Abstract:
:Although bone age estimates are traditionally used to monitor children receiving growth hormone therapy, few data support this practice. Bone age determination is fraught with technical difficulties, resulting in high interobserver differences. Longitudinal studies show that an individual's bone age can change erratically over time. The resulting errors in predicted adult heights based on these bone age determinations are large. Moreover, growth hormone therapy appears to accelerate bone maturation. The radiographic evidence of this acceleration can be delayed. In this setting, improvements in predicted adult heights can be artifactually large. Routine monitoring of bone age during GH therapy is unnecessary. Bayley and Pinneau, bone age determination, Greulich and Pyle, predicted height, radiography, Tanner and Whitehouse.
journal_name
Pediatricsjournal_title
Pediatricsauthors
Wilson DMsubject
Has Abstractpub_date
1999-10-01 00:00:00pages
1036-9issue
4 Pt 2eissn
0031-4005issn
1098-4275journal_volume
104pub_type
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