[The genes of the Pascuense population].

Abstract:

:An analysis of the interaction of evolutionary factors such as migration, mutation, selection random drift, and consanguinity upon the genome of Easter islanders is attempted. As many primitive populations, the Easter islanders genome has at least 2/3 of genetic loci in an isogenic state. The HLA system is reduced; other polymorphisms present high genic frequencies differentiating Easter islanders from other Andean and european populations. They are more similar to polynesians, with whom they share language and culture. Migration has been the main factor affecting the Easter islanders genome, leading to a ten fold increase in population and a 60% caucasian admixture. A linkage disequilibrium of the HLA9, w10 haplotype exists. In XIX century generations consanguinity was very low (alpha coefficient 7 x 10(-5) which may be explained by the exogamic tradition of the population; this acted as a factor opposed to random drift. A recent decrease in infant mortality rate leads to a relaxation of natural selection and contributes to hybridization of the population.

journal_name

Rev Med Chil

journal_title

Revista medica de Chile

authors

Cruz-Coke R

subject

Has Abstract

pub_date

1989-06-01 00:00:00

pages

685-94

issue

6

eissn

0034-9887

issn

0717-6163

journal_volume

117

pub_type

杂志文章,评审
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    doi:/S0034-98872007001100015

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    更新日期:2007-11-01 00:00:00

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    pub_type: 杂志文章,随机对照试验

    doi:/S0034-98872010000400006

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    更新日期:2011-05-01 00:00:00

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    pub_type: 杂志文章

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    authors: Solis F,Castillo B,Mardones G

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  • [Detection of bone marrow micrometastases in patients with gallbladder cancer].

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    abstract::Although the use of cadaveric split or living donor liver transplantation is a valid option for liver transplants, they have several complications, being the "small-for-size syndrome" one of the most frequent. This entity is mainly due to the incapacity that the graft has to meet the blood drainage demands. We report ...

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    authors: Yarur A,Castro L,Segovia R,Roblero JP,Uribe M,Ferrario M,Buckel E

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  • [Prevalence of cardial or fundic mucosa and Helicobacter pylori in the squamous-columnar mucosa in patients with chronic patological gastroesophageal reflux without intestinal metaplasia comparated with controls].

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