Dominant lethal test with rats exposed to 1,3-dichloropropene by inhalation.

abstract：:Micronucleus (MN) expression in peripheral blood lymphocytes is well established as a standard method for monitoring chromosome damage in human populations. The first results of an analysis of pooled data from laboratories using the cytokinesis-block micronucleus (CBMN) assay and participating in the HUMN (HUman Micro...

journal_title：Environmental and molecular mutagenesis

authors： Bonassi S,Fenech M,Lando C,Lin YP,Ceppi M,Chang WP,Holland N,Kirsch-Volders M,Zeiger E,Ban S,Barale R,Bigatti MP,Bolognesi C,Jia C,Di Giorgio M,Ferguson LR,Fucic A,Lima OG,Hrelia P,Krishnaja AP,Lee TK,Migliore L

更新日期：2001-01-01 00:00:00

abstract：:Risk estimates for radiation-induced cancer in humans are based on epidemiological data largely drawn from the Japanese atomic bomb survivor studies, which received an acute high dose rate (HDR) ionising radiation. Limited knowledge exists about the effects of chronic low dose rate (LDR) exposure, particularly with re...

journal_title：Environmental and molecular mutagenesis

authors： Graupner A,Eide DM,Brede DA,Ellender M,Lindbo Hansen E,Oughton DH,Bouffler SD,Brunborg G,Olsen AK

更新日期：2017-10-01 00:00:00

abstract：:Isothiocyanates (ITCs) are commonly found in cruciferous vegetables. A variety of biological activities have been ascribed to ITCs, such as inhibition of cytochrome P450 enzymes and induction of phase II enzymes in animal models. ITCs are also able to block cell-cycle progression and induce apoptosis in human cancer c...

journal_title：Environmental and molecular mutagenesis

authors： Fimognari C,Berti F,Cantelli-Forti G,Hrelia P

更新日期：2005-12-01 00:00:00

abstract：:Peripheral lymphocytes from Taiwanese women (n = 35) exposed to polychlorinated aromatic hydrocarbons and from matched controls (n = 24) were assessed for the levels of sister chromatid exchanges (SCEs) after a 72-hour incubation of whole blood in the presence or absence of alpha-naphthoflavone (ANF) and for chromosom...

journal_title：Environmental and molecular mutagenesis

authors： Lundgren K,Collman GW,Wang-Wuu S,Tiernan T,Taylor M,Thompson CL,Lucier GW

更新日期：1988-01-01 00:00:00

abstract：:Antioxidant vitamins are able to deactivate highly bioactive molecules, such as free radicals, that are generated during cellular biochemical processes. Doxorubicin (DXR) is a cancer chemotherapeutic agent that generates free radicals as a byproduct. In the present study, the Drosophila melanogaster somatic wing spot ...

journal_title：Environmental and molecular mutagenesis

authors： Costa WF,Nepomuceno JC

更新日期：2006-01-01 00:00:00

abstract：:DNA polymerase κ (Pol κ) is a specialized DNA polymerase involved in translesion DNA synthesis. Although its bypass activities across lesions are well characterized in biochemistry, its cellular protective roles against genotoxic insults are still elusive. To better understand the in vivo protective roles, we have est...

journal_title：Environmental and molecular mutagenesis

authors： Kanemaru Y,Suzuki T,Niimi N,Grúz P,Matsumoto K,Adachi N,Honma M,Nohmi T

更新日期：2015-10-01 00:00:00

abstract：:DNA is exposed to endogenous and environmental factors that can form stable lesions. If not repaired, these lesions can lead to transcription/replication blocking or mutagenic bypass. Our previous work has focused on 8,5'-cyclopurine 2'-deoxyribonucleosides, a unique class of oxidatively induced DNA lesions that are s...

journal_title：Environmental and molecular mutagenesis

authors： Abraham J,Brooks PJ

更新日期：2011-05-01 00:00:00

abstract：:Several types of diesel exhaust particles (DEPs) have been used for toxicology studies, including a high-organic automobile DEP (A-DEP) from Japan, and a low-organic forklift DEP developed by the National Institute of Standards and Technology (N-DEP). However, these DEPs were not characterized extensively for chemical...

journal_title：Environmental and molecular mutagenesis

authors： Mutlu E,Warren SH,Matthews PP,King C,Linak WP,Kooter IM,Schmid JE,Ross JA,Gilmour MI,Demarini DM

更新日期：2013-12-01 00:00:00

abstract：:Combinations of antiretroviral drugs that include nucleoside reverse transcriptase inhibitors (NRTIs) are superior to single-agent regimens in treating or preventing HIV infection, but the potential long-term health hazards of these treatments in humans are uncertain. In earlier studies, our group found that coexposur...

journal_title：Environmental and molecular mutagenesis

authors： Meng Q,Su T,O'Neill JP,Walker VE

更新日期：2002-01-01 00:00:00

abstract：:The endogenous X-linked PIG-A gene is involved in the synthesis of glycosyl phosphatidyl inositol (GPI) anchors that tether specific protein markers to the exterior of mammalian cell cytoplasmic membranes. Earlier studies in rodent models indicate that Pig-a mutant red blood cells (RBCs) can be induced in animals trea...

journal_title：Environmental and molecular mutagenesis

authors： Dobrovolsky VN,Elespuru RK,Bigger CA,Robison TW,Heflich RH

更新日期：2011-12-01 00:00:00

abstract：:The effects of ultrasound on the cytoskeleton, comprising microtubules, had been studied decades ago. Nonetheless, very little attention has been paid to the effects of ultrasound on the mitotic spindle, which is also formed by microtubules. In this study, we treated human fibroblasts and human cancer cells (HeLa and ...

journal_title：Environmental and molecular mutagenesis

authors： Udroiu I,Coluzzi E,Bedini A,Giliberti C,Palomba R,Sgura A

更新日期：2019-08-01 00:00:00

abstract：:Several genotoxicity endpoints have been evaluated to define nonlinear dose-responses for SN 1 and SN 2 alkylating genotoxicants. Dose-response studies acknowledging the process of multistage tumorigenesis are important; however, data pertaining nonlinearity are not yet available. In this communication, the role of DN...

journal_title：Environmental and molecular mutagenesis

authors： Becker K,Thomas AD,Kaina B

更新日期：2014-03-01 00:00:00

abstract：:Understanding chemically induced changes in mutational spectra can aid in deciphering mechanisms of mutagenesis. In this paper, we propose the use of statistical methods that are based upon the mutation frequency, rather than simple mutant counts which have no relationship to the mutation frequency. These methods have...

journal_title：Environmental and molecular mutagenesis

authors： Carr GJ,Gorelick NJ

更新日期：1996-01-01 00:00:00

abstract：:Based on the assumption that compounds having similar toxic modes of action induce specific gene expression changes, the toxicity of unknown compounds can be predicted after comparison of their molecular fingerprints with those obtained with compounds of known toxicity. These predictive models will therefore rely on t...

journal_title：Environmental and molecular mutagenesis

authors： Thybaud V,Le Fevre AC,Boitier E

更新日期：2007-06-01 00:00:00

abstract：:DNA adducts of carcinogenic polycyclic aromatic hydrocarbons (PAHs) play a critical role in the etiology of gastrointestinal tract cancers in humans and other species orally exposed to PAHs. Yet, the precise localization of PAH-DNA adducts in the gastrointestinal tract, and the long-term postmortem PAH-DNA adduct stab...

journal_title：Environmental and molecular mutagenesis

authors： Poirier MC,Beland FA,Divi KV,Damon AL,Ali M,Vanlandingham MM,Churchwell MI,Von Tungeln LS,Dwyer JE,Divi RL,Beauchamp G,Martineau D

更新日期：2020-02-01 00:00:00

abstract：:Noncovalent DNA interactions, e.g., DNA intercalation and DNA groove-binding, have not been well studied relative to covalent interactions largely due to the inability of predicting and detecting such events in intact cells. We have adapted an in vitro bleomycin amplification method for DNA intercalation for use in cu...

journal_title：Environmental and molecular mutagenesis

authors： Snyder RD,Hendry LB

更新日期：2005-03-01 00:00:00

abstract：:The extractable organic material (EOM) from atmospheric total suspended particles (TSP) contains several organic compounds including non-substituted polycyclic aromatic hydrocarbons (PAHs), alkyl-PAHs, and nitro-PAHs. These chemicals seem to be among the key drivers of TSP genotoxicity. We have shown previously that t...

journal_title：Environmental and molecular mutagenesis

authors： Maselli BS,Cunha V,Lim H,Bergvall C,Westerholm R,Dreij K,Watanabe T,Cardoso AA,Pozza SA,Umbuzeiro GA,Kummrow F

更新日期：2020-06-01 00:00:00

abstract：:Identification of mutations induced by xenotoxins is a common task in the field of genetic toxicology. Mutations are often detected by clonally expanding potential mutant cells and genotyping each viable clone by Sanger sequencing. Such a "clone-by-clone" approach requires significant time and effort, and sometimes is...

journal_title：Environmental and molecular mutagenesis

authors： Revollo JR,Crabtree NM,Pearce MG,Pacheco-Martinez MM,Dobrovolsky VN

更新日期：2016-03-01 00:00:00

abstract：:Exposure to inorganic arsenic increases the risk of basal cell carcinoma (BCC). Arsenic metabolism is a susceptibility factor for arsenic toxicity, and specific haplotypes in arsenic (+3 oxidation state) methyltransferase (AS3MT) have been associated with increased urinary fractions of the most toxic arsenic metabolit...

journal_title：Environmental and molecular mutagenesis

authors： Engström KS,Vahter M,Fletcher T,Leonardi G,Goessler W,Gurzau E,Koppova K,Rudnai P,Kumar R,Broberg K

更新日期：2015-01-01 00:00:00

abstract：:Radiation and many chemicals have been found to induce homologous genetic recombination. Experimental systems that allow the detection and characterization of recombinagens exist in organisms as diverse as bacteria, fungi, plants, insects, and mammals. Recombination plays an important role in many biological processes...

journal_title：Environmental and molecular mutagenesis

authors： Hoffmann GR

更新日期：1994-01-01 00:00:00

abstract：:A working group of five statisticians experienced in the use of statistical methods in mutagenicity reviewed aspects of the statistical analysis of genotoxicity test procedures. Issues discussed included methods for integrating biological importance and statistical significance, the relationship of the experimental un...

journal_title：Environmental and molecular mutagenesis

authors： Lovell DP,Yoshimura I,Hothorn LA,Margolin BH,Soper K

更新日期：2000-01-01 00:00:00

abstract：:V(D)J recombinase-mediated recombination between the T-cell receptor (TCR) gamma variable (GV) genes at chromosome 7p15 and the TCR beta joining (BJ) genes at 7q35 leads to the formation of a hybrid TCR gene. These TCR gamma/beta interlocus rearrangements occur at classic V(D)J recombination signal sequences (RSS) and...

journal_title：Environmental and molecular mutagenesis

authors： Ballinger SW,Judice SA,Nicklas JA,Albertini RJ,O'Neill JP

更新日期：2002-01-01 00:00:00

abstract：:The Benchmark Dose (BMD) method is the favored approach for quantitative dose-response analysis where uncertainty measurements are delineated between the upper (BMDU) and lower (BMDL) confidence bounds, or confidence intervals (CIs). Little has been published on the accurate interpretation of uncertainty measurements ...

journal_title：Environmental and molecular mutagenesis

authors： Wheeldon RP,Dertinger SD,Bryce SM,Bemis JC,Johnson GE

更新日期：2021-01-11 00:00:00

abstract：:Male Swiss mice are tested under uniform 50-Hz electric field intensities of 100, 170, 220, and 290 kV/m. These values on the basis of equal induced current density are equivalent to the case of a human exposed to field intensities of nearly 8, 14, 18, and 24 kV/m, respectively. The latter values may be found beneath ...

journal_title：Environmental and molecular mutagenesis

authors： el Nahas SM,Oraby HA

更新日期：1989-01-01 00:00:00

abstract：:We have used an SV40-based shuttle vector, pZ189, to investigate the capacity of HeLa cell extracts to reproduce the in vivo process of mutation fixation. We showed previously that when UV-irradiated pZ189 is replicated in these extracts, bypass of UV photoproducts occurs, resulting in base substitution mutations in t...

journal_title：Environmental and molecular mutagenesis

authors： Carty MP,el-Saleh S,Zernik-Kobak M,Dixon K

更新日期：1995-01-01 00:00:00

abstract：:National and international regulatory agencies historically have used genotoxicity information as part of a weight-of-evidence approach to evaluate potential human carcinogenicity. Additionally, some agencies consider heritable mutation a regulatory endpoint. Furthermore, genotoxicity has the potential to contribute t...

journal_title：Environmental and molecular mutagenesis

authors： Cimino MC

更新日期：2006-06-01 00:00:00

abstract：:Previous population-based studies have identified subject characteristics that, when combined, can account for approximately 20% of the observed interindividual variation in baseline SCE rates. In the present investigation, a classic twin study design was used to address the issue of the relevance of genetic factors t...

journal_title：Environmental and molecular mutagenesis

authors： Hirsch BA,Sentz KK,McGue M

更新日期：1992-01-01 00:00:00

abstract：:The genotoxicity of humic acid and its possible interaction with the herbicides alachlor and maleic hydrazide have been evaluated in cultured human lymphocytes from two donors. Humic acid and the two herbicides have been tested (alone and combined) for sister-chromatid exchange (SCE) induction. In addition, the effect...

journal_title：Environmental and molecular mutagenesis

authors： Ribas G,Carbonell E,Creus A,Xamena N,Marcos R

更新日期：1997-01-01 00:00:00

abstract：:Lung cancer is the leading cause of cancer mortality in Taiwanese women. Cigarette smoking cannot explain the high lung cancer mortality in this population because less than 10% of women in Taiwan are smokers. Therefore, environmental factors other than smoking may play an important role in lung cancer development in ...

journal_title：Environmental and molecular mutagenesis

authors： Cheng YW,Hsieh LL,Lin PP,Chen CP,Chen CY,Lin TS,Su JM,Lee H

更新日期：2001-01-01 00:00:00

abstract：:Coal tar (CT) is a thick black liquid produced as a by-product of coal carbonization to produce coke or manufactured gas. It is comprised a complex mixture of polycyclic aromatic compounds, including a wide range of polycyclic aromatic hydrocarbons (PAHs), many of which are genotoxic and carcinogenic. CT is used in so...

journal_title：Environmental and molecular mutagenesis

authors： Long AS,Watson M,Arlt VM,White PA

更新日期：2016-08-01 00:00:00