the treatment of febrile neutropenic patients. DESIGN:Open, prospective and randomized clinical study. PATIENTS:Fifty two patients (26 female) aged 16 to 80 years old with 60 episodes of neutropenia were studied. They were randomly assign...
journal_title:Revista medica de Chile
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1995-03-01 00:00:00
abstract::Prader-Willi syndrome is an uncommon multisystem genetic disorder caused by defects of chromosome 15 (15qll-ql3), often due to deletions or uniparental disomy The syndrome is characterized by neonatal hypotonia, dysmorphic facial features, short stature, motor and mental disabilities, behavioral changes, hyperphagia, ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872009000200012
更新日期:2009-02-01 00:00:00
abstract:BACKGROUND:Professional Social Responsibility is now imperative for the practice of medicine. However, there are no instruments to assess it among physicians. AIM:To construct and evaluate the factorial structure and reliability of a questionnaire designed to measure socially responsible behavior in physicians. MATER...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872014000100014
更新日期:2014-01-01 00:00:00
abstract::Doppler-duplex has been widely used to quantify blood flow. Nevertheless, its usefulness in assessing portal vein flow (PVF) has been questioned due to technical problems: vessel cross sectional area measurements, interobserver variability, and PVF changes related to physiological events. This study was aimed to measu...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1991-05-01 00:00:00
abstract:BACKGROUND:The pathogenesis of secondary failure to hypoglycemic agents is heterogeneous. Some patients are true insulin dependent diabetics with a slow autoimmune disease suggested by their positive islet cell antibodies. Others, have an increased insulin resistance. AIM:To assess the frequency of positive islet cell...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1995-10-01 00:00:00
abstract:BACKGROUND:Inferior vena cava (IVC) filters are used to prevent massive pulmonary embolism in cases where anticoagulation is contraindicated or has failed. It is usually implanted below the renal veins. In a few cases it is necessary to deploy the filter above them, with theoretical risk of secondary renal failure. AI...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872008001200005
更新日期:2008-12-01 00:00:00
abstract::We evaluated 77 patients with symptomatic mitral stenosis for balloon valvuloplasty. Five patients were excluded from the procedure due to the presence of intra-atrial thrombi or mitral valve endocarditis as detected by 2D echocardiography. The mean age of the 72 treated patients was 38 +/- 11 years, 68 were NYHA func...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
abstract::Priapism is a rare complication of hematological diseases. Among leukemia, it is most frequently seen in patients with chronic myeloid leukemia, due to the high leukocyte counts that these patients achieve. We report a 22 years old male who presented with a priapism lasting more than 24 hours. Thirty six hours after a...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1998-08-01 00:00:00
abstract:BACKGROUND:The ideal number of nuclear medicine specialists in relation to the needs of a given population should be defined by the institutions training such specialists. AIM:To establish the relationship between the number of gammacameras, nuclear medicine specialists and the number of inhabitants in different count...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1996-12-01 00:00:00