[In vitro comparative activity of moxifloxacin and other antimicrobials against respiratory pathogens].

Abstract:

BACKGROUND:Respiratory pathogens are becoming increasingly resistant to antimicrobials. A new group of drugs, called respiratory quinolones have been synthesized to overcome this problem. AIM:To study the in vitro susceptibility of respiratory pathogens to old and new antimicrobials. MATERIALS AND METHODS:Forty five strains of S pneumoniae, 44 strains of H influenzae, 21 strains of M catarrhalis, 10 strains of methicillin susceptible S aureus and 20 strains of methicillin resistant S aureus were studied. All were isolated from community acquired respiratory infections during 1999. Minimal inhibitory concentrations of moxifloxacin, amoxicillin, amoxicillin/clavulanic acid, clarithromycin, azithromycin, ciprofloxacin and levofloxacin were determined using the Etest method. Beta-lactamase production by H influenzae and M catarrhalis was also studied. RESULTS:S pneumoniae strains were 100% susceptible to quinolones and cotrimoxazole, 2% were resistant to macrolides, 11% were resistant to amoxicillin/clavulanic acid and 47% were resistant to cefuroxime. H influenzae was 100% susceptible to quinolones, azithromycin and amoxicillin/clavulanic acid. There was a 53% resistance to cotrimoxazole, 21% to amoxicillin, 9% to clarithromycin and 7% to cefuroxime. M catarrahalis was 100% susceptible to quinolones and 100% resistant to amoxicillin, 5% resistant to macrolides, 14% resistant to amoxicillin/clavulanic acid, 20% to cefuroxime and 30% to cotrimoxazole. Methicillin susceptible S aureus was susceptible to all antimicrobials and methicillin resistant S aureus was resistant to all. CONCLUSIONS:Maxifloxacin and the new respiratory quinolones can be useful in the treatment of respiratory infections.

journal_name

Rev Med Chil

journal_title

Revista medica de Chile

authors

Prado V,Giangrieco M,Durán C,Ojeda A,van Flaskamp R

subject

Has Abstract

pub_date

2000-12-01 00:00:00

pages

1319-26

issue

12

eissn

0034-9887

issn

0717-6163

journal_volume

128

pub_type

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