Dose and temporal evaluation of ethylene oxide-induced mutagenicity in the lungs of male big blue mice following inhalation exposure to carcinogenic concentrations.

abstract：:Under the exposome paradigm all nongenetic factors contributing to disease are considered to be 'environmental' including chemicals, drugs, infectious agents, and psychosocial stress. We can consider these collectively as environmental stressors. Exposomics is the comprehensive analysis of exposure to all environmenta...

journal_title：Environmental and molecular mutagenesis

authors： Smith MT,de la Rosa R,Daniels SI

更新日期：2015-12-01 00:00:00

abstract：:In this study we evaluated the antigenotoxic and cytoprotective capabilities of WR-2721 [S-2-(3-aminopropylamino)-ethylphosphorothioic acid (amifostine)] in different normal tissues of BALB/c mice treated with idarubicin [4-demethoxydaunorubicin (IDA)]. The aminothiol WR-2721 is a pro-drug that requires dephosphorylat...

journal_title：Environmental and molecular mutagenesis

authors： de Campos Nebel M,Larripa I,González-Cid M

更新日期：2002-01-01 00:00:00

abstract：:Malignant gliomas are heterogeneous populations of dynamically interacting cells. Genomic and transcriptional changes define this cellular hierarchy and allow certain tumor cells to co-opt metabolic machinery and adopt gene expression profiles that promote cellular reprogramming. Resultant expansion of privileged subp...

journal_title：Environmental and molecular mutagenesis

authors： Baulch JE,Geidzinski E,Tran KK,Yu L,Zhou YH,Limoli CL

更新日期：2016-06-01 00:00:00

abstract：:Human immunodeficiency virus (HIV)-infected pregnant women are administered nucleoside-analogue antiretrovirals to reduce maternal-infant viral transmission. The current protocol recommends treating newborns for 6 additional weeks postpartum. The treatment is effective, but the risk of drug-induced chromosomal damage ...

journal_title：Environmental and molecular mutagenesis

authors： Bishop JB,Witt KL,Tice RR,Wolfe GW

更新日期：2004-01-01 00:00:00

abstract：:Bhawalpur is a major cotton-growing area in Pakistan. Cotton picking in Pakistan is carried out by females and as a result of the intensive use of pesticides during the growing season these females are exposed to pesticide residues in the picking season. In the present study, peripheral blood was obtained from 69 cott...

journal_title：Environmental and molecular mutagenesis

authors： Ali T,Bhalli JA,Rana SM,Khan QM

更新日期：2008-06-01 00:00:00

abstract：:The induction and nature of mutations in the lacI transgene were evaluated in multiple tissues after exposure of adult male B6C3F1 lacI transgenic mice to cyclophosphamide (CP). Mice were given a single i.p. injection of 25 mg CP/kg, 100 mg CP/kg, or vehicle (PBS) and then necropsied 6 weeks after treatment to allow D...

journal_title：Environmental and molecular mutagenesis

authors： Gorelick NJ,Andrews JL,deBoer JG,Young R,Gibson DP,Walker VE

更新日期：1999-01-01 00:00:00

abstract：:Experimental features of a transgenic mouse mutation assay based on a lacI target transgene from Escherichia coli are considered in detail. Sources of variability in the experimental protocol that can affect the statistical nature of the observations are examined with the goal of identifying sources of excess variatio...

journal_title：Environmental and molecular mutagenesis

authors： Piegorsch WW,Lockhart AM,Margolin BH,Tindall KR,Gorelick NJ,Short JM,Carr GJ,Thompson ED,Shelby MD

更新日期：1994-01-01 00:00:00

abstract：:Tandem-base mutations (TBM) are associated with ultraviolet light and other mutagens. Herein, we report an age- and tissue-specific difference in the frequency of spontaneous TBM in Big Blue transgenic mice. A total of 390 mutants from liver and adipose tissue contained 17 and 4 TBM, respectively, while no TBM were de...

journal_title：Environmental and molecular mutagenesis

authors： Buettner VL,Hill KA,Halangoda A,Sommer SS

更新日期：1999-01-01 00:00:00

abstract：:This laboratory has previously described a method for scoring the incidence of rodent blood Pig-a mutant phenotype erythrocytes using immunomagnetic separation in conjunction with flow cytometric analysis (In Vivo MutaFlow®). The current work extends this approach to human blood. The frequencies of CD59- and CD55-nega...

journal_title：Environmental and molecular mutagenesis

authors： Dertinger SD,Avlasevich SL,Bemis JC,Chen Y,MacGregor JT

更新日期：2015-05-01 00:00:00

abstract：:Alkylating treatments predominantly induce G: C = greater than A:T transitions, consistent with the predicted significance of the miscoding potential of the O6-alG lesion. However, the frequency and distribution of these events induced by any one compound may be diagnostic. SN1 agents that act via an alkyldiazonium ca...

journal_title：Environmental and molecular mutagenesis

authors： Horsfall MJ,Gordon AJ,Burns PA,Zielenska M,van der Vliet GM,Glickman BW

更新日期：1990-01-01 00:00:00

abstract：:The influence of several methodological factors on mean values of sister chromatid exchanges (SCEs) and micronuclei (MN) in peripheral lymphocytes of 1,650 subjects was analyzed. Donors belonged to a general healthy population living in Pisa and in two nearby small cities: Cascina and Navacchio (Ca-Na). Blood samples ...

journal_title：Environmental and molecular mutagenesis

authors： Barale R,Marrazzini A,Bacci E,Di Sibio A,Tessa A,Cocchi L,Scarcelli V,Lubrano V,Vassalle C,Landi S

更新日期：1998-01-01 00:00:00

abstract：:Arsenic is a world health problem due to the seriousness of its effects, mainly related with the increase of cancer. In Chile, the geological characteristics of the northern region, associated with the development of the copper mining and smelting activities, have contributed to increase the environmental levels of ar...

journal_title：Environmental and molecular mutagenesis

authors： Paiva L,Martínez V,Creus A,Quinteros D,Marcos R

更新日期：2008-04-01 00:00:00

abstract：:Micronucleus (MN) expression in peripheral blood lymphocytes is well established as a standard method for monitoring chromosome damage in human populations. The first results of an analysis of pooled data from laboratories using the cytokinesis-block micronucleus (CBMN) assay and participating in the HUMN (HUman Micro...

journal_title：Environmental and molecular mutagenesis

authors： Bonassi S,Fenech M,Lando C,Lin YP,Ceppi M,Chang WP,Holland N,Kirsch-Volders M,Zeiger E,Ban S,Barale R,Bigatti MP,Bolognesi C,Jia C,Di Giorgio M,Ferguson LR,Fucic A,Lima OG,Hrelia P,Krishnaja AP,Lee TK,Migliore L

更新日期：2001-01-01 00:00:00

abstract：:DNA adducts of carcinogenic polycyclic aromatic hydrocarbons (PAHs) play a critical role in the etiology of gastrointestinal tract cancers in humans and other species orally exposed to PAHs. Yet, the precise localization of PAH-DNA adducts in the gastrointestinal tract, and the long-term postmortem PAH-DNA adduct stab...

journal_title：Environmental and molecular mutagenesis

authors： Poirier MC,Beland FA,Divi KV,Damon AL,Ali M,Vanlandingham MM,Churchwell MI,Von Tungeln LS,Dwyer JE,Divi RL,Beauchamp G,Martineau D

更新日期：2020-02-01 00:00:00

abstract：:Exposure to emissions from laser printers during the printing process is commonplace worldwide, both in the home and workplace environment. In the present study, cytotoxic and genotoxic effects of the emission from five low to medium-throughput laser printers were investigated with respect to the release of ozone (O(3...

journal_title：Environmental and molecular mutagenesis

authors： Tang T,Gminski R,Könczöl M,Modest C,Armbruster B,Mersch-Sundermann V

更新日期：2012-03-01 00:00:00

abstract：:DNA is exposed to endogenous and environmental factors that can form stable lesions. If not repaired, these lesions can lead to transcription/replication blocking or mutagenic bypass. Our previous work has focused on 8,5'-cyclopurine 2'-deoxyribonucleosides, a unique class of oxidatively induced DNA lesions that are s...

journal_title：Environmental and molecular mutagenesis

authors： Abraham J,Brooks PJ

更新日期：2011-05-01 00:00:00

abstract：:As a contribution to the second round of rodent carcinogenesis prediction organised by the U.S. National Institute of Environmental Health Sciences (NIEHS), speculative predictions for 30 chemicals currently under evaluation in U.S. National Toxicology Program (NTP) rodent bioassays are presented. Core chemical data r...

journal_title：Environmental and molecular mutagenesis

authors： Bootman J

更新日期：1996-01-01 00:00:00

abstract：:Diesel exhaust (DE) is a major airborne pollutant of urban areas. It contains various polycyclic aromatic hydrocarbons (PAH) and nitrated PAHs. In this study, gpt delta mice were treated with inhalation of 1 or 3 mg m(-3) DE, or a single intratracheal instillation of diesel exhaust particles (DEP) or DEP extract. In t...

journal_title：Environmental and molecular mutagenesis

authors： Hashimoto AH,Amanuma K,Hiyoshi K,Sugawara Y,Goto S,Yanagisawa R,Takano H,Masumura K,Nohmi T,Aoki Y

更新日期：2007-10-01 00:00:00

abstract：:Experiments described herein were designed to evaluate the performance characteristics of a flow cytometry-based system that scores the incidence of peripheral blood micronucleated reticulocytes (MN-RETs). These procedures represent the continued refinement of a previously reported anti-CD71-based method (Dertinger et...

journal_title：Environmental and molecular mutagenesis

authors： Dertinger SD,Camphausen K,Macgregor JT,Bishop ME,Torous DK,Avlasevich S,Cairns S,Tometsko CR,Menard C,Muanza T,Chen Y,Miller RK,Cederbrant K,Sandelin K,Pontén I,Bolcsfoldi G

更新日期：2004-01-01 00:00:00

abstract：:The in vivo model Drosophila melanogaster was used here to determine the detrimental effects induced by silver nanoparticles (AgNPs) exposure. The main aim was to explore its interaction with the intestinal barrier and the genotoxic effects induced in hemocytes. The observed effects were compared with those obtained b...

journal_title：Environmental and molecular mutagenesis

authors： Alaraby M,Romero S,Hernández A,Marcos R

更新日期：2019-04-01 00:00:00

abstract：:Experiments are described which elucidate some of the technical problems associated with the direct sequencing of polymerase chain reaction (PCR) amplified DNA. Sequencing primer purity, labeling methodology, and template preparation were explored. Conditions are presented for the routine sequencing of single- and dou...

journal_title：Environmental and molecular mutagenesis

authors： Zimmerman LJ,Fuscoe JC

更新日期：1991-01-01 00:00:00

abstract：:The evaluation of the relationship between the dose to DNA of a mutagen/carcinogen and in vivo somatic cell mutagenesis may provide information on the mechanisms leading to induced mutational events. This can be achieved, for example, by coupling test systems that permit the detection of somatic mutation and recombina...

journal_title：Environmental and molecular mutagenesis

authors： Zordan M,Osti M,Pavanello S,Costa R,Levis AG

更新日期：1994-01-01 00:00:00

abstract：:A set of stable nitroxide free radicals that are used as spin labels have been shown to possess metal-independent superoxide dismutase-like activity. Unlike superoxide dismutase (SOD), these compounds are low molecular weight, and readily penetrate into the cell. A representative nitroxide, 4-hydroxy-2,2,6,6-tetrameth...

journal_title：Environmental and molecular mutagenesis

authors： DeGraff WG,Krishna MC,Russo A,Mitchell JB

更新日期：1992-01-01 00:00:00

abstract：:The hydroxyl radical scavengers thiourea, ethanol, and dimethyl sulfoxide significantly reduced the killing of Escherichia coli elicited by low concentrations of H2O2 (resulting in mode 1 killing) when treatments with the oxidant and the scavengers were performed in a complete growth medium (K medium) but not in M9 sa...

journal_title：Environmental and molecular mutagenesis

authors： Brandi G,Salvaggio L,Cattabeni F,Cantoni O

更新日期：1991-01-01 00:00:00

abstract：:Aldehydes are widespread environmental and industrial compounds, able to stimulate a range of adverse health effects (e.g., general toxicity, allergenic reactions, mutagenicity, and carcinogenicity). We have previously presented quantitative structure-activity relationships (QSARs) for the genotoxicity of simple and a...

journal_title：Environmental and molecular mutagenesis

authors： Benigni R,Conti L,Crebelli R,Rodomonte A,Vari' MR

更新日期：2005-12-01 00:00:00

abstract：:The centrosome, also known as the microtubule organizing center of the cell, is a membrane-less organelle composed of a pair of barrel-shaped centrioles surrounded by electron-dense pericentriolar material. The centrosome progresses through the centrosome cycle in step with the cell cycle such that centrosomes are dup...

journal_title：Environmental and molecular mutagenesis

authors： Lukasiewicz KB,Lingle WL

更新日期：2009-10-01 00:00:00

abstract：:Methyl 3,4-diphenyl-5-hydroxylamino-2-furoate (N-OH-MDPF) (I), methyl 3,4-diphenyl-5-acetoxyamino-2-furoate (N-OAc-MDPF) (II), methyl 3,4-diphenyl-N-hydroxy-5-acetylamino-2-furoate (N-OH-MDPAF) (III), and methyl 3,4-diphenyl-N-acetoxy-5-acetylamino-2-furoate (N-OAc-MDPAF) (IV) were synthesized and tested for mutagenic...

journal_title：Environmental and molecular mutagenesis

authors： Swaminathan S,Hatcher JF,Yamamoto K,Tanaka A,Ichikawa M,Bryan GT

更新日期：1991-01-01 00:00:00

abstract：:DNA damage and its subsequent repair occur heterogeneously throughout the genome, which reflects the nature of the damaging agents, gross chromosomal structure, the specific nucleotide sequence, and transcriptional status. We selected to investigate the repair of DNA damage in an artificial, transgenic situation. Here...

journal_title：Environmental and molecular mutagenesis

authors： Yang H,Kotturi GP,de Boer JG,Glickman BW

更新日期：1999-01-01 00:00:00

abstract：:There is scientific and regulatory interest in using mutation assays in transgenic mice in safety assessments for new chemicals and drugs. Currently these assays are in the process of being validated, and protocols for routine testing are being defined. Some of the issues and results to date with regard to assay valid...

journal_title：Environmental and molecular mutagenesis

authors： Gorelick NJ

更新日期：1995-01-01 00:00:00

abstract：:The efficiency of the micronucleus test to assess radiation-induced chromosomal damage in human spermatozoa has been investigated. Micronuclei were scored in human sperm-hamster egg hybrids at the two-cell stage, after exposure of human spermatozoa to in vitro gamma-rays at doses of 0.00, 0.10, 0.25, 0.50, 1.00, 2.00,...

journal_title：Environmental and molecular mutagenesis

authors： Tusell L,Alvarez R,Caballín MR,Genescà A,Miró R,Ribas M,Egozcue J

更新日期：1995-01-01 00:00:00