Abstract:
:Staphylococcus aureus is a major human and veterinary pathogen worldwide. Methicillin-resistant S. aureus (MRSA) poses a significant and enduring problem to the treatment of infection by such strains. Resistance is usually conferred by the acquisition of a nonnative gene encoding a penicillin-binding protein (PBP2a), with significantly lower affinity for β-lactams. This resistance allows cell-wall biosynthesis, the target of β-lactams, to continue even in the presence of typically inhibitory concentrations of antibiotic. PBP2a is encoded by the mecA gene, which is carried on a distinct mobile genetic element (SCCmec), the expression of which is controlled through a proteolytic signal transduction pathway comprising a sensor protein (MecR1) and a repressor (MecI). Many of the molecular and biochemical mechanisms underlying methicillin resistance in S. aureus have been elucidated, including regulatory events and the structure of key proteins. Here we review recent advances in this area.
journal_name
Annu Rev Biochemjournal_title
Annual review of biochemistryauthors
Peacock SJ,Paterson GKdoi
10.1146/annurev-biochem-060614-034516subject
Has Abstractpub_date
2015-01-01 00:00:00pages
577-601eissn
0066-4154issn
1545-4509journal_volume
84pub_type
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journal_title:Annual review of biochemistry
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journal_title:Annual review of biochemistry
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journal_title:Annual review of biochemistry
pub_type: 杂志文章,评审
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更新日期:2000-01-01 00:00:00
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journal_title:Annual review of biochemistry
pub_type: 杂志文章,评审
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更新日期:2005-01-01 00:00:00
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journal_title:Annual review of biochemistry
pub_type: 杂志文章,评审
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更新日期:2003-01-01 00:00:00
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journal_title:Annual review of biochemistry
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更新日期:1997-01-01 00:00:00
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更新日期:2017-06-20 00:00:00
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journal_title:Annual review of biochemistry
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更新日期:2004-01-01 00:00:00
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journal_title:Annual review of biochemistry
pub_type: 杂志文章
doi:10.1146/annurev-biochem-060614-034157
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更新日期:2015-01-01 00:00:00
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journal_title:Annual review of biochemistry
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journal_title:Annual review of biochemistry
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更新日期:2009-01-01 00:00:00
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journal_title:Annual review of biochemistry
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更新日期:2006-01-01 00:00:00
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journal_title:Annual review of biochemistry
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更新日期:1999-01-01 00:00:00
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journal_title:Annual review of biochemistry
pub_type: 杂志文章,评审
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更新日期:2009-01-01 00:00:00
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journal_title:Annual review of biochemistry
pub_type: 杂志文章,评审
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更新日期:2016-06-02 00:00:00
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更新日期:1996-01-01 00:00:00