Mutational spectra in transgenic animal research: data analysis and study design based upon the mutant or mutation frequency.

abstract：:A working group of five statisticians experienced in the use of statistical methods in mutagenicity reviewed aspects of the statistical analysis of genotoxicity test procedures. Issues discussed included methods for integrating biological importance and statistical significance, the relationship of the experimental un...

journal_title：Environmental and molecular mutagenesis

authors： Lovell DP,Yoshimura I,Hothorn LA,Margolin BH,Soper K

更新日期：2000-01-01 00:00:00

abstract：:As a contribution to the second round of rodent carcinogenesis prediction organised by the U.S. National Institute of Environmental Health Sciences (NIEHS), speculative predictions for 30 chemicals currently under evaluation in U.S. National Toxicology Program (NTP) rodent bioassays are presented. Core chemical data r...

journal_title：Environmental and molecular mutagenesis

authors： Bootman J

更新日期：1996-01-01 00:00:00

abstract：:The placenta is a readily available source of material for molecular epidemiological investigations. As such, DNA damage in this tissue can be indicative of maternal exposure to environmental pollutants such as polycyclic aromatic hydrocarbons (PAHs). Previous reports have demonstrated that (32)P-postlabeling (PPL) is...

journal_title：Environmental and molecular mutagenesis

authors： Marafie EM,Marafie I,Emery SJ,Waters R,Jones NJ

更新日期：2000-01-01 00:00:00

abstract：:The effects of long-term smoking on mitochondrial DNA (mtDNA) deletions in hair follicles were investigated in subjects with different antioxidant capacity. Twenty-two male smokers with a smoking index of greater than 5 pack-years and without any known systemic diseases were recruited for this study. Forty healthy non...

journal_title：Environmental and molecular mutagenesis

authors： Liu CS,Chen HW,Lii CK,Tsai CS,Kuo CL,Wei YH

更新日期：2002-01-01 00:00:00

abstract：:Benzene is an important industrial chemical and widespread environmental pollutant known to induce leukemia and other blood disorders. To be carcinogenic, benzene must be metabolized to produce toxic metabolites. To investigate whether single nucleotide polymorphisms (SNPs) in the metabolic enzyme genes are associated...

journal_title：Environmental and molecular mutagenesis

authors： Xing C,Chen Q,Li G,Zhang L,Zheng M,Zou Z,Hou L,Wang QF,Liu X,Guo X

更新日期：2013-07-01 00:00:00

abstract：:Third instar larvae of Drosophila melanogaster transdihybrid for mwh and flr were exposed to varying concentrations of cisplatin by feeding on dry media wetted with aqueous solutions of the test compound. Larval feeding continued until pupation, and surviving transdihybrid adults were collected seven days following co...

journal_title：Environmental and molecular mutagenesis

authors： Katz AJ

更新日期：1987-01-01 00:00:00

abstract：:The L5178Y mouse lymphoma cell mutagenesis assay is used to detect the mutagenic activity of chemicals in a mammalian cell system. To evaluate this assay we compared the results of assays performed independently on 63 chemicals by laboratories at SRI International and Litton Bionetics, Inc. The two laboratories used s...

journal_title：Environmental and molecular mutagenesis

authors： Caspary WJ,Daston DS,Myhr BC,Mitchell AD,Rudd CJ,Lee PS

更新日期：1988-01-01 00:00:00

abstract：:Malignant gliomas are heterogeneous populations of dynamically interacting cells. Genomic and transcriptional changes define this cellular hierarchy and allow certain tumor cells to co-opt metabolic machinery and adopt gene expression profiles that promote cellular reprogramming. Resultant expansion of privileged subp...

journal_title：Environmental and molecular mutagenesis

authors： Baulch JE,Geidzinski E,Tran KK,Yu L,Zhou YH,Limoli CL

更新日期：2016-06-01 00:00:00

abstract：:The human transcriptome is complex, comprising multiple transcript types, mostly in the form of non-coding RNA (ncRNA). The majority of ncRNA is of the long form (lncRNA, ≥ 200 bp), which plays an important role in gene regulation through multiple mechanisms including epigenetics, chromatin modification, control of tr...

journal_title：Environmental and molecular mutagenesis

authors： McHale CM,Zhang L,Thomas R,Smith MT

更新日期：2013-08-01 00:00:00

abstract：:DNA adducts of carcinogenic polycyclic aromatic hydrocarbons (PAHs) play a critical role in the etiology of gastrointestinal tract cancers in humans and other species orally exposed to PAHs. Yet, the precise localization of PAH-DNA adducts in the gastrointestinal tract, and the long-term postmortem PAH-DNA adduct stab...

journal_title：Environmental and molecular mutagenesis

authors： Poirier MC,Beland FA,Divi KV,Damon AL,Ali M,Vanlandingham MM,Churchwell MI,Von Tungeln LS,Dwyer JE,Divi RL,Beauchamp G,Martineau D

更新日期：2020-02-01 00:00:00

abstract：:Amsacrine (4'-(9-acridinylamino)methanesulphon-m-anisidide) is an antileukemic drug which inhibits topoisomerase II (topo II) enzymes. We studied effects of two concentrations of amsacrine on the GM10115A cell line. This is a Chinese hamster line containing a single human chromosome 4, which can be readily visualised ...

journal_title：Environmental and molecular mutagenesis

authors： Ferguson LR,Whiteside G,Holdaway KM,Baguley BC

更新日期：1996-01-01 00:00:00

abstract：:Although not mutagenic by Ames test, 2,5-dimethylfuran (DMF), a leading biofuel candidate, was found to induce chromosomal damage in cultured murine cells, suggesting that it may be genotoxic. We sought to prioritize the environmental and biological impacts of using DMF as a combustible biofuel. First, we assessed DMF...

journal_title：Environmental and molecular mutagenesis

authors： Phuong J,Kim S,Thomas R,Zhang L

更新日期：2012-07-01 00:00:00

abstract：:Risk estimates for radiation-induced cancer in humans are based on epidemiological data largely drawn from the Japanese atomic bomb survivor studies, which received an acute high dose rate (HDR) ionising radiation. Limited knowledge exists about the effects of chronic low dose rate (LDR) exposure, particularly with re...

journal_title：Environmental and molecular mutagenesis

authors： Graupner A,Eide DM,Brede DA,Ellender M,Lindbo Hansen E,Oughton DH,Bouffler SD,Brunborg G,Olsen AK

更新日期：2017-10-01 00:00:00

abstract：:To protect human and ecosystem health, it is necessary to develop sensitive assays and to identify responsive cells and species (and their life stages). In this study, the relative genotoxicity of two inorganic arsenicals: trivalent sodium arsenite (As(3+)) and pentavalent sodium arsenate (As(5+)), was evaluated in tw...

journal_title：Environmental and molecular mutagenesis

authors： Raisuddin S,Jha AN

更新日期：2004-01-01 00:00:00

abstract：:Exposure to inorganic arsenic increases the risk of basal cell carcinoma (BCC). Arsenic metabolism is a susceptibility factor for arsenic toxicity, and specific haplotypes in arsenic (+3 oxidation state) methyltransferase (AS3MT) have been associated with increased urinary fractions of the most toxic arsenic metabolit...

journal_title：Environmental and molecular mutagenesis

authors： Engström KS,Vahter M,Fletcher T,Leonardi G,Goessler W,Gurzau E,Koppova K,Rudnai P,Kumar R,Broberg K

更新日期：2015-01-01 00:00:00

abstract：:O6-alkylguanine DNA-alkyltransferase (AGT) is a widely distributed DNA repair protein that protects living organisms from endogenous and exogenous alkylation damage to DNA at the O6-position of guanine. The search of the C. elegans genome database for an AGT protein revealed the presence of a protein (cAGT-2) with som...

journal_title：Environmental and molecular mutagenesis

authors： Kanugula S,Pegg AE

更新日期：2001-01-01 00:00:00

abstract：:A rapid and simple procedure for the micronucleus test (MNT) in vitro using Chinese hamster ovary (CHO) cells was established in our laboratory. The assay is intended to quickly screen chromosomal aberrations in vitro within the framework of industrial genotoxicity studies. To test the sensitivity of the assay in the ...

journal_title：Environmental and molecular mutagenesis

authors： Miller BM,Pujadas E,Gocke E

更新日期：1995-01-01 00:00:00

abstract：:The Pig-a assay is an emerging and promising in vivo method to determine mutagenic potential of chemicals. Since its development in 2008, remarkable progress has been made in harmonizing and characterizing the test procedures, primarily using known mutagenic chemicals. The purpose of the present study was to evaluate ...

journal_title：Environmental and molecular mutagenesis

authors： Ji Z,Settivari RS,LeBaron MJ

更新日期：2019-01-01 00:00:00

abstract：:The aim of this study was to investigate genotoxic effects of lamivudine (an analogue of cytidine) using in vitro sister chromatid exchange (SCE), chromosome aberration (CA), and micronucleus (MN) tests in human peripheral lymphocytes. The cells were treated with 75, 100, 125, and 150 microg/ml concentrations of lamiv...

journal_title：Environmental and molecular mutagenesis

authors： Bayram S,Topaktaş M

更新日期：2008-05-01 00:00:00

abstract：:Antioxidant vitamins are able to deactivate highly bioactive molecules, such as free radicals, that are generated during cellular biochemical processes. Doxorubicin (DXR) is a cancer chemotherapeutic agent that generates free radicals as a byproduct. In the present study, the Drosophila melanogaster somatic wing spot ...

journal_title：Environmental and molecular mutagenesis

authors： Costa WF,Nepomuceno JC

更新日期：2006-01-01 00:00:00

abstract：:Peripheral lymphocytes from Taiwanese women (n = 35) exposed to polychlorinated aromatic hydrocarbons and from matched controls (n = 24) were assessed for the levels of sister chromatid exchanges (SCEs) after a 72-hour incubation of whole blood in the presence or absence of alpha-naphthoflavone (ANF) and for chromosom...

journal_title：Environmental and molecular mutagenesis

authors： Lundgren K,Collman GW,Wang-Wuu S,Tiernan T,Taylor M,Thompson CL,Lucier GW

更新日期：1988-01-01 00:00:00

abstract：:Noncovalent DNA interactions, e.g., DNA intercalation and DNA groove-binding, have not been well studied relative to covalent interactions largely due to the inability of predicting and detecting such events in intact cells. We have adapted an in vitro bleomycin amplification method for DNA intercalation for use in cu...

journal_title：Environmental and molecular mutagenesis

authors： Snyder RD,Hendry LB

更新日期：2005-03-01 00:00:00

abstract：:Studies of the mutagenicity and antimutagenicity of hispidulin and hortensin, the flavonoids from Millingtonia hortensis L. (Bignoniaceae), were performed using the liquid preincubation method of the Salmonella/microsome test. At the highest dose tested, 100 micrograms/plate, both compounds showed no mutagenicity and ...

journal_title：Environmental and molecular mutagenesis

authors： Chulasiri M,Bunyapraphatsara N,Moongkarndi P

更新日期：1992-01-01 00:00:00

abstract：:Contamination of ground water by industrial waste poses potential health hazards for man and his environment. The improper disposal of toxic wastes could allow genotoxic chemicals to percolate into ground waters, and these contaminated ground waters may produce toxicity, including mutation and eventually cancer, in ex...

journal_title：Environmental and molecular mutagenesis

authors： Chandra S,Chauhan LK,Murthy RC,Gupta SK

更新日期：2006-06-01 00:00:00

abstract：:A study of meiotic and postmeiotic germ-cell-stage sensitivity of male mice to induction of unscheduled DNA synthesis (UDS) by acrylamide showed that DNA repair could be detected in early spermatocytes (after the last scheduled DNA synthesis) through about mid-spermatid stages. No DNA repair could be detected in later...

journal_title：Environmental and molecular mutagenesis

authors： Sega GA,Generoso EE,Brimer PA

更新日期：1990-01-01 00:00:00

abstract：:311 chemicals were tested under code, for mutagenicity, in Salmonella typhimurium; 35 of the chemicals were tested more than once in the same or different laboratories. The tests were conducted using a preincubation protocol in the absence of exogenous metabolic activation, and in the presence of liver S-9 from Aroclo...

journal_title：Environmental and molecular mutagenesis

authors： Zeiger E,Anderson B,Haworth S,Lawlor T,Mortelmans K

更新日期：1992-01-01 00:00:00

abstract：:Polybrominated diphenyl ethers (PBDEs), which are widely used as flame retardants, are considered persistent organic pollutants. To date, the available toxicological data on PBDEs are limited and were primarily obtained by studying technical blends. The present study was undertaken to investigate the genotoxicity of t...

journal_title：Environmental and molecular mutagenesis

authors： Evandri MG,Mastrangelo S,Costa LG,Bolle P

更新日期：2003-01-01 00:00:00

abstract：:Environmental tobacco smoke (ETS) is a major source of indoor air pollution. Extractable-respirable particulate (ERP) from the ETS-contaminated indoor air (ERP-ETS) was collected from six passenger train cars and one control room. The mutagenicity of ERP-ETS was tested in the Ames/Salmonella test in the presence of ma...

journal_title：Environmental and molecular mutagenesis

authors： Zhou R,Yu G,Zhou Y,Zeng X

更新日期：1999-01-01 00:00:00

abstract：:A wild-type strain of herpes simplex virus type 1 (HSV-1:KOS) encoding a functional thymidine kinase (tk+) and a tk- mutant strain (HSV-1:PTK3B) were used to study the role of the viral tk in the repair of UV-irradiated HSV-1 in human cells. UV survival of HSV-1:PTK3B was substantially reduced compared with that of HS...

journal_title：Environmental and molecular mutagenesis

authors： Intine RV,Rainbow AJ

更新日期：1990-01-01 00:00:00

abstract：:Animal studies have linked perinatal bisphenol A (BPA) exposure to altered DNA methylation, but little attention is given to analyzing multiple physiologically relevant doses. Utilizing the viable yellow agouti (A(vy)) mouse, we examine the effects of developmental exposure through maternal diet to 50 ng BPA/kg (n = 1...

journal_title：Environmental and molecular mutagenesis

authors： Anderson OS,Nahar MS,Faulk C,Jones TR,Liao C,Kannan K,Weinhouse C,Rozek LS,Dolinoy DC

更新日期：2012-06-01 00:00:00