Confirmation of the chromosome damaging effects of lamivudine in in vitro human peripheral blood lymphocytes.

abstract：:The genome is programmed by the epigenome. Two of the fundamental components of the epigenome are chromatin structure and covalent modification of the DNA molecule itself by methylation. DNA methylation patterns are sculpted during development and it has been a long held belief that they remain stable after birth in s...

journal_title：Environmental and molecular mutagenesis

authors： Szyf M,McGowan P,Meaney MJ

更新日期：2008-01-01 00:00:00

abstract：:Griseofulvin is an orally administered antifungal drug that affects microtubule formation in vitro and interferes with microtubule dynamics in vivo as clearly shown for mitotic cells in several cell systems. This article reports the effects of griseofulvin on in vitro maturation of porcine oocytes and subsequent effec...

journal_title：Environmental and molecular mutagenesis

authors： Miao YL,Zhang X,Zhao JG,Spate L,Zhao MT,Murphy CN,Prather RS,Sun QY,Schatten H

更新日期：2012-08-01 00:00:00

abstract：:The mutational spectrum for 28 X-ray induced mutations and 2 spontaneous mutations, previously determined by genetic and cytogenetic methods, consisted of 20 multilocus deficiencies (19 induced and 1 spontaneous) and 10 intragenic mutations (9 induced and 1 spontaneous). One of the X-ray induced intragenic mutations w...

journal_title：Environmental and molecular mutagenesis

authors： Mahmoud J,Fossett NG,Arbour-Reily P,McDaniel M,Tucker A,Chang SH,Lee WR

更新日期：1991-01-01 00:00:00

abstract：:The Benchmark Dose (BMD) method is the favored approach for quantitative dose-response analysis where uncertainty measurements are delineated between the upper (BMDU) and lower (BMDL) confidence bounds, or confidence intervals (CIs). Little has been published on the accurate interpretation of uncertainty measurements ...

journal_title：Environmental and molecular mutagenesis

authors： Wheeldon RP,Dertinger SD,Bryce SM,Bemis JC,Johnson GE

更新日期：2021-01-11 00:00:00

abstract：:The genotoxicity of humic acid and its possible interaction with the herbicides alachlor and maleic hydrazide have been evaluated in cultured human lymphocytes from two donors. Humic acid and the two herbicides have been tested (alone and combined) for sister-chromatid exchange (SCE) induction. In addition, the effect...

journal_title：Environmental and molecular mutagenesis

authors： Ribas G,Carbonell E,Creus A,Xamena N,Marcos R

更新日期：1997-01-01 00:00:00

abstract：:We have applied the alkaline comet assay to study the functional impact of gene polymorphisms in base excision repair (APEX1 Asp148Glu, XRCC1 Arg194Trp, XRCC1 Arg399Gln) and homologous recombination repair (XRCC3 Thr241Met, NBS1 Glu185Gln), two pathways that play crucial roles in the repair of DNA damage induced by me...

journal_title：Environmental and molecular mutagenesis

authors： Ryk C,Routledge MN,Allan JM,Wild CP,Kumar R,Lambert B,Hou S

更新日期：2008-12-01 00:00:00

abstract：:Respirable crystalline silica has been classified as a human lung carcinogen. Ultrafine (diameter < 100 nm) silica particles may be important in carcinogenesis, although the mechanisms remain unclear. In the present study, WIL2-NS cells were incubated for 6, 24, and 48 hr with 0, 30, 60, and 120 microg/ml ultrafine cr...

journal_title：Environmental and molecular mutagenesis

authors： Wang JJ,Sanderson BJ,Wang H

更新日期：2007-03-01 00:00:00

abstract：:Polluted soil sampled from a former coking plant in Lorraine (France) was studied for its genotoxicity and reproductive effects on the Eisenia fetida earthworm. Genotoxicity was investigated by means of the single-cell gel electrophoresis (comet) assay on the coelomocytes of earthworms after 4 and 10 days of exposure ...

journal_title：Environmental and molecular mutagenesis

authors： Bonnard M,Eom IC,Morel JL,Vasseur P

更新日期：2009-01-01 00:00:00

abstract：:In this study we compared the ability of extractable organic material from particulate and semivolatile fractions of gasoline emission to induce mutations in bacteria and form adducts with calf thymus (CT) DNA with corresponding data obtained from diesel exhaust. Exhaust particles from gasoline-powered passenger cars ...

journal_title：Environmental and molecular mutagenesis

authors： Pohjola SK,Lappi M,Honkanen M,Savela K

更新日期：2003-01-01 00:00:00

abstract：:The modulating effects of tannic acid (TA) on somatic mutation and mitotic recombination induced by methylmethanesulfonate (MMS), nitrogen mustard (HN2), and mitomycin C (MMC) were evaluated in the standard (ST) cross of the wing spot test in Drosophila melanogaster using co- and posttreatment protocols. It was shown ...

journal_title：Environmental and molecular mutagenesis

authors： Lehmann M,Graf U,Reguly ML,Rodrigues De Andrade HH

更新日期：2000-01-01 00:00:00

abstract：:Molecular analysis of proaerolysin selected glycosylphosphatidylinositol anchor (GPI-a) deficient isolates in the TK6 cell line was performed. Initial studies found that the expected X-linked PIGA mutations were rare among the spontaneous isolates but did increase modestly after ethyl methane sulfate (EMS) treatment (...

journal_title：Environmental and molecular mutagenesis

authors： Nicklas JA,Carter EW,Albertini RJ

更新日期：2015-10-01 00:00:00

abstract：:Increased telomerase expression has been implicated in the pathogenesis of lung cancer and, since the primary cause of lung cancer is smoking, an association between telomerase reactivation and tobacco smoke has been proposed. In this work an investigation has been performed to assess the relationship between tobacco ...

journal_title：Environmental and molecular mutagenesis

authors： Marcon F,Siniscalchi E,Andreoli C,Allione A,Fiorito G,Medda E,Guarrera S,Matullo G,Crebelli R

更新日期：2017-10-01 00:00:00

abstract：:DNA interstrand crosslinks (ICLs) are covalent linkages between two strands of DNA, and their presence interferes with essential metabolic processes such as transcription and replication. These lesions are extremely toxic, and their repair is essential for genome stability and cell survival. In this review, we will di...

journal_title：Environmental and molecular mutagenesis

authors： Sharma S,Canman CE

更新日期：2012-12-01 00:00:00

abstract：:Mentha piperita or peppermint is currently used for alleviating nausea, flatulence, and vomiting. In the present investigation, we evaluated the chemopreventive, antigenotoxic, and antioxidative effects of an aqueous extract of Mentha piperita leaves. One-day-old Swiss albino mice were treated with a single subcutaneo...

journal_title：Environmental and molecular mutagenesis

authors： Samarth RM,Panwar M,Kumar A

更新日期：2006-04-01 00:00:00

abstract：:In this study we evaluated the antigenotoxic and cytoprotective capabilities of WR-2721 [S-2-(3-aminopropylamino)-ethylphosphorothioic acid (amifostine)] in different normal tissues of BALB/c mice treated with idarubicin [4-demethoxydaunorubicin (IDA)]. The aminothiol WR-2721 is a pro-drug that requires dephosphorylat...

journal_title：Environmental and molecular mutagenesis

authors： de Campos Nebel M,Larripa I,González-Cid M

更新日期：2002-01-01 00:00:00

abstract：:Ethylene oxide (EO) is a direct acting alkylating agent; in vitro and in vivo studies indicate that it is both a mutagen and a carcinogen. However, it remains unclear whether the mode of action (MOA) for cancer for EO is a mutagenic MOA, specifically via point mutation. To investigate the MOA for EO-induced mouse lung...

journal_title：Environmental and molecular mutagenesis

authors： Manjanatha MG,Shelton SD,Chen Y,Parsons BL,Myers MB,McKim KL,Gollapudi BB,Moore NP,Haber LT,Allen B,Moore MM

更新日期：2017-04-01 00:00:00

abstract：:Coal tar (CT) is a thick black liquid produced as a by-product of coal carbonization to produce coke or manufactured gas. It is comprised a complex mixture of polycyclic aromatic compounds, including a wide range of polycyclic aromatic hydrocarbons (PAHs), many of which are genotoxic and carcinogenic. CT is used in so...

journal_title：Environmental and molecular mutagenesis

authors： Long AS,Watson M,Arlt VM,White PA

更新日期：2016-08-01 00:00:00

abstract：:DNA damage and its subsequent repair occur heterogeneously throughout the genome, which reflects the nature of the damaging agents, gross chromosomal structure, the specific nucleotide sequence, and transcriptional status. We selected to investigate the repair of DNA damage in an artificial, transgenic situation. Here...

journal_title：Environmental and molecular mutagenesis

authors： Yang H,Kotturi GP,de Boer JG,Glickman BW

更新日期：1999-01-01 00:00:00

abstract：:The cytotoxicity of streptozotocin (STZ) was investigated in Chinese hamster fibroblast lines (CHO-9 and V79) in comparison to two other alkylating agents, methylnitrosourea (MNU) and ethylnitrosourea (ENU), using cell survival as the endpoint. It was found that V79 cells were far more resistant to methylation induced...

journal_title：Environmental and molecular mutagenesis

authors： Capucci MS,Hoffmann ME,De Groot A,Natarajan AT

更新日期：1995-01-01 00:00:00

abstract：:Cultured rodent and human cells typically display similar clonal survival characteristics following exposure to ultraviolet light (UV). However, compared to human cells, cultured cells from mice, rats, and hamsters are generally deficient in excision repair of the most prominent DNA lesion produced by UV, the cyclobut...

journal_title：Environmental and molecular mutagenesis

authors： Hanawalt PC

更新日期：2001-01-01 00:00:00

abstract：:Radiation and many chemicals have been found to induce homologous genetic recombination. Experimental systems that allow the detection and characterization of recombinagens exist in organisms as diverse as bacteria, fungi, plants, insects, and mammals. Recombination plays an important role in many biological processes...

journal_title：Environmental and molecular mutagenesis

authors： Hoffmann GR

更新日期：1994-01-01 00:00:00

abstract：:Unpublished results from our laboratory showed that colchicine increased the incidence of hyperploid mouse metaphase II (MII) oocytes when injected at the same time as human chorionic gonadotrophin (HCG). The objective of the present study was to determine whether the time of administering colchicine influenced the in...

journal_title：Environmental and molecular mutagenesis

authors： Mailhes JB,Yuan ZP

更新日期：1987-01-01 00:00:00

abstract：:Molindone hydrochloride is a dihydroindolone neuroleptic with dopamine D2 and D5 receptor antagonist activity. As an integral component of its preclinical safety evaluation, molindone hydrochloride was evaluated in a series of in vitro and in vivo genetic toxicology assays. In the bacterial reverse gene mutation assay...

journal_title：Environmental and molecular mutagenesis

authors： Krishna G,Gopalakrishnan G,Goel S

更新日期：2016-05-01 00:00:00

abstract：:Human sulfotransferase (SULT) 1A1, 1A2, and 1A3 cDNA genes were subcloned separately into the pTrc99A(KM) vector. The generated plasmids were introduced into the Salmonella typhimurium O-acetyltransferase-deficient strain NM6000 (TA1538/1,8-DNP/pSK1002), resulting in the new strains NM7001, NM7002, and NM7003. We comp...

journal_title：Environmental and molecular mutagenesis

authors： Oda Y,Zhang Y,Buchinger S,Reifferscheid G,Yang M

更新日期：2012-03-01 00:00:00

abstract：:The potential of 1,3-dichloropropene (1,3-DCP) to induce dominant lethal mutations in the germ cells of male CD rats following inhalation exposure was investigated. Groups of 11-week-old males (30 animals/group) were exposed to 1,3-DCP vapors by inhalation at targeted concentrations of 0 (negative control), 10, 60, an...

journal_title：Environmental and molecular mutagenesis

authors： Gollapudi BB,Cieszlak FS,Day SJ,Carney EW

更新日期：1998-01-01 00:00:00

abstract：:Malignant gliomas are heterogeneous populations of dynamically interacting cells. Genomic and transcriptional changes define this cellular hierarchy and allow certain tumor cells to co-opt metabolic machinery and adopt gene expression profiles that promote cellular reprogramming. Resultant expansion of privileged subp...

journal_title：Environmental and molecular mutagenesis

authors： Baulch JE,Geidzinski E,Tran KK,Yu L,Zhou YH,Limoli CL

更新日期：2016-06-01 00:00:00

abstract：:This laboratory has previously described a method for scoring the incidence of rodent blood Pig-a mutant phenotype erythrocytes using immunomagnetic separation in conjunction with flow cytometric analysis (In Vivo MutaFlow®). The current work extends this approach to human blood. The frequencies of CD59- and CD55-nega...

journal_title：Environmental and molecular mutagenesis

authors： Dertinger SD,Avlasevich SL,Bemis JC,Chen Y,MacGregor JT

更新日期：2015-05-01 00:00:00

abstract：:The evaluation of the relationship between the dose to DNA of a mutagen/carcinogen and in vivo somatic cell mutagenesis may provide information on the mechanisms leading to induced mutational events. This can be achieved, for example, by coupling test systems that permit the detection of somatic mutation and recombina...

journal_title：Environmental and molecular mutagenesis

authors： Zordan M,Osti M,Pavanello S,Costa R,Levis AG

更新日期：1994-01-01 00:00:00

abstract：:The monoterpene indole alkaloid brachycerine from Psychotria brachyceras has been shown to be induced by UV and to have in vitro antioxidant activity, indicating a possible protective role against the secondary effects of this radiation. In this work, we have studied the antioxidant properties of brachycerine and a cr...

journal_title：Environmental and molecular mutagenesis

authors： do Nascimento NC,Fragoso V,Moura DJ,e Silva AC,Fett-Neto AG,Saffi J

更新日期：2007-12-01 00:00:00

abstract：:Monohaloacetic acids (monoHAAs) are a major class of drinking water disinfection by-products (DBPs) and are cytotoxic, genotoxic, mutagenic, and teratogenic. We propose a model of toxic action based on monoHAA-mediated inhibition of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) as a target cytosolic enzyme. This mo...

journal_title：Environmental and molecular mutagenesis

authors： Dad A,Jeong CH,Pals JA,Wagner ED,Plewa MJ

更新日期：2013-10-01 00:00:00