Abstract:
:The determination of several structures of nuclear receptor ligand binding domains (LBD) has led to new insights into the mechanism of action of this very important class of receptors. This review describes and compares the different LBD structures and their relationship to the function of the nuclear receptors. The role of the ligand in the LBD structures and the implications of ligand structure on receptor activity are also discussed. Structural information regarding interactions between the LBD and coactivator proteins and the potential role of these interactions in ligand agonism and antagonism is reviewed. Different pathways for nuclear receptor signaling and the use of new ligands to investigate these pathways are also described.
journal_name
Annu Rev Biochemjournal_title
Annual review of biochemistryauthors
Weatherman RV,Fletterick RJ,Scanlan TSdoi
10.1146/annurev.biochem.68.1.559subject
Has Abstractpub_date
1999-01-01 00:00:00pages
559-81eissn
0066-4154issn
1545-4509journal_volume
68pub_type
杂志文章,评审abstract::Experimental analysis of enzymatic transition-state structures uses kinetic isotope effects (KIEs) to report on bonding and geometry differences between reactants and the transition state. Computational correlation of experimental values with chemical models permits three-dimensional geometric and electrostatic assign...
journal_title:Annual review of biochemistry
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abstract::Inactivation of the transcription factor p53, through either direct mutation or aberrations in one of its many regulatory pathways, is a hallmark of virtually every tumor. In recent years, screening for p53 activators and a better understanding of the molecular mechanisms of oncogenic perturbations of p53 function hav...
journal_title:Annual review of biochemistry
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journal_title:Annual review of biochemistry
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abstract::The existence and function of actin in the nucleus has been hotly debated for forty years. Recently, beta-actin was found to be a component of mammalian SWI/SNF-like BAF chromatin remodeling complexes and still more recently other SWI/SNF-related chromatin remodeling complexes in yeast, flies, and man. Although the fu...
journal_title:Annual review of biochemistry
pub_type: 杂志文章,评审
doi:10.1146/annurev.biochem.71.110601.135507
更新日期:2002-01-01 00:00:00
abstract::This review focuses on eukaryotic translesion synthesis (TLS) DNA polymerases, and the emphasis is on Saccharomyces cerevisiae and human Y-family polymerases (Pols) eta, iota, kappa, and Rev1, as well as on Polzeta, which is a member of the B-family polymerases. The fidelity, mismatch extension ability, and lesion byp...
journal_title:Annual review of biochemistry
pub_type: 杂志文章,评审
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更新日期:2005-01-01 00:00:00
abstract::It is impossible to do justice in one review article to a researcher of the stature of Christopher Dobson. His career spanned almost five decades, resulting in more than 870 publications and a legacy that will continue to influence the lives of many for decades to come. In this review, I have attempted to capture Chri...
journal_title:Annual review of biochemistry
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journal_title:Annual review of biochemistry
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更新日期:1995-01-01 00:00:00
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journal_title:Annual review of biochemistry
pub_type: 杂志文章,评审
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更新日期:2004-01-01 00:00:00
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更新日期:1997-01-01 00:00:00
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journal_title:Annual review of biochemistry
pub_type: 杂志文章,评审
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更新日期:1992-01-01 00:00:00
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更新日期:2015-01-01 00:00:00
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journal_title:Annual review of biochemistry
pub_type: 杂志文章,评审
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更新日期:2017-06-20 00:00:00
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journal_title:Annual review of biochemistry
pub_type: 杂志文章,评审
doi:10.1146/annurev.bi.64.070195.002335
更新日期:1995-01-01 00:00:00
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更新日期:2012-01-01 00:00:00
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journal_title:Annual review of biochemistry
pub_type: 杂志文章,评审
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更新日期:2002-01-01 00:00:00
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journal_title:Annual review of biochemistry
pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00
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journal_title:Annual review of biochemistry
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journal_title:Annual review of biochemistry
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更新日期:1996-01-01 00:00:00
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journal_title:Annual review of biochemistry
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更新日期:2018-06-20 00:00:00
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journal_title:Annual review of biochemistry
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更新日期:2011-01-01 00:00:00
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journal_title:Annual review of biochemistry
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doi:10.1146/annurev-biochem-060614-034352
更新日期:2016-06-02 00:00:00
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journal_title:Annual review of biochemistry
pub_type: 杂志文章,评审
doi:10.1146/annurev.biochem.69.1.961
更新日期:2000-01-01 00:00:00
abstract::Early influences led me first to medical school with a view to microbiology, but I felt the lack of a deeper foundation and changed to chemistry, which in turn led me to physics and mathematics. I moved to the University of Cape Town to work on the X-ray crystallography of some small organic compounds. I developed a n...
journal_title:Annual review of biochemistry
pub_type: 传,历史文章,杂志文章
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更新日期:2010-01-01 00:00:00
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journal_title:Annual review of biochemistry
pub_type: 杂志文章,评审
doi:10.1146/annurev.biochem.74.082803.133400
更新日期:2005-01-01 00:00:00
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journal_title:Annual review of biochemistry
pub_type: 杂志文章,评审
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更新日期:2012-01-01 00:00:00
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journal_title:Annual review of biochemistry
pub_type: 杂志文章,评审
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更新日期:2006-01-01 00:00:00
abstract::The fastest simple, kinetically two-state protein folds a million times more rapidly than the slowest. Here we review many recent theories of protein folding kinetics in terms of their ability to qualitatively rationalize, if not quantitatively predict, this fundamental experimental observation. ...
journal_title:Annual review of biochemistry
pub_type: 杂志文章,评审
doi:10.1146/annurev.biochem.73.011303.073904
更新日期:2004-01-01 00:00:00