DNA mismatch repair.

Abstract:

:DNA mismatch repair (MMR) is an evolutionarily conserved process that corrects mismatches generated during DNA replication and escape proofreading. MMR proteins also participate in many other DNA transactions, such that inactivation of MMR can have wide-ranging biological consequences, which can be either beneficial or detrimental. We begin this review by briefly considering the multiple functions of MMR proteins and the consequences of impaired function. We then focus on the biochemical mechanism of MMR replication errors. Emphasis is on structure-function studies of MMR proteins, on how mismatches are recognized, on the process by which the newly replicated strand is identified, and on excision of the replication error.

journal_name

Annu Rev Biochem

authors

Kunkel TA,Erie DA

doi

10.1146/annurev.biochem.74.082803.133243

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

681-710

eissn

0066-4154

issn

1545-4509

journal_volume

74

pub_type

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