听力与言语-语言病理学

行为科学

医学伦理学

你正在浏览Annual Review of Biochemistry期刊下所有文献
  • Chemical Biology Framework to Illuminate Proteostasis.

    abstract::Protein folding in the cell is mediated by an extensive network of >1,000 chaperones, quality control factors, and trafficking mechanisms collectively termed the proteostasis network. While the components and organization of this network are generally well established, our understanding of how protein-folding problems...

    journal_title:Annual review of biochemistry

    pub_type: 杂志文章

    doi:10.1146/annurev-biochem-013118-111552

    authors: Sebastian RM,Shoulders MD

    更新日期:2020-06-20 00:00:00

  • Christopher Dobson, 1949-2019: Mentor, Friend, Scientist Extraordinaire.

    abstract::It is impossible to do justice in one review article to a researcher of the stature of Christopher Dobson. His career spanned almost five decades, resulting in more than 870 publications and a legacy that will continue to influence the lives of many for decades to come. In this review, I have attempted to capture Chri...

    journal_title:Annual review of biochemistry

    pub_type: 杂志文章

    doi:10.1146/annurev-biochem-011520-105226

    authors: Robinson CV

    更新日期:2020-06-20 00:00:00

  • Standing on the Shoulders of Viruses.

    abstract::My coworkers and I have used animal viruses and their interaction with host cells to investigate cellular processes difficult to study by other means. This approach has allowed us to branch out in many directions, including membrane protein characterization, endocytosis, secretion, protein folding, quality control, an...

    journal_title:Annual review of biochemistry

    pub_type: 杂志文章

    doi:10.1146/annurev-biochem-011320-103928

    authors: Helenius A

    更新日期:2020-06-20 00:00:00

  • Single-Molecule Kinetics in Living Cells.

    abstract::In the past decades, advances in microscopy have made it possible to study the dynamics of individual biomolecules in vitro and resolve intramolecular kinetics that would otherwise be hidden in ensemble averages. More recently, single-molecule methods have been used to image, localize, and track individually labeled m...

    journal_title:Annual review of biochemistry

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-biochem-013118-110801

    authors: Elf J,Barkefors I

    更新日期:2019-06-20 00:00:00

  • Soluble Methane Monooxygenase.

    abstract::Aerobic life is possible because the molecular structure of oxygen (O2) makes direct reaction with most organic materials at ambient temperatures an exceptionally slow process. Of course, these reactions are inherently very favorable, and they occur rapidly with the release of a great deal of energy at high temperatur...

    journal_title:Annual review of biochemistry

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-biochem-013118-111529

    authors: Banerjee R,Jones JC,Lipscomb JD

    更新日期:2019-06-20 00:00:00

  • Transition Metal Sequestration by the Host-Defense Protein Calprotectin.

    abstract::In response to microbial infection, the human host deploys metal-sequestering host-defense proteins, which reduce nutrient availability and thereby inhibit microbial growth and virulence. Calprotectin (CP) is an abundant antimicrobial protein released from neutrophils and epithelial cells at sites of infection. CP seq...

    journal_title:Annual review of biochemistry

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-biochem-062917-012312

    authors: Zygiel EM,Nolan EM

    更新日期:2018-06-20 00:00:00

  • Principles of Protein Stability and Their Application in Computational Design.

    abstract::Proteins are increasingly used in basic and applied biomedical research. Many proteins, however, are only marginally stable and can be expressed in limited amounts, thus hampering research and applications. Research has revealed the thermodynamic, cellular, and evolutionary principles and mechanisms that underlie marg...

    journal_title:Annual review of biochemistry

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-biochem-062917-012102

    authors: Goldenzweig A,Fleishman SJ

    更新日期:2018-06-20 00:00:00

  • Defining Adult Stem Cells by Function, not by Phenotype.

    abstract::Central to the classical hematopoietic stem cell (HSC) paradigm is the concept that the maintenance of blood cell numbers is exclusively executed by a discrete physical entity: the transplantable HSC. The HSC paradigm has served as a stereotypic template in stem cell biology, yet the search for rare, hardwired profess...

    journal_title:Annual review of biochemistry

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-biochem-062917-012341

    authors: Clevers H,Watt FM

    更新日期:2018-06-20 00:00:00

  • Regulation of Clathrin-Mediated Endocytosis.

    abstract::Clathrin-mediated endocytosis (CME) is the major endocytic pathway in mammalian cells. It is responsible for the uptake of transmembrane receptors and transporters, for remodeling plasma membrane composition in response to environmental changes, and for regulating cell surface signaling. CME occurs via the assembly an...

    journal_title:Annual review of biochemistry

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-biochem-062917-012644

    authors: Mettlen M,Chen PH,Srinivasan S,Danuser G,Schmid SL

    更新日期:2018-06-20 00:00:00

  • Ancient Biomolecules and Evolutionary Inference.

    abstract::Over the past three decades, studies of ancient biomolecules-particularly ancient DNA, proteins, and lipids-have revolutionized our understanding of evolutionary history. Though initially fraught with many challenges, today the field stands on firm foundations. Researchers now successfully retrieve nucleotide and amin...

    journal_title:Annual review of biochemistry

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-biochem-062917-012002

    authors: Cappellini E,Prohaska A,Racimo F,Welker F,Pedersen MW,Allentoft ME,de Barros Damgaard P,Gutenbrunner P,Dunne J,Hammann S,Roffet-Salque M,Ilardo M,Moreno-Mayar JV,Wang Y,Sikora M,Vinner L,Cox J,Evershed RP,Willerslev E

    更新日期:2018-06-20 00:00:00

  • Protein Misfolding, Amyloid Formation, and Human Disease: A Summary of Progress Over the Last Decade.

    abstract::Peptides and proteins have been found to possess an inherent tendency to convert from their native functional states into intractable amyloid aggregates. This phenomenon is associated with a range of increasingly common human disorders, including Alzheimer and Parkinson diseases, type II diabetes, and a number of syst...

    journal_title:Annual review of biochemistry

    pub_type: 历史文章,杂志文章,评审

    doi:10.1146/annurev-biochem-061516-045115

    authors: Chiti F,Dobson CM

    更新日期:2017-06-20 00:00:00

  • Mitochondrial Machineries for Protein Import and Assembly.

    abstract::Mitochondria are essential organelles with numerous functions in cellular metabolism and homeostasis. Most of the >1,000 different mitochondrial proteins are synthesized as precursors in the cytosol and are imported into mitochondria by five transport pathways. The protein import machineries of the mitochondrial membr...

    journal_title:Annual review of biochemistry

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-biochem-060815-014352

    authors: Wiedemann N,Pfanner N

    更新日期:2017-06-20 00:00:00

  • Molecular Characteristics and Biological Functions of Surface-Active and Surfactant Proteins.

    abstract::Many critical biological processes take place at hydrophobic:hydrophilic interfaces, and a wide range of organisms produce surface-active proteins and peptides that reduce surface and interfacial tension and mediate growth and development at these boundaries. Microorganisms produce both small lipid-associated peptides...

    journal_title:Annual review of biochemistry

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-biochem-061516-044847

    authors: Sunde M,Pham CLL,Kwan AH

    更新日期:2017-06-20 00:00:00

  • Mechanics and Single-Molecule Interrogation of DNA Recombination.

    abstract::The repair of DNA by homologous recombination is an essential, efficient, and high-fidelity process that mends DNA lesions formed during cellular metabolism; these lesions include double-stranded DNA breaks, daughter-strand gaps, and DNA cross-links. Genetic defects in the homologous recombination pathway undermine ge...

    journal_title:Annual review of biochemistry

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-biochem-060614-034352

    authors: Bell JC,Kowalczykowski SC

    更新日期:2016-06-02 00:00:00

  • The p53 Pathway: Origins, Inactivation in Cancer, and Emerging Therapeutic Approaches.

    abstract::Inactivation of the transcription factor p53, through either direct mutation or aberrations in one of its many regulatory pathways, is a hallmark of virtually every tumor. In recent years, screening for p53 activators and a better understanding of the molecular mechanisms of oncogenic perturbations of p53 function hav...

    journal_title:Annual review of biochemistry

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-biochem-060815-014710

    authors: Joerger AC,Fersht AR

    更新日期:2016-06-02 00:00:00

  • Nucleic Acid-Based Nanodevices in Biological Imaging.

    abstract::The nanoscale engineering of nucleic acids has led to exciting molecular technologies for high-end biological imaging. The predictable base pairing, high programmability, and superior new chemical and biological methods used to access nucleic acids with diverse lengths and in high purity, coupled with computational to...

    journal_title:Annual review of biochemistry

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-biochem-060815-014244

    authors: Chakraborty K,Veetil AT,Jaffrey SR,Krishnan Y

    更新日期:2016-06-02 00:00:00

  • Protein export into malaria parasite-infected erythrocytes: mechanisms and functional consequences.

    abstract::Phylum Apicomplexa comprises a large group of obligate intracellular parasites of high medical and veterinary importance. These organisms succeed intracellularly by effecting remarkable changes in a broad range of diverse host cells. The transformation of the host erythrocyte is particularly striking in the case of th...

    journal_title:Annual review of biochemistry

    pub_type: 杂志文章

    doi:10.1146/annurev-biochem-060614-034157

    authors: Spillman NJ,Beck JR,Goldberg DE

    更新日期:2015-01-01 00:00:00

  • Magic angle spinning NMR of proteins: high-frequency dynamic nuclear polarization and (1)H detection.

    abstract::Magic angle spinning (MAS) NMR studies of amyloid and membrane proteins and large macromolecular complexes are an important new approach to structural biology. However, the applicability of these experiments, which are based on (13)C- and (15)N-detected spectra, would be enhanced if the sensitivity were improved. Here...

    journal_title:Annual review of biochemistry

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-biochem-060614-034206

    authors: Su Y,Andreas L,Griffin RG

    更新日期:2015-01-01 00:00:00

  • Application of the protein semisynthesis strategy to the generation of modified chromatin.

    abstract::Histone proteins are subject to a host of posttranslational modifications (PTMs) that modulate chromatin structure and function. Such control is achieved by the direct alteration of the intrinsic physical properties of the chromatin fiber or by regulating the recruitment and activity of a host of trans-acting nuclear ...

    journal_title:Annual review of biochemistry

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-biochem-060614-034429

    authors: Holt M,Muir T

    更新日期:2015-01-01 00:00:00

  • Structure, dynamics, assembly, and evolution of protein complexes.

    abstract::The assembly of individual proteins into functional complexes is fundamental to nearly all biological processes. In recent decades, many thousands of homomeric and heteromeric protein complex structures have been determined, greatly improving our understanding of the fundamental principles that control symmetric and a...

    journal_title:Annual review of biochemistry

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-biochem-060614-034142

    authors: Marsh JA,Teichmann SA

    更新日期:2015-01-01 00:00:00

  • Termination of Transcription of Short Noncoding RNAs by RNA Polymerase II.

    abstract::The RNA polymerase II transcription cycle is often divided into three major stages: initiation, elongation, and termination. Research over the last decade has blurred these divisions and emphasized the tightly regulated transitions that occur as RNA polymerase II synthesizes a transcript from start to finish. Transcri...

    journal_title:Annual review of biochemistry

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-biochem-060614-034457

    authors: Arndt KM,Reines D

    更新日期:2015-01-01 00:00:00

  • Mechanisms of Methicillin Resistance in Staphylococcus aureus.

    abstract::Staphylococcus aureus is a major human and veterinary pathogen worldwide. Methicillin-resistant S. aureus (MRSA) poses a significant and enduring problem to the treatment of infection by such strains. Resistance is usually conferred by the acquisition of a nonnative gene encoding a penicillin-binding protein (PBP2a), ...

    journal_title:Annual review of biochemistry

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-biochem-060614-034516

    authors: Peacock SJ,Paterson GK

    更新日期:2015-01-01 00:00:00

  • Progress toward synthetic cells.

    abstract::The complexity of even the simplest known life forms makes efforts to synthesize living cells from inanimate components seem like a daunting task. However, recent progress toward the creation of synthetic cells, ranging from simple protocells to artificial cells approaching the complexity of bacteria, suggests that th...

    journal_title:Annual review of biochemistry

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-biochem-080411-124036

    authors: Blain JC,Szostak JW

    更新日期:2014-01-01 00:00:00

  • Hydrogen tunneling links protein dynamics to enzyme catalysis.

    abstract::The relationship between protein dynamics and function is a subject of considerable contemporary interest. Although protein motions are frequently observed during ligand binding and release steps, the contribution of protein motions to the catalysis of bond making/breaking processes is more difficult to probe and veri...

    journal_title:Annual review of biochemistry

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-biochem-051710-133623

    authors: Klinman JP,Kohen A

    更新日期:2013-01-01 00:00:00

  • GTPase networks in membrane traffic.

    abstract::Members of the Rab or ARF/Sar branches of the Ras GTPase superfamily regulate almost every step of intracellular membrane traffic. A rapidly growing body of evidence indicates that these GTPases do not act as lone agents but are networked to one another through a variety of mechanisms to coordinate the individual even...

    journal_title:Annual review of biochemistry

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-biochem-052810-093700

    authors: Mizuno-Yamasaki E,Rivera-Molina F,Novick P

    更新日期:2012-01-01 00:00:00

  • Endoplasmic reticulum stress and type 2 diabetes.

    abstract::Given the functional importance of the endoplasmic reticulum (ER), an organelle that performs folding, modification, and trafficking of secretory and membrane proteins to the Golgi compartment, the maintenance of ER homeostasis in insulin-secreting β-cells is very important. When ER homeostasis is disrupted, the ER ge...

    journal_title:Annual review of biochemistry

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-biochem-072909-095555

    authors: Back SH,Kaufman RJ

    更新日期:2012-01-01 00:00:00

  • Structural perspective of peptidoglycan biosynthesis and assembly.

    abstract::The peptidoglycan biosynthetic pathway is a critical process in the bacterial cell and is exploited as a target for the design of antibiotics. This pathway culminates in the production of the peptidoglycan layer, which is composed of polymerized glycan chains with cross-linked peptide substituents. This layer forms th...

    journal_title:Annual review of biochemistry

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-biochem-061809-112742

    authors: Lovering AL,Safadi SS,Strynadka NC

    更新日期:2012-01-01 00:00:00

  • Ubiquitin and proteasomes in transcription.

    abstract::Regulation of gene transcription is vitally important for the maintenance of normal cellular homeostasis. Failure to correctly regulate gene expression, or to deal with problems that arise during the transcription process, can lead to cellular catastrophe and disease. One of the ways cells cope with the challenges of ...

    journal_title:Annual review of biochemistry

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-biochem-052110-120012

    authors: Geng F,Wenzel S,Tansey WP

    更新日期:2012-01-01 00:00:00

  • Regulation of HSF1 function in the heat stress response: implications in aging and disease.

    abstract::To dampen proteotoxic stresses and maintain protein homeostasis, organisms possess a stress-responsive molecular machinery that detects and neutralizes protein damage. A prominent feature of stressed cells is the increased synthesis of heat shock proteins (Hsps) that aid in the refolding of misfolded peptides and rest...

    journal_title:Annual review of biochemistry

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-biochem-060809-095203

    authors: Anckar J,Sistonen L

    更新日期:2011-01-01 00:00:00

  • Enzymatic transition states, transition-state analogs, dynamics, thermodynamics, and lifetimes.

    abstract::Experimental analysis of enzymatic transition-state structures uses kinetic isotope effects (KIEs) to report on bonding and geometry differences between reactants and the transition state. Computational correlation of experimental values with chemical models permits three-dimensional geometric and electrostatic assign...

    journal_title:Annual review of biochemistry

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-biochem-061809-100742

    authors: Schramm VL

    更新日期:2011-01-01 00:00:00

  • Structural biology of the Toll-like receptor family.

    abstract::Innate immune receptors respond to common structural patterns in microbial molecules and are called pattern recognition receptors. Toll-like receptors (TLRs) play critical roles in the innate immune system by recognizing microbial lipids, carbohydrates, nucleic acids, and proteins. Precise definition of the ligand "pa...

    journal_title:Annual review of biochemistry

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-biochem-052909-141507

    authors: Kang JY,Lee JO

    更新日期:2011-01-01 00:00:00

  • Assembly of bacterial inner membrane proteins.

    abstract::Numerous membrane proteins form multisubunit protein complexes, which contain both integral and peripheral subunits, in addition to prosthetic groups. Bacterial membrane proteins are inserted into the inner membrane by the Sec translocase and YidC insertase. Their folding can be facilitated by YidC and the phospholipi...

    journal_title:Annual review of biochemistry

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-biochem-060409-092524

    authors: Dalbey RE,Wang P,Kuhn A

    更新日期:2011-01-01 00:00:00

  • Protein folding and modification in the mammalian endoplasmic reticulum.

    abstract::Analysis of the human genome reveals that approximately a third of all open reading frames code for proteins that enter the endoplasmic reticulum (ER), demonstrating the importance of this organelle for global protein maturation. The path taken by a polypeptide through the secretory pathway starts with its translocati...

    journal_title:Annual review of biochemistry

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-biochem-062209-093836

    authors: Braakman I,Bulleid NJ

    更新日期:2011-01-01 00:00:00

  • Signals and combinatorial functions of histone modifications.

    abstract::Alterations of chromatin structure have been shown to be crucial for response to cell signaling and for programmed gene expression in development. Posttranslational histone modifications influence changes in chromatin structure both directly and by targeting or activating chromatin-remodeling complexes. Histone modifi...

    journal_title:Annual review of biochemistry

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-biochem-061809-175347

    authors: Suganuma T,Workman JL

    更新日期:2011-01-01 00:00:00

  • From virus structure to chromatin: X-ray diffraction to three-dimensional electron microscopy.

    abstract::Early influences led me first to medical school with a view to microbiology, but I felt the lack of a deeper foundation and changed to chemistry, which in turn led me to physics and mathematics. I moved to the University of Cape Town to work on the X-ray crystallography of some small organic compounds. I developed a n...

    journal_title:Annual review of biochemistry

    pub_type: 传,历史文章,杂志文章

    doi:10.1146/annurev.biochem.79.091407.093947

    authors: Klug A

    更新日期:2010-01-01 00:00:00

  • Essentials for ATP synthesis by F1F0 ATP synthases.

    abstract::The majority of cellular energy in the form of adenosine triphosphate (ATP) is synthesized by the ubiquitous F(1)F(0) ATP synthase. Power for ATP synthesis derives from an electrochemical proton (or Na(+)) gradient, which drives rotation of membranous F(0) motor components. Efficient rotation not only requires a signi...

    journal_title:Annual review of biochemistry

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.biochem.78.081307.104803

    authors: von Ballmoos C,Wiedenmann A,Dimroth P

    更新日期:2009-01-01 00:00:00

  • A journey in the world of DNA rings and beyond.

    abstract::I was born in China and would have remained there but for the tumultuous events that led many of my generation to the United States for graduate studies. Norman Davidson introduced me to DNA when I became a postdoctoral fellow in his group at the California Institute of Technology in 1964, and a fortuitous conversatio...

    journal_title:Annual review of biochemistry

    pub_type: 传,历史文章,杂志文章

    doi:10.1146/annurev.biochem.78.030107.090101

    authors: Wang JC

    更新日期:2009-01-01 00:00:00

  • Mechanisms of endocytosis.

    abstract::Endocytic mechanisms control the lipid and protein composition of the plasma membrane, thereby regulating how cells interact with their environments. Here, we review what is known about mammalian endocytic mechanisms, with focus on the cellular proteins that control these events. We discuss the well-studied clathrin-m...

    journal_title:Annual review of biochemistry

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.biochem.78.081307.110540

    authors: Doherty GJ,McMahon HT

    更新日期:2009-01-01 00:00:00

  • The biology of chromatin remodeling complexes.

    abstract::The packaging of chromosomal DNA by nucleosomes condenses and organizes the genome, but occludes many regulatory DNA elements. However, this constraint also allows nucleosomes and other chromatin components to actively participate in the regulation of transcription, chromosome segregation, DNA replication, and DNA rep...

    journal_title:Annual review of biochemistry

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.biochem.77.062706.153223

    authors: Clapier CR,Cairns BR

    更新日期:2009-01-01 00:00:00

  • Translation at the single-molecule level.

    abstract::Decades of studies have established translation as a multistep, multicomponent process that requires intricate communication to achieve high levels of speed, accuracy, and regulation. A crucial next step in understanding translation is to reveal the functional significance of the large-scale motions implied by static ...

    journal_title:Annual review of biochemistry

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.biochem.77.070606.101431

    authors: Marshall RA,Aitken CE,Dorywalska M,Puglisi JD

    更新日期:2008-01-01 00:00:00

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