Morbid obesity in an adolescent with Prader-Willi syndrome.

Abstract:

:Prader-Willi syndrome is an uncommon multisystem genetic disorder caused by defects of chromosome 15 (15qll-ql3), often due to deletions or uniparental disomy The syndrome is characterized by neonatal hypotonia, dysmorphic facial features, short stature, motor and mental disabilities, behavioral changes, hyperphagia, precocious obesity and hypogonadotropic hypogonadism. We present a 17 year-old woman, with a previous genetic diagnosis of Prader-Willi syndrome and BMI of 74 Kg/m(2), that was admitted in anasarca, with marked cyanosis, dyspnea and oliguria. She presented high levels of blood urea, creatinine and aminotransferases, in addition to hyperkalemia and hyperuricemia. She had been in regular use of fluoxetine during the last six months, and evolved with severe high blood pressure and respiratory failure, which needed intensive care support. Moreover, sequels and clear signs of recent self-injuries were observed in her trunk, forearms and hands. The findings of morbid obesity, anasarca, self-injury, hyperuricemia and hypoxemia in Prader-Willi syndrome are emphasized.

journal_name

Rev Med Chil

journal_title

Revista medica de Chile

authors

Santos VM,Henrique de Paula F,Osterne EM,Nery NS,Turra TZ

doi

/S0034-98872009000200012

subject

Has Abstract

pub_date

2009-02-01 00:00:00

pages

264-8

issue

2

eissn

0034-9887

issn

0717-6163

pii

S0034-98872009000200012

journal_volume

137

pub_type

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