Abstract:
:The past few years have seen exciting advances in understanding the structure and function of catalytic RNA. Crystal structures of several ribozymes have provided detailed insight into the folds of RNA molecules. Models of other biologically important RNAs have been constructed based on structural, phylogenetic, and biochemical data. However, many questions regarding the catalytic mechanisms of ribozymes remain. This review compares the structures and possible catalytic mechanisms of four small self-cleaving RNAs: the hammerhead, hairpin, hepatitis delta virus, and in vitro-selected lead-dependent ribozymes. The organization of these small catalysts is contrasted to that of larger ribozymes, such as the group I intron.
journal_name
Annu Rev Biochemjournal_title
Annual review of biochemistryauthors
Doherty EA,Doudna JAdoi
10.1146/annurev.biochem.69.1.597subject
Has Abstractpub_date
2000-01-01 00:00:00pages
597-615eissn
0066-4154issn
1545-4509pii
69/1/597journal_volume
69pub_type
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