Molecular epidemiologic studies of polycyclic aromatic hydrocarbon-DNA adducts and breast cancer.

abstract：:The types of chromosomal aberrations during the aging of Crepis capillaris (Hawksbeard; fam. Asteraceae) seeds were investigated. Seeds were stored at 22 degrees C for 2, 4, 6, and 8 years. Chromosomal aberrations were analyzed in metaphase chromosomes at the first and second mitotic cycles. A colchicine block was use...

journal_title：Environmental and molecular mutagenesis

authors： Dimitrov BD

更新日期：1994-01-01 00:00:00

abstract：:Acute lymphoblastic leukemia (ALL) is the most common form of pediatric cancer. Although exposure to environmental agents appears to predispose individuals to this disease, little attention has been paid to the role of genetic susceptibility to environmental exposures in the etiology of childhood ALL. The enzymes GSTM...

journal_title：Environmental and molecular mutagenesis

authors： Canalle R,Burim RV,Tone LG,Takahashi CS

更新日期：2004-01-01 00:00:00

abstract：:The genotoxic effects associated with automobile painting were analyzed using a panel of biomarkers. Chromosomal aberrations (CAs), sister chromatid exchange (SCE), and micronuclei were evaluated in 25 car painters (12 smokers, 13 nonsmokers) working in different automobile paint-shops in Italy and in 37 control subje...

journal_title：Environmental and molecular mutagenesis

authors： Testa A,Festa F,Ranaldi R,Giachelia M,Tirindelli D,De Marco A,Owczarek M,Guidotti M,Cozzi R

更新日期：2005-10-01 00:00:00

abstract：:Amoxicillin (AMO), a drug used in the treatment of infections caused by susceptible bacteria, has been evaluated for its ability to induce genotoxicity in human peripheral blood lymphocytes. The potential genotoxic effects of AMO were investigated in vitro by the sister chromatid exchange (SCE), chromosomal aberration...

journal_title：Environmental and molecular mutagenesis

authors： Istifli ES,Topaktaş M

更新日期：2010-04-01 00:00:00

abstract：:Malignant gliomas are heterogeneous populations of dynamically interacting cells. Genomic and transcriptional changes define this cellular hierarchy and allow certain tumor cells to co-opt metabolic machinery and adopt gene expression profiles that promote cellular reprogramming. Resultant expansion of privileged subp...

journal_title：Environmental and molecular mutagenesis

authors： Baulch JE,Geidzinski E,Tran KK,Yu L,Zhou YH,Limoli CL

更新日期：2016-06-01 00:00:00

abstract：:Riddelliine (RID) is a pyrrolizidine alkaloid found in plants of the genera Crotalaria, Amsinckia, and Senecio in the United States. RID has been extensively studied in a wide variety of in vitro short-term genotoxicity tests and has yielded positive responses in most test systems; however, there are fewer data availa...

journal_title：Environmental and molecular mutagenesis

authors： Mirsalis JC,Steinmetz KL,Blazak WF,Spalding JW

更新日期：1993-01-01 00:00:00

abstract：:The transporter associated with antigen processing 2 (TAP2) is involved in the development of multidrug resistance and the etiology of immunological diseases. In this study, we investigated whether the expression of TAP2 can be perturbed by single nucleotide polymorphisms (SNPs) located in 3'-untranslated region (3'-U...

journal_title：Environmental and molecular mutagenesis

authors： Knox B,Wang Y,Rogers LJ,Xuan J,Yu D,Guan H,Chen J,Shi T,Ning B,Kadlubar SA

更新日期：2018-03-01 00:00:00

abstract：:DNA polymerase κ (Pol κ) is a specialized DNA polymerase involved in translesion DNA synthesis. Although its bypass activities across lesions are well characterized in biochemistry, its cellular protective roles against genotoxic insults are still elusive. To better understand the in vivo protective roles, we have est...

journal_title：Environmental and molecular mutagenesis

authors： Kanemaru Y,Suzuki T,Niimi N,Grúz P,Matsumoto K,Adachi N,Honma M,Nohmi T

更新日期：2015-10-01 00:00:00

abstract：:The human transcriptome is complex, comprising multiple transcript types, mostly in the form of non-coding RNA (ncRNA). The majority of ncRNA is of the long form (lncRNA, ≥ 200 bp), which plays an important role in gene regulation through multiple mechanisms including epigenetics, chromatin modification, control of tr...

journal_title：Environmental and molecular mutagenesis

authors： McHale CM,Zhang L,Thomas R,Smith MT

更新日期：2013-08-01 00:00:00

abstract：:Metronidazole (MTZ) is used for the treatment of many infectious diseases, including vaginal infections. While data indicate that MTZ is mutagenic and induces micronuclei in rodents, there is no information on the genotoxicity of MTZ in epithelial vaginal cells or cervical cells. In the present study, we have instille...

journal_title：Environmental and molecular mutagenesis

authors： Ornelas-Aguirre JM,Gómez-Meda BC,Zamora-Perez AL,Ramos-Ibarra ML,Batista-González CM,Zúñiga-González GM

更新日期：2006-06-01 00:00:00

abstract：:Two freshwater species of planarians, Girardia schubarti Marcus and G. tigrina Girard, were used for measuring chromosome aberration (CA) induction under laboratory conditions. Three genotoxicants were tested: methyl methanesulfonate (MMS), a direct-acting genotoxicant; cyclophosphamide, a metabolism-dependent genotox...

journal_title：Environmental and molecular mutagenesis

authors： Lau AH,Knakievicz T,Prá D,Erdtmann B

更新日期：2007-07-01 00:00:00

abstract：:Bhawalpur is a major cotton-growing area in Pakistan. Cotton picking in Pakistan is carried out by females and as a result of the intensive use of pesticides during the growing season these females are exposed to pesticide residues in the picking season. In the present study, peripheral blood was obtained from 69 cott...

journal_title：Environmental and molecular mutagenesis

authors： Ali T,Bhalli JA,Rana SM,Khan QM

更新日期：2008-06-01 00:00:00

abstract：:Under the exposome paradigm all nongenetic factors contributing to disease are considered to be 'environmental' including chemicals, drugs, infectious agents, and psychosocial stress. We can consider these collectively as environmental stressors. Exposomics is the comprehensive analysis of exposure to all environmenta...

journal_title：Environmental and molecular mutagenesis

authors： Smith MT,de la Rosa R,Daniels SI

更新日期：2015-12-01 00:00:00

abstract：:The Pig-a assay is an emerging and promising in vivo method to determine mutagenic potential of chemicals. Since its development in 2008, remarkable progress has been made in harmonizing and characterizing the test procedures, primarily using known mutagenic chemicals. The purpose of the present study was to evaluate ...

journal_title：Environmental and molecular mutagenesis

authors： Ji Z,Settivari RS,LeBaron MJ

更新日期：2019-01-01 00:00:00

abstract：:The purpose of this study was to examine whether changes in the repair capacity of blood cells could be used as a valuable biomarker for radiation exposure. To characterize the repair kinetics in nonirradiated and irradiated cells we first performed in vitro split dose experiments. DNA damage and DNA repair capacity w...

journal_title：Environmental and molecular mutagenesis

authors： Plappert UG,Stocker B,Fender H,Fliedner TM

更新日期：1997-01-01 00:00:00

abstract：:The potential of 1,3-dichloropropene (1,3-DCP) to induce dominant lethal mutations in the germ cells of male CD rats following inhalation exposure was investigated. Groups of 11-week-old males (30 animals/group) were exposed to 1,3-DCP vapors by inhalation at targeted concentrations of 0 (negative control), 10, 60, an...

journal_title：Environmental and molecular mutagenesis

authors： Gollapudi BB,Cieszlak FS,Day SJ,Carney EW

更新日期：1998-01-01 00:00:00

abstract：:Aristolochic acid (AA) is a potent human nephrotoxin and carcinogen. We previously reported that AA treatment resulted in DNA damage and mutation in the kidney and liver of rats. In this study, we have determined the DNA adducts and mutations induced by AA in rat spleen. Big Blue® transgenic rats were gavaged with 0, ...

journal_title：Environmental and molecular mutagenesis

authors： McDaniel LP,Elander ER,Guo X,Chen T,Arlt VM,Mei N

更新日期：2012-06-01 00:00:00

abstract：:A set of stable nitroxide free radicals that are used as spin labels have been shown to possess metal-independent superoxide dismutase-like activity. Unlike superoxide dismutase (SOD), these compounds are low molecular weight, and readily penetrate into the cell. A representative nitroxide, 4-hydroxy-2,2,6,6-tetrameth...

journal_title：Environmental and molecular mutagenesis

authors： DeGraff WG,Krishna MC,Russo A,Mitchell JB

更新日期：1992-01-01 00:00:00

abstract：:In the present work we analyse some properties of the pso4-1 (= xs9) mutant of the yeast Saccharomyces cerevisiae, which is blocked in both reverse mutation and recombination. We have applied the "apparent survival test" as a method to characterize putative inducible error-prone repair activities related to the PSO4 g...

journal_title：Environmental and molecular mutagenesis

authors： Severgnini A,Lillo O,Nunes E

更新日期：1991-01-01 00:00:00

abstract：:Nitrous acid (NA) is often presumed to cause base substitutions in organisms with double-stranded DNA as a direct consequence of oxidative deamination of adenine and of cytosine residues. Here we summarize evidence indicating that other mechanisms are involved in the case of NA-induced G/C-->A/T transition mutations. ...

journal_title：Environmental and molecular mutagenesis

authors： Hartman Z,Henrikson EN,Hartman PE,Cebula TA

更新日期：1994-01-01 00:00:00

abstract：:Interactions between bleomycin (BLM) and conventional or unconventional intercalating agents were analyzed in an assay for mitotic gene conversion at the trp5 locus and reversion of the ilv1-92 allele in Saccharomyces cerevisiae strain D7. BLM is a potent recombinagen and mutagen in the assay. Various chemicals modula...

journal_title：Environmental and molecular mutagenesis

authors： Hoffmann GR,Laterza AM,Sylvia KE,Tartaglione JP

更新日期：2011-03-01 00:00:00

abstract：:The major pathway of bioactivation of procarcinogenic heterocyclic aromatic amines (HCAs) is cytochrome P450 1A2 (CYP1A2)-catalyzed N-hydroxylation and subsequent esterification by O-acetyltransferase (O-AT). We have previously reported that an umu tester strain, Salmonella typhimurium OY1001/1A2, endogenously coexpre...

journal_title：Environmental and molecular mutagenesis

authors： Aryal P,Terashita T,Guengerich FP,Shimada T,Oda Y

更新日期：2000-01-01 00:00:00

abstract：:Exposure to high concentrations of hexavalent chromium [Cr(VI)] in drinking water was associated with an increased incidence of oral tumors in F344 rats in a 2-year cancer bioassay conducted by the National Toxicology Program. These tumors primarily occurred at 180 ppm Cr(VI) and appeared to originate from the gingiva...

journal_title：Environmental and molecular mutagenesis

authors： Thompson CM,Young RR,Suh M,Dinesdurage HR,Elbekai RH,Harris MA,Rohr AC,Proctor DM

更新日期：2015-08-01 00:00:00

abstract：:Exposure to inorganic arsenic increases the risk of basal cell carcinoma (BCC). Arsenic metabolism is a susceptibility factor for arsenic toxicity, and specific haplotypes in arsenic (+3 oxidation state) methyltransferase (AS3MT) have been associated with increased urinary fractions of the most toxic arsenic metabolit...

journal_title：Environmental and molecular mutagenesis

authors： Engström KS,Vahter M,Fletcher T,Leonardi G,Goessler W,Gurzau E,Koppova K,Rudnai P,Kumar R,Broberg K

更新日期：2015-01-01 00:00:00

abstract：:Mentha piperita or peppermint is currently used for alleviating nausea, flatulence, and vomiting. In the present investigation, we evaluated the chemopreventive, antigenotoxic, and antioxidative effects of an aqueous extract of Mentha piperita leaves. One-day-old Swiss albino mice were treated with a single subcutaneo...

journal_title：Environmental and molecular mutagenesis

authors： Samarth RM,Panwar M,Kumar A

更新日期：2006-04-01 00:00:00

abstract：:Structural, and numeric chromosome aberrations (CA), sister-chromatid exchange (SCE), phytohemagglutinin stimulation (LI), proliferative rate index (PRI), and UV light-induced unscheduled DNA-synthesis (UDS) were investigated in peripheral blood lymphocytes (PBL) of 48 historical controls ("Controls"); of 14 hospital ...

journal_title：Environmental and molecular mutagenesis

authors： Major J,Jakab MG,Tompa A

更新日期：1996-01-01 00:00:00

abstract：:Human exposure to airborne particulate matter (PM) is associated with adverse cardiopulmonary health effects, including lung cancer. Ambient PM represents a heterogeneous mixture of chemical classes including transition metals, polycyclic aromatic hydrocarbons (PAHs) and their derivatives such as nitro-PAHs, many of w...

journal_title：Environmental and molecular mutagenesis

authors： Jarvis IWH,Enlo-Scott Z,Nagy E,Mudway IS,Tetley TD,Arlt VM,Phillips DH

更新日期：2018-05-01 00:00:00

abstract：:Although not mutagenic by Ames test, 2,5-dimethylfuran (DMF), a leading biofuel candidate, was found to induce chromosomal damage in cultured murine cells, suggesting that it may be genotoxic. We sought to prioritize the environmental and biological impacts of using DMF as a combustible biofuel. First, we assessed DMF...

journal_title：Environmental and molecular mutagenesis

authors： Phuong J,Kim S,Thomas R,Zhang L

更新日期：2012-07-01 00:00:00

abstract：:The objective of our study was to develop a micronucleus (MN) assay for detecting genotoxic damage after inhalation exposure in mouse alveolar Type II and Clara cells, potential target cells for lung carcinogens. Ten male C57BL/6J mice were exposed to ethylene oxide (630 mg/m(3)) for 4 hr via inhalation; 10 unexposed ...

journal_title：Environmental and molecular mutagenesis

authors： Lindberg HK,Falck GC,Catalán J,Santonen T,Norppa H

更新日期：2010-03-01 00:00:00

abstract：:Several genotoxicity endpoints have been evaluated to define nonlinear dose-responses for SN 1 and SN 2 alkylating genotoxicants. Dose-response studies acknowledging the process of multistage tumorigenesis are important; however, data pertaining nonlinearity are not yet available. In this communication, the role of DN...

journal_title：Environmental and molecular mutagenesis

authors： Becker K,Thomas AD,Kaina B

更新日期：2014-03-01 00:00:00