A multi-biomarker analysis of DNA damage in automobile painters.

abstract：:The evaluation of the relationship between the dose to DNA of a mutagen/carcinogen and in vivo somatic cell mutagenesis may provide information on the mechanisms leading to induced mutational events. This can be achieved, for example, by coupling test systems that permit the detection of somatic mutation and recombina...

journal_title：Environmental and molecular mutagenesis

authors： Zordan M,Osti M,Pavanello S,Costa R,Levis AG

更新日期：1994-01-01 00:00:00

abstract：:The Mouse Lymphoma Assay (MLA) Workgroup of the International Workshop on Genotoxicity Test Procedures held a second harmonization meeting just prior to the U.S. Environmental Mutagen Society Meeting in New Orleans, LA, in April 2000. The discussion focused on several important aspects of the MLA, including: 1) cytoto...

journal_title：Environmental and molecular mutagenesis

authors： Moore MM,Honma M,Clements J,Harrington-Brock K,Awogi T,Bolcsfoldi G,Cifone M,Collard D,Fellows M,Flanders K,Gollapudi B,Jenkinson P,Kirby P,Kirchner S,Kraycer J,McEnaney S,Muster W,Myhr B,O'Donovan M,Oliver J,Ould

更新日期：2002-01-01 00:00:00

abstract：:Mutagenicity is an important toxicological endpoint that requires thorough evaluation during the industrial chemical registration process. Regulatory requirements for mutagenicity assessment in registration of industrial chemicals vary in geographic regions (and in some cases by intended application). Here we compile ...

journal_title：Environmental and molecular mutagenesis

authors： Ji Z,Ball NS,LeBaron MJ

更新日期：2017-06-01 00:00:00

abstract：:The Benchmark Dose (BMD) method is the favored approach for quantitative dose-response analysis where uncertainty measurements are delineated between the upper (BMDU) and lower (BMDL) confidence bounds, or confidence intervals (CIs). Little has been published on the accurate interpretation of uncertainty measurements ...

journal_title：Environmental and molecular mutagenesis

authors： Wheeldon RP,Dertinger SD,Bryce SM,Bemis JC,Johnson GE

更新日期：2021-01-11 00:00:00

abstract：:Three carbamate insecticides (propoxur, methomyl, and aldicarb) were evaluated for their ability to induce micronuclei (MN) in vitro using cultured Chinese hamster ovary (CHO) cells, and in vivo in mouse bone marrow erythrocytes. In vitro, all three insecticides induced a significant increase in micronucleated binucle...

journal_title：Environmental and molecular mutagenesis

authors： Wei LY,Chao JS,Hong CC

更新日期：1997-01-01 00:00:00

abstract：:Cultured rodent and human cells typically display similar clonal survival characteristics following exposure to ultraviolet light (UV). However, compared to human cells, cultured cells from mice, rats, and hamsters are generally deficient in excision repair of the most prominent DNA lesion produced by UV, the cyclobut...

journal_title：Environmental and molecular mutagenesis

authors： Hanawalt PC

更新日期：2001-01-01 00:00:00

abstract：:The in vivo model Drosophila melanogaster was used here to determine the detrimental effects induced by silver nanoparticles (AgNPs) exposure. The main aim was to explore its interaction with the intestinal barrier and the genotoxic effects induced in hemocytes. The observed effects were compared with those obtained b...

journal_title：Environmental and molecular mutagenesis

authors： Alaraby M,Romero S,Hernández A,Marcos R

更新日期：2019-04-01 00:00:00

abstract：:Occupational exposure to wood dust is associated with the occurrence of nasal cancer. In this study, we investigated micronuclei and nuclear changes (NCs: binucleates, karyorrhexis, karyolysis, and the "broken egg" effect) in exfoliated buccal cells of 20 workers exposed to wood dust and 20 age- and sex-matched contro...

journal_title：Environmental and molecular mutagenesis

authors： Celik A,Kanik A

更新日期：2006-12-01 00:00:00

abstract：:Iron oxide nanoparticles (ION) with superparamagnetic properties hold great promise for use in various biomedical applications; specific examples include use as contrast agents for magnetic resonance imaging, in targeted drug delivery, and for induced hyperthermia cancer treatments. Increasing potential applications r...

journal_title：Environmental and molecular mutagenesis

authors： Valdiglesias V,Kiliç G,Costa C,Fernández-Bertólez N,Pásaro E,Teixeira JP,Laffon B

更新日期：2015-03-01 00:00:00

abstract：:The kinetics of micronucleus (MN) induction and decline in blood normochromatic erythrocytes (NCE) of mice subchronically exposed to benzene was investigated during and after exposure. Swiss (ICR) male mice (10/group) were given 0.0, 36.6, 73.2, and 146.4 mg/kg body weight benzene by gavage daily for 14 days, except f...

journal_title：Environmental and molecular mutagenesis

authors： Rithidech K,Au WW,Ramanujam VM,Whorton EB Jr,Legator MS

更新日期：1988-01-01 00:00:00

abstract：:Exposure to high concentrations of hexavalent chromium [Cr(VI)] in drinking water was associated with an increased incidence of oral tumors in F344 rats in a 2-year cancer bioassay conducted by the National Toxicology Program. These tumors primarily occurred at 180 ppm Cr(VI) and appeared to originate from the gingiva...

journal_title：Environmental and molecular mutagenesis

authors： Thompson CM,Young RR,Suh M,Dinesdurage HR,Elbekai RH,Harris MA,Rohr AC,Proctor DM

更新日期：2015-08-01 00:00:00

abstract：:Peripheral lymphocytes from Taiwanese women (n = 35) exposed to polychlorinated aromatic hydrocarbons and from matched controls (n = 24) were assessed for the levels of sister chromatid exchanges (SCEs) after a 72-hour incubation of whole blood in the presence or absence of alpha-naphthoflavone (ANF) and for chromosom...

journal_title：Environmental and molecular mutagenesis

authors： Lundgren K,Collman GW,Wang-Wuu S,Tiernan T,Taylor M,Thompson CL,Lucier GW

更新日期：1988-01-01 00:00:00

abstract：:This study presents the first application of an in vivo alkaline comet assay using haemocytes of Drosophila melanogaster larvae. These cells, which play a role similar to that of mammalian blood, can be easily obtained and represent an overall exposure of the treated larvae. To validate the assay, we evaluated the res...

journal_title：Environmental and molecular mutagenesis

authors： Carmona ER,Guecheva TN,Creus A,Marcos R

更新日期：2011-03-01 00:00:00

abstract：:Perturbation of DNA replication by chemical-DNA adducts produced by exposure to mutagenic/carcinogenic chemicals results in mutagenic or cytotoxic damage in the DNA. Demonstration of a correlation between cell cycle dependency of cytotoxicity and point mutation at the Na+/K+ ATPase gene could suggest that the two cons...

journal_title：Environmental and molecular mutagenesis

authors： Smith GJ,Grisham JW,Bentley KS

更新日期：1988-01-01 00:00:00

abstract：:The monoterpene indole alkaloid brachycerine from Psychotria brachyceras has been shown to be induced by UV and to have in vitro antioxidant activity, indicating a possible protective role against the secondary effects of this radiation. In this work, we have studied the antioxidant properties of brachycerine and a cr...

journal_title：Environmental and molecular mutagenesis

authors： do Nascimento NC,Fragoso V,Moura DJ,e Silva AC,Fett-Neto AG,Saffi J

更新日期：2007-12-01 00:00:00

abstract：:Experiments are described which elucidate some of the technical problems associated with the direct sequencing of polymerase chain reaction (PCR) amplified DNA. Sequencing primer purity, labeling methodology, and template preparation were explored. Conditions are presented for the routine sequencing of single- and dou...

journal_title：Environmental and molecular mutagenesis

authors： Zimmerman LJ,Fuscoe JC

更新日期：1991-01-01 00:00:00

abstract：:Based on the assumption that compounds having similar toxic modes of action induce specific gene expression changes, the toxicity of unknown compounds can be predicted after comparison of their molecular fingerprints with those obtained with compounds of known toxicity. These predictive models will therefore rely on t...

journal_title：Environmental and molecular mutagenesis

authors： Thybaud V,Le Fevre AC,Boitier E

更新日期：2007-06-01 00:00:00

abstract：:The phenoxyherbicide and peroxisome proliferator 2-methyl-4-chlorophenoxyacetic acid (MCPA) was tested for its ability to induce sister-chromatid exchanges (SCE) in chick embryos. Erbitox E30 (a commercial formulation containing 28% MCPA sodium potassium salt as active ingredient) was injected into the air chamber in ...

journal_title：Environmental and molecular mutagenesis

authors： Arias E

更新日期：1992-01-01 00:00:00

abstract：:Iron oxide nanoparticles (ION) are gaining importance as diagnostic and therapeutic tool of central nervous system diseases. Although oleic acid-coated ION (O-ION) have been described as stable and biocompatible, their potential neurotoxicity was scarcely evaluated in human nervous cells so far. The primary aim of thi...

journal_title：Environmental and molecular mutagenesis

authors： Fernández-Bertólez N,Costa C,Brandão F,Duarte JA,Teixeira JP,Pásaro E,Valdiglesias V,Laffon B

更新日期：2019-12-01 00:00:00

abstract：:The influence of several methodological factors on mean values of sister chromatid exchanges (SCEs) and micronuclei (MN) in peripheral lymphocytes of 1,650 subjects was analyzed. Donors belonged to a general healthy population living in Pisa and in two nearby small cities: Cascina and Navacchio (Ca-Na). Blood samples ...

journal_title：Environmental and molecular mutagenesis

authors： Barale R,Marrazzini A,Bacci E,Di Sibio A,Tessa A,Cocchi L,Scarcelli V,Lubrano V,Vassalle C,Landi S

更新日期：1998-01-01 00:00:00

abstract：:The frequency of 6-thioguanine resistant (TGr) mutants induced in human G0 phase T-lymphocytes by 200 cGy of gamma irradiation is greatly enhanced by incubation with cytosine arabinoside (ara-C) after irradiation. The mutant frequency increased with increasing incubation time in ara-C for up to 2 hr. This mutation ind...

journal_title：Environmental and molecular mutagenesis

authors： O'Neill JP,Sullivan LM,Hunter TC,Nicklas JA

更新日期：1991-01-01 00:00:00

abstract：:The effects of long-term smoking on mitochondrial DNA (mtDNA) deletions in hair follicles were investigated in subjects with different antioxidant capacity. Twenty-two male smokers with a smoking index of greater than 5 pack-years and without any known systemic diseases were recruited for this study. Forty healthy non...

journal_title：Environmental and molecular mutagenesis

authors： Liu CS,Chen HW,Lii CK,Tsai CS,Kuo CL,Wei YH

更新日期：2002-01-01 00:00:00

abstract：:Risk estimates for radiation-induced cancer in humans are based on epidemiological data largely drawn from the Japanese atomic bomb survivor studies, which received an acute high dose rate (HDR) ionising radiation. Limited knowledge exists about the effects of chronic low dose rate (LDR) exposure, particularly with re...

journal_title：Environmental and molecular mutagenesis

authors： Graupner A,Eide DM,Brede DA,Ellender M,Lindbo Hansen E,Oughton DH,Bouffler SD,Brunborg G,Olsen AK

更新日期：2017-10-01 00:00:00

abstract：:The Ames Salmonella/microsomal assay was employed to test the mutagenicity of some benzamines (aniline, and o- and p-phenylenediamine) and their nitro-derivatives (p-nitroaniline, 2-nitro-p-phenylenediamine, 3- and 4-nitro-o-phenylenediamine), using strains TA98 and TA100 and their nitroreductase-deficient mutants, TA...

journal_title：Environmental and molecular mutagenesis

authors： Chung KT,Murdock CA,Zhou Y,Stevens SE Jr,Li YS,Wei CI,Fernando SY,Chou MW

更新日期：1996-01-01 00:00:00

abstract：:Halogenated acetonitriles (HANs) are known to be water disinfectant by-products. Their mutagenicity and carcinogenicity have been shown in different test systems in vivo and in vitro. They also have clastogenic properties. In this study, the ability of HAN to induce single-strand breaks on the DNA of HeLa S3 cells was...

journal_title：Environmental and molecular mutagenesis

authors： Muller-Pillet V,Joyeux M,Ambroise D,Hartemann P

更新日期：2000-01-01 00:00:00

abstract：:311 chemicals were tested under code, for mutagenicity, in Salmonella typhimurium; 35 of the chemicals were tested more than once in the same or different laboratories. The tests were conducted using a preincubation protocol in the absence of exogenous metabolic activation, and in the presence of liver S-9 from Aroclo...

journal_title：Environmental and molecular mutagenesis

authors： Zeiger E,Anderson B,Haworth S,Lawlor T,Mortelmans K

更新日期：1992-01-01 00:00:00

abstract：:Lack of cell surface glycosylphosphatidylinositol (GPI)-anchored protein(s) has been used as a reporter of Pig-a gene mutation in several model systems. As an extension of this work, our laboratory initiated development of an in vitro mutation assay based on the flow cytometric assessment of CD90.2 expression on the c...

journal_title：Environmental and molecular mutagenesis

authors： Bemis JC,Avlasevich SL,Labash C,McKinzie P,Revollo J,Dobrovolsky VN,Dertinger SD

更新日期：2018-01-01 00:00:00

abstract：:In this study, the genotoxic effects of a widely used herbicide, trifluralin, and its commercial formulation, Treflan, were evaluated using the micronucleus test in a commercially important fish species, Oreochromis niloticus (Nile Tilapia). Fish were exposed to 1, 5, and 10 microg/L doses of trifluralin and Treflan f...

journal_title：Environmental and molecular mutagenesis

authors： Könen S,Cavaş T

更新日期：2008-07-01 00:00:00

abstract：:Two phenotypic classes of selectable tk-/- mutants have been isolated from the TK6 human lymphoblast cell line; one has a normal growth rate (tkn) relative to the parental cell line; the other has a slow growth rate (tks). Complete karyotypes of metaphase chromosomes were prepared and analyzed from 16 tks mutants (eig...

journal_title：Environmental and molecular mutagenesis

authors： Kodama Y,Boreiko CJ,Skopek TR,Recio L

更新日期：1989-01-01 00:00:00

abstract：:The nuclease P1 modification of the 32P-postlabeling technique was used to study the biological activity of 7H-dibenzo[c,g]carbazole (DBC) and some of its derivatives, including N-methyldibenzo[c,g]carbazole (N-MeDBC), 5,9-dimethyldibenzo[c,g]carbazole (5,9-diMeDBC), 5,9,N-trimethyldibenzo[c,g]carbazole (5,9,N-triMeDB...

journal_title：Environmental and molecular mutagenesis

authors： Gábelová A,Périn-Roussel O,Jounaidi Y,Périn F

更新日期：1997-01-01 00:00:00