当前位置： SCI文献检索 > ENVIRONMENTAL AND MOLECULAR MUTAGENESIS期刊下所有文献 > Mutations in the lungs of gpt delta transgenic mice following inhalation of diesel exhaust.

Mutations in the lungs of gpt delta transgenic mice following inhalation of diesel exhaust.

Abstract：

:Diesel exhaust (DE) is a major airborne pollutant of urban areas. It contains various polycyclic aromatic hydrocarbons (PAH) and nitrated PAHs. In this study, gpt delta mice were treated with inhalation of 1 or 3 mg m(-3) DE, or a single intratracheal instillation of diesel exhaust particles (DEP) or DEP extract. In the lungs of mice treated with inhalation of 3 mg m(-3) DE for 12 weeks, the mutant frequency (MF) was 3.2-fold higher than that of the control group (1.90 x 10(-5) and 0.59 x 10(-5), respectively). An instillation of DEP and DEP extract resulted in a significant dose-dependent linear increase in MF. In mice treated with 0.5 mg DEP and 0.2 mg DEP extract, the MFs were 3.0- and 2.7-fold higher than that of the control group, respectively. The mutagenic potency (MF mg(-1)) of DEP extract (5.6 x 10(-5)) was double that of DEP (2.7 x 10(-5)), suggesting that the mutagenicity of the latter is derived primarily from compounds in the extract, which itself is responsible for ca. 50% of the weight of DEP. G:C-->A:T transitions were the predominant gpt mutation induced by all three treatments and G:C-->T:A transversions were induced by DEP and DEP extract. Guanine bases centered in nucleotide sequences such as GGA, TGA, CGG, and CGT were the major mutation targets of all three treatments. Thus, our results suggest that the mutagens contained in DEP such as PAH and nitrated PAHs induce mutations and may be responsible for carcinogenesis caused by inhalation of DE.

journal_name

Environ Mol Mutagen

journal_title

Environmental and molecular mutagenesis

authors

Hashimoto AH,Amanuma K,Hiyoshi K,Sugawara Y,Goto S,Yanagisawa R,Takano H,Masumura K,Nohmi T,Aoki Y

doi

10.1002/em.20335

subject

Has Abstract

pub_date

2007-10-01 00:00:00

pages

682-93

issue

8

eissn

0893-6692

issn

1098-2280

journal_volume

48

pub_type

杂志文章

相关文献

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS文献大全
  • Sources of polycyclic aromatic hydrocarbon exposure in non-occupationally exposed Koreans.

    abstract：:Urinary 1-hydroxypyrene (1-OHP), an exposure biomarker for polycyclic aromatic hydrocarbons (PAHs), was used to identify potential sources of PAH exposure for 660 Koreans who were not occupationally exposed to PAHs (65% male; 35% female; mean age, 36.5 +/- 11.1 years). In this study, 74% of subjects had detectable lev...

    journal_title：Environmental and molecular mutagenesis

    pub_type： 杂志文章

    doi：10.1002/em.10196

    authors： Yang M,Kim S,Lee E,Cheong HK,Chang SS,Kang D,Choi Y,Lee SM,Jang JY

    更新日期：2003-01-01 00:00:00

  • Evaluation of genetic damage in open-cast coal mine workers using the buccal micronucleus cytome assay.

    abstract：:Coal is the largest fossil fuel source used for the generation of energy. However, coal extraction and its use constitute important pollution factors; thus, risk characterization and estimation are extremely important for the safety of coal workers and the environment. Candiota is located to the southeast of the state...

    journal_title：Environmental and molecular mutagenesis

    pub_type： 杂志文章

    doi：10.1002/em.21744

    authors： Rohr P,da Silva J,da Silva FR,Sarmento M,Porto C,Debastiani R,Dos Santos CE,Dias JF,Kvitko K

    更新日期：2013-01-01 00:00:00

  • Pyruvate remediation of cell stress and genotoxicity induced by haloacetic acid drinking water disinfection by-products.

    abstract：:Monohaloacetic acids (monoHAAs) are a major class of drinking water disinfection by-products (DBPs) and are cytotoxic, genotoxic, mutagenic, and teratogenic. We propose a model of toxic action based on monoHAA-mediated inhibition of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) as a target cytosolic enzyme. This mo...

    journal_title：Environmental and molecular mutagenesis

    pub_type： 杂志文章

    doi：10.1002/em.21795

    authors： Dad A,Jeong CH,Pals JA,Wagner ED,Plewa MJ

    更新日期：2013-10-01 00:00:00

  • Reduction of benzene toxicity by toluene.

    abstract：:BDF1 mice were exposed in inhalation chambers to benzene (900 ppm, 300 ppm) and/or toluene (500 ppm, 250 ppm) 6 hr per day, 5 days per week, for up to 8 weeks. Benzene alone induced a slight anemia after 4 and 8 weeks and a reduction of BFU-E and CFU-E numbers in the marrow. The coexposure to toluene reduced the degre...

    journal_title：Environmental and molecular mutagenesis

    pub_type： 杂志文章

    doi：10.1002/em.2850240405

    authors： Plappert U,Barthel E,Seidel HJ

    更新日期：1994-01-01 00:00:00

  • Cytocidal and filamentous response of Escherichia coli cells exposed to low concentrations of hydrogen peroxide and hydroxyl radical scavengers.

    abstract：:The hydroxyl radical scavengers thiourea, ethanol, and dimethyl sulfoxide significantly reduced the killing of Escherichia coli elicited by low concentrations of H2O2 (resulting in mode 1 killing) when treatments with the oxidant and the scavengers were performed in a complete growth medium (K medium) but not in M9 sa...

    journal_title：Environmental and molecular mutagenesis

    pub_type： 杂志文章

    doi：10.1002/em.2850180105

    authors： Brandi G,Salvaggio L,Cattabeni F,Cantoni O

    更新日期：1991-01-01 00:00:00

  • Application of toxicogenomics to genetic toxicology risk assessment.

    abstract：:Based on the assumption that compounds having similar toxic modes of action induce specific gene expression changes, the toxicity of unknown compounds can be predicted after comparison of their molecular fingerprints with those obtained with compounds of known toxicity. These predictive models will therefore rely on t...

    journal_title：Environmental and molecular mutagenesis

    pub_type： 杂志文章

    doi：10.1002/em.20304

    authors： Thybaud V,Le Fevre AC,Boitier E

    更新日期：2007-06-01 00:00:00

  • Evaluation of the potential of riddelliine to induce unscheduled DNA synthesis, S-phase synthesis, or micronuclei following in vivo treatment with multiple doses.

    abstract：:Riddelliine (RID) is a pyrrolizidine alkaloid found in plants of the genera Crotalaria, Amsinckia, and Senecio in the United States. RID has been extensively studied in a wide variety of in vitro short-term genotoxicity tests and has yielded positive responses in most test systems; however, there are fewer data availa...

    journal_title：Environmental and molecular mutagenesis

    pub_type： 杂志文章

    doi：10.1002/em.2850210310

    authors： Mirsalis JC,Steinmetz KL,Blazak WF,Spalding JW

    更新日期：1993-01-01 00:00:00

  • Types of chromosomal aberrations induced by seed aging in Crepis capillaris.

    abstract：:The types of chromosomal aberrations during the aging of Crepis capillaris (Hawksbeard; fam. Asteraceae) seeds were investigated. Seeds were stored at 22 degrees C for 2, 4, 6, and 8 years. Chromosomal aberrations were analyzed in metaphase chromosomes at the first and second mitotic cycles. A colchicine block was use...

    journal_title：Environmental and molecular mutagenesis

    pub_type： 杂志文章

    doi：10.1002/em.2850230410

    authors： Dimitrov BD

    更新日期：1994-01-01 00:00:00

  • The use of benchmark dose uncertainty measurements for robust comparative potency analyses.

    abstract：:The Benchmark Dose (BMD) method is the favored approach for quantitative dose-response analysis where uncertainty measurements are delineated between the upper (BMDU) and lower (BMDL) confidence bounds, or confidence intervals (CIs). Little has been published on the accurate interpretation of uncertainty measurements ...

    journal_title：Environmental and molecular mutagenesis

    pub_type： 杂志文章

    doi：10.1002/em.22422

    authors： Wheeldon RP,Dertinger SD,Bryce SM,Bemis JC,Johnson GE

    更新日期：2021-01-11 00:00:00

  • Hepatic mRNA, microRNA, and miR-34a-target responses in mice after 28 days exposure to doses of benzo(a)pyrene that elicit DNA damage and mutation.

    abstract：:Benzo(a)pyrene (BaP) is a mutagenic carcinogen that is ubiquitous in our environment. To better understand the toxic effects of BaP and to explore the relationship between toxicity and toxicogenomics profiles, we assessed global mRNA and microRNA (miRNA) expression in Muta™Mouse. Adult male mice were exposed by oral g...

    journal_title：Environmental and molecular mutagenesis

    pub_type： 杂志文章

    doi：10.1002/em.20668

    authors： Malik AI,Williams A,Lemieux CL,White PA,Yauk CL

    更新日期：2012-01-01 00:00:00

  • Genotoxicity of hydrochlorothiazide in cultured human lymphocytes. I. Evaluation of chromosome delay and chromosome breakage.

    abstract：:Hypertension is often treated with diuretics, like hydrochlorothiazide (HCTZ). Previous results on the in vitro genotoxicity of HCTZ are equivocal. In the present study, we have evaluated the genotoxicity of HCTZ in cultured human lymphocytes using the Cytokinesis Blocked Micronucleus (CBMN) assay. In addition, micron...

    journal_title：Environmental and molecular mutagenesis

    pub_type： 杂志文章

    doi：10.1002/em.20180

    authors： Andrianopoulos C,Stephanou G,Demopoulos NA

    更新日期：2006-04-01 00:00:00

  • Determination of genotoxic and other effects in mice following short term repeated-dose and subchronic inhalation exposure to phosphine.

    abstract：:Phosphine is an important fumigant in the grain industry and has been reported to be genotoxic in occupationally exposed fumigators. This study reports on the effects of phosphine inhalation exposure at up to, and exceeding, occupational relevant levels in a subchronic (0.3, 1.0 and 4.5 ppm, 13 weeks) and a short term...

    journal_title：Environmental and molecular mutagenesis

    pub_type： 杂志文章

    doi：10.1002/em.2850240202

    authors： Barbosa A,Rosinova E,Dempsey J,Bonin AM

    更新日期：1994-01-01 00:00:00

  • Microsomal epoxide hydrolase (EPHX1) polymorphisms are associated with aberrant promoter methylation of ERCC3 and hematotoxicity in benzene-exposed workers.

    abstract：:Benzene is an important industrial chemical and widespread environmental pollutant known to induce leukemia and other blood disorders. To be carcinogenic, benzene must be metabolized to produce toxic metabolites. To investigate whether single nucleotide polymorphisms (SNPs) in the metabolic enzyme genes are associated...

    journal_title：Environmental and molecular mutagenesis

    pub_type： 杂志文章

    doi：10.1002/em.21786

    authors： Xing C,Chen Q,Li G,Zhang L,Zheng M,Zou Z,Hou L,Wang QF,Liu X,Guo X

    更新日期：2013-07-01 00:00:00

  • Frequencies and relative levels of clustered damages in DNA exposed to gamma rays in radioquenching vs. nonradioquenching conditions.

    abstract：:Clustered damage induced by ionizing radiation--two or more oxidized bases, abasic sites, or strand breaks within a few DNA helical turns--have been postulated to be major lethal and/or mutagenic sites. Although they have recently been shown to be induced in genomic DNAs by ionizing photons and particles, little is kn...

    journal_title：Environmental and molecular mutagenesis

    pub_type： 杂志文章

    doi：10.1002/em.1067

    authors： Sutherland BM,Bennett PV,Weinert E,Sidorkina O,Laval J

    更新日期：2001-01-01 00:00:00

  • Bioassay-directed fractionation and sub-fractionation for mutagenicity and chemical analysis of diesel exhaust particles.

    abstract：:Several types of diesel exhaust particles (DEPs) have been used for toxicology studies, including a high-organic automobile DEP (A-DEP) from Japan, and a low-organic forklift DEP developed by the National Institute of Standards and Technology (N-DEP). However, these DEPs were not characterized extensively for chemical...

    journal_title：Environmental and molecular mutagenesis

    pub_type： 杂志文章

    doi：10.1002/em.21812

    authors： Mutlu E,Warren SH,Matthews PP,King C,Linak WP,Kooter IM,Schmid JE,Ross JA,Gilmour MI,Demarini DM

    更新日期：2013-12-01 00:00:00

  • Analysis of bleomycin-induced mutagenic functions related to the PSO4 (= xs9) gene of Saccharomyces cerevisiae.

    abstract：:In the present work we analyse some properties of the pso4-1 (= xs9) mutant of the yeast Saccharomyces cerevisiae, which is blocked in both reverse mutation and recombination. We have applied the "apparent survival test" as a method to characterize putative inducible error-prone repair activities related to the PSO4 g...

    journal_title：Environmental and molecular mutagenesis

    pub_type： 杂志文章

    doi：10.1002/em.2850180204

    authors： Severgnini A,Lillo O,Nunes E

    更新日期：1991-01-01 00:00:00

  • Monitoring humans for somatic mutation in the endogenous PIG-a gene using red blood cells.

    abstract：:The endogenous X-linked PIG-A gene is involved in the synthesis of glycosyl phosphatidyl inositol (GPI) anchors that tether specific protein markers to the exterior of mammalian cell cytoplasmic membranes. Earlier studies in rodent models indicate that Pig-a mutant red blood cells (RBCs) can be induced in animals trea...

    journal_title：Environmental and molecular mutagenesis

    pub_type： 杂志文章

    doi：10.1002/em.20667

    authors： Dobrovolsky VN,Elespuru RK,Bigger CA,Robison TW,Heflich RH

    更新日期：2011-12-01 00:00:00

  • Freshwater planarians as novel organisms for genotoxicity testing: Analysis of chromosome aberrations.

    abstract：:Two freshwater species of planarians, Girardia schubarti Marcus and G. tigrina Girard, were used for measuring chromosome aberration (CA) induction under laboratory conditions. Three genotoxicants were tested: methyl methanesulfonate (MMS), a direct-acting genotoxicant; cyclophosphamide, a metabolism-dependent genotox...

    journal_title：Environmental and molecular mutagenesis

    pub_type： 杂志文章

    doi：10.1002/em.20307

    authors： Lau AH,Knakievicz T,Prá D,Erdtmann B

    更新日期：2007-07-01 00:00:00

  • Differential antigenotoxic and cytoprotective effect of amifostine in idarubicin-treated mice.

    abstract：:In this study we evaluated the antigenotoxic and cytoprotective capabilities of WR-2721 [S-2-(3-aminopropylamino)-ethylphosphorothioic acid (amifostine)] in different normal tissues of BALB/c mice treated with idarubicin [4-demethoxydaunorubicin (IDA)]. The aminothiol WR-2721 is a pro-drug that requires dephosphorylat...

    journal_title：Environmental and molecular mutagenesis

    pub_type： 杂志文章

    doi：10.1002/em.1081

    authors： de Campos Nebel M,Larripa I,González-Cid M

    更新日期：2002-01-01 00:00:00

  • Influence of DNA repair gene polymorphisms on the initial repair of MMS-induced DNA damage in human lymphocytes as measured by the alkaline comet assay.

    abstract：:We have applied the alkaline comet assay to study the functional impact of gene polymorphisms in base excision repair (APEX1 Asp148Glu, XRCC1 Arg194Trp, XRCC1 Arg399Gln) and homologous recombination repair (XRCC3 Thr241Met, NBS1 Glu185Gln), two pathways that play crucial roles in the repair of DNA damage induced by me...

    journal_title：Environmental and molecular mutagenesis

    pub_type： 杂志文章

    doi：10.1002/em.20415

    authors： Ryk C,Routledge MN,Allan JM,Wild CP,Kumar R,Lambert B,Hou S

    更新日期：2008-12-01 00:00:00

  • Molecular analyses of in vivo hprt mutations in human T-lymphocytes: IV. Studies in newborns.

    abstract：:In order to characterize in vivo gene mutations that occur during fetal development, molecular analyses were undertaken of mutant 6-thioguanine resistant T-lymphocytes isolated from placental cord blood samples of 13 normal male newborns. These mutant T-cells were studied to define hypoxanthine-guanine phosphoribosylt...

    journal_title：Environmental and molecular mutagenesis

    pub_type： 杂志文章

    doi：10.1002/em.2850140404

    authors： McGinniss MJ,Nicklas JA,Albertini RJ

    更新日期：1989-01-01 00:00:00

  • Genetic toxicology testing of the antimalarial drugs chloroquine and a new analog, AQ-13.

    abstract：:AQ-13 ([N1-(7-chloro-quinolin-4yl)-3-(N3,N3-diethylamino)propylamine] dihydrochloride trihydrate) is an aminoquinoline antimalarial drug that is effective against chloroquine-resistant strains of Plasmodium falciparum. It is structurally similar to the widely used chloroquine diphosphate (CQ). We evaluated these drugs...

    journal_title：Environmental and molecular mutagenesis

    pub_type： 杂志文章

    doi：10.1002/em.1052

    authors： Riccio ES,Lee PS,Winegar RA,Krogstad DJ,De D,Mirsalis JC

    更新日期：2001-01-01 00:00:00

  • Simple and alpha,beta-unsaturated aldehydes: correct prediction of genotoxic activity through structure-activity relationship models.

    abstract：:Aldehydes are widespread environmental and industrial compounds, able to stimulate a range of adverse health effects (e.g., general toxicity, allergenic reactions, mutagenicity, and carcinogenicity). We have previously presented quantitative structure-activity relationships (QSARs) for the genotoxicity of simple and a...

    journal_title：Environmental and molecular mutagenesis

    pub_type： 杂志文章

    doi：10.1002/em.20158

    authors： Benigni R,Conti L,Crebelli R,Rodomonte A,Vari' MR

    更新日期：2005-12-01 00:00:00

  • The SOS system: A complex and tightly regulated response to DNA damage.

    abstract：:Genomes of all living organisms are constantly threatened by endogenous and exogenous agents that challenge the chemical integrity of DNA. Most bacteria have evolved a coordinated response to DNA damage. In Escherichia coli, this inducible system is termed the SOS response. The SOS global regulatory network consists o...

    journal_title：Environmental and molecular mutagenesis

    pub_type： 杂志文章,评审

    doi：10.1002/em.22267

    authors： Maslowska KH,Makiela-Dzbenska K,Fijalkowska IJ

    更新日期：2019-05-01 00:00:00

  • Association between atmospheric ozone levels and damage to human nasal mucosa in Florence, Italy.

    abstract：:We evaluated the effects of urban air pollutants on human nasal mucosa over an 8-month period on 102 subjects living in Florence, Tuscany, Italy. A group of subjects living in a city with a lower level of pollution (Sassari, Sardinia, Italy) was also analyzed. Nasal mucosa cells were harvested by brushing, a noninvasi...

    journal_title：Environmental and molecular mutagenesis

    pub_type： 杂志文章

    doi：10.1002/em.10188

    authors： Pacini S,Giovannelli L,Gulisano M,Peruzzi B,Polli G,Boddi V,Ruggiero M,Bozzo C,Stomeo F,Fenu G,Pezzatini S,Pitozzi V,Dolara P

    更新日期：2003-01-01 00:00:00

  • Reduction in the mutagenicity of synthetic dyes by successive treatment with activated sludge and the ligninolytic fungus, Irpex lacteus.

    abstract：:Synthetic dyes are released in wastewater from textile manufacturing plants, and many of these dyes are genotoxic. In the present study, the mutagenicity of azo, anthraquinone, and triphenyl methane dyes was investigated before and after successive biodegradation with activated sludge and the ligninolytic fungus, Irpe...

    journal_title：Environmental and molecular mutagenesis

    pub_type： 杂志文章

    doi：10.1002/em.20224

    authors： Malachová K,Pavlícková Z,Novotný C,Svobodová K,Lednická D,Musílková E

    更新日期：2006-08-01 00:00:00

  • DNA sequence analysis of interlocus recombination between the human T-cell receptor gamma variable (GV) and beta diversity-joining (BD/BJ) sequences on chromosome 7 (inversion 7).

    abstract：:V(D)J recombinase-mediated recombination between the T-cell receptor (TCR) gamma variable (GV) genes at chromosome 7p15 and the TCR beta joining (BJ) genes at 7q35 leads to the formation of a hybrid TCR gene. These TCR gamma/beta interlocus rearrangements occur at classic V(D)J recombination signal sequences (RSS) and...

    journal_title：Environmental and molecular mutagenesis

    pub_type： 杂志文章

    doi：10.1002/em.10099

    authors： Ballinger SW,Judice SA,Nicklas JA,Albertini RJ,O'Neill JP

    更新日期：2002-01-01 00:00:00

  • Confirmation of the chromosome damaging effects of lamivudine in in vitro human peripheral blood lymphocytes.

    abstract：:The aim of this study was to investigate genotoxic effects of lamivudine (an analogue of cytidine) using in vitro sister chromatid exchange (SCE), chromosome aberration (CA), and micronucleus (MN) tests in human peripheral lymphocytes. The cells were treated with 75, 100, 125, and 150 microg/ml concentrations of lamiv...

    journal_title：Environmental and molecular mutagenesis

    pub_type： 杂志文章

    doi：10.1002/em.20393

    authors： Bayram S,Topaktaş M

    更新日期：2008-05-01 00:00:00

  • Tandem-base mutations occur in mouse liver and adipose tissue preferentially as G:C to T:A transversions and accumulate with age.

    abstract：:Tandem-base mutations (TBM) are associated with ultraviolet light and other mutagens. Herein, we report an age- and tissue-specific difference in the frequency of spontaneous TBM in Big Blue transgenic mice. A total of 390 mutants from liver and adipose tissue contained 17 and 4 TBM, respectively, while no TBM were de...

    journal_title：Environmental and molecular mutagenesis

    pub_type： 杂志文章

    doi：10.1002/(sici)1098-2280(1999)33:4<320::aid-em9>3.0

    authors： Buettner VL,Hill KA,Halangoda A,Sommer SS

    更新日期：1999-01-01 00:00:00

  • Mutagenicity of N- and O-acetyl derivatives of methyl 3,4-diphenyl-5-hydroxylamino-2-furoate and N-hydroxy-4-aminobiphenyl in Salmonella typhimurium.

    abstract：:Methyl 3,4-diphenyl-5-hydroxylamino-2-furoate (N-OH-MDPF) (I), methyl 3,4-diphenyl-5-acetoxyamino-2-furoate (N-OAc-MDPF) (II), methyl 3,4-diphenyl-N-hydroxy-5-acetylamino-2-furoate (N-OH-MDPAF) (III), and methyl 3,4-diphenyl-N-acetoxy-5-acetylamino-2-furoate (N-OAc-MDPAF) (IV) were synthesized and tested for mutagenic...

    journal_title：Environmental and molecular mutagenesis

    pub_type： 杂志文章

    doi：10.1002/em.2850170204

    authors： Swaminathan S,Hatcher JF,Yamamoto K,Tanaka A,Ichikawa M,Bryan GT

    更新日期：1991-01-01 00:00:00