Tandem-base mutations occur in mouse liver and adipose tissue preferentially as G:C to T:A transversions and accumulate with age.

abstract：:Molecular analysis of proaerolysin selected glycosylphosphatidylinositol anchor (GPI-a) deficient isolates in the TK6 cell line was performed. Initial studies found that the expected X-linked PIGA mutations were rare among the spontaneous isolates but did increase modestly after ethyl methane sulfate (EMS) treatment (...

journal_title：Environmental and molecular mutagenesis

authors： Nicklas JA,Carter EW,Albertini RJ

更新日期：2015-10-01 00:00:00

abstract：:The effects of ultrasound on the cytoskeleton, comprising microtubules, had been studied decades ago. Nonetheless, very little attention has been paid to the effects of ultrasound on the mitotic spindle, which is also formed by microtubules. In this study, we treated human fibroblasts and human cancer cells (HeLa and ...

journal_title：Environmental and molecular mutagenesis

authors： Udroiu I,Coluzzi E,Bedini A,Giliberti C,Palomba R,Sgura A

更新日期：2019-08-01 00:00:00

abstract：:Prostate cancer (PC) is commonly diagnosed cancer in men but only a few risk factors, such as family history, ethnicity, and age have been established. Chromosomal instability is another possible risk factor but this has not been adequately explained previously. In this study, we tested the hypotheses that peripheral ...

journal_title：Environmental and molecular mutagenesis

authors： Dhillon VS,Yeoh E,Salisbury C,Butters J,Di Matteo A,Olver I,Fenech M

更新日期：2018-12-01 00:00:00

abstract：:Coumarin (1,2-benzopyrone), a natural food constituent, prevents polycyclic aromatic hydrocarbon-induced neoplasms in rats and mice, but has not been studied with other chemical carcinogens. We examined coumarin chemoprotection against aflatoxin B1 using the 6-thioguanine resistance mutation assay in two different Chi...

journal_title：Environmental and molecular mutagenesis

authors： Goeger DE,Anderson KE,Hsie AW

更新日期：1998-01-01 00:00:00

abstract：:To protect human and ecosystem health, it is necessary to develop sensitive assays and to identify responsive cells and species (and their life stages). In this study, the relative genotoxicity of two inorganic arsenicals: trivalent sodium arsenite (As(3+)) and pentavalent sodium arsenate (As(5+)), was evaluated in tw...

journal_title：Environmental and molecular mutagenesis

authors： Raisuddin S,Jha AN

更新日期：2004-01-01 00:00:00

abstract：:Quinoline is a specific and potent carcinogen to the rat and mouse liver. Studies are described here in which it was evaluated for its ability to initiate unscheduled DNA synthesis (UDS) in the rat liver in vivo. Although some individual animals showed indications of a marginal response the absence of clear group posi...

journal_title：Environmental and molecular mutagenesis

authors： Ashby J,Mohammed R,Lefevre PA,Bandara L

更新日期：1989-01-01 00:00:00

abstract：:A multicolor fluorescence in situ hybridization (FISH) method was developed to detect aneuploidy and diploidy in epididymal sperm of rats using DNA probes specific for chromosomes 4 and Y. Fourteen healthy young-adult rats from three strains were evaluated: inbred Fisher 344/N/ehs, outbred Sprague-Dawley, and outbred ...

journal_title：Environmental and molecular mutagenesis

authors： Lowe XR,de Stoppelaar JM,Bishop J,Cassel M,Hoebee B,Moore D 2nd,Wyrobek AJ

更新日期：1998-01-01 00:00:00

abstract：:Several genotoxicity endpoints have been evaluated to define nonlinear dose-responses for SN 1 and SN 2 alkylating genotoxicants. Dose-response studies acknowledging the process of multistage tumorigenesis are important; however, data pertaining nonlinearity are not yet available. In this communication, the role of DN...

journal_title：Environmental and molecular mutagenesis

authors： Becker K,Thomas AD,Kaina B

更新日期：2014-03-01 00:00:00

abstract：:Evidence is provided that antitopoisomerase drugs induce chromosomal aberrations via the formation of DNA double strand breaks. Camptothecin, an inhibitor of DNA topoisomerase I, produced only chromatid-type aberrations, and in order to be effective it has to be present during the DNA replication. The fact that it ind...

journal_title：Environmental and molecular mutagenesis

authors： Palitti F

更新日期：1993-01-01 00:00:00

abstract：:The potential of 1,3-dichloropropene (1,3-DCP) to induce dominant lethal mutations in the germ cells of male CD rats following inhalation exposure was investigated. Groups of 11-week-old males (30 animals/group) were exposed to 1,3-DCP vapors by inhalation at targeted concentrations of 0 (negative control), 10, 60, an...

journal_title：Environmental and molecular mutagenesis

authors： Gollapudi BB,Cieszlak FS,Day SJ,Carney EW

更新日期：1998-01-01 00:00:00

abstract：:Male Swiss mice are tested under uniform 50-Hz electric field intensities of 100, 170, 220, and 290 kV/m. These values on the basis of equal induced current density are equivalent to the case of a human exposed to field intensities of nearly 8, 14, 18, and 24 kV/m, respectively. The latter values may be found beneath ...

journal_title：Environmental and molecular mutagenesis

authors： el Nahas SM,Oraby HA

更新日期：1989-01-01 00:00:00

abstract：:BDF1 mice were exposed in inhalation chambers to benzene (900 ppm, 300 ppm) and/or toluene (500 ppm, 250 ppm) 6 hr per day, 5 days per week, for up to 8 weeks. Benzene alone induced a slight anemia after 4 and 8 weeks and a reduction of BFU-E and CFU-E numbers in the marrow. The coexposure to toluene reduced the degre...

journal_title：Environmental and molecular mutagenesis

authors： Plappert U,Barthel E,Seidel HJ

更新日期：1994-01-01 00:00:00

abstract：:Studies of the mutagenicity and antimutagenicity of hispidulin and hortensin, the flavonoids from Millingtonia hortensis L. (Bignoniaceae), were performed using the liquid preincubation method of the Salmonella/microsome test. At the highest dose tested, 100 micrograms/plate, both compounds showed no mutagenicity and ...

journal_title：Environmental and molecular mutagenesis

authors： Chulasiri M,Bunyapraphatsara N,Moongkarndi P

更新日期：1992-01-01 00:00:00

abstract：:The nuclease P1 modification of the 32P-postlabeling technique was used to study the biological activity of 7H-dibenzo[c,g]carbazole (DBC) and some of its derivatives, including N-methyldibenzo[c,g]carbazole (N-MeDBC), 5,9-dimethyldibenzo[c,g]carbazole (5,9-diMeDBC), 5,9,N-trimethyldibenzo[c,g]carbazole (5,9,N-triMeDB...

journal_title：Environmental and molecular mutagenesis

authors： Gábelová A,Périn-Roussel O,Jounaidi Y,Périn F

更新日期：1997-01-01 00:00:00

abstract：:The centrosome, also known as the microtubule organizing center of the cell, is a membrane-less organelle composed of a pair of barrel-shaped centrioles surrounded by electron-dense pericentriolar material. The centrosome progresses through the centrosome cycle in step with the cell cycle such that centrosomes are dup...

journal_title：Environmental and molecular mutagenesis

authors： Lukasiewicz KB,Lingle WL

更新日期：2009-10-01 00:00:00

abstract：:In this study we evaluated the antigenotoxic and cytoprotective capabilities of WR-2721 [S-2-(3-aminopropylamino)-ethylphosphorothioic acid (amifostine)] in different normal tissues of BALB/c mice treated with idarubicin [4-demethoxydaunorubicin (IDA)]. The aminothiol WR-2721 is a pro-drug that requires dephosphorylat...

journal_title：Environmental and molecular mutagenesis

authors： de Campos Nebel M,Larripa I,González-Cid M

更新日期：2002-01-01 00:00:00

abstract：:Peripheral lymphocytes from Taiwanese women (n = 35) exposed to polychlorinated aromatic hydrocarbons and from matched controls (n = 24) were assessed for the levels of sister chromatid exchanges (SCEs) after a 72-hour incubation of whole blood in the presence or absence of alpha-naphthoflavone (ANF) and for chromosom...

journal_title：Environmental and molecular mutagenesis

authors： Lundgren K,Collman GW,Wang-Wuu S,Tiernan T,Taylor M,Thompson CL,Lucier GW

更新日期：1988-01-01 00:00:00

abstract：:Lead is a widely existing environmental pollutant with potential carcinogenicity. To investigate the association of blood lead level (B-Pb) with potential chromosomal damage and cancer, we analyzed micronucleus (MN) frequency of peripheral blood lymphocytes (PBLs) and the methylation status of six human tumor suppress...

journal_title：Environmental and molecular mutagenesis

authors： Yu LB,Tu YT,Huang JW,Zhang YN,Zheng GQ,Xu XW,Wang JW,Xiao JQ,Christiani DC,Xia ZL

更新日期：2018-07-01 00:00:00

abstract：:Two freshwater species of planarians, Girardia schubarti Marcus and G. tigrina Girard, were used for measuring chromosome aberration (CA) induction under laboratory conditions. Three genotoxicants were tested: methyl methanesulfonate (MMS), a direct-acting genotoxicant; cyclophosphamide, a metabolism-dependent genotox...

journal_title：Environmental and molecular mutagenesis

authors： Lau AH,Knakievicz T,Prá D,Erdtmann B

更新日期：2007-07-01 00:00:00

abstract：:The transporter associated with antigen processing 2 (TAP2) is involved in the development of multidrug resistance and the etiology of immunological diseases. In this study, we investigated whether the expression of TAP2 can be perturbed by single nucleotide polymorphisms (SNPs) located in 3'-untranslated region (3'-U...

journal_title：Environmental and molecular mutagenesis

authors： Knox B,Wang Y,Rogers LJ,Xuan J,Yu D,Guan H,Chen J,Shi T,Ning B,Kadlubar SA

更新日期：2018-03-01 00:00:00

abstract：:The purpose of this study was to examine whether changes in the repair capacity of blood cells could be used as a valuable biomarker for radiation exposure. To characterize the repair kinetics in nonirradiated and irradiated cells we first performed in vitro split dose experiments. DNA damage and DNA repair capacity w...

journal_title：Environmental and molecular mutagenesis

authors： Plappert UG,Stocker B,Fender H,Fliedner TM

更新日期：1997-01-01 00:00:00

abstract：:In vitro transcriptional signatures that predict toxicities can facilitate chemical screening. We previously developed a transcriptomic biomarker (known as TGx-28.65) for classifying agents as genotoxic (DNA damaging) and non-genotoxic in human lymphoblastoid TK6 cells. Because TK6 cells do not express cytochrome P450...

journal_title：Environmental and molecular mutagenesis

authors： Yauk CL,Buick JK,Williams A,Swartz CD,Recio L,Li HH,Fornace AJ Jr,Thomson EM,Aubrecht J

更新日期：2016-05-01 00:00:00

abstract：:N-Hydroxymethylacrylamide (NHMA), a mouse carcinogen inactive in the Salmonella assay and mouse micronucleus (MN) assay, was tested for reproductive effects in a mouse continuous breeding study. In that study, increased embryonic deaths were observed after 13 weeks exposure of parental animals to NHMA via drinking wat...

journal_title：Environmental and molecular mutagenesis

authors： Witt KL,Hughes LA,Burka LT,McFee AF,Mathews JM,Black SL,Bishop JB

更新日期：2003-01-01 00:00:00

abstract：:Micronuclei were assessed among the bone marrow PCEs of mice 28 hr after exposures to 1 to 8 Gy of X-rays and at 6-hr intervals from 12-60 hr after exposures to 2 or 6 Gy. At 28 hr, the frequency of micronuclei declined as the exposure level increased from 1 to 8 Gy. The peak proportion of micronucleated PCEs appeared...

journal_title：Environmental and molecular mutagenesis

authors： McFee AF,Cook SB,Abbott MG

更新日期：1994-01-01 00:00:00

abstract：:The hydroxyl radical scavengers thiourea, ethanol, and dimethyl sulfoxide significantly reduced the killing of Escherichia coli elicited by low concentrations of H2O2 (resulting in mode 1 killing) when treatments with the oxidant and the scavengers were performed in a complete growth medium (K medium) but not in M9 sa...

journal_title：Environmental and molecular mutagenesis

authors： Brandi G,Salvaggio L,Cattabeni F,Cantoni O

更新日期：1991-01-01 00:00:00

abstract：:The influence of several methodological factors on mean values of sister chromatid exchanges (SCEs) and micronuclei (MN) in peripheral lymphocytes of 1,650 subjects was analyzed. Donors belonged to a general healthy population living in Pisa and in two nearby small cities: Cascina and Navacchio (Ca-Na). Blood samples ...

journal_title：Environmental and molecular mutagenesis

authors： Barale R,Marrazzini A,Bacci E,Di Sibio A,Tessa A,Cocchi L,Scarcelli V,Lubrano V,Vassalle C,Landi S

更新日期：1998-01-01 00:00:00

abstract：:A collaborative international trial was conducted to evaluate the reproducibility and transferability of an in vivo mutation assay based on the enumeration of CD59-negative rat erythrocytes, a phenotype that is indicative of Pig-a gene mutation. Fourteen laboratories participated in this study, where anti-CD59-PE, SYT...

journal_title：Environmental and molecular mutagenesis

authors： Dertinger SD,Phonethepswath S,Weller P,Nicolette J,Murray J,Sonders P,Vohr HW,Shi J,Krsmanovic L,Gleason C,Custer L,Henwood A,Sweder K,Stankowski LF Jr,Roberts DJ,Giddings A,Kenny J,Lynch AM,Defrain C,Nesslany F,v

更新日期：2011-12-01 00:00:00

abstract：:The frequency of 6-thioguanine resistant (TGr) mutants induced in human G0 phase T-lymphocytes by 200 cGy of gamma irradiation is greatly enhanced by incubation with cytosine arabinoside (ara-C) after irradiation. The mutant frequency increased with increasing incubation time in ara-C for up to 2 hr. This mutation ind...

journal_title：Environmental and molecular mutagenesis

authors： O'Neill JP,Sullivan LM,Hunter TC,Nicklas JA

更新日期：1991-01-01 00:00:00

abstract：:Mutagenicity is an important toxicological endpoint that requires thorough evaluation during the industrial chemical registration process. Regulatory requirements for mutagenicity assessment in registration of industrial chemicals vary in geographic regions (and in some cases by intended application). Here we compile ...

journal_title：Environmental and molecular mutagenesis

authors： Ji Z,Ball NS,LeBaron MJ

更新日期：2017-06-01 00:00:00

abstract：:The term "the DNA damage response" (DDR) encompasses a sophisticated array of cellular initiatives set in motion as cells are exposed to DNA-damaging events. It has been known for over half a century that all organisms have the ability to restore genomic integrity through DNA repair. More recent discoveries of signal ...

journal_title：Environmental and molecular mutagenesis

authors： Ljungman M

更新日期：2010-10-01 00:00:00