Human erythrocyte PIG-A assay: an easily monitored index of gene mutation requiring low volume blood samples.

abstract：:Micronuclei were assessed among the bone marrow PCEs of mice 28 hr after exposures to 1 to 8 Gy of X-rays and at 6-hr intervals from 12-60 hr after exposures to 2 or 6 Gy. At 28 hr, the frequency of micronuclei declined as the exposure level increased from 1 to 8 Gy. The peak proportion of micronucleated PCEs appeared...

journal_title：Environmental and molecular mutagenesis

authors： McFee AF,Cook SB,Abbott MG

更新日期：1994-01-01 00:00:00

abstract：:The purpose of this study was to examine whether changes in the repair capacity of blood cells could be used as a valuable biomarker for radiation exposure. To characterize the repair kinetics in nonirradiated and irradiated cells we first performed in vitro split dose experiments. DNA damage and DNA repair capacity w...

journal_title：Environmental and molecular mutagenesis

authors： Plappert UG,Stocker B,Fender H,Fliedner TM

更新日期：1997-01-01 00:00:00

abstract：:A cross-sectional study was designed to determine whether occupational exposure to a complex mixture of pesticides results in a significant increase of DNA damage in farmers chronically exposed to pesticides in open fields. Leukocytes from 47 agriculture workers exposed to pesticides and 50 controls were evaluated wit...

journal_title：Environmental and molecular mutagenesis

authors： Bhalli JA,Ali T,Asi MR,Khalid ZM,Ceppi M,Khan QM

更新日期：2009-01-01 00:00:00

abstract：:A recent study conducted by our group showed that the NAT2 fast acetylator genotype is associated with an increasing risk for the development of colorectal cancer (CRC), especially for females. We therefore examined whether a higher risk of CRC in females with the NAT2 fast acetylator genotype was associated with the ...

journal_title：Environmental and molecular mutagenesis

authors： Huang CC,Chien WP,Wong RH,Cheng YW,Chen MC,Lee H

更新日期：2009-03-01 00:00:00

abstract：:Three carbamate insecticides (propoxur, methomyl, and aldicarb) were evaluated for their ability to induce micronuclei (MN) in vitro using cultured Chinese hamster ovary (CHO) cells, and in vivo in mouse bone marrow erythrocytes. In vitro, all three insecticides induced a significant increase in micronucleated binucle...

journal_title：Environmental and molecular mutagenesis

authors： Wei LY,Chao JS,Hong CC

更新日期：1997-01-01 00:00:00

abstract：:To protect human and ecosystem health, it is necessary to develop sensitive assays and to identify responsive cells and species (and their life stages). In this study, the relative genotoxicity of two inorganic arsenicals: trivalent sodium arsenite (As(3+)) and pentavalent sodium arsenate (As(5+)), was evaluated in tw...

journal_title：Environmental and molecular mutagenesis

authors： Raisuddin S,Jha AN

更新日期：2004-01-01 00:00:00

abstract：:Most women with breast cancer can become pregnant and give birth while undergoing radiation therapy and breastfeeding is generally not contraindicated. The induction of long-lived reactive species in proteins, such as casein by X-ray radiation and DNA damage to unexposed organisms, has been shown when ingesting irradi...

journal_title：Environmental and molecular mutagenesis

authors： Solórzano-Meléndez A,Rodrigo-Alarcón R,Gómez-Meda BC,Zamora-Pérez AL,Ortiz-García RG,Bayardo-López LH,González-Virgen R,Gallegos-Arreola MP,Zúñiga-González GM

更新日期：2021-01-26 00:00:00

abstract：:Atmospheric pollution represents a relevant environmental hazard which has been associated with considerable excess mortality, morbidity, and increased rates of respiratory diseases in humans. To date, more than 3,000 environmental chemical compounds have been identified in the ambient atmosphere, including a variety ...

journal_title：Environmental and molecular mutagenesis

authors： Bolognesi C,Merlo F,Rabboni R,Valerio F,Abbondandolo A

更新日期：1997-01-01 00:00:00

abstract：:Cultured rodent and human cells typically display similar clonal survival characteristics following exposure to ultraviolet light (UV). However, compared to human cells, cultured cells from mice, rats, and hamsters are generally deficient in excision repair of the most prominent DNA lesion produced by UV, the cyclobut...

journal_title：Environmental and molecular mutagenesis

authors： Hanawalt PC

更新日期：2001-01-01 00:00:00

abstract：:To determine the influence of DNA repair by Ogt alkyltransferase on the distribution of alkylnitrosourea-induced mutations, we have analysed in Ogt-proficient and Ogt-deficient bacterial strains the DNA sequence changes of a total of 357 independent mutations occurring within the initial part of the lacl gene of Esche...

journal_title：Environmental and molecular mutagenesis

authors： Vidal A,Abril N,Pueyo C

更新日期：1997-01-01 00:00:00

abstract：:Understanding chemically induced changes in mutational spectra can aid in deciphering mechanisms of mutagenesis. In this paper, we propose the use of statistical methods that are based upon the mutation frequency, rather than simple mutant counts which have no relationship to the mutation frequency. These methods have...

journal_title：Environmental and molecular mutagenesis

authors： Carr GJ,Gorelick NJ

更新日期：1996-01-01 00:00:00

abstract：:A quantitative structure-activity relationship (QSAR) has been formulated for 15 polycyclic aromatic nitro compounds acting on E. coli PQ37. Upon damage of DNA by these substances beta-galactosidase is induced and can be easily assayed colorimetrically, hence, this is a short-term test for mutagenicity. The QSAR (log ...

journal_title：Environmental and molecular mutagenesis

authors： Debnath AK,Hansch C

更新日期：1992-01-01 00:00:00

abstract：:Riddelliine (RID) is a pyrrolizidine alkaloid found in plants of the genera Crotalaria, Amsinckia, and Senecio in the United States. RID has been extensively studied in a wide variety of in vitro short-term genotoxicity tests and has yielded positive responses in most test systems; however, there are fewer data availa...

journal_title：Environmental and molecular mutagenesis

authors： Mirsalis JC,Steinmetz KL,Blazak WF,Spalding JW

更新日期：1993-01-01 00:00:00

abstract：:311 chemicals were tested under code, for mutagenicity, in Salmonella typhimurium; 35 of the chemicals were tested more than once in the same or different laboratories. The tests were conducted using a preincubation protocol in the absence of exogenous metabolic activation, and in the presence of liver S-9 from Aroclo...

journal_title：Environmental and molecular mutagenesis

authors： Zeiger E,Anderson B,Haworth S,Lawlor T,Mortelmans K

更新日期：1992-01-01 00:00:00

abstract：:Gravid Swiss Webster dams were injected via tail vein with a single (1.1, 2.2, or 3.3 mmol/kg) dose of ethyl carbamate (urethane) on days 13-17 of pregnancy. Relative sister chromatid exchange (SCE) responses in maternal bone marrow vs. individual fetal liver cells were assessed. In addition, in order to evaluate the ...

journal_title：Environmental and molecular mutagenesis

authors： Neeper-Bradley TL,Conner MK

更新日期：1989-01-01 00:00:00

abstract：:Environmental tobacco smoke (ETS) is a major source of indoor air pollution. Extractable-respirable particulate (ERP) from the ETS-contaminated indoor air (ERP-ETS) was collected from six passenger train cars and one control room. The mutagenicity of ERP-ETS was tested in the Ames/Salmonella test in the presence of ma...

journal_title：Environmental and molecular mutagenesis

authors： Zhou R,Yu G,Zhou Y,Zeng X

更新日期：1999-01-01 00:00:00

abstract：:The phenoxyherbicide and peroxisome proliferator 2-methyl-4-chlorophenoxyacetic acid (MCPA) was tested for its ability to induce sister-chromatid exchanges (SCE) in chick embryos. Erbitox E30 (a commercial formulation containing 28% MCPA sodium potassium salt as active ingredient) was injected into the air chamber in ...

journal_title：Environmental and molecular mutagenesis

authors： Arias E

更新日期：1992-01-01 00:00:00

abstract：:Diesel exhaust (DE) is a major airborne pollutant of urban areas. It contains various polycyclic aromatic hydrocarbons (PAH) and nitrated PAHs. In this study, gpt delta mice were treated with inhalation of 1 or 3 mg m(-3) DE, or a single intratracheal instillation of diesel exhaust particles (DEP) or DEP extract. In t...

journal_title：Environmental and molecular mutagenesis

authors： Hashimoto AH,Amanuma K,Hiyoshi K,Sugawara Y,Goto S,Yanagisawa R,Takano H,Masumura K,Nohmi T,Aoki Y

更新日期：2007-10-01 00:00:00

abstract：:A collaborative international trial was conducted to evaluate the reproducibility and transferability of an in vivo mutation assay based on the enumeration of CD59-negative rat erythrocytes, a phenotype that is indicative of Pig-a gene mutation. Fourteen laboratories participated in this study, where anti-CD59-PE, SYT...

journal_title：Environmental and molecular mutagenesis

authors： Dertinger SD,Phonethepswath S,Weller P,Nicolette J,Murray J,Sonders P,Vohr HW,Shi J,Krsmanovic L,Gleason C,Custer L,Henwood A,Sweder K,Stankowski LF Jr,Roberts DJ,Giddings A,Kenny J,Lynch AM,Defrain C,Nesslany F,v

更新日期：2011-12-01 00:00:00

abstract：:A mutagenesis moonshot addressing the influence of the environment on our genetic wellbeing was launched just 2 months before astronauts landed on the moon. Its impetus included the discovery that X-rays (Muller HJ. [1927]: Science 64:84-87) and chemicals (Auerbach and Robson. [1946]: Nature 157:302) were germ-cell mu...

journal_title：Environmental and molecular mutagenesis

authors： DeMarini DM

更新日期：2020-01-01 00:00:00

abstract：:AQ-13 ([N1-(7-chloro-quinolin-4yl)-3-(N3,N3-diethylamino)propylamine] dihydrochloride trihydrate) is an aminoquinoline antimalarial drug that is effective against chloroquine-resistant strains of Plasmodium falciparum. It is structurally similar to the widely used chloroquine diphosphate (CQ). We evaluated these drugs...

journal_title：Environmental and molecular mutagenesis

authors： Riccio ES,Lee PS,Winegar RA,Krogstad DJ,De D,Mirsalis JC

更新日期：2001-01-01 00:00:00

abstract：:DNA adducts of carcinogenic polycyclic aromatic hydrocarbons (PAHs) play a critical role in the etiology of gastrointestinal tract cancers in humans and other species orally exposed to PAHs. Yet, the precise localization of PAH-DNA adducts in the gastrointestinal tract, and the long-term postmortem PAH-DNA adduct stab...

journal_title：Environmental and molecular mutagenesis

authors： Poirier MC,Beland FA,Divi KV,Damon AL,Ali M,Vanlandingham MM,Churchwell MI,Von Tungeln LS,Dwyer JE,Divi RL,Beauchamp G,Martineau D

更新日期：2020-02-01 00:00:00

abstract：:In this study we evaluated the antigenotoxic and cytoprotective capabilities of WR-2721 [S-2-(3-aminopropylamino)-ethylphosphorothioic acid (amifostine)] in different normal tissues of BALB/c mice treated with idarubicin [4-demethoxydaunorubicin (IDA)]. The aminothiol WR-2721 is a pro-drug that requires dephosphorylat...

journal_title：Environmental and molecular mutagenesis

authors： de Campos Nebel M,Larripa I,González-Cid M

更新日期：2002-01-01 00:00:00

abstract：:Mutagenicity is an important toxicological endpoint that requires thorough evaluation during the industrial chemical registration process. Regulatory requirements for mutagenicity assessment in registration of industrial chemicals vary in geographic regions (and in some cases by intended application). Here we compile ...

journal_title：Environmental and molecular mutagenesis

authors： Ji Z,Ball NS,LeBaron MJ

更新日期：2017-06-01 00:00:00

abstract：:The Ames Salmonella/microsomal assay was employed to test the mutagenicity of some benzamines (aniline, and o- and p-phenylenediamine) and their nitro-derivatives (p-nitroaniline, 2-nitro-p-phenylenediamine, 3- and 4-nitro-o-phenylenediamine), using strains TA98 and TA100 and their nitroreductase-deficient mutants, TA...

journal_title：Environmental and molecular mutagenesis

authors： Chung KT,Murdock CA,Zhou Y,Stevens SE Jr,Li YS,Wei CI,Fernando SY,Chou MW

更新日期：1996-01-01 00:00:00

abstract：:Oxidative damage (lipid peroxidation, LPO) induced in a completely defined system containing glutathione (GSH), purified gamma-glutamyl transpeptidase (GGT), and EDTA- and ADP-chelated ferric iron was enhanced by catalytic amounts of cupric ions and by ceruloplasmin (CP). The enhancement depended on GSH concentration,...

journal_title：Environmental and molecular mutagenesis

authors： Glass GA,Stark AA

更新日期：1997-01-01 00:00:00

abstract：:Mitochondrial dysfunction is a global term used in the context of "unhealthy" mitochondria. In practical terms, mitochondria are extremely complex and highly adaptive in structure, chemical and enzymatic composition, subcellular distribution and functional interaction with other components of cells. Consequently, alte...

journal_title：Environmental and molecular mutagenesis

authors： Roede JR,Jones DP

更新日期：2010-06-01 00:00:00

abstract：:Coal tar (CT) is a thick black liquid produced as a by-product of coal carbonization to produce coke or manufactured gas. It is comprised a complex mixture of polycyclic aromatic compounds, including a wide range of polycyclic aromatic hydrocarbons (PAHs), many of which are genotoxic and carcinogenic. CT is used in so...

journal_title：Environmental and molecular mutagenesis

authors： Long AS,Watson M,Arlt VM,White PA

更新日期：2016-08-01 00:00:00

abstract：:Tryptophan is metabolized through serotonin, indole, and kynurenine (KN) pathways. Uptake of an excess amount of tryptophan accompanied with vitamin B6 deficiency may result in the accumulation of higher concentrations of metabolites mainly from the KN pathways in the bladder. These metabolites could interact with nit...

journal_title：Environmental and molecular mutagenesis

authors： Chung KT,Gadupudi GS

更新日期：2011-03-01 00:00:00

abstract：:The human transcriptome is complex, comprising multiple transcript types, mostly in the form of non-coding RNA (ncRNA). The majority of ncRNA is of the long form (lncRNA, ≥ 200 bp), which plays an important role in gene regulation through multiple mechanisms including epigenetics, chromatin modification, control of tr...

journal_title：Environmental and molecular mutagenesis

authors： McHale CM,Zhang L,Thomas R,Smith MT

更新日期：2013-08-01 00:00:00