[Active and refractory ulcerative proctitis: an update].

Abstract:

:Ulcerative colitis (UC) is a chronic inflammatory disease of unknown etiology that affects a variable length of the colon, starting from the rectum. When the disease is confined to the rectum is called ulcerative proctitis (UP). Several studies have unsuccessfully attempted to determine the factors that determine the extent of involvement. The goals of therapy in UP are to induce and maintain remission of symptoms and disease. Topical treatment with 5-aminosalicylates (5-ASA) is the treatment of choice to induce remission. In the maintenance phase, long-term follow up studies suggest that treatment with 5-ASA is better than placebo, to maintain the disease inactive. For those patients that do not respond to treatment with topical 5-ASA or have a moderate to severe disease, there are additional therapies such as oral 5-ASA, topical or systemic corticosteroids, immunomodulators, biological therapies (Infliximab) and cyclosporine. Surgery is seldom needed.

journal_name

Rev Med Chil

journal_title

Revista medica de Chile

authors

Caselli M G,Pinedo M G,Zúñiga D A,Alvarez L M

doi

/S0034-98872010000100016

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

109-16

issue

1

eissn

0034-9887

issn

0717-6163

pii

S0034-98872010000100016

journal_volume

138

pub_type

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