Variable efficacy of glucocorticoids in congenital adrenal hyperplasia.

Abstract:

:We have examined the suppression of urinary pregnanetriol and 17-ketosteroids during treatment with cortisol, cortisone, prednisone, and dexamethasone in eight patients with congenital adrenal hyperplasia. A large individual variation in response to each agent was observed. In some individuals, cortisone is less effective than its generally accepted potency would indicate. At equivalent glucocorticoid dosage, dexamethasone was twice as effective as the other steroids in suppressing urinary 17-ketosteroids and pregnanetriol. The potency of dexamethasone in suppressing adrenal function was 80 times that of cortisol, about twice its generally accepted potency as a glucocorticoid or anti-inflammatory agent.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Hansen JW,Loriaux DL

subject

Has Abstract

pub_date

1976-06-01 00:00:00

pages

942-7

issue

6

eissn

0031-4005

issn

1098-4275

journal_volume

57

pub_type

杂志文章
  • Hepatitis a vaccination coverage among adolescents in the United States.

    abstract:OBJECTIVE:Hepatitis A infection causes severe disease among adolescents and adults. The Advisory Committee on Immunization Practices instituted incremental recommendations for hepatitis A vaccination (HepA) at 2 years of age based on risk (1996), in selected states (1999), and universally at 1 year of age, with vaccina...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2011-2197

    authors: Dorell CG,Yankey D,Byrd KK,Murphy TV

    更新日期:2012-02-01 00:00:00

  • Thrombotic storm in a teenager with previously undiagnosed ulcerative colitis.

    abstract::Venous thrombosis can complicate inflammatory bowel diseases, both in adult and pediatric patients, and a few adult cases of thrombotic storm, ie, thrombosis at multiple sites occurring over a period of a few days to a few weeks, have been described. However, venous thrombosis as the first manifestation of an inflamma...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2012-2365

    authors: Maggi U,Rossi G,Avesani EC,Artoni A,Caprioli F,Napolitano L,Martinelli I

    更新日期:2013-04-01 00:00:00

  • Comparison of urinary lactic dehydrogenase with antibody-coated bacteria in the urine sediment as means of localizing the site of urinary tract infection.

    abstract::Two noninvasive methods of localizing the site of urinary tract infection, urinary lactic dehydrogenase (LDH) isoenzymes and antibody coating of bacteria in the urinary sediment, have been prospectively compared with the bladder washout technique in a series of children with urinary tract infection. Fifteen children h...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Lorentz WB Jr,Resnick MI

    更新日期:1979-11-01 00:00:00

  • Comparison of findings on cranial ultrasound and magnetic resonance imaging in preterm infants.

    abstract:OBJECTIVE:To compare findings on hard copies of cranial ultrasound (US) and magnetic resonance imaging (MRI) obtained between birth and term in a group of preterm infants. PARTICIPANTS AND METHODS:Infants born at or below a gestational age of 30 weeks who underwent cranial US scan and MRI on the same day were eligible...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.107.4.719

    authors: Maalouf EF,Duggan PJ,Counsell SJ,Rutherford MA,Cowan F,Azzopardi D,Edwards AD

    更新日期:2001-04-01 00:00:00

  • Circumcision policy statement.

    abstract::Male circumcision is a common procedure, generally performed during the newborn period in the United States. In 2007, the American Academy of Pediatrics (AAP) formed a multidisciplinary task force of AAP members and other stakeholders to evaluate the recent evidence on male circumcision and update the Academy's 1999 r...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2012-1989

    authors: American Academy of Pediatrics Task Force on Circumcision.

    更新日期:2012-09-01 00:00:00

  • Dietary Fats and Atherosclerosis From Childhood to Adulthood.

    abstract:BACKGROUND:The association of dietary fat distribution with markers of subclinical atherosclerosis during early life is unknown. We examined whether success in achieving the main target of an infancy-onset dietary intervention based on the distribution of dietary fat was associated with aortic and carotid intima-media ...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1542/peds.2019-2786

    authors: Laitinen TT,Nuotio J,Rovio SP,Niinikoski H,Juonala M,Magnussen CG,Jokinen E,Lagström H,Jula A,Viikari JSA,Rönnemaa T,Simell O,Raitakari OT,Pahkala K

    更新日期:2020-04-01 00:00:00

  • A note on interdisciplinary research in developmental/behavioral pediatrics/psychology.

    abstract::In sum, we have offered a few observations about the practice of interdisciplinary research. Now, in addition to our rather specific suggestions, we want to add a few general comments about the interactions of professionals who are actually involved in interdisciplinary research. Collaboration between physicians and p...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Ellison PH,Kopp CB

    更新日期:1985-05-01 00:00:00

  • Increased risk of gastrointestinal perforations in neonates mechanically ventilated with either face mask or nasal prongs.

    abstract::Twenty cases of gastrointestinal perforations not associated with necrotizing enterocolitis or a bowel obstruction (GPNN) were reviewed. Fifteen infants suffered perforations during cycle ventilation. Perforations were localized in the stomach, duodenum, ileum, and jejunum. To determine if the type of mechanical venti...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Garland JS,Nelson DB,Rice T,Neu J

    更新日期:1985-09-01 00:00:00

  • Hepatitis B virus infection in Honolulu students.

    abstract:OBJECTIVES:To determine hepatitis B virus (HBV) carrier and infection rates and HBV epidemiology in Honolulu students. DESIGN:Cross-sectional survey. SETTING:Honolulu public elementary, intermediate, and high schools. PATIENTS:A volunteer sample of 4936 students from 43 Honolulu schools. MAIN OUTCOME MEASURES:HBV c...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Pon EW,Ren H,Margolis H,Zhao Z,Schatz GC,Diwan A

    更新日期:1993-10-01 00:00:00

  • Does bed sharing affect the risk of SIDS? American Academy of Pediatrics. Task Force on Infant Positioning and SIDS.

    abstract::The American Academy of Pediatrics endorses and accepts as its policy the position on bed sharing as articulated below by a panel of experts convened by the National Institute of Child Health and Human Development (NICHD). The Panel attended a conference sponsored by the NICHD entitled "Infant Sleep Environment and SI...

    journal_title:Pediatrics

    pub_type: 指南,杂志文章

    doi:

    authors:

    更新日期:1997-08-01 00:00:00

  • Recommendations for Prevention and Control of Influenza in Children, 2015-2016.

    abstract::The purpose of this statement is to update recommendations for routine use of seasonal influenza vaccine and antiviral medications for the prevention and treatment of influenza in children. The American Academy of Pediatrics recommends annual seasonal influenza immunization for all people 6 months and older, including...

    journal_title:Pediatrics

    pub_type: 杂志文章,实务指引

    doi:10.1542/peds.2015-2920

    authors: Committee on Infectious Diseases, American Academy of Pediatrics.

    更新日期:2015-10-01 00:00:00

  • Global Climate Change and Children's Health.

    abstract::Rising global temperatures are causing major physical, chemical, and ecological changes in the planet. There is wide consensus among scientific organizations and climatologists that these broad effects, known as "climate change," are the result of contemporary human activity. Climate change poses threats to human heal...

    journal_title:Pediatrics

    pub_type: 指南,杂志文章

    doi:10.1542/peds.2015-3232

    authors: COUNCIL ON ENVIRONMENTAL HEALTH.

    更新日期:2015-11-01 00:00:00

  • Missed opportunities for childhood vaccinations in office practices and the effect on vaccination status.

    abstract::To determine the rate of childhood under-vaccination, rate and types of missed opportunities (MOs) for vaccinations, and the contribution of MOs to the undervaccination of preschool-age children, the authors conducted a retrospective medical chart review in seven primary care settings in the Rochester, NY, area: a hos...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Szilagyi PG,Rodewald LE,Humiston SG,Raubertas RF,Cove LA,Doane CB,Lind PH,Tobin MS,Roghmann KJ,Hall CB

    更新日期:1993-01-01 00:00:00

  • Marijuana and Tobacco Coexposure in Hospitalized Children.

    abstract:BACKGROUND:The impact of secondhand marijuana smoke exposure on children is unknown. New methods allow for the detection of marijuana smoke exposure in children. METHODS:We studied children who were hospitalized in Colorado and had a parent participating in a smoking cessation study; all children had urine samples rem...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2018-0820

    authors: Wilson KM,Torok MR,Wei B,Wang L,Lowary M,Blount BC

    更新日期:2018-12-01 00:00:00

  • Rhabdomyolysis and myoglobinemia in neonates.

    abstract::Serial myoglobin determinations were made in 20 neonates during the first week of life to determine whether birth asphyxia results in ischemic damage to muscle with the subsequent pathologic release of myoglobin. Serum myoglobin values were significantly elevated in asphyxiated infants compared with control infants. H...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Kasik JW,Leuschen MP,Bolam DL,Nelson RM

    更新日期:1985-08-01 00:00:00

  • Screening children to identify families at increased risk for cardiovascular disease.

    abstract:OBJECTIVES:Atherosclerotic cardiovascular disease is the leading cause of death in the United States. Atherosclerosis begins early in life; however, children and young and middle-aged adults are not universally screened for the presence of modifiable cardiovascular disease risk factors. The purpose of this study was to...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-0680

    authors: Reis EC,Kip KE,Marroquin OC,Kiesau M,Hipps L Jr,Peters RE,Reis SE

    更新日期:2006-12-01 00:00:00

  • Neonatal Acute Kidney Injury.

    abstract::In recent years, there have been significant advancements in our understanding of acute kidney injury (AKI) and its impact on outcomes across medicine. Research based on single-center cohorts suggests that neonatal AKI is very common and associated with poor outcomes. In this state-of-the-art review on neonatal AKI, w...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2014-3819

    authors: Selewski DT,Charlton JR,Jetton JG,Guillet R,Mhanna MJ,Askenazi DJ,Kent AL

    更新日期:2015-08-01 00:00:00

  • The walking school bus and children's physical activity: a pilot cluster randomized controlled trial.

    abstract:OBJECTIVE:To evaluate the impact of a "walking school bus" program on children's rates of active commuting to school and physical activity. METHODS:We conducted a pilot cluster randomized controlled trial among 4th-graders from 8 schools in Houston, Texas (N = 149). Random allocation to treatment or control conditions...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1542/peds.2010-3486

    authors: Mendoza JA,Watson K,Baranowski T,Nicklas TA,Uscanga DK,Hanfling MJ

    更新日期:2011-09-01 00:00:00

  • Two pediatric cases of variant neurogenic stress cardiomyopathy after intracranial hemorrhage.

    abstract::Takotsubo cardiomyopathy, also known as stress-induced cardiomyopathy, is an acquired form of left ventricular systolic dysfunction seen in the setting of physiologic stress and the absence of coronary artery disease. It is thought to be caused by excessive sympathetic stimulation. It is well described in the adult li...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2013-1881

    authors: Wittekind SG,Yanay O,Johnson EM,Gibbons EF

    更新日期:2014-10-01 00:00:00

  • Measles outbreak in a pediatric practice: airborne transmission in an office setting.

    abstract::In February 1981, a measles outbreak occurred in a pediatric practice in DeKalb County, GA. The source case, a 12-year-old boy vaccinated against measles at 11 1/2 months of age, was in the office for one hour on the second day of rash, primarily in a single examining room. On examination, he was noted to be coughing ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Bloch AB,Orenstein WA,Ewing WM,Spain WH,Mallison GF,Herrmann KL,Hinman AR

    更新日期:1985-04-01 00:00:00

  • The effect of a community intervention trial on parental knowledge and awareness of antibiotic resistance and appropriate antibiotic use in children.

    abstract:BACKGROUND:Overuse of antibiotics for children's upper respiratory infections is widespread and contributes to the emergence of antibiotic-resistant bacteria. OBJECTIVE:To assess changes in knowledge and awareness regarding antibiotic resistance and appropriate antibiotic use after community-wide educational intervent...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.107.1.e6

    authors: Trepka MJ,Belongia EA,Chyou PH,Davis JP,Schwartz B

    更新日期:2001-01-01 00:00:00

  • Pathogenesis of the prune-belly syndrome: a functional urethral obstruction caused by prostatic hypoplasia.

    abstract::Abdominal muscle deficiency, urinary tract abnormalities, and cryptorchidism are the three major features of the prune-belly syndrome, also referred to as triad syndrome or Eagle-Barrett syndrome. The etiology is unclear and the pathogenesis a subject of continuing debate. Clinical and pathologic experience with seven...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Moerman P,Fryns JP,Goddeeris P,Lauweryns JM

    更新日期:1984-04-01 00:00:00

  • Adolescents' perceptions of light and intermittent smoking in the United States.

    abstract:BACKGROUND:Light smoking, consuming a few cigarettes daily, and intermittent, or nondaily, smoking patterns are increasingly common but carry health risks comparable to heavier smoking patterns. Nearly all smokers begin smoking as adolescents, who are at risk for developing these smoking patterns. Previous research sug...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2014-2502

    authors: Amrock SM,Weitzman M

    更新日期:2015-02-01 00:00:00

  • Cow's Milk Allergy and Bone Mineral Density in Prepubertal Children.

    abstract:BACKGROUND AND OBJECTIVES:Recent data suggest that cow's milk allergy (CMA) has become more persistent, prolonging treatment via strict elimination of cow's milk products into a period of skeletal growth. The objectives of this study were to compare bone mineral density (BMD), vitamin D status, and dietary intakes of c...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2015-1742

    authors: Mailhot G,Perrone V,Alos N,Dubois J,Delvin E,Paradis L,Des Roches A

    更新日期:2016-05-01 00:00:00

  • Annual summary of vital statistics--1980.

    abstract::Data for this article, as in previous reports, are drawn principally from the Monthly Vital Statistics Report, published by the National Center for Health Statistics. The international data come from the Demographic Yearbook and the quarterly Population and Vital Statistics Report, both published by the Statistical Of...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Wegman ME

    更新日期:1981-12-01 00:00:00

  • Detection of congenital cataracts and other ocular media opacities.

    abstract::Congenital cataracts and other ocular media opacities are a leading cause of preventable childhood blindness. Because of the importance of early recognition and treatment of congenital media opacities in newborn infants, we designed a study to determine the ability of relatively inexperienced examiners to detect such ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Ruttum MS,Nelson DB,Wamser MJ,Balliff M

    更新日期:1987-05-01 00:00:00

  • Growth hormone increases breast milk volumes in mothers of preterm infants.

    abstract:AIMS:To determine the galactopoietic response to recombinant human growth hormone (hGH) in mothers of premature infants with inadequate lactation. STUDY DESIGN:Prospective placebo-controlled, double-blind trial. SUBJECTS:Twenty healthy mothers on no concurrent medication, with infants born between 26 and 34 weeks' ge...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Gunn AJ,Gunn TR,Rabone DL,Breier BH,Blum WF,Gluckman PD

    更新日期:1996-08-01 00:00:00

  • Changes in children's physical activity over 12 months: longitudinal results from the SPEEDY study.

    abstract:OBJECTIVE:We measured physical activity changes among 10-year-old British children over 12 months and assessed biological and demographic determinants. METHODS:Physical activity was measured with accelerometers (counts per minute) over ≥3 days at baseline and 1 year later in a prospective study of 844 children (41.6% ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2010-0048

    authors: Corder K,van Sluijs EM,Ekelund U,Jones AP,Griffin SJ

    更新日期:2010-10-01 00:00:00

  • Rapid loading of critically ill patients with carbamazepine suspension.

    abstract::To determine the rate and factors that affect carbamazepine absorption, six patients being treated in the pediatric intensive care unit for frequent seizures received loading doses (7.4 to 10.4 mg/kg) of carbamazepine suspension by either nasogastric or nasoduodenal tube. Carbamazepine serum concentrations were determ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Miles MV,Lawless ST,Tennison MB,Zaritsky AL,Greenwood RS

    更新日期:1990-08-01 00:00:00

  • Exemplar pediatric collaborative improvement networks: achieving results.

    abstract::A number of pediatric collaborative improvement networks have demonstrated improved care and outcomes for children. Regionally, Cincinnati Children's Hospital Medical Center Physician Hospital Organization has sustained key asthma processes, substantially increased the percentage of their asthma population receiving "...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2012-3786F

    authors: Billett AL,Colletti RB,Mandel KE,Miller M,Muething SE,Sharek PJ,Lannon CM

    更新日期:2013-06-01 00:00:00