Abstract:
BACKGROUND:Computer-assisted diagnostic systems are not substantially more accurate than the clinician in the differential diagnosis of jaundice but may help in optimal selection and sequencing of tests. The present study aimed to assess with an electronic diagnostic tool the pattern of ordering tests and the diagnostic contribution and related financial cost of each test in jaundiced patients with pancreatobiliary carcinoma, in an effort to make the clinician's diagnostic behaviour more efficient and economical. METHODS:Clinical and diagnostic test data were prospectively gathered from 356 jaundiced patients with pancreatobiliary carcinoma and entered in a Bayesian diagnostic programme. The test results were added to the existing diagnostic evidence, and the programme calculated the diagnostic contribution of each test. RESULTS:A total of 1804 diagnostic tests were ordered. Quantitative assessment of the diagnostic contribution of each test showed that percutaneous transhepatic cholangiography and computed tomography were associated with the highest provision of information. The most cost-effective tests were ultrasonography and liver function tests. CONCLUSIONS:It is possible to determine objectively the diagnostic contribution of each test in establishing the diagnosis of pancreatobiliary carcinoma. The observed physician behaviour in ordering the various diagnostic tests might be improved with regard to its efficacy and its cost-effectiveness profile.
journal_name
Scand J Gastroenteroljournal_title
Scandinavian journal of gastroenterologyauthors
de Bree E,Tsiftsis DD,Santos RM,Lavelle SM,Cuervas-Mons V,Gauthier A,Gips C,Malchow-Moeller A,Molino G,Rohr G,Theodossi A,Tsantoulas Ddoi
10.1080/003655200750024038subject
Has Abstractpub_date
2000-04-01 00:00:00pages
438-45issue
4eissn
0036-5521issn
1502-7708journal_volume
35pub_type
杂志文章abstract::In 12 patients with active ulcerative colitis (UC) the rectal epithelial cells were analyzed for HLA-DR antigens by an immunohistochemical technique. The clinical, rectoscopic, and histologic stages were also determined. The investigations were carried out at the beginning of the study and 2 weeks and 3 months later. ...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365528609003088
更新日期:1986-04-01 00:00:00
abstract::Autoimmune enteropathy is a rare disorder characterized by severe and protracted diarrhea, weight loss from malabsorption and immune-mediated damage to the intestinal mucosa, generally occurring in infants and young children, although some cases of adult onset have been reported in the literature. Pathogenetic mechani...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章,评审
doi:10.1080/00365520902783691
更新日期:2009-01-01 00:00:00
abstract::To explore the effect of hepatectomy on the secretion of lysosomal enzymes into the pancreatic juice when stimulated by gut hormones, we evaluated the cerulein-stimulated amylase output and cathepsin B output into pancreatic juice, the amylase and cathepsin B content in pancreatic tissue, and the distribution of cathe...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365529008998564
更新日期:1990-12-01 00:00:00
abstract:BACKGROUND:The DNA mismatch repair gene mutations underlying hereditary non-polyposis colorectal cancer syndrome (HNPCC) also predispose, besides colorectal and endometrial cancer, to gastric cancer. usually of the intestinal type. The carcinogenetic pathway behind the elevated gastric cancer risk is largely unknown. ...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.1080/00365520252903134
更新日期:2002-05-01 00:00:00
abstract:BACKGROUND:There have been no reports that low serum cholesterol levels increase the risk of colorectal adenoma, although many studies have shown that they do increase the risk of colorectal cancer. Alcohol intake, which is associated with a risk of colorectal adenomas, and serum cholesterol levels are closely related....
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.1080/003655202761020597
更新日期:2002-11-01 00:00:00
abstract:BACKGROUND:In theory, the optimal method for diagnosing acute hepatitis C is nucleotide amplification. This is because of the significant delay in the emergence of hepatitis C virus (HCV) antibodies. We studied whether the use of HCV polymerase chain reaction (PCR) screening for acute HCV infection in a clinical settin...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.1080/00365520310002526
更新日期:2003-05-01 00:00:00
abstract:BACKGROUND:Spontaneous bacterial peritonitis (SBP) is a complication to decompensated cirrhosis. Fluoroquinolones may prevent SBP. However, predictive markers for SBP are wanted. Guidelines suggest that patients with ascitic fluid protein below 15 g/l receive fluoroquinolones to prevent SBP. This study aimed to assess ...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.1080/00365521.2017.1411973
更新日期:2018-02-01 00:00:00
abstract::Twenty-four grossly obese patients were operated on with horizontal gastroplasty. One patient died postoperatively of pulmonary embolism. The remaining 23 were extensively studied before and repeatedly after surgery. Eighteen months postoperatively the average weight loss was 34.4 kg (range, 1-71 kg). Seven patients h...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365528509089660
更新日期:1985-03-01 00:00:00
abstract::Six pigs (49-69 kg) were anaesthetized and fitted with cannulas in the brachiocephalic artery and portal and jugular veins. In addition, inlet-outlet perfusion cannulas were placed in segments of the small and large intestine. Intravenous infusion of urea for 2 h increased arterial plasma urea from a base-line level o...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365529209000129
更新日期:1992-07-01 00:00:00
abstract:BACKGROUND:Hypertensive esophageal contraction, called nutcracker esophagus (NE), is the most common motility abnormality associated with cardiac-like chest pain. However, its significance for the development of symptoms has been a matter of controversy for decades, and recently it has been suggested that NE might repr...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.1080/003655201750305413
更新日期:2001-09-01 00:00:00
abstract:OBJECTIVES:Assessing the experience of screening procedures is crucial for improving the quality and acceptance of colonoscopy in colorectal cancer screening. The aim of the study was to investigate the colonoscopy experience and associated factors among individuals who underwent a colonoscopy in the Screening of Swedi...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.1080/00365521.2020.1820568
更新日期:2020-11-01 00:00:00
abstract::Understanding the physiology of gastroesophageal junction (GEJ) is important as failure of its function is associated with reflux disease, hiatus hernia, and cancer. In recent years, there have been impressive developments in high resolution technologies allowing measurement of luminal pressure, pH, and impedance. One...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章,评审
doi:10.3109/00365521.2012.746394
更新日期:2013-04-01 00:00:00
abstract:OBJECTIVE:The aim of the present study was to compare the ability of four clinical prediction rules to predict adverse outcome in perforated peptic ulcer (PPU): the Boey score, the American Society of Anesthesiologists (ASA) score, the Acute Physiology and Chronic Health Evaluation (APACHE) II score, and the sepsis sco...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章,多中心研究
doi:10.3109/00365521.2011.639078
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Colon gas volume analysis using abdominal radiographs is an objective and reproducible method for evaluating functional bowel disorders. The aim of this study was to clarify the relevance of colon gas distribution and transit time in rectosigmoid cancer patients after surgery. METHODS:Segmental colon gas vo...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.1080/00365520310000898
更新日期:2003-04-01 00:00:00
abstract:BACKGROUND:Tumor necrosis factor alpha (TNF alpha) and beta (TNF beta) appear to play an important role in the regulation of the inflammatory response. The aim of the present study was to investigate the intrinsic capacity of peripheral blood mononuclear cells (PBMC) to produce these cytokines. METHODS:PBMC from 41 pa...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365529509101613
更新日期:1995-11-01 00:00:00
abstract:INTRODUCTION:Cholangitis and biliary sepsis are severe infectious diseases, which are often observed in patients with choledocholithiasis. The antimicrobial therapy is effective if started as soon as the diagnosis is made. Therefore, the profile of bile pathogens and its susceptibility to a number of antibiotics were e...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365521.2011.560676
更新日期:2011-07-01 00:00:00
abstract::The effect of experimental amyloidosis on the morphology of the Paneth cells of the mouse was investigated by using light and fluorescence microscopy. Amyloidosis was induced by daily subcutaneous casein injections for 4 weeks. It was found that the number of secretory granules of the Paneth cells increased in the jej...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.1203/00006450-199404000-00010
更新日期:1977-01-01 00:00:00
abstract::The effect of antral balloon distension on acid secretion and the plasma gastrin concentration was studied in 8 duodenal ulcer patients. Antral distension significantly increased the acid secretion to about 30% of the peak acid response to pentagastrin without any change in the plasma gastrin concentration. Antral dis...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:
更新日期:1976-01-01 00:00:00
abstract:OBJECTIVE:Intercellular adhesion molecule-1 (ICAM-1) is important in ulcerative colitis (UC) by mediating the arrest and further migration of neutrophils. In vitro studies have shown that colonocytes from chronically inflamed colon and cultured colon cancer cells are capable of expressing ICAM-1. The aim of this study ...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.1080/00365520510024241
更新日期:2006-03-01 00:00:00
abstract::Small-intestinal mucosal biopsy specimens obtained by a Watson capsule were assessed by light (LM) and scanning electron (SEM) microscopy in 18 patients with various sites of Crohn's disease and in 6 healthy controls. By means of LM, partial villous atrophy of the upper small-intestinal mucosa was assessed in six pati...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:
更新日期:1984-05-01 00:00:00
abstract:BACKGROUND:The fate of asymptomatic gallstones has not been investigated in many studies with a long-term follow-up. We wanted to examine the subsequent rate of cholecystectomy and gallstone-related symptoms in a population examined in 1983. METHODS:Among the persons examined in 1983, unknown (perceived as silent) gal...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365521.2011.571710
更新日期:2011-07-01 00:00:00
abstract::The strength and the validity of the multi-crossover model (MCO model) were investigated to optimalize the procedure for correctly classifying individual responders to a given therapy. One hundred and fifteen patients with non-ulcer dyspepsia from seven Norwegian hospitals were included in a 6-week double-blind MCO-de...
journal_title:Scandinavian journal of gastroenterology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.3109/00365529108998597
更新日期:1991-07-01 00:00:00
abstract::In 1964 1.6-1.8% of the population in Copenhagen County - with a population of approx. 500,000 - were referred for a radiological examination of the stomach. The incidence, the same in both sexes, increased with increasing age, being 1% at the age of 20 years and 3-4% at the age of 70 years. The probability of demonst...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:
更新日期:1976-01-01 00:00:00
abstract:BACKGROUND:There is a striking male predominance in esophageal cancer patients. Sex hormones have been suggested as a contributing factor and these are influenced by age and race. In this study, we examined the male-to-female incidence rate ratios of esophageal cancer in the United States. METHODS:We used data from 13...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365521.2011.551890
更新日期:2011-05-01 00:00:00
abstract:INTRODUCTION:With immunosuppressive therapy of inflammatory bowel diseases (IBDs) becoming more aggressive, the risk of serious infections is increasing. Guidelines are currently being modified in respect to advisable immunizations. The aim of this study was to evaluate the immunization habits of IBD patients in daily ...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365521.2011.574734
更新日期:2011-07-01 00:00:00
abstract:OBJECTIVE:Some biliary neoplasms secrete copious mucin into bile ducts, yet the management of mucobilia is not well known. The objective of this study was to analyze 16 patients with copious mucin in the biliary tract stressing the diagnostic and therapeutic aspects of endoscopic retrograde cholangiography (ERC). MATE...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.1080/00365520802029856
更新日期:2008-01-01 00:00:00
abstract::In a 24-month trial of a combination therapy with ursodeoxycholic acid and chenodeoxycholic acid complete dissolution of radiolucent gallstones was achieved in 15 of 55 patients (27.3%). A decrease of stone volume of greater than 35% was achieved in a further 28 patients (50.9%). In 12 patients (21.8%) inadequate comp...
journal_title:Scandinavian journal of gastroenterology
pub_type: 临床试验,杂志文章
doi:10.3109/00365529108996496
更新日期:1991-04-01 00:00:00
abstract::The effect of short-time somatostatin infusion on gastric and intestinal propulsion of an oral glucose load was examined in healthy subjects by means of a multiple indicator dilution technique. The early gastric emptying rate was enhanced by somatostatin, indicating delayed gastric inhibition. After withdrawal of the ...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365527809181925
更新日期:1978-01-01 00:00:00
abstract:BACKGROUND:This is a retrospective study of 32 consecutive patients referred in the period 1992-2000 for management of serious bile duct injuries caused by elective laparoscopic cholecystectomy. METHODS:The patients were referred on median 29 days (0 days to 34 months). Only 7 patients were referred immediately after ...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.1080/003655202317316123
更新日期:2002-04-01 00:00:00
abstract::During the period 1 January 1980 to 30 June 1986, a total of 543 small-intestinal biopsy specimens from adults with gastrointestinal symptoms were available for routine analysis with correlated scanning electron microscopy and light microscopy. Adhesion of microorganisms was found in 77 biopsy specimens. Microorganism...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365528909089229
更新日期:1989-09-01 00:00:00