[Imipenem/cilastatin versus ceftazidime-amikacin in the treatment of febrile neutropenic patients].

Abstract:

AIM:To compare the efficacy of imipenem/cilastatine and ceftazidime-amikacin in the treatment of febrile neutropenic patients. DESIGN:Open, prospective and randomized clinical study. PATIENTS:Fifty two patients (26 female) aged 16 to 80 years old with 60 episodes of neutropenia were studied. They were randomly assigned to receive imipenem/cilastatine in doses of 500 mg iv qid or the combination of ceftazidime 1 to 1.5 g iv tid and amikacin 7.5 mg/kg iv bid. RESULTS:Global response to initial therapy was 53% in patients receiving imipenem/cilastatine and 37% in those receiving ceftazidime-amikacin (p = ns). When other antimicrobial were added, a 90 and 85% infection eradication success was achieved respectively. Six febrile episodes in the group receiving imipenem/cilastatine and 12 episodes in the group receiving ceftazidime-amikacin had Gram positive cocci as the sole infectious agent (p < 0.04). A lower duration of neutropenia had a favorable influence on treatment outcome. Three patients receiving imipenem/cilastatine (10%) and four receiving ceftazidime-amikacin (13%) died. Superinfections and toxicity related to antibiotics were minimal in both groups. CONCLUSIONS:Imipenem/cilastatine and the combination of ceftazidime with amikacin were equally effective in the treatment of febrile episodes in neutropenic patients.

journal_name

Rev Med Chil

journal_title

Revista medica de Chile

authors

Pérez C,Sirham M,Labarca J,Grebe G,Lira P,Oliva J,Duhalde M,Ocqueteau M,Acuña G

subject

Has Abstract

pub_date

1995-03-01 00:00:00

pages

312-20

issue

3

eissn

0034-9887

issn

0717-6163

journal_volume

123

pub_type

临床试验,杂志文章,随机对照试验
  • [Unstable angina: invasive or conservative management?].

    abstract::Acute coronary syndromes without ST segment elevation (Non-Q-Infarction and unstable angina) share a common pathophysiology, have no indication of thrombolysis, and should not routinely be catheterized on an emergency basis on admission. They should be put in bed rest, given anti-ischemic medications, aspirin and hepa...

    journal_title:Revista medica de Chile

    pub_type: 评论,社论

    doi:

    authors: Florenzano F

    更新日期:1998-11-01 00:00:00

  • [Acoustic analysis of wheezing in infants with acute bronchial obstruction. A follow-up study ].

    abstract:BACKGROUND:There is some information about wheeze characteristics in infants, however it is not clear whether the different wheeze patterns relates to prognosis and evolution during the first two years of life. OBJECTIVES:To characterize wheezing and spectral pattern of lung sounds in infants with acute bronchiolitis ...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Sánchez I,Navarro H,Bertrand P,Alvarez C,Lisboa C

    更新日期:2002-07-01 00:00:00

  • [Proposing a data mining scaffolding for preventing harmful alcohol consumption in Chilean adolescents].

    abstract:BACKGROUND:Adolescent alcohol and drug consumption are important public health problems in the Chilean young population. AIM:The purpose of this study was to examine the potential ofa data mining approach in scaffolding policy making, using the particular case of differential risks of harmful alcohol consumption in ad...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:10.4067/S0034-98872013000500013

    authors: Marcelo Villalón C,Cuellar C

    更新日期:2013-05-01 00:00:00

  • [Default mode network and Alzheimer's disease].

    abstract::Brain functioning is mainly intrinsic, not primarily reflexive. This is supported by the high energy requirements of the resting brain (20% of all the energy consumed) which only marginally increases with changes in brain activity. Modern neuroimaging and neurophysiological techniques have led to the discovery of the ...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章,评审

    doi:10.4067/S0034-98872013000300014

    authors: Vergara E F,Behrens MI

    更新日期:2013-03-01 00:00:00

  • [The medical history of Edgar Allan Poe].

    abstract::Edgar Allan Poe, one of the best American storytellers and poets, suffered an episodic behaviour disorder partially triggered by alcohol and opiate use. Much confusion still exists about the last days of his turbulent life and the cause of his death at an early age. Different etiologies have been proposed to explain h...

    journal_title:Revista medica de Chile

    pub_type: 传,历史文章,杂志文章

    doi:10.4067/s0034-98872007000900019

    authors: Miranda C M

    更新日期:2007-09-01 00:00:00

  • [Hygiene and urban health as seen by physicians, architects and planners during the first half of the twentieth century].

    abstract::Physicians took part in the promotion of public policies that regulated urban and architectural work, before engineers, architects, planners, and even before the State had a chance to take part in the formulation of such policies. Starting in the late nineteenth century, and especially during the first decade of the t...

    journal_title:Revista medica de Chile

    pub_type: 历史文章,杂志文章

    doi:10.4067/S0034-98872016000100015

    authors: Ibarra M

    更新日期:2016-01-01 00:00:00

  • [Medical care in Santiago, 1993].

    abstract::Results of morbidity and medical care surveys performed in Santiago in 1993-94 are presented in this paper. The study has been done in an aleatory population sample of 4,700 people coming from 1,000 dwellings. Main results are as following: The Health National Fund (FONASA) is the most important financing medical care...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Medina E,Kaempffer AM,Cornejo E,Hernández E,Wall V

    更新日期:1995-01-01 00:00:00

  • [Aneurysmal bone cyst of the maxilla. Report of one case].

    abstract::Aneurysmal bone cysts are benign fibro osseous lesions, rarely present in maxillary region. We report the CT and morphological findings of aneurysmal bone cyst of the maxilla in a 15 years old female. The patient was subjected to a maxillectomy, preserving the orbit floor. The postoperative evolution has been uneventf...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:10.4067/s0034-98872005001100012

    authors: Guzmán G P,Baeza O A,Araya O J,Roa S J,Brevis O L,Torres L P

    更新日期:2005-11-01 00:00:00

  • [Clinical usefulness of rheumatoid factor in synovial fluid. Re-evaluation].

    abstract::The aim of this work is to analyze the usefulness of rheumatoid factor determination in synovial fluid. One hundred twenty nine patients (29 with rheumatoid arthritis), in whom rheumatoid factor was simultaneously determined in serum and synovial fluid, were retrospectively analyzed. Serum rheumatoid factor had a 48% ...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Sari L,Astorga G,Carvajal P,Gatica H

    更新日期:1993-12-01 00:00:00

  • [A new equation to predict urine creatinine values using data from Chilean population].

    abstract:BACKGROUND:Evaluation of 24-hour collection accuracy is based on urinary creatinine excretion (UCr), usually using wide ranges indexed by weight. Equations that predict the expected UCr are also available. AIM:To generate an equation for estimating UCr in Chilean population and evaluate its performance in comparison t...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:10.4067/S0034-98872020000600734

    authors: Huidobro Espinosa JP,Sepúlveda RA,Muñoz GM

    更新日期:2020-06-01 00:00:00

  • [HDL cholesterol: a new target in the treatment of lipid disorders and atherosclerosis?].

    abstract::Low plasma HDL cholesterol levels are an independent risk factor for atherosclerotic cardiovascular disease. During the past years, the study of HDL has been stimulated by the discovery of novel genes and proteins, which have provided new insights into the molecular and cellular mechanisms involved in HDL metabolism. ...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章,评审

    doi:10.4067/s0034-98872005000700011

    authors: Laris Mdel R,Arteaga A,Cuevas A,Rigotti A

    更新日期:2005-07-01 00:00:00

  • [Gastric adenocarcinoma appearing 32 years after the resection of a gastric lymphoma. Report of one case].

    abstract::The association of gastric lymphoma and gastric adenocarcinoma in the same patient is uncommon. We report a 76 year-old male with a previous history of massive upper gastrointestinal bleeding who required a subtotal gastrectomy with Billroth II reconstruction in 1974. Pathology demonstrated a gastric lympho-histiocyti...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:/S0034-98872008001000013

    authors: Butte JM,Torres J,Duarte I,Guzmán S,Llanos O

    更新日期:2008-10-01 00:00:00

  • [Focal hepatic lesions observed by echotomography with special reference to hydatidosis].

    abstract::This article reports the results of 1080 ultrasonographic examinations of the liver in a clinic of the Ninth Region of Chile, using a SSD 620 Aloka equipment. In 61 examinations (5.6%) a focal liver lesion was found. Of these, 9 (14.7% of lesions) appeared as malignant (6 metastasis and 3 hepatomas) and 52 (85.3% of l...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Calderón C

    更新日期:1994-03-01 00:00:00

  • [Diethylpropion in magisterial formulations. Influence of cellulosis derivatives on in vitro stability and availability].

    abstract::The aim of this work was to assess the degree of interaction between diethylpropion and some cellulosic derivatives widely used in anorexigenic prescriptions. Our in vitro results show that sodium carboxymethylcellulose and methylcellulose cause a significant degradation of diethylpropion, the first having a greater e...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Gómez M,Alvarez A,Cid E

    更新日期:1993-09-01 00:00:00

  • [Quadriceps myopathy: a type of late focal dystrophy in a case].

    abstract::A 62 years old male with a slowly progressive focal myopathy is presented. He had noticed weakness in the lower limbs for three years and weakness in the upper limbs for one year. He had bilateral atrophy of quadriceps and biceps muscles, absence of knee jerks and hypertrophy of the calves. Needle EMG showed myopathic...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Cartier L,Hernández JE,Stuardo A,González J,Villagra R

    更新日期:1995-01-01 00:00:00

  • [Itraconazole 800 mg for the prophylaxis of fungal infections in patients with acute leukemia and severe neutropenia].

    abstract:BACKGROUND:Systemic fungal infections and specifically invasive aspergillosis (IA) are associated with a high morbi-mortality rate in patients with hematologic malignancies. Itraconazole kinetic studies show that plasma levels are not satisfactory, even though there is a reduction of the severity in clinical cases. AI...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:/S0034-98872011000900003

    authors: Andrade M A,Puga L B,Guerra C C,Molina E J,Capurro C M

    更新日期:2011-09-01 00:00:00

  • [Evolution of atypical gynecological cervical smears in a captive population].

    abstract:BACKGROUND:An atypical cervical smear may represent a wide variety of lesions, from banal diseases to invasive neoplastic lesions. AIM:To study the evolution of atypical cervical smears in a highly controlled women population. MATERIAL AND METHODS:A retrospective analysis of 117 women with atypical cervical smears, d...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Vilches K,Escalona A

    更新日期:1998-03-01 00:00:00

  • [Proportion of patients with heart failure in a specialized clinic eligible for novel therapies].

    abstract:BACKGROUND:Pharmacological treatment improves survival in patients with heart failure with reduced ejection fraction. The use of sacubutril/valsartan and ivabradine has been recently approved and incorporated in the latest guidelines. AIM:To identify candidates eligible for these therapies among patients treated in a ...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:10.4067/S0034-98872019000300330

    authors: Rossel V,Duarte M,Muñoz P,Bravo C,Bobadilla G,Verdugo F,Guardamagna C

    更新日期:2019-03-01 00:00:00

  • [Learning strategies of autonomous medical students].

    abstract:BACKGROUND:Understanding how autonomous students are capable of regulating their own learning process is essential to develop self-directed teaching methods. AIM:To understand how self-directed medical students approach learning in medical schools at University of Concepción, Chile. MATERIAL AND METHODS:A qualitative...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:10.4067/S0034-98872015001200011

    authors: Márquez U C,Fasce H E,Ortega B J,Bustamante D C,Pérez V C,Ibáñez G P,Ortiz M L,Espinoza P C,Bastías V N

    更新日期:2015-12-01 00:00:00

  • [Hospital case management].

    abstract::Due to demographic changes, rising health expenditures, and the reimbursement mechanisms of insurers in the past 30 years, physicians and nurses have had to change the way services are delivered. Concepts such as cost effectiveness and patient safety have also led to the emergence of case management. Case management, ...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章,评审

    doi:10.4067/S0034-98872013001100010

    authors: Eymin G,Zuleta J

    更新日期:2013-11-01 00:00:00

  • [HRP/WHO: special program of research, development and research training in human reproduction, of the World Health Organization].

    abstract::The history, objectives and aims of this programme are described in detail. The principal goals achieved on anticonception, reproductive biology and abortion are analyzed, with special reference to the research done in Chile. The strengthening of research capabilities at national level was pointed out with special men...

    journal_title:Revista medica de Chile

    pub_type: 历史文章,杂志文章

    doi:

    authors: Lavín P

    更新日期:1998-07-01 00:00:00

  • [The diagnosis of death].

    abstract::This paper undertakes an analysis of the scientific criteria used in the diagnosis of death and underscores the importance of intellectual rigor in the definition of medical concepts, particularly regarding such a critical issue as the diagnosis of death. Under the cardiorespiratory criterion, death is defined as "the...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章,评审

    doi:10.4067/s0034-98872004000100015

    authors: Echeverría C,Goic A,Lavados M,Quintana C,Rojas A,Serani A,Vacarezza R,Grupo de Estudios de Etica Clínica de la Sociedad Médica de Santiago.

    更新日期:2004-01-01 00:00:00

  • [Effects of ursodeoxycholic acid in patients with cholestasis of pregnancy].

    abstract::In an open, pilot study, the efficacy and safety of ursodeoxycholic acid (UDCA) in the treatment of intrahepatic cholestasis of pregnancy was investigated. Four patients received 1 g/day of UDCA during 20 days and another 2 patients received 2 identical periods of treatment separated by a 14-day interval free of drug....

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Palma J,Reyes H,Ribalta J,Iglesias J,González M,Hernández I,Alvarez C,Molina C,Danitz AM

    更新日期:1991-02-01 00:00:00

  • [Hodgkin lymphoma in Chile: experience of the national adult cancer program].

    abstract:BACKGROUND:Hodgkin lymphoma is a highly curable disease. AIM:To evaluate the clinical characteristics and the treatment results of Hodgkin lymphoma patients of the National Cancer Program in Chile. PATIENTS AND METHODS:Prospective assessment of 682 patients treated in 18 adult cancer centers. Progression free surviva...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章,多中心研究

    doi:10.4067/s0034-98872007000300009

    authors: Cabrera ME,García H,Lois V,León A,Peña K,Rossle A,Cerda B,Rojas H,Meneses P,Merino C,Aspillaga A,Vittini de C,Oliva J,Hales C,Rosas J,Programa Nacional de Cáncer del Adulto, Ministerio de Salud.

    更新日期:2007-03-01 00:00:00

  • [Idiopathic granulomatous hepatitis with bilateral orchiepididymitis and skin eruption].

    abstract::We report a 52 years old male admitted for fever lasting one month, dry cough, headache and malaise. Initial laboratory work up showed an AST of 172 U/l, and ALT of 252 U/l, a GGT of 353 U/l and alkaline phosphatases of 952 U/l. An abdominal CAT scan disclosed a mild hepatosplenomegaly. A liver biopsy showed a granulo...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Rodríguez M,Montagud JB,Robert J,Mayol MJ,Merino J

    更新日期:2002-11-01 00:00:00

  • [Hemolysis, serositis and exanthema induced by Mycoplasma pneumoniae infection. Report of one case].

    abstract::Mycoplasma infections have extrapulmonary manifestations that may be associated with respiratory symptoms and may have skin, heart, gastrointestinal, rheumatologic, neurologic, hematologic involvement. Cold agglutinin mediated autoimmune hemolytic anemia is the most common hematological manifestation. We report a 27-y...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:10.4067/S0034-98872014001000015

    authors: Mondaca P R,Pizarro C V,Cares V,Eymin G

    更新日期:2014-10-01 00:00:00

  • [Early determinants of acute kidney injury during experimental intra-abdominal sepsis].

    abstract:BACKGROUND:Sepsis-induced acute kidney injury (AKI) is an early and frequent organ dysfunction, associated with increased mortality. AIM:To evaluate the impact of macrohemodynamic and microcirculatory changes on renal function and histology during an experimental model of intra-abdominal sepsis. MATERIAL AND METHODS:...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:10.4067/S0034-98872014000500001

    authors: Regueira T,Andresen M,Mercado M,Lillo F,Soto D

    更新日期:2014-05-01 00:00:00

  • [Pet cats, medicine and art].

    abstract::The author in this short text remembers the passing of a beloved pet cat. Cats are beautiful animals and wonderful companions. They evolved together with humans in Africa, subsequently spread over the five continents with them, and became the subject of many human cultural activities, including art, poetry and religio...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:10.4067/S0034-98872019000100091

    authors: Cabello C F

    更新日期:2019-01-01 00:00:00

  • [Calculation of costs per inpatient day in an intensive care unit].

    abstract:BACKGROUND:Intensive medicine is especially expensive and requires an efficient management. AIM:To measure the real costs of diseases treated in an intensive care unit and compare them with the costs assigned by the Chilean National Health Fund (FONASA) for 2008. MATERIAL AND METHODS:Retrospective review of 225 patie...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:/S0034-98872010000500005

    authors: Alvear V S,Canteros J,Rodríguez P

    更新日期:2010-05-01 00:00:00

  • [Addisonian crisis caused by metastatic lung cancer. Report of one case].

    abstract::Addisonian crisis as a first manifestation of metastatic disease secondary to cancer is uncommon. We report a 63-year-old man with a history of one year of fatigue, weakness, weight loss and repeated symptomatic hypoglycemia. The cortisol stimulation test with ACTH confirmed primary adrenal insufficiency. While receiv...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:/S0034-98872011000900013

    authors: Utreras C,Díaz RE,Ascui R,Caro R,Véliz J,Wohllk N

    更新日期:2011-09-01 00:00:00