Sources of variability in data from a lacI transgenic mouse mutation assay.

abstract：:N-Hydroxymethylacrylamide (NHMA), a mouse carcinogen inactive in the Salmonella assay and mouse micronucleus (MN) assay, was tested for reproductive effects in a mouse continuous breeding study. In that study, increased embryonic deaths were observed after 13 weeks exposure of parental animals to NHMA via drinking wat...

journal_title：Environmental and molecular mutagenesis

authors： Witt KL,Hughes LA,Burka LT,McFee AF,Mathews JM,Black SL,Bishop JB

更新日期：2003-01-01 00:00:00

abstract：:Halogenated acetonitriles (HANs) are known to be water disinfectant by-products. Their mutagenicity and carcinogenicity have been shown in different test systems in vivo and in vitro. They also have clastogenic properties. In this study, the ability of HAN to induce single-strand breaks on the DNA of HeLa S3 cells was...

journal_title：Environmental and molecular mutagenesis

authors： Muller-Pillet V,Joyeux M,Ambroise D,Hartemann P

更新日期：2000-01-01 00:00:00

abstract：:A collaborative international trial was conducted to evaluate the reproducibility and transferability of an in vivo mutation assay based on the enumeration of CD59-negative rat erythrocytes, a phenotype that is indicative of Pig-a gene mutation. Fourteen laboratories participated in this study, where anti-CD59-PE, SYT...

journal_title：Environmental and molecular mutagenesis

authors： Dertinger SD,Phonethepswath S,Weller P,Nicolette J,Murray J,Sonders P,Vohr HW,Shi J,Krsmanovic L,Gleason C,Custer L,Henwood A,Sweder K,Stankowski LF Jr,Roberts DJ,Giddings A,Kenny J,Lynch AM,Defrain C,Nesslany F,v

更新日期：2011-12-01 00:00:00

abstract：:It is estimated that 15% of all cancers are etiologically linked to viral infection. Specific cancers including adult T-cell leukemia, hepatocellular carcinoma, and uterine cervical cancer are associated with infection by human T-cell leukemia virus type I, hepatitis B virus, and high-risk human papilloma virus, respe...

journal_title：Environmental and molecular mutagenesis

authors： Gatza ML,Chandhasin C,Ducu RI,Marriott SJ

更新日期：2005-03-01 00:00:00

abstract：:Experiments described herein were designed to evaluate the performance characteristics of a flow cytometry-based system that scores the incidence of peripheral blood micronucleated reticulocytes (MN-RETs). These procedures represent the continued refinement of a previously reported anti-CD71-based method (Dertinger et...

journal_title：Environmental and molecular mutagenesis

authors： Dertinger SD,Camphausen K,Macgregor JT,Bishop ME,Torous DK,Avlasevich S,Cairns S,Tometsko CR,Menard C,Muanza T,Chen Y,Miller RK,Cederbrant K,Sandelin K,Pontén I,Bolcsfoldi G

更新日期：2004-01-01 00:00:00

abstract：:Azidothymidine (AZT) is a nucleoside reverse transcriptase inhibitor (NRTI) that is used for reducing mother-to-child transmission of human immunodeficiency virus I. Combinations of AZT and 3'-thiacytidine (3TC) are even more effective than AZT alone. AZT, however, is a mutagen and carcinogen in rodent models and 3TC ...

journal_title：Environmental and molecular mutagenesis

authors： Dobrovolsky VN,Shaddock JG,Mittelstaedt RA,Bishop ME,Lewis SM,Lee FW,Aidoo A,Leakey JE,Dunnick JK,Heflich RH

更新日期：2007-04-01 00:00:00

abstract：:The human transcriptome is complex, comprising multiple transcript types, mostly in the form of non-coding RNA (ncRNA). The majority of ncRNA is of the long form (lncRNA, ≥ 200 bp), which plays an important role in gene regulation through multiple mechanisms including epigenetics, chromatin modification, control of tr...

journal_title：Environmental and molecular mutagenesis

authors： McHale CM,Zhang L,Thomas R,Smith MT

更新日期：2013-08-01 00:00:00

abstract：:Non-isotopic in situ hybridization using a mouse gamma (major) satellite probe DNA was applied to detect centromeres in micronuclei, which were induced in vitro in mouse liver cells by ionizing radiation and by vinblastine sulfate. In a cytokinesis-blocked micronucleus assay a dose-dependent induction of micronuclei w...

journal_title：Environmental and molecular mutagenesis

authors： Salassidis K,Huber R,Zitzelsberger H,Bauchinger M

更新日期：1992-01-01 00:00:00

abstract：:The induction and nature of mutations in the lacI transgene were evaluated in multiple tissues after exposure of adult male B6C3F1 lacI transgenic mice to cyclophosphamide (CP). Mice were given a single i.p. injection of 25 mg CP/kg, 100 mg CP/kg, or vehicle (PBS) and then necropsied 6 weeks after treatment to allow D...

journal_title：Environmental and molecular mutagenesis

authors： Gorelick NJ,Andrews JL,deBoer JG,Young R,Gibson DP,Walker VE

更新日期：1999-01-01 00:00:00

abstract：:Evidence is provided that antitopoisomerase drugs induce chromosomal aberrations via the formation of DNA double strand breaks. Camptothecin, an inhibitor of DNA topoisomerase I, produced only chromatid-type aberrations, and in order to be effective it has to be present during the DNA replication. The fact that it ind...

journal_title：Environmental and molecular mutagenesis

authors： Palitti F

更新日期：1993-01-01 00:00:00

abstract：:Respirable crystalline silica has been classified as a human lung carcinogen. Ultrafine (diameter < 100 nm) silica particles may be important in carcinogenesis, although the mechanisms remain unclear. In the present study, WIL2-NS cells were incubated for 6, 24, and 48 hr with 0, 30, 60, and 120 microg/ml ultrafine cr...

journal_title：Environmental and molecular mutagenesis

authors： Wang JJ,Sanderson BJ,Wang H

更新日期：2007-03-01 00:00:00

abstract：:To determine the influence of DNA repair by Ogt alkyltransferase on the distribution of alkylnitrosourea-induced mutations, we have analysed in Ogt-proficient and Ogt-deficient bacterial strains the DNA sequence changes of a total of 357 independent mutations occurring within the initial part of the lacl gene of Esche...

journal_title：Environmental and molecular mutagenesis

authors： Vidal A,Abril N,Pueyo C

更新日期：1997-01-01 00:00:00

abstract：:Previous population-based studies have identified subject characteristics that, when combined, can account for approximately 20% of the observed interindividual variation in baseline SCE rates. In the present investigation, a classic twin study design was used to address the issue of the relevance of genetic factors t...

journal_title：Environmental and molecular mutagenesis

authors： Hirsch BA,Sentz KK,McGue M

更新日期：1992-01-01 00:00:00

abstract：:Experiments are described which elucidate some of the technical problems associated with the direct sequencing of polymerase chain reaction (PCR) amplified DNA. Sequencing primer purity, labeling methodology, and template preparation were explored. Conditions are presented for the routine sequencing of single- and dou...

journal_title：Environmental and molecular mutagenesis

authors： Zimmerman LJ,Fuscoe JC

更新日期：1991-01-01 00:00:00

abstract：:To evaluate whether blood-based genotoxicity endpoints can provide temporal and dose-response data within the low-dose carcinogenic range that could contribute to carcinogenic mode of action (MoA) assessments, we evaluated the sensitivity of flow cytometry-based micronucleus and Pig-a gene mutation assays at and below...

journal_title：Environmental and molecular mutagenesis

authors： Dertinger SD,Phonethepswath S,Avlasevich SL,Torous DK,Mereness J,Cottom J,Bemis JC,Macgregor JT

更新日期：2014-05-01 00:00:00

abstract：:To what extent noncovalent chemical-DNA interactions, in particular weak nonbonded DNA intercalation, contribute to genotoxic responses in mammalian cells has not been fully elucidated. Moreover, with the exception of predominantly flat, multiple-fused-ring structures, our ability to predict intercalation ability of n...

journal_title：Environmental and molecular mutagenesis

authors： Snyder RD,Ewing DE,Hendry LB

更新日期：2004-01-01 00:00:00

abstract：:A rapid and simple procedure for the micronucleus test (MNT) in vitro using Chinese hamster ovary (CHO) cells was established in our laboratory. The assay is intended to quickly screen chromosomal aberrations in vitro within the framework of industrial genotoxicity studies. To test the sensitivity of the assay in the ...

journal_title：Environmental and molecular mutagenesis

authors： Miller BM,Pujadas E,Gocke E

更新日期：1995-01-01 00:00:00

abstract：:Vanillin (VA) modulates the genotoxicity of chemical and physical agents in a complex manner. Previous studies indicate that VA inhibits the mutagenicity but increases the mitotic homologous recombination caused by at least some genotoxic agents. In the present study, we have evaluated the effects of VA on the repair ...

journal_title：Environmental and molecular mutagenesis

authors： Furlanetto MP,Sinigaglia M,Amaral VS,Dihl RR,de Andrade HH

更新日期：2007-01-01 00:00:00

abstract：:Tandem-base mutations (TBM) are associated with ultraviolet light and other mutagens. Herein, we report an age- and tissue-specific difference in the frequency of spontaneous TBM in Big Blue transgenic mice. A total of 390 mutants from liver and adipose tissue contained 17 and 4 TBM, respectively, while no TBM were de...

journal_title：Environmental and molecular mutagenesis

authors： Buettner VL,Hill KA,Halangoda A,Sommer SS

更新日期：1999-01-01 00:00:00

abstract：:Paraoxon (diethyl-p-nitrophenylphosphate) is the toxic, but non-mutagenic metabolite of the organophosphorus ester (OP) insecticide parathion. Although this agent has been used as a deacetylase inhibitor in many studies, we discovered a mutagenic synergy with paraoxon and plant-activated m-phenylenediamine or with dir...

journal_title：Environmental and molecular mutagenesis

authors： Wagner ED,Repetny K,Tan JS,Gichner T,Plewa MJ

更新日期：1997-01-01 00:00:00

abstract：:DNA is exposed to endogenous and environmental factors that can form stable lesions. If not repaired, these lesions can lead to transcription/replication blocking or mutagenic bypass. Our previous work has focused on 8,5'-cyclopurine 2'-deoxyribonucleosides, a unique class of oxidatively induced DNA lesions that are s...

journal_title：Environmental and molecular mutagenesis

authors： Abraham J,Brooks PJ

更新日期：2011-05-01 00:00:00

abstract：:Antioxidant vitamins are able to deactivate highly bioactive molecules, such as free radicals, that are generated during cellular biochemical processes. Doxorubicin (DXR) is a cancer chemotherapeutic agent that generates free radicals as a byproduct. In the present study, the Drosophila melanogaster somatic wing spot ...

journal_title：Environmental and molecular mutagenesis

authors： Costa WF,Nepomuceno JC

更新日期：2006-01-01 00:00:00

abstract：:We describe an in vivo mutagenesis model that utilizes reverse mutation and forward mutation at the endogenous Aprt locus. Reverse mutation provides an in situ method for detecting environments or agents that cause point mutations. Forward mutation detects large chromosomal events, including mitotic recombination, chr...

journal_title：Environmental and molecular mutagenesis

authors： Stambrook PJ,Shao C,Stockelman M,Boivin G,Engle SJ,Tischfield JA

更新日期：1996-01-01 00:00:00

abstract：:The influence of several methodological factors on mean values of sister chromatid exchanges (SCEs) and micronuclei (MN) in peripheral lymphocytes of 1,650 subjects was analyzed. Donors belonged to a general healthy population living in Pisa and in two nearby small cities: Cascina and Navacchio (Ca-Na). Blood samples ...

journal_title：Environmental and molecular mutagenesis

authors： Barale R,Marrazzini A,Bacci E,Di Sibio A,Tessa A,Cocchi L,Scarcelli V,Lubrano V,Vassalle C,Landi S

更新日期：1998-01-01 00:00:00

abstract：:AQ-13 ([N1-(7-chloro-quinolin-4yl)-3-(N3,N3-diethylamino)propylamine] dihydrochloride trihydrate) is an aminoquinoline antimalarial drug that is effective against chloroquine-resistant strains of Plasmodium falciparum. It is structurally similar to the widely used chloroquine diphosphate (CQ). We evaluated these drugs...

journal_title：Environmental and molecular mutagenesis

authors： Riccio ES,Lee PS,Winegar RA,Krogstad DJ,De D,Mirsalis JC

更新日期：2001-01-01 00:00:00

abstract：:Cytochrome P450 (CYP), glutathione-S-transferase (GST), and N-acetyltransferase (NAT) are crucial for metabolism and clearance of xenobiotics. This study investigated whether CYP, GST, and NAT single nucleotide polymorphisms (SNPs) are associated with colorectal cancer (CRC) in patients with Lynch syndrome. The intera...

journal_title：Environmental and molecular mutagenesis

authors： Kamiza AB,You JF,Wang WC,Tang R,Chang CY,Chien HT,Lai CH,Chiu LL,Lo TP,Hung KY,Hsiung CA,Yeh CC

更新日期：2018-01-01 00:00:00

abstract：:Three carbamate insecticides (propoxur, methomyl, and aldicarb) were evaluated for their ability to induce micronuclei (MN) in vitro using cultured Chinese hamster ovary (CHO) cells, and in vivo in mouse bone marrow erythrocytes. In vitro, all three insecticides induced a significant increase in micronucleated binucle...

journal_title：Environmental and molecular mutagenesis

authors： Wei LY,Chao JS,Hong CC

更新日期：1997-01-01 00:00:00

abstract：:Several types of diesel exhaust particles (DEPs) have been used for toxicology studies, including a high-organic automobile DEP (A-DEP) from Japan, and a low-organic forklift DEP developed by the National Institute of Standards and Technology (N-DEP). However, these DEPs were not characterized extensively for chemical...

journal_title：Environmental and molecular mutagenesis

authors： Mutlu E,Warren SH,Matthews PP,King C,Linak WP,Kooter IM,Schmid JE,Ross JA,Gilmour MI,Demarini DM

更新日期：2013-12-01 00:00:00

abstract：:Most women with breast cancer can become pregnant and give birth while undergoing radiation therapy and breastfeeding is generally not contraindicated. The induction of long-lived reactive species in proteins, such as casein by X-ray radiation and DNA damage to unexposed organisms, has been shown when ingesting irradi...

journal_title：Environmental and molecular mutagenesis

authors： Solórzano-Meléndez A,Rodrigo-Alarcón R,Gómez-Meda BC,Zamora-Pérez AL,Ortiz-García RG,Bayardo-López LH,González-Virgen R,Gallegos-Arreola MP,Zúñiga-González GM

更新日期：2021-01-26 00:00:00

abstract：:Synthetic dyes are released in wastewater from textile manufacturing plants, and many of these dyes are genotoxic. In the present study, the mutagenicity of azo, anthraquinone, and triphenyl methane dyes was investigated before and after successive biodegradation with activated sludge and the ligninolytic fungus, Irpe...

journal_title：Environmental and molecular mutagenesis

authors： Malachová K,Pavlícková Z,Novotný C,Svobodová K,Lednická D,Musílková E

更新日期：2006-08-01 00:00:00