Abstract:
:Phylum Apicomplexa comprises a large group of obligate intracellular parasites of high medical and veterinary importance. These organisms succeed intracellularly by effecting remarkable changes in a broad range of diverse host cells. The transformation of the host erythrocyte is particularly striking in the case of the malaria parasite Plasmodium falciparum. P. falciparum exports hundreds of proteins that mediate a complex cellular renovation marked by changes in the permeability, rigidity, and cytoadherence properties of the host erythrocyte. The past decade has seen enormous progress in understanding the identity and function of these exported effectors, as well as the mechanisms by which they are trafficked into the host cell. Here we review these advances, place them in the context of host manipulation by related apicomplexans, and propose key directions for future research.
journal_name
Annu Rev Biochemjournal_title
Annual review of biochemistryauthors
Spillman NJ,Beck JR,Goldberg DEdoi
10.1146/annurev-biochem-060614-034157subject
Has Abstractpub_date
2015-01-01 00:00:00pages
813-41eissn
0066-4154issn
1545-4509journal_volume
84pub_type
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