Abstract:
:DNA mismatch repair (MMR) is an evolutionarily conserved process that corrects mismatches generated during DNA replication and escape proofreading. MMR proteins also participate in many other DNA transactions, such that inactivation of MMR can have wide-ranging biological consequences, which can be either beneficial or detrimental. We begin this review by briefly considering the multiple functions of MMR proteins and the consequences of impaired function. We then focus on the biochemical mechanism of MMR replication errors. Emphasis is on structure-function studies of MMR proteins, on how mismatches are recognized, on the process by which the newly replicated strand is identified, and on excision of the replication error.
journal_name
Annu Rev Biochemjournal_title
Annual review of biochemistryauthors
Kunkel TA,Erie DAdoi
10.1146/annurev.biochem.74.082803.133243subject
Has Abstractpub_date
2005-01-01 00:00:00pages
681-710eissn
0066-4154issn
1545-4509journal_volume
74pub_type
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