Abstract:
:Pyruvate carboxylase (PC) has been quantified in rat liver and kidney cortex under experimental conditions that modify the gluconeogenic response in both organs: fasting, carbon tetrachloride-induced liver degeneration and alloxan-induced diabetes. Enzymatic activity has been assayed by a 14CO2-fixation method. The amount of enzyme has been determined by competitive ELISA using antibodies raised against the purified rat kidney cortex enzyme. Purified fractions of rat-liver and rat-kidney cortex PC have been used as standards. Fasting and carbon tetrachloride administration induced a significant increase (25% to 30%) in the amount of enzyme in liver and kidney cortex. Alloxan-induced diabetes produced a nearly two-fold increase in the hepatic levels of enzyme without a significant modification in the content of the renal enzyme. These results are discussed on the basis of the different metabolic implications of both organs during the physiological or toxic treatments.
journal_name
Arch Physiol Biochemjournal_title
Archives of physiology and biochemistryauthors
Salto R,Sola M,Oliver FJ,Vargas AMdoi
10.1076/apab.104.7.845.13111subject
Has Abstractpub_date
1996-12-01 00:00:00pages
845-50issue
7eissn
1381-3455issn
1744-4160journal_volume
104pub_type
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journal_title:Archives of physiology and biochemistry
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journal_title:Archives of physiology and biochemistry
pub_type: 临床试验,杂志文章
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journal_title:Archives of physiology and biochemistry
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