Searching for biological rhythms: peak detection in the periodogram of unequally spaced data.


:The classical power spectrum, computed in the frequency domain, outranks traditionally used periodograms derived in the time domain (such as the chi2 periodogram) regarding the search for biological rhythms. Unfortunately, classical power spectral analysis is not possible with unequally spaced data (e.g., time series with missing data). The Lomb-Scargle periodogram fixes this shortcoming. However, peak detection in the Lomb-Scargle periodogram of unequally spaced data requires some careful consideration. To guide researchers in the proper evaluation of detected peaks, therefore, a novel procedure and a computer program have recently become available. It is recommended that the Lomb-Scargle periodogram be the default method of periodogram analysis in future biomedical applications of rhythm investigation.


J Biol Rhythms


Van Dongen HP,Olofsen E,VanHartevelt JH,Kruyt EW




Has Abstract


1999-12-01 00:00:00












  • The circatidal rhythm persists without the optic lobe in the mangrove cricket Apteronemobius asahinai.

    abstract::Whether the circatidal rhythm is generated by a machinery common to the circadian clock is one of the important and interesting questions in chronobiology. The mangrove cricket Apteronemobius asahinai shows a circatidal rhythm generating active and inactive phases and a circadian rhythm modifying the circatidal rhythm...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Takekata H,Numata H,Shiga S

    更新日期:2014-02-01 00:00:00

  • Cycle of period gene expression in a diurnal mammal (Spermophilus tridecemlineatus): implications for nonphotic phase shifting.

    abstract::Ground squirrels, Spermophilus tridecemlineatus, were kept in a 12:12 h light-dark cycle. As expected for a diurnal species, their locomotor activity occurred almost entirely in the daytime. Expression of mPer1 and mPer2 in the suprachiasmatic nucleus was studied at six time points by in situ hybridization. For both t...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Mrosovsky N,Edelstein K,Hastings MH,Maywood ES

    更新日期:2001-10-01 00:00:00

  • Rapid Jetlag Resetting of Behavioral, Physiological, and Molecular Rhythms in Proestrous Female Mice.

    abstract::A gradual adaptation to a shifted light-dark (LD) cycle is a key element of the circadian clock system and believed to be controlled by the central circadian pacemaker, the suprachiasmatic nucleus (SCN). Endocrine factors have a strong influence on the regulation of the circadian clock network and alter acute photic r...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Pilorz V,Kolms B,Oster H

    更新日期:2020-12-01 00:00:00

  • Vasoactive intestinal polypeptide entrains circadian rhythms in astrocytes.

    abstract::Many mammalian cell types show daily rhythms in gene expression driven by a circadian pacemaker. For example, cultured astrocytes display circadian rhythms in Period1 and Period2 expression. It is not known, however, how or which intercellular factors synchronize and sustain rhythmicity in astrocytes. Because astrocyt...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Marpegan L,Krall TJ,Herzog ED

    更新日期:2009-04-01 00:00:00

  • Circadian synchronization and rhythmicity in larval photoperception-defective mutants of Drosophila.

    abstract::A single light episode during the first larval stage can set the phase of adult Drosophila activity rhythms, showing that a light-sensitive circadian clock is functional in larvae and is capable of keeping time throughout development. These behavioral data are supported by the finding that neurons expressing clock pro...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Malpel S,Klarsfeld A,Rouyer F

    更新日期:2004-02-01 00:00:00

  • The circadian clock starts ticking at a developmentally early stage.

    abstract::Although overt diurnal rhythms of behavior do not begin until well after birth, molecular studies suggest that the circadian clock may begin much earlier at a cellular level: mouse embryonic fibroblasts, for example, already possess robust clocks. By multiple criteria, we found no circadian clock present in mouse embr...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Kowalska E,Moriggi E,Bauer C,Dibner C,Brown SA

    更新日期:2010-12-01 00:00:00

  • Photoperiod history differentially impacts reproduction and immune function in adult Siberian hamsters.

    abstract::Seasonal changes in numerous aspects of mammalian immune function arise as a result of the annual variation in environmental day length (photoperiod), but it is not known if absolute photoperiod or relative change in photoperiod drives these changes. This experiment tested the hypothesis that an individual's history o...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Prendergast BJ,Pyter LM

    更新日期:2009-12-01 00:00:00

  • The Clock Keeps Ticking: Circadian Rhythms of Free-Ranging Polar Bears.

    abstract::Life in the Arctic presents organisms with multiple challenges, including extreme photic conditions, cold temperatures, and annual loss and daily movement of sea ice. Polar bears (Ursus maritimus) evolved under these unique conditions, where they rely on ice to hunt their main prey, seals. However, very little is know...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Ware JV,Rode KD,Robbins CT,Leise T,Weil CR,Jansen HT

    更新日期:2020-04-01 00:00:00

  • Metabolic rate changes proportionally to circadian frequency in tau mutant Syrian hamsters.

    abstract::The tau mutation in Syrian hamsters (Mesocricetus auratus) is phenotypically expressed in a period of the circadian rhythm of about 20 h in homozygotes (SS) and about 22 h in heterozygotes (S+). The authors investigate whether this well-defined model for variation in circadian period exhibits associated changes in ene...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Oklejewicz M,Hut RA,Daan S,Loudon AS,Stirland AJ

    更新日期:1997-10-01 00:00:00

  • Beyond intuitive modeling: combining biophysical models with innovative experiments to move the circadian clock field forward.

    abstract::Two major approaches have been used to model circadian clocks. Qualitative modeling, used prior to the recent wealth of detailed molecular knowledge, makes general predictions but cannot provide detailed mechanistic insights. The more recent biophysical approach, on the other hand, incorporates the biochemical events ...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章,评审


    authors: Forger D,Gonze D,Virshup D,Welsh DK

    更新日期:2007-06-01 00:00:00

  • The colony environment, but not direct contact with conspecifics, influences the development of circadian rhythms in honey bees.

    abstract::Honey bee (Apis mellifera) workers emerge from the pupae with no circadian rhythms in behavior or brain clock gene expression but show strong rhythms later in life. This postembryonic development of circadian rhythms is reminiscent of that of infants of humans and other primates but contrasts with most insects, which ...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Eban-Rothschild A,Shemesh Y,Bloch G

    更新日期:2012-06-01 00:00:00

  • Dual entrainment by light and food in the Svalbard ptarmigan (Lagopus mutus hyperboreus).

    abstract::The possibility that feeding may act as a zeitgeber has been investigated in captive Svalbard ptarmigan by recording feeding or food-searching activity (FA) in birds given periodic access to food (PAF) under light-dark (LD) cycles or in continuous bright (LL) or dim light (DD) conditions. Except during LL, anticipator...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Reierth E,Stokkan KA

    更新日期:1998-10-01 00:00:00

  • Regulation of circadian photic responses by nitric oxide.

    abstract::A role for nitric oxide in circadian responses to light has been indicated in previous studies. To determine the specific function of NO-, the authors manipulated NO- and nitric oxide synthase (NOS) activity prior to light pulses that would normally induce phase shifts. The NOS inhibitor, L-NAME, selectively attenuate...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Melo L,Golombek DA,Ralph MR

    更新日期:1997-08-01 00:00:00

  • Investigation of Dose-Response Relationships for Effects of White Light Exposure on Correlates of Alertness and Executive Control during Regular Daytime Working Hours.

    abstract::To date, it is largely unknown which light settings define the optimum to steer alertness and cognitive control during regular daytime working hours. In the current article, we used a multimeasure approach combined with a relatively large sample size ( N = 60) and a large range of intensity levels (20-2000 lux at eye ...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Smolders KCHJ,Peeters ST,Vogels IMLC,de Kort YAW

    更新日期:2018-12-01 00:00:00

  • PER2 Differentially Regulates Clock Phosphorylation versus Transcription by Reciprocal Switching of CK1ε Activity.

    abstract::Casein kinase 1ε (CK1ε) performs key phosphorylation reactions in the circadian clock mechanism that determine period. We show that the central clock protein PERIOD2 (PER2) not only acts as a transcriptional repressor but also inhibits the autoinactivation of CK1ε, thereby promoting CK1ε activity. Moreover, PER2 recip...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Qin X,Mori T,Zhang Y,Johnson CH

    更新日期:2015-06-01 00:00:00

  • Flies in the north: locomotor behavior and clock neuron organization of Drosophila montana.

    abstract::The circadian clock plays an important role in adaptation in time and space by synchronizing changes in physiological, developmental, and behavioral traits of organisms with daily and seasonal changes in their environment. We have studied some features of the circadian activity and clock organization in a northern Dro...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Kauranen H,Menegazzi P,Costa R,Helfrich-Förster C,Kankainen A,Hoikkala A

    更新日期:2012-10-01 00:00:00

  • Phase determination of circadian gene expression in Synechococcus elongatus PCC 7942.

    abstract::The authors analyzed the upstream regulatory region of purF, a gene that is expressed in a minority phase that peaks at dawn (class 2 circadian phasing) in Synechococcus elongatus, to determine whether specific cis elements are responsible for this characteristic expression pattern. Fusions of various promoter-bearing...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Min H,Liu Y,Johnson CH,Golden SS

    更新日期:2004-04-01 00:00:00

  • Magnesium Regulates the Circadian Oscillator in Cyanobacteria.

    abstract::The circadian clock controls 24-h biological rhythms in our body, influencing many time-related activities such as sleep and wake. The simplest circadian clock is found in cyanobacteria, with the proteins KaiA, KaiB, and KaiC generating a self-sustained circadian oscillation of KaiC phosphorylation and dephosphorylati...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Jeong YM,Dias C,Diekman C,Brochon H,Kim P,Kaur M,Kim YS,Jang HI,Kim YI

    更新日期:2019-08-01 00:00:00

  • Unexpected c-fos gene expression in the suprachiasmatic nucleus of mice entrained to a skeleton photoperiod.

    abstract::Several authors have suggested that the transcriptional regulatory protein c-Fos might be part of the mechanism for photic entrainment of the circadian pacemaker in the suprachiasmatic nucleus (SCN) to environmental light:dark cycles. This hypothesis has been based on evidence gathered using single light pulses admini...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Schwartz WJ,Peters RV,Aronin N,Bennett MR

    更新日期:1996-03-01 00:00:00

  • Microarray analysis of natural socially regulated plasticity in circadian rhythms of honey bees.

    abstract::Honey bee workers care for ("nurse") the brood around the clock without circadian rhythmicity, but then they forage outside with strong circadian rhythms and a consolidated nightly rest. This chronobiological plasticity is associated with variation in the expression of the canonical "clock genes" that regulate the cir...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Rodriguez-Zas SL,Southey BR,Shemesh Y,Rubin EB,Cohen M,Robinson GE,Bloch G

    更新日期:2012-02-01 00:00:00

  • Functionally Complete Excision of Conditional Alleles in the Mouse Suprachiasmatic Nucleus by Vgat-ires-Cre.

    abstract::Mice with targeted gene disruption have provided important information about the molecular mechanisms of circadian clock function. A full understanding of the roles of circadian-relevant genes requires manipulation of their expression in a tissue-specific manner, ideally including manipulation with high efficiency wit...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Weaver DR,van der Vinne V,Giannaris EL,Vajtay TJ,Holloway KL,Anaclet C

    更新日期:2018-04-01 00:00:00

  • Cry1-/- circadian rhythmicity depends on SCN intercellular coupling.

    abstract::In mammals, the suprachiasmatic nucleus (SCN) is the central pacemaker organizing circadian rhythms of behavior and physiology. At the cellular level, the mammalian clock consists of autoregulatory feedback loops involving a set of "clock genes," including the Cryptochrome (Cry) genes, Cry1 and Cry2. Experimental evid...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Evans JA,Pan H,Liu AC,Welsh DK

    更新日期:2012-12-01 00:00:00

  • Reduced Effective Emotion Regulation in Night Owls.

    abstract::Previous research has demonstrated a clear link between late chronotype and depression. The vulnerability factors underpinning this link, however, are unclear. Here the relationship between two specific emotion regulation strategies, cognitive reappraisal and expressive suppression, and chronotype was investigated usi...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Watts AL,Norbury R

    更新日期:2017-08-01 00:00:00

  • Changes in Female Drosophila Sleep following Mating Are Mediated by SPSN-SAG Neurons.

    abstract::Female Drosophila melanogaster, like many other organisms, exhibit different behavioral repertoires after mating with a male. These postmating responses (PMRs) include increased egg production and laying, increased rejection behavior (avoiding further male advances), decreased longevity, altered gustation and decrease...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Garbe DS,Vigderman AS,Moscato E,Dove AE,Vecsey CG,Kayser MS,Sehgal A

    更新日期:2016-12-01 00:00:00

  • Photoperiodic regulation of behavioral responses to bacterial and viral mimetics: a test of the winter immunoenhancement hypothesis.

    abstract::Siberian hamsters (Phodopus sungorus) exhibit changes in immune function following adaptation to short photoperiods, including a marked attenuation of energetically expensive thermoregulatory and behavioral responses to gram-negative bacterial infections. Whether this seasonal attenuation of the immune response is idi...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Baillie SR,Prendergast BJ

    更新日期:2008-02-01 00:00:00

  • Organization of the primate circadian system.

    abstract::The circadian timing system has three principal elements: the retina, the intergeniculate leaflet (IGL) of the thalamus, and the suprachiasmatic nucleus (SCN). Since the human circadian timing system cannot be studied experimentally, we have used another primate, the macaque monkey, to help provide insight into the or...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章,评审


    authors: Moore RY

    更新日期:1993-01-01 00:00:00

  • Circadian Health and Light: A Report on the National Heart, Lung, and Blood Institute's Workshop.

    abstract::Despite the omnipresence of artificial and natural light exposure, there exists little guidance in the United States and elsewhere on light exposure in terms of timing, intensity, spectrum, and other light characteristics known to affect human health, performance, and well-being; in parallel, there is little informati...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Mason IC,Boubekri M,Figueiro MG,Hasler BP,Hattar S,Hill SM,Nelson RJ,Sharkey KM,Wright KP,Boyd WA,Brown MK,Laposky AD,Twery MJ,Zee PC

    更新日期:2018-10-01 00:00:00

  • The intergeniculate leaflet partially mediates effects of light on circadian rhythms.

    abstract::Photic signals affect circadian activity rhythms by both phasic and tonic mechanisms that modulate pacemaker phase and period. In mammals, the effects of light on circadian activity are mediated by the retina, which communicates with the suprahiasmatic nucleus (SCN) by two different anatomical routes: the retino-hypot...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Pickard GE,Ralph MR,Menaker M

    更新日期:1987-04-01 00:00:00

  • Simulation of day-length encoding in the SCN: from single-cell to tissue-level organization.

    abstract::The circadian pacemaker of the SCN is a heterogeneous structure containing many single-cell oscillators that display phase differences in gene expression and electrical activity rhythms. Thus far, it is unknown how single neurons contribute to the population signal measured from the SCN. The authors used single-unit e...

    journal_title:Journal of biological rhythms

    pub_type: 杂志文章


    authors: Rohling J,Wolters L,Meijer JH

    更新日期:2006-08-01 00:00:00

  • A new ImageJ plug-in "ActogramJ" for chronobiological analyses.

    abstract::While the rapid development of personal computers and high-throughput recording systems for circadian rhythms allow chronobiologists to produce huge amounts of data, the software to analyze them often lags behind. Here, we announce newly developed chronobiology software that is easy to use, compatible with many differ...

    journal_title:Journal of biological rhythms

    pub_type: 信件


    authors: Schmid B,Helfrich-Förster C,Yoshii T

    更新日期:2011-10-01 00:00:00