Abstract:
:Mechanisms of chemical reaction can often be predicted by determining the dependence of the lifetime of reaction intermediates on the structure of the reactants. When there is no lifetime in the presence of another reactant or catalyst the reaction proceeds through an enforced concerted mechanism. Noncovalent binding interactions between enzymes and their substrates provide a major contribution to catalysis by decreasing entropy and by destabilizing the ground state relative to the transition state, as well as by covalent and noncovalent chemical interactions with the substrate. Movement in biological systems, such as muscle contraction and the active transport of ions, is generally brought about through a series of alternating chemical and vectorial steps that involve a series of changes in the specificity for catalysis of the chemical and vectorial reactions. These changes divide the overall reaction into segments so that neither the chemical nor the vectorial reaction will be completed unless the other is also completed.
journal_name
Annu Rev Biochemjournal_title
Annual review of biochemistryauthors
Jencks WPdoi
10.1146/annurev.biochem.66.1.1subject
Has Abstractpub_date
1997-01-01 00:00:00pages
1-18eissn
0066-4154issn
1545-4509journal_volume
66pub_type
传,历史文章,杂志文章abstract::The repair of DNA by homologous recombination is an essential, efficient, and high-fidelity process that mends DNA lesions formed during cellular metabolism; these lesions include double-stranded DNA breaks, daughter-strand gaps, and DNA cross-links. Genetic defects in the homologous recombination pathway undermine ge...
journal_title:Annual review of biochemistry
pub_type: 杂志文章,评审
doi:10.1146/annurev-biochem-060614-034352
更新日期:2016-06-02 00:00:00
abstract::The structure and integrity of telomeres are essential for genome stability. Telomere dysregulation can lead to cell death, cell senescence, or abnormal cell proliferation. The maintenance of telomere repeats in most eukaryotic organisms requires telomerase, which consists of a reverse transcriptase (RT) and an RNA te...
journal_title:Annual review of biochemistry
pub_type: 杂志文章,评审
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journal_title:Annual review of biochemistry
pub_type: 杂志文章,评审
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更新日期:1995-01-01 00:00:00
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journal_title:Annual review of biochemistry
pub_type: 杂志文章,评审
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更新日期:2012-01-01 00:00:00
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journal_title:Annual review of biochemistry
pub_type: 杂志文章,评审
doi:10.1146/annurev.biochem.76.053105.094237
更新日期:2007-01-01 00:00:00
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journal_title:Annual review of biochemistry
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更新日期:2008-01-01 00:00:00
abstract::Magic angle spinning (MAS) NMR studies of amyloid and membrane proteins and large macromolecular complexes are an important new approach to structural biology. However, the applicability of these experiments, which are based on (13)C- and (15)N-detected spectra, would be enhanced if the sensitivity were improved. Here...
journal_title:Annual review of biochemistry
pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00
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journal_title:Annual review of biochemistry
pub_type: 杂志文章,评审
doi:10.1146/annurev-biochem-062917-012102
更新日期:2018-06-20 00:00:00
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journal_title:Annual review of biochemistry
pub_type: 杂志文章,评审
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更新日期:2004-01-01 00:00:00
abstract::It is impossible to do justice in one review article to a researcher of the stature of Christopher Dobson. His career spanned almost five decades, resulting in more than 870 publications and a legacy that will continue to influence the lives of many for decades to come. In this review, I have attempted to capture Chri...
journal_title:Annual review of biochemistry
pub_type: 杂志文章
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journal_title:Annual review of biochemistry
pub_type: 杂志文章,评审
doi:10.1146/annurev-biochem-061809-175347
更新日期:2011-01-01 00:00:00
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journal_title:Annual review of biochemistry
pub_type: 杂志文章,评审
doi:10.1146/annurev-biochem-062917-012312
更新日期:2018-06-20 00:00:00
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journal_title:Annual review of biochemistry
pub_type: 杂志文章
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journal_title:Annual review of biochemistry
pub_type: 杂志文章,评审
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更新日期:2016-06-02 00:00:00
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journal_title:Annual review of biochemistry
pub_type: 杂志文章,评审
doi:10.1146/annurev-biochem-061516-044847
更新日期:2017-06-20 00:00:00
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journal_title:Annual review of biochemistry
pub_type: 杂志文章,评审
doi:10.1146/annurev.biochem.78.081307.110540
更新日期:2009-01-01 00:00:00
abstract::The protein kinase Akt/PKB is activated via a multistep process by a variety of signals. In the early steps of this process, PI-3 kinase-generated D3-phosphorylated phosphoinositides bind the Akt PH domain and induce the translocation of the kinase to the plasma membrane where it co-localizes with phosphoinositide-dep...
journal_title:Annual review of biochemistry
pub_type: 杂志文章,评审
doi:10.1146/annurev.biochem.68.1.965
更新日期:1999-01-01 00:00:00
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journal_title:Annual review of biochemistry
pub_type: 杂志文章,评审
doi:10.1146/annurev-biochem-051710-133623
更新日期:2013-01-01 00:00:00
abstract::Death-associated protein kinase (DAPk) is the founding member of a newly classified family of Ser/Thr kinases, whose members not only possess significant homology in their catalytic domains, but also share cell death-associated functions. The realization that DAPk is a tumor suppressor gene, whose expression is lost i...
journal_title:Annual review of biochemistry
pub_type: 杂志文章,评审
doi:10.1146/annurev.biochem.75.103004.142615
更新日期:2006-01-01 00:00:00
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journal_title:Annual review of biochemistry
pub_type: 杂志文章,评审
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更新日期:1992-01-01 00:00:00
abstract::This review is concerned with the structures and mechanisms of a superfamily of regulatory GTP hydrolases (G proteins). G proteins include Ras and its close homologs, translation elongation factors, and heterotrimeric G proteins. These proteins share a common structural core, exemplified by that of p21ras (Ras), and s...
journal_title:Annual review of biochemistry
pub_type: 杂志文章,评审
doi:10.1146/annurev.biochem.66.1.639
更新日期:1997-01-01 00:00:00
abstract::Phylum Apicomplexa comprises a large group of obligate intracellular parasites of high medical and veterinary importance. These organisms succeed intracellularly by effecting remarkable changes in a broad range of diverse host cells. The transformation of the host erythrocyte is particularly striking in the case of th...
journal_title:Annual review of biochemistry
pub_type: 杂志文章
doi:10.1146/annurev-biochem-060614-034157
更新日期:2015-01-01 00:00:00
abstract::The bacterial TolC protein plays a common role in the expulsion of diverse molecules, which include protein toxins and antibacterial drugs, from the cell. TolC is a trimeric 12-stranded alpha/beta barrel, comprising an alpha-helical trans-periplasmic tunnel embedded in the outer membrane by a contiguous beta-barrel ch...
journal_title:Annual review of biochemistry
pub_type: 杂志文章,评审
doi:10.1146/annurev.biochem.73.011303.074104
更新日期:2004-01-01 00:00:00
abstract::Clathrin-mediated endocytosis (CME) is the major endocytic pathway in mammalian cells. It is responsible for the uptake of transmembrane receptors and transporters, for remodeling plasma membrane composition in response to environmental changes, and for regulating cell surface signaling. CME occurs via the assembly an...
journal_title:Annual review of biochemistry
pub_type: 杂志文章,评审
doi:10.1146/annurev-biochem-062917-012644
更新日期:2018-06-20 00:00:00
abstract::Staphylococcus aureus is a major human and veterinary pathogen worldwide. Methicillin-resistant S. aureus (MRSA) poses a significant and enduring problem to the treatment of infection by such strains. Resistance is usually conferred by the acquisition of a nonnative gene encoding a penicillin-binding protein (PBP2a), ...
journal_title:Annual review of biochemistry
pub_type: 杂志文章,评审
doi:10.1146/annurev-biochem-060614-034516
更新日期:2015-01-01 00:00:00
abstract::Inactivation of the transcription factor p53, through either direct mutation or aberrations in one of its many regulatory pathways, is a hallmark of virtually every tumor. In recent years, screening for p53 activators and a better understanding of the molecular mechanisms of oncogenic perturbations of p53 function hav...
journal_title:Annual review of biochemistry
pub_type: 杂志文章,评审
doi:10.1146/annurev-biochem-060815-014710
更新日期:2016-06-02 00:00:00
abstract::Microtubules are polymers that are essential for, among other functions, cell transport and cell division in all eukaryotes. The regulation of the microtubule system includes transcription of different tubulin isotypes, folding of /¿-tubulin heterodimers, post-translation modification of tubulin, and nucleotide-based ...
journal_title:Annual review of biochemistry
pub_type: 杂志文章,评审
doi:10.1146/annurev.biochem.69.1.277
更新日期:2000-01-01 00:00:00
abstract::Active transport between the nucleus and cytoplasm involves primarily three classes of macromolecules: substrates, adaptors, and receptors. Some transport substrates bind directly to an import or an export receptor while others require one or more adaptors to mediate formation of a receptor-substrate complex. Once ass...
journal_title:Annual review of biochemistry
pub_type: 杂志文章,评审
doi:10.1146/annurev.biochem.67.1.265
更新日期:1998-01-01 00:00:00
abstract::Genetic, biochemical, and spectroscopic studies have established a new function for an intracellular protein, i.e., guiding and inserting a copper cofactor into the active site of a target enzyme. Studies of these new proteins have revealed a fundamental aspect of copper physiology, namely the vast overcapacity of the...
journal_title:Annual review of biochemistry
pub_type: 杂志文章,评审
doi:10.1146/annurev.biochem.70.1.677
更新日期:2001-01-01 00:00:00
abstract::Cys2His2 zinc finger proteins offer a stable and versatile framework for the design of proteins that recognize desired target sites on double-stranded DNA. Individual fingers from these proteins have a simple beta beta alpha structure that folds around a central zinc ion, and tandem sets of fingers can contact neighbo...
journal_title:Annual review of biochemistry
pub_type: 杂志文章,评审
doi:10.1146/annurev.biochem.70.1.313
更新日期:2001-01-01 00:00:00