Abstract:
:Many critical biological processes take place at hydrophobic:hydrophilic interfaces, and a wide range of organisms produce surface-active proteins and peptides that reduce surface and interfacial tension and mediate growth and development at these boundaries. Microorganisms produce both small lipid-associated peptides and amphipathic proteins that allow growth across water:air boundaries, attachment to surfaces, predation, and improved bioavailability of hydrophobic substrates. Higher-order organisms produce surface-active proteins with a wide variety of functions, including the provision of protective foam environments for vulnerable reproductive stages, evaporative cooling, and gas exchange across airway membranes. In general, the biological functions supported by these diverse polypeptides require them to have an amphipathic nature, and this is achieved by a diverse range of molecular structures, with some proteins undergoing significant conformational change or intermolecular association to generate the structures that are surface active.
journal_name
Annu Rev Biochemjournal_title
Annual review of biochemistryauthors
Sunde M,Pham CLL,Kwan AHdoi
10.1146/annurev-biochem-061516-044847subject
Has Abstractpub_date
2017-06-20 00:00:00pages
585-608eissn
0066-4154issn
1545-4509journal_volume
86pub_type
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