Hypermethylation of CpG islands is associated with increasing chromosomal damage in chinese lead-exposed workers.

abstract：:2,6-Dicyano-4-nitroaniline and 2-cyano-4-nitroaniline (CNNA; 2-amino-5-nitrobenzonitrile) are potent mutagens in the Ames test, even though unsubstituted nitroanilines (NAs) are no more than weak mutagens. These compounds are putative reduction products of many commercial azo dyes, including Disperse Blue 165, Dispers...

journal_title：Environmental and molecular mutagenesis

authors： Josephy PD,Dhanoa J,Elzawy G,Heney K,Petrie L,Senis C

更新日期：2018-03-01 00:00:00

abstract：:Cytochrome P450 (CYP), glutathione-S-transferase (GST), and N-acetyltransferase (NAT) are crucial for metabolism and clearance of xenobiotics. This study investigated whether CYP, GST, and NAT single nucleotide polymorphisms (SNPs) are associated with colorectal cancer (CRC) in patients with Lynch syndrome. The intera...

journal_title：Environmental and molecular mutagenesis

authors： Kamiza AB,You JF,Wang WC,Tang R,Chang CY,Chien HT,Lai CH,Chiu LL,Lo TP,Hung KY,Hsiung CA,Yeh CC

更新日期：2018-01-01 00:00:00

abstract：:V(D)J recombinase-mediated recombination between the T-cell receptor (TCR) gamma variable (GV) genes at chromosome 7p15 and the TCR beta joining (BJ) genes at 7q35 leads to the formation of a hybrid TCR gene. These TCR gamma/beta interlocus rearrangements occur at classic V(D)J recombination signal sequences (RSS) and...

journal_title：Environmental and molecular mutagenesis

authors： Ballinger SW,Judice SA,Nicklas JA,Albertini RJ,O'Neill JP

更新日期：2002-01-01 00:00:00

abstract：:Isothiocyanates (ITCs) are commonly found in cruciferous vegetables. A variety of biological activities have been ascribed to ITCs, such as inhibition of cytochrome P450 enzymes and induction of phase II enzymes in animal models. ITCs are also able to block cell-cycle progression and induce apoptosis in human cancer c...

journal_title：Environmental and molecular mutagenesis

authors： Fimognari C,Berti F,Cantelli-Forti G,Hrelia P

更新日期：2005-12-01 00:00:00

abstract：:DNA polymerase κ (Pol κ) is a specialized DNA polymerase involved in translesion DNA synthesis. Although its bypass activities across lesions are well characterized in biochemistry, its cellular protective roles against genotoxic insults are still elusive. To better understand the in vivo protective roles, we have est...

journal_title：Environmental and molecular mutagenesis

authors： Kanemaru Y,Suzuki T,Niimi N,Grúz P,Matsumoto K,Adachi N,Honma M,Nohmi T

更新日期：2015-10-01 00:00:00

abstract：:Polluted soil sampled from a former coking plant in Lorraine (France) was studied for its genotoxicity and reproductive effects on the Eisenia fetida earthworm. Genotoxicity was investigated by means of the single-cell gel electrophoresis (comet) assay on the coelomocytes of earthworms after 4 and 10 days of exposure ...

journal_title：Environmental and molecular mutagenesis

authors： Bonnard M,Eom IC,Morel JL,Vasseur P

更新日期：2009-01-01 00:00:00

abstract：:Unpublished results from our laboratory showed that colchicine increased the incidence of hyperploid mouse metaphase II (MII) oocytes when injected at the same time as human chorionic gonadotrophin (HCG). The objective of the present study was to determine whether the time of administering colchicine influenced the in...

journal_title：Environmental and molecular mutagenesis

authors： Mailhes JB,Yuan ZP

更新日期：1987-01-01 00:00:00

abstract：:The influence of several methodological factors on mean values of sister chromatid exchanges (SCEs) and micronuclei (MN) in peripheral lymphocytes of 1,650 subjects was analyzed. Donors belonged to a general healthy population living in Pisa and in two nearby small cities: Cascina and Navacchio (Ca-Na). Blood samples ...

journal_title：Environmental and molecular mutagenesis

authors： Barale R,Marrazzini A,Bacci E,Di Sibio A,Tessa A,Cocchi L,Scarcelli V,Lubrano V,Vassalle C,Landi S

更新日期：1998-01-01 00:00:00

abstract：:The Benchmark Dose (BMD) method is the favored approach for quantitative dose-response analysis where uncertainty measurements are delineated between the upper (BMDU) and lower (BMDL) confidence bounds, or confidence intervals (CIs). Little has been published on the accurate interpretation of uncertainty measurements ...

journal_title：Environmental and molecular mutagenesis

authors： Wheeldon RP,Dertinger SD,Bryce SM,Bemis JC,Johnson GE

更新日期：2021-01-11 00:00:00

abstract：:Azidothymidine (AZT) is a nucleoside reverse transcriptase inhibitor (NRTI) that is used for reducing mother-to-child transmission of human immunodeficiency virus I. Combinations of AZT and 3'-thiacytidine (3TC) are even more effective than AZT alone. AZT, however, is a mutagen and carcinogen in rodent models and 3TC ...

journal_title：Environmental and molecular mutagenesis

authors： Dobrovolsky VN,Shaddock JG,Mittelstaedt RA,Bishop ME,Lewis SM,Lee FW,Aidoo A,Leakey JE,Dunnick JK,Heflich RH

更新日期：2007-04-01 00:00:00

abstract：:The 1960s witnessed detailed studies on the genetic properties of a large number of histidine-requiring mutants of Salmonella typhimurium. The early 1970s saw development of selected strains, the Ames strains, for use in rapid, cheap, sensitive, and manipulable tests of chemicals and chemical mixtures for genotoxic ac...

journal_title：Environmental and molecular mutagenesis

authors： Hartman PE

更新日期：1989-01-01 00:00:00

abstract：:In this study we compared the ability of extractable organic material from particulate and semivolatile fractions of gasoline emission to induce mutations in bacteria and form adducts with calf thymus (CT) DNA with corresponding data obtained from diesel exhaust. Exhaust particles from gasoline-powered passenger cars ...

journal_title：Environmental and molecular mutagenesis

authors： Pohjola SK,Lappi M,Honkanen M,Savela K

更新日期：2003-01-01 00:00:00

abstract：:Therapy-related leukemia has been a recognized sequela of cancer treatment for decades with "signature" abnormalities of chromosomes 5, 7, and 11 observed in treated patients. Risk to oncology personnel handling anti-cancer agents has also been documented by non-specific measures of genotoxicity in blood and urine. Us...

journal_title：Environmental and molecular mutagenesis

authors： McDiarmid MA,Rogers B,Oliver MS

更新日期：2014-05-01 00:00:00

abstract：:Halogenated acetonitriles (HANs) are known to be water disinfectant by-products. Their mutagenicity and carcinogenicity have been shown in different test systems in vivo and in vitro. They also have clastogenic properties. In this study, the ability of HAN to induce single-strand breaks on the DNA of HeLa S3 cells was...

journal_title：Environmental and molecular mutagenesis

authors： Muller-Pillet V,Joyeux M,Ambroise D,Hartemann P

更新日期：2000-01-01 00:00:00

abstract：:Quinoline is a specific and potent carcinogen to the rat and mouse liver. Studies are described here in which it was evaluated for its ability to initiate unscheduled DNA synthesis (UDS) in the rat liver in vivo. Although some individual animals showed indications of a marginal response the absence of clear group posi...

journal_title：Environmental and molecular mutagenesis

authors： Ashby J,Mohammed R,Lefevre PA,Bandara L

更新日期：1989-01-01 00:00:00

abstract：:Arsenic is a world health problem due to the seriousness of its effects, mainly related with the increase of cancer. In Chile, the geological characteristics of the northern region, associated with the development of the copper mining and smelting activities, have contributed to increase the environmental levels of ar...

journal_title：Environmental and molecular mutagenesis

authors： Paiva L,Martínez V,Creus A,Quinteros D,Marcos R

更新日期：2008-04-01 00:00:00

abstract：:Although not mutagenic by Ames test, 2,5-dimethylfuran (DMF), a leading biofuel candidate, was found to induce chromosomal damage in cultured murine cells, suggesting that it may be genotoxic. We sought to prioritize the environmental and biological impacts of using DMF as a combustible biofuel. First, we assessed DMF...

journal_title：Environmental and molecular mutagenesis

authors： Phuong J,Kim S,Thomas R,Zhang L

更新日期：2012-07-01 00:00:00

abstract：:Contamination of ground water by industrial waste poses potential health hazards for man and his environment. The improper disposal of toxic wastes could allow genotoxic chemicals to percolate into ground waters, and these contaminated ground waters may produce toxicity, including mutation and eventually cancer, in ex...

journal_title：Environmental and molecular mutagenesis

authors： Chandra S,Chauhan LK,Murthy RC,Gupta SK

更新日期：2006-06-01 00:00:00

abstract：:Cultured rodent and human cells typically display similar clonal survival characteristics following exposure to ultraviolet light (UV). However, compared to human cells, cultured cells from mice, rats, and hamsters are generally deficient in excision repair of the most prominent DNA lesion produced by UV, the cyclobut...

journal_title：Environmental and molecular mutagenesis

authors： Hanawalt PC

更新日期：2001-01-01 00:00:00

abstract：:The induction and nature of mutations in the lacI transgene were evaluated in multiple tissues after exposure of adult male B6C3F1 lacI transgenic mice to cyclophosphamide (CP). Mice were given a single i.p. injection of 25 mg CP/kg, 100 mg CP/kg, or vehicle (PBS) and then necropsied 6 weeks after treatment to allow D...

journal_title：Environmental and molecular mutagenesis

authors： Gorelick NJ,Andrews JL,deBoer JG,Young R,Gibson DP,Walker VE

更新日期：1999-01-01 00:00:00

abstract：:Risk estimates for radiation-induced cancer in humans are based on epidemiological data largely drawn from the Japanese atomic bomb survivor studies, which received an acute high dose rate (HDR) ionising radiation. Limited knowledge exists about the effects of chronic low dose rate (LDR) exposure, particularly with re...

journal_title：Environmental and molecular mutagenesis

authors： Graupner A,Eide DM,Brede DA,Ellender M,Lindbo Hansen E,Oughton DH,Bouffler SD,Brunborg G,Olsen AK

更新日期：2017-10-01 00:00:00

abstract：:Diesel exhaust (DE) is a major airborne pollutant of urban areas. It contains various polycyclic aromatic hydrocarbons (PAH) and nitrated PAHs. In this study, gpt delta mice were treated with inhalation of 1 or 3 mg m(-3) DE, or a single intratracheal instillation of diesel exhaust particles (DEP) or DEP extract. In t...

journal_title：Environmental and molecular mutagenesis

authors： Hashimoto AH,Amanuma K,Hiyoshi K,Sugawara Y,Goto S,Yanagisawa R,Takano H,Masumura K,Nohmi T,Aoki Y

更新日期：2007-10-01 00:00:00

abstract：:Coumarin (1,2-benzopyrone), a natural food constituent, prevents polycyclic aromatic hydrocarbon-induced neoplasms in rats and mice, but has not been studied with other chemical carcinogens. We examined coumarin chemoprotection against aflatoxin B1 using the 6-thioguanine resistance mutation assay in two different Chi...

journal_title：Environmental and molecular mutagenesis

authors： Goeger DE,Anderson KE,Hsie AW

更新日期：1998-01-01 00:00:00

abstract：:Fluorescence in situ hybridization with 7, 17, X, and Y chromosome-specific DNA probe was used to investigate the ability of Adriamycin (AM) to induce aneuploidy in interphase human lymphocytes. The reliability of the probes was tested by hybridization to metaphases and interphase nuclei of untreated normal lymphocyte...

journal_title：Environmental and molecular mutagenesis

authors： Aly MS,Othman OE,El Nahas SM

更新日期：1999-01-01 00:00:00

abstract：:To what extent noncovalent chemical-DNA interactions, in particular weak nonbonded DNA intercalation, contribute to genotoxic responses in mammalian cells has not been fully elucidated. Moreover, with the exception of predominantly flat, multiple-fused-ring structures, our ability to predict intercalation ability of n...

journal_title：Environmental and molecular mutagenesis

authors： Snyder RD,Ewing DE,Hendry LB

更新日期：2004-01-01 00:00:00

abstract：:Human sulfotransferase (SULT) 1A1, 1A2, and 1A3 cDNA genes were subcloned separately into the pTrc99A(KM) vector. The generated plasmids were introduced into the Salmonella typhimurium O-acetyltransferase-deficient strain NM6000 (TA1538/1,8-DNP/pSK1002), resulting in the new strains NM7001, NM7002, and NM7003. We comp...

journal_title：Environmental and molecular mutagenesis

authors： Oda Y,Zhang Y,Buchinger S,Reifferscheid G,Yang M

更新日期：2012-03-01 00:00:00

abstract：:Riddelliine (RID) is a pyrrolizidine alkaloid found in plants of the genera Crotalaria, Amsinckia, and Senecio in the United States. RID has been extensively studied in a wide variety of in vitro short-term genotoxicity tests and has yielded positive responses in most test systems; however, there are fewer data availa...

journal_title：Environmental and molecular mutagenesis

authors： Mirsalis JC,Steinmetz KL,Blazak WF,Spalding JW

更新日期：1993-01-01 00:00:00

abstract：:Vanillin (VA) modulates the genotoxicity of chemical and physical agents in a complex manner. Previous studies indicate that VA inhibits the mutagenicity but increases the mitotic homologous recombination caused by at least some genotoxic agents. In the present study, we have evaluated the effects of VA on the repair ...

journal_title：Environmental and molecular mutagenesis

authors： Furlanetto MP,Sinigaglia M,Amaral VS,Dihl RR,de Andrade HH

更新日期：2007-01-01 00:00:00

abstract：:DNA damage induced by physical activity and/or exercise has been reported under different conditions but not for individuals maintaining physical fitness by regular strenuous exercise. Therefore, we compared levels of DNA damage in blood leukocytes of 40 healthy individuals (35 males, 5 females) who regularly exercise...

journal_title：Environmental and molecular mutagenesis

authors： Gandhi G,Chopra G

更新日期：2009-05-01 00:00:00

abstract：:Genomes of all living organisms are constantly threatened by endogenous and exogenous agents that challenge the chemical integrity of DNA. Most bacteria have evolved a coordinated response to DNA damage. In Escherichia coli, this inducible system is termed the SOS response. The SOS global regulatory network consists o...

journal_title：Environmental and molecular mutagenesis

authors： Maslowska KH,Makiela-Dzbenska K,Fijalkowska IJ

更新日期：2019-05-01 00:00:00