Mutagenicity and antimutagenicity of hispidulin and hortensin, the flavonoids from Millingtonia hortensis L.


:Studies of the mutagenicity and antimutagenicity of hispidulin and hortensin, the flavonoids from Millingtonia hortensis L. (Bignoniaceae), were performed using the liquid preincubation method of the Salmonella/microsome test. At the highest dose tested, 100 micrograms/plate, both compounds showed no mutagenicity and no cytotoxicity toward S. typhimurium strains TA98 and TA100 either in the presence or absence of S9 mix. However, these substances were antimutagens toward 2-aminoanthracene, aflatoxin B1 (in TA98), and dimethylnitrosamine (in TA100); but neither substance inhibited the direct mutagenic activity of 2-(2-furyl)-3-(5-nitro-2-furyl) acrylamide nor that of sodium azide in strains TA98 and TA100, respectively.


Environ Mol Mutagen


Chulasiri M,Bunyapraphatsara N,Moongkarndi P




Has Abstract


1992-01-01 00:00:00












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    pub_type: 杂志文章,评审


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    pub_type: 杂志文章,评审


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    journal_title:Environmental and molecular mutagenesis

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    journal_title:Environmental and molecular mutagenesis

    pub_type: 杂志文章


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    pub_type: 杂志文章


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    journal_title:Environmental and molecular mutagenesis

    pub_type: 杂志文章,评审


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    journal_title:Environmental and molecular mutagenesis

    pub_type: 杂志文章


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    更新日期:1994-01-01 00:00:00

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    journal_title:Environmental and molecular mutagenesis

    pub_type: 杂志文章


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    journal_title:Environmental and molecular mutagenesis

    pub_type: 杂志文章


    authors: Neeper-Bradley TL,Conner MK

    更新日期:1989-01-01 00:00:00