Abstract：
:Numerous studies have used the classic van der Pol oscillator, which contains a cubic nonlinearity, to model the effect of light on the human circadian pacemaker. Jewett and Kronauer demonstrated that Aschoff's rule could be incorporated into van der Pol type models and used a van der Pol type oscillator with higher order nonlinearities. Kronauer, Forger, and Jewett have proposed a model for light preprocessing, Process L, representing a biochemical process that converts a light signal into an effective drive on the circadian pacemaker. In the paper presented here, the authors use the classic van der Pol oscillator with Process L and Jewett and Kronauer's model of Aschoff's rule to model the human circadian pacemaker. This simpler cubic model predicts the results of a three-pulse human phase response curve experiment and a two-pulse amplitude reduction study with as much, or more, accuracy as the models of Jewett and Kronauer and Kronauer, Forger, and Jewett, which both employ a nonlinearity of degree 7. This suggests that this simpler cubic model should be considered as a potential alternative to other models of the human circadian system currently available.
journal_name
J Biol Rhythmsjournal_title
Journal of biological rhythmsauthors
Forger DB,Jewett ME,Kronauer REdoi
10.1177/074873099129000867subject
Has Abstractpub_date
1999-12-01 00:00:00pages
532-7issue
6eissn
0748-7304issn
1552-4531journal_volume
14pub_type
杂志文章abstract：:The aim of this study was to replicate and extend previous work in which the authors observed lower, shorter, and advanced nocturnal melatonin secretion patterns in premenstrually depressed patients compared to those in healthy control women. The authors also sought to test the hypothesis that the therapeutic effect o...
journal_title：Journal of biological rhythms
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1177/074873049701200107
更新日期：1997-02-01 00:00:00
abstract：:Systematic treatment of hamsters with triazolam (TRZ) or novel wheel (NW) access will yield PRCs similar to those for neuropeptide Y. Both TRZ and NW access require an intact intergeniculate leaflet (IGL) to modulate circadian rhythm phase. It is commonly suggested that both stimulus types influence rhythm phase respo...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/074873098129000327
更新日期：1998-12-01 00:00:00
abstract：:The classical power spectrum, computed in the frequency domain, outranks traditionally used periodograms derived in the time domain (such as the chi2 periodogram) regarding the search for biological rhythms. Unfortunately, classical power spectral analysis is not possible with unequally spaced data (e.g., time series ...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/074873099129000984
更新日期：1999-12-01 00:00:00
abstract：:In many animals, the circadian clock plays a role in adapting to the coming season by measuring day length. The mechanism for measuring day length and its neuronal circuits remains elusive, however. Under laboratory conditions, the fruit fly, Drosophila melanogaster, displays 2 activity peaks: one in the morning and o...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730417738612
更新日期：2018-02-01 00:00:00
abstract：:In Drosophila melanogaster, disruption of night by even short light exposures results in degradation of the clock protein TIMELESS (TIM), leading to shifts in the fly molecular and behavioral rhythms. Several lines of evidence indicate that light entrainment of the brain clock involves the blue-light photoreceptor cry...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/074873040101600303
更新日期：2001-06-01 00:00:00
abstract：:Mice homozygous for a dominant-negative allele of the Clock gene (Clock (Δ19/Δ19)) have slightly but significantly decreased male fertility. The molecular mechanism for this reduction in fertility is unknown. In the present study, we used a small hairpin RNA (shRNA) strategy to specifically knock down the Clock gene e...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730413486873
更新日期：2013-06-01 00:00:00
abstract：:Rats anticipate a fixed daily feeding time by entrainment of a component of their multioscillatory circadian system. The range of stimuli capable of entraining this component is little studied. Previous studies suggest that restricted water access is not an effective entrainment stimulus, as measured by general locomo...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/074873049200700206
更新日期：1992-07-01 00:00:00
abstract：:Rhodopsin 7 ( Rh7), a new invertebrate Rhodopsin gene, was discovered in the genome of Drosophila melanogaster in 2000, but its function has remained elusive. We generated an Rh7 null mutant ( Rh70) by P element-mediated mutagenesis and found that an absence of Rh7 had significant effects on fly activity patterns duri...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730417721826
更新日期：2017-10-01 00:00:00
abstract：:Temperature compensation of circadian rhythms in neuronal firing rate was investigated in the suprachiasmatic nucleus (SCN) of ground squirrels and rats in vitro. A reduction in SCN temperature from 37 to 25 degrees C reduced peak firing rates by > 70% in rats but only by approximately 21% in squirrels; trough firing ...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
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更新日期：1996-06-01 00:00:00
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journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730408328933
更新日期：2009-02-01 00:00:00
abstract：:Arctic and subarctic environments are exposed to extreme light: dark (LD) regimes, including periods of constant light (LL) and constant dark (DD) and large daily changes in day length, but very little is known about circadian rhythms of mammals at high latitudes. The authors investigated the circadian rhythms of a su...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730404264200
更新日期：2004-06-01 00:00:00
abstract：:We examine theoretical models for circadian oscillations based on transcriptional regulation in Drosophila and Neurospora. For Drosophila, the molecular model is based on the negative feedback exerted on the expression of the per and tim genes by the complex formed between the PER and TIM proteins. For Neurospora, sim...
journal_title：Journal of biological rhythms
pub_type： 杂志文章,评审
doi：10.1177/074873099129000948
更新日期：1999-12-01 00:00:00
abstract：:While the rapid development of personal computers and high-throughput recording systems for circadian rhythms allow chronobiologists to produce huge amounts of data, the software to analyze them often lags behind. Here, we announce newly developed chronobiology software that is easy to use, compatible with many differ...
journal_title：Journal of biological rhythms
pub_type： 信件
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更新日期：2011-10-01 00:00:00
abstract：:The circadian timing system has three principal elements: the retina, the intergeniculate leaflet (IGL) of the thalamus, and the suprachiasmatic nucleus (SCN). Since the human circadian timing system cannot be studied experimentally, we have used another primate, the macaque monkey, to help provide insight into the or...
journal_title：Journal of biological rhythms
pub_type： 杂志文章,评审
doi：
更新日期：1993-01-01 00:00:00
abstract：:The retinohypothalamic tract (RHT), a monosynaptic retinal projection to the SCN, is the major path by which light entrains the circadian system to the external photoperiod. The circadian system of rodents effectively integrates or counts photons, and the magnitude of the rhythm phase response is proportional to the t...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730405280458
更新日期：2005-12-01 00:00:00
abstract：:The role of the intergeniculate leaflet of the thalamus (IGL) in photoperiod responsiveness was examined in a laboratory-selected line of photoperiod nonresponsive (NR) Siberian hamsters. NR hamsters fail to exhibit typical winter-type responses (i.e., gonadal regression and development of winter-type pelage) when exp...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730406287996
更新日期：2006-06-01 00:00:00
abstract：:The circadian clock controls 24-h biological rhythms in our body, influencing many time-related activities such as sleep and wake. The simplest circadian clock is found in cyanobacteria, with the proteins KaiA, KaiB, and KaiC generating a self-sustained circadian oscillation of KaiC phosphorylation and dephosphorylati...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730419851655
更新日期：2019-08-01 00:00:00
abstract：:The pineal organ of the lizard Anolis carolinensis acts as a transducer of photoperiodic information, since light can affect the pineal melatonin rhythm (PMR). The synthesis and secretion of melatonin may be a major mechanism whereby a circadian pacemaker within the pineal can control circadian clocks located elsewher...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/074873048700200303
更新日期：1987-10-01 00:00:00
abstract：:Aging alters numerous aspects of circadian biology, including the amplitude of rhythms generated by the suprachiasmatic nuclei (SCN) of the hypothalamus, the site of the central circadian pacemaker in mammals, and the response of the pacemaker to environmental stimuli such as light. Although previous studies have desc...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
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journal_title：Journal of biological rhythms
pub_type： 杂志文章
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更新日期：2010-04-01 00:00:00
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journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730412440851
更新日期：2012-06-01 00:00:00
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journal_title：Journal of biological rhythms
pub_type： 杂志文章
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更新日期：1991-07-01 00:00:00
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journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/074873040101600107
更新日期：2001-02-01 00:00:00
abstract：:The safety and efficacy of chemotherapeutics can vary as a function of the time of their delivery during the day. This study aimed to improve the treatment of glioblastoma (GBM), the most common brain cancer, by testing whether the efficacy of the DNA alkylator temozolomide (TMZ) varies with the time of its administra...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730417696788
更新日期：2017-04-01 00:00:00
abstract：:Among the scientific resources that Colin Pittendrigh passed on to his colleagues after his death in 1996 were two unpublished papers. These manuscripts, developed first in the mid-1960s and continually updated and refined through the late 1970s, centered on the development and experimental exploration of a model of c...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/0748730417716685
更新日期：2017-08-01 00:00:00
abstract：:A rhythm mutant of Drosophila melanogaster was induced by chemical mutagenesis and isolated by testing for locomotor activity rhythms, which in the new variant had periods of approximately 16 hr. The sex-linked mutation responsible for this ultrashort period causes 20-hr rhythms when heterozygous with a normal X. This...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
doi：10.1177/074873049400900303
更新日期：1994-01-01 00:00:00
abstract：:Ground squirrels, Spermophilus tridecemlineatus, were kept in a 12:12 h light-dark cycle. As expected for a diurnal species, their locomotor activity occurred almost entirely in the daytime. Expression of mPer1 and mPer2 in the suprachiasmatic nucleus was studied at six time points by in situ hybridization. For both t...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
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更新日期：2001-10-01 00:00:00
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journal_title：Journal of biological rhythms
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更新日期：1998-02-01 00:00:00
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journal_title：Journal of biological rhythms
pub_type： 杂志文章
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更新日期：2001-12-01 00:00:00
abstract：:The large repertoire of circadian rhythms in diverse organisms depends on oscillating central clock genes, input pathways for entrainment, and output pathways for controlling rhythmic behaviors. Stress-activated p38 MAP Kinases (p38K), although sparsely investigated in this context, show circadian rhythmicity in mamma...
journal_title：Journal of biological rhythms
pub_type： 杂志文章
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更新日期：2014-12-01 00:00:00
