Abstract:
:D-amino acids have been detected in a variety of peptides synthesized by animal cells. These include opiate and antimicrobial peptides from amphibian skin, neuropeptides from snail ganglia, a hormone from crustaceans, and a constituent of a spider venom. cDNA cloning has shown that at those positions where a D-amino acid is found in the end-product, a normal codon for the corresponding L-amino acid is present. This implies that the D-residues are formed from L-amino acids by a posttranslational reaction. A prototype enzyme catalyzing such a reaction has recently been isolated from the venom of the funnel web spider.
journal_name
Annu Rev Biochemjournal_title
Annual review of biochemistryauthors
Kreil Gdoi
10.1146/annurev.biochem.66.1.337subject
Has Abstractpub_date
1997-01-01 00:00:00pages
337-45eissn
0066-4154issn
1545-4509journal_volume
66pub_type
杂志文章,评审abstract::Proteins are increasingly used in basic and applied biomedical research. Many proteins, however, are only marginally stable and can be expressed in limited amounts, thus hampering research and applications. Research has revealed the thermodynamic, cellular, and evolutionary principles and mechanisms that underlie marg...
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更新日期:1997-01-01 00:00:00
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