Abstract:
BACKGROUND:The current recommendations for treatment of patients with newly diagnosed acute promyelocytic leukemia (APL) include all-trans-retinoic acid (ATRA) and anthracycline based chemotherapy. AIM:To evaluate the results of the Chilean protocol following the LPA99 regimen of the Spanish PETHEMA group, except for the replacement of Idarubicin by Daunorubicin. PATIENTS AND METHODS:Induction consisted of Daunorubicin 45 mg/m² on days 2, 4, 6 and 8 plus ATRA 45 mg/m² daily until complete remission. Patients in complete remission (CR) received three monthly chemotherapy courses: Daunorubicin 45 mg/m²/d/4days i.v. and ATRA 45 mg/m²/d/15 days p.o. (course no. 1); Mitoxantrone 10 mg/m²/d/5 days i.v. and ATRA 45 mg/m²/d/15 days p.o. (course no. 2); Daunorubicin 60 mg/m²/d/ day 1 i.v. in the low risk group, and 1 and 2 in the intermediate-high risk groups and ATRA 45 mg/m²/d/15 days p.o. (course no. 3). Maintenance therapy consisted of mercaptopurine 90 mg/m²/d p.o., methotrexate 15 mg/m²/wk p.o. and, ATRA intermittently, 45 mg/m²/d p.o. for 15 days every three months. RESULTS:Between January 2000 and December 2005, 56 patients with newly diagnosed APL from 10 centers were enrolled. A total of 46 patients achieved CR (85%), 8 (15%) died of early complications, seven patients relapsed, with a 16% relapse risk at three years. The 5-year Kaplan-Meier estimates of overall survival and relapse-free survival were 64% and 84% respectively. CONCLUSIONS:These data indicate that this protocol has a good antileukemic effect but further reduction of early death and relapse, especially in the high risk group is needed.
journal_name
Rev Med Chiljournal_title
Revista medica de Chileauthors
Undurraga MS,Puga B,Cabrera ME,Palma T,Rossle A,Vergara CG,Rojas B,Aspillaga Adoi
10.4067/S0034-98872013001000001subject
Has Abstractpub_date
2013-10-01 00:00:00pages
1231-9issue
10eissn
0034-9887issn
0717-6163pii
S0034-98872013001000001journal_volume
141pub_type
杂志文章abstract::A 37-year-old female with systemic lupus erythematosus and chronic treatment with steroids developed spontaneous bilateral rupture of tendons of both quadriceps muscles below the patella. Surgical treatment was undertaken with good results. The histologic features and a review of the literature are included. ...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:
更新日期:1990-09-01 00:00:00
abstract:BACKGROUND:The number of nonagenarians is rapidly growing in Chile. This age group is mainly female, with higher frailty markers and in higher risk of being placed at nursing homes. AIM:To describe features of nonagenarian women and compare them with a group of women between 60-89 years, both living in nursing homes, ...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872004000100005
更新日期:2004-01-01 00:00:00
abstract::Kidney graft loss because arterial thrombosis is not common and is related to risk factors such as recurrent vascular hemodialysis access thrombosis, collagen-vascular disease, repeated miscarriage, diabetes mellitus and thrombophilia. Patients having this last disorder have an increased risk of repeated thrombosis in...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872007000100014
更新日期:2007-01-01 00:00:00
abstract::Semiotics and Semiology share a similar etymology and meaning: the study of signs. In Medicine, signs are objective manifestations of disease, as opposed to the subjective nature of symptoms. Medical semiology comprises the study of symptoms, somatic signs and laboratory signs, history taking and physical examination ...
journal_title:Revista medica de Chile
pub_type: 历史文章,杂志文章
doi:10.4067/s0034-98872018000300387
更新日期:2018-03-01 00:00:00
abstract::Amiodarone is a benzofuranic derivative widely used in cardiologic practice because of its excellent antiarrhythmic properties. Due to its high iodine content, it interferes with thyroid physiology and can cause either hyper or hypothyroidism. Amiodarone-induced hyperthyroidism should be considered as a serious compli...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1989-03-01 00:00:00
abstract::Using mapping techniques, 32 consecutive gallbladder carcinomas diagnosed in our department were studied. The defined lesions were dysplasia, carcinoma in situ and superficial spreading carcinoma. A total of 2257 lesions were recorded from 1072 inclusions. All the defined lesions were present in about 10% of all secti...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:The absence of lymph node involvement (N0) in gastric cancer is associated with a better survival. However some N0 gastric tumors still have a bad prognosis. AIM:To study demographic and morphological variables associated with prognosis in N0 gastric carcinoma. MATERIAL AND METHODS:Review of pathological r...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872011000400003
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:Environmental and genetic factors (viruses, toxins and diet) are involved in the aetiology of type 1 diabetes. Among the dietary factors, the role of breast feeding and exposure to cow's milk proteins deserve special attention. AIM:To determine the anti-BSA-IgG levels in type 1 diabetic children and to anal...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2003-08-01 00:00:00
abstract::We present a case of a 28 year old woman with paroxysmal left posterior fascicular ventricular tachycardia (LPFVT). Ventricular tachycardia was not inducible after completing of left ventricle 3D reconstruction. Even though catheter ablation was not performed, no LPFVT recurrence has been documented during 60 months f...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872010000800011
更新日期:2010-08-01 00:00:00
abstract::A serologic study for prevalence of Chagas infection was performed in Salamanca, Northern Chile. Indirect immunofluorescence and indirect hemagglutination reactions were used in samples from 1529 females and 698 males representing 10% of the population. A total of 499 positive results were obtained. The incidence of i...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1991-04-01 00:00:00
abstract::Embryo cryopreservation improves efficiency and security of assisted reproduction techniques. Nonetheless, it can be questionable, so it must be justified from technical, legal and ethical points of view. This article analyses these perspectives. Embryo cryopreservation maximizes the probability of pregnancy, avoids n...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872014000700011
更新日期:2014-07-01 00:00:00
abstract::We report a 70-year-old woman, who had recently consumed shellfish, that was admitted to the intensive care unit with septic shock and died 19 hours later due to a multi-organic failure. Microbiological, serological and molecular assays confirmed a hemolytic tdh+ Vibrio cholerae non-01, non 0139 as the etiologic agent...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872009000900008
更新日期:2009-09-01 00:00:00
abstract:BACKGROUND:In 1992, a consensus conference defined the terms systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis and septic shock. Since then, numerous reports have validated the prognostic usefulness of these operative definitions. AIM:To evaluate if sepsis severity criteria, as defined by the Conse...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1999-11-01 00:00:00
abstract:BACKGROUND:The dual potential to promote tolerance or inflammation when facing self-antigens makes dendritic cells (DCs) fundamental players in autoimmunity. There is an association between smoking and DCs maturation in patients with rheumatoid arthritis (RA). However, ethnicity is a key factor in autoimmune disorders....
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872018000200150
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:Hepatitis B vaccine has demonstrated to be very effective and safe preventing hepatitis B virus infection. Long term protection induced by hepatitis B vaccination depends on the initial immune response and the declining rate of anti-HBs titers. AIM. To investigate early and late response to hepatitis B vacci...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1993-05-01 00:00:00
abstract::During colonial times the Royal University of San Felipe was founded in 1738. The first plan for medical studies was outlined in 1779. During the Independence, the National Institute created in 1813 took over higher education. The first Course of Medicine was dictated there in 1833. The University of San Felipe was re...
journal_title:Revista medica de Chile
pub_type: 传,历史文章,杂志文章
doi:
更新日期:1992-01-01 00:00:00
abstract::We studied 501 prostitutes from the northern and eastern areas of Santiago in november and december, 1987. HIV infection was studied by the HIV antibody and also by HIV antigen. At that time no positive reactors were found. Prostitutes from the northern area were older, of a lower socioeconomic background and less pro...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1989-06-01 00:00:00
abstract::Obesity has a high prevalence among children. On the other hand, acute respiratory infections especially of viral origin, are an important cause of morbidity and mortality in this age group. During the recent pandemic of influenza A (H1N1) virus, obesity was identified as a novel independent risk factor for severity m...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:10.4067/S0034-98872016000900012
更新日期:2016-09-01 00:00:00
abstract::Garengeot's hernia corresponds to the presence of the appendix within a femoral hernia, associated or not with acute appendicitis. The diagnosis of this uncommon situation is usually done during surgery. Furthermore, the clinical presentation as necrotizing fasciitis is a rare condition. We report a 54 years old obese...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/s0034-98872018000500660
更新日期:2018-05-01 00:00:00
abstract::Persistent left superior vena cava is the most common venous congenital malformation and is usually asymptomatic. Its presence could increase the difficulty for transvenous lead implantation. We report a 71-year-old woman with an idiopathic dilated cardiomyopathy, atrial fibrillation and heart failure that required bi...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872012000100012
更新日期:2012-01-01 00:00:00
abstract::Geographical hematology of Bernard and Ruffie, or Hemato-sero-anthropology, intends to establish relationships between hereditary genetic characters of the blood and human races. Blood groups, haptoglobins, abnormal hemoglobin and other biological traits such as color vision are related to the origin of human races, t...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1997-09-01 00:00:00
abstract::A 45 year old male who manipulated tropical fish ponds developed painless nodular plaques in both hands. Biopsy showed mononuclear infiltrate of the dermis with few granulomata. Repeated cultures revealed M. marinum (diagnosis confirmed at the WHO/PAHO Reference Center in Canada). Good initial results were obtained wi...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1992-09-01 00:00:00
abstract:BACKGROUND:New vaccination strategies are needed to control the increasing problem of pertussis in teenagers and adults. AIM:To determine the immunogenicity and reactogenicity of a diphtheria-tetanus-acellular pertussis (dTpa) vaccine with reduced antigen content. MATERIAL AND METHODS:A single dose of the dTpa vaccin...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:2002-05-01 00:00:00
abstract::The practice of Medicine is exposed to everyday's ethical ventures that, even though not fundamental in a philosophical scope, are most crucial given its incidence and consequences to accessibility and equity in health care. A very special perception must emerge to allow us looking for those situations where moral con...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:Evaluation of 24-hour collection accuracy is based on urinary creatinine excretion (UCr), usually using wide ranges indexed by weight. Equations that predict the expected UCr are also available. AIM:To generate an equation for estimating UCr in Chilean population and evaluate its performance in comparison t...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:10.4067/S0034-98872020000600734
更新日期:2020-06-01 00:00:00
abstract::This paper reviews the sentences dictated between 1993 and 2002 by the Supreme Courts of Canada and the Unites States, the House of Lords and Supreme Court of the United Kingdom and the European Human Rights Court, about the validity of the legal prohibition of assistance for suicide. These sentences constituted a jud...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:10.4067/S0034-98872016000400009
更新日期:2016-04-01 00:00:00
abstract::Mirizzi syndrome is estimated to occur in about 1% of cases requiring urgent or elective biliary tract surgery. The key anatomic finding is extrinsic compression of the common duct by a stone located in the gallbladder or cystic duct. Among patients operated on in the last 12 years we have found 77 patients meeting cr...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:
更新日期:1989-05-01 00:00:00
abstract:BACKGROUND:A change in the social structure of medicine and its impact on clients has occurred in the last decades. AIM:To perform a survey about subjective wellbeing among physicians. MATERIAL AND METHODS:A physician’ professional satisfaction survey consisting in 90 questions, was applied to 580 physicians (7...
journal_title:Revista medica de Chile
pub_type: 杂志文章
doi:/S0034-98872011001000009
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND:We report a 35-year-old female patient with a one year history of a pustular and painful erythematous dermatitis, located in great folds, pubis and abdomen. She was evaluated in primary health care, receiving antifungal treatment, antimicrobials, topical and systemic non-steroidal anti-inflammatory drugs, wi...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:10.4067/S0034-98872012000500012
更新日期:2012-05-01 00:00:00
abstract::Celiac disease (CD), with a 1% worldwide prevalence, is an enteropathy caused by an autoimmune reaction to gluten in genetically susceptible individuals, which codify for histocompatibility molecules HLA DQ-2/DQ-8. From the anatomical point of view, CD is characterized by intestinal villous atrophy, crypt hyperplasia,...
journal_title:Revista medica de Chile
pub_type: 杂志文章,评审
doi:/S0034-98872009001200012
更新日期:2009-12-01 00:00:00