Pilot studies evaluating the nongenotoxic rodent carcinogens phenobarbital and clofibrate in the rat Pig-a assay.

abstract：:O6-alkylguanine DNA-alkyltransferase (AGT) is a widely distributed DNA repair protein that protects living organisms from endogenous and exogenous alkylation damage to DNA at the O6-position of guanine. The search of the C. elegans genome database for an AGT protein revealed the presence of a protein (cAGT-2) with som...

journal_title：Environmental and molecular mutagenesis

authors： Kanugula S,Pegg AE

更新日期：2001-01-01 00:00:00

abstract：:Cytochrome P450 (CYP), glutathione-S-transferase (GST), and N-acetyltransferase (NAT) are crucial for metabolism and clearance of xenobiotics. This study investigated whether CYP, GST, and NAT single nucleotide polymorphisms (SNPs) are associated with colorectal cancer (CRC) in patients with Lynch syndrome. The intera...

journal_title：Environmental and molecular mutagenesis

authors： Kamiza AB,You JF,Wang WC,Tang R,Chang CY,Chien HT,Lai CH,Chiu LL,Lo TP,Hung KY,Hsiung CA,Yeh CC

更新日期：2018-01-01 00:00:00

abstract：:Loss of heterozygosity (LOH) is a critical event in the development of human cancers. LOH is thought to result from either a large deletion or recombination between homologous alleles during repair of DNA double-strand breaks (DSBs). These types of genetic alterations produce mutations in the TK gene mutation assay, w...

journal_title：Environmental and molecular mutagenesis

authors： Honma M

更新日期：2005-03-01 00:00:00

abstract：:The objective of our study was to develop a micronucleus (MN) assay for detecting genotoxic damage after inhalation exposure in mouse alveolar Type II and Clara cells, potential target cells for lung carcinogens. Ten male C57BL/6J mice were exposed to ethylene oxide (630 mg/m(3)) for 4 hr via inhalation; 10 unexposed ...

journal_title：Environmental and molecular mutagenesis

authors： Lindberg HK,Falck GC,Catalán J,Santonen T,Norppa H

更新日期：2010-03-01 00:00:00

abstract：:A transplacental carcinogenicity study was conducted by exposing pregnant Swiss (CD-1) mice to 0, 50, 100, 200, or 300 mg 3'-azido-3'-deoxythymidine (AZT)/kg body weight (BW) daily for the duration of gestation (18-19 days) [National Toxicology Program,2006]. The incidence of alveolar/bronchiolar adenomas and carcinom...

journal_title：Environmental and molecular mutagenesis

authors： Koujitani T,Ton TV,Lahousse SA,Hong HH,Wakamatsu N,Sills RC

更新日期：2008-12-01 00:00:00

abstract：:In vitro transcriptional signatures that predict toxicities can facilitate chemical screening. We previously developed a transcriptomic biomarker (known as TGx-28.65) for classifying agents as genotoxic (DNA damaging) and non-genotoxic in human lymphoblastoid TK6 cells. Because TK6 cells do not express cytochrome P450...

journal_title：Environmental and molecular mutagenesis

authors： Yauk CL,Buick JK,Williams A,Swartz CD,Recio L,Li HH,Fornace AJ Jr,Thomson EM,Aubrecht J

更新日期：2016-05-01 00:00:00

abstract：:We describe an in vivo mutagenesis model that utilizes reverse mutation and forward mutation at the endogenous Aprt locus. Reverse mutation provides an in situ method for detecting environments or agents that cause point mutations. Forward mutation detects large chromosomal events, including mitotic recombination, chr...

journal_title：Environmental and molecular mutagenesis

authors： Stambrook PJ,Shao C,Stockelman M,Boivin G,Engle SJ,Tischfield JA

更新日期：1996-01-01 00:00:00

abstract：:V(D)J recombinase-mediated recombination between the T-cell receptor (TCR) gamma variable (GV) genes at chromosome 7p15 and the TCR beta joining (BJ) genes at 7q35 leads to the formation of a hybrid TCR gene. These TCR gamma/beta interlocus rearrangements occur at classic V(D)J recombination signal sequences (RSS) and...

journal_title：Environmental and molecular mutagenesis

authors： Ballinger SW,Judice SA,Nicklas JA,Albertini RJ,O'Neill JP

更新日期：2002-01-01 00:00:00

abstract：:It is known that N-nitrosopyrrolidine (NPYR), a carcinogen in rodents, is metabolically activated by microsomal cytochrome P450 to form an alpha-hydroxylated derivative, which induces mutations. The mutations have been demonstrated by use of Salmonella typhimurium and Escherichia coli. We discovered directly acting mu...

journal_title：Environmental and molecular mutagenesis

authors： Arimoto-Kobayashi S,Inada N,Anma N,Shimada H,Hayatsu H

更新日期：1999-01-01 00:00:00

abstract：:Aristolochic acid (AA) is a potent human nephrotoxin and carcinogen. We previously reported that AA treatment resulted in DNA damage and mutation in the kidney and liver of rats. In this study, we have determined the DNA adducts and mutations induced by AA in rat spleen. Big Blue® transgenic rats were gavaged with 0, ...

journal_title：Environmental and molecular mutagenesis

authors： McDaniel LP,Elander ER,Guo X,Chen T,Arlt VM,Mei N

更新日期：2012-06-01 00:00:00

abstract：:Maintenance of the mitochondrial genome is essential for proper cellular function. For this purpose, mitochondrial DNA (mtDNA) needs to be faithfully replicated, transcribed, translated, and repaired in the face of constant onslaught from endogenous and environmental agents. Although only 13 polypeptides are encoded w...

journal_title：Environmental and molecular mutagenesis

authors： Sharma N,Pasala MS,Prakash A

更新日期：2019-10-01 00:00:00

abstract：:Data on human trisomic conceptuses suggest that the extra chromosome commonly has a maternal origin, and the amount and position of crossing-over on nondisjoined chromosomes is commonly altered. These observations may provide important clues to the etiology of human germ cell aneuploidy, especially in regard to evalua...

journal_title：Environmental and molecular mutagenesis

authors： Ferguson LR,Allen JW,Mason JM

更新日期：1996-01-01 00:00:00

abstract：:Bhawalpur is a major cotton-growing area in Pakistan. Cotton picking in Pakistan is carried out by females and as a result of the intensive use of pesticides during the growing season these females are exposed to pesticide residues in the picking season. In the present study, peripheral blood was obtained from 69 cott...

journal_title：Environmental and molecular mutagenesis

authors： Ali T,Bhalli JA,Rana SM,Khan QM

更新日期：2008-06-01 00:00:00

abstract：:Prostate cancer (PC) is commonly diagnosed cancer in men but only a few risk factors, such as family history, ethnicity, and age have been established. Chromosomal instability is another possible risk factor but this has not been adequately explained previously. In this study, we tested the hypotheses that peripheral ...

journal_title：Environmental and molecular mutagenesis

authors： Dhillon VS,Yeoh E,Salisbury C,Butters J,Di Matteo A,Olver I,Fenech M

更新日期：2018-12-01 00:00:00

abstract：:In the present work we analyse some properties of the pso4-1 (= xs9) mutant of the yeast Saccharomyces cerevisiae, which is blocked in both reverse mutation and recombination. We have applied the "apparent survival test" as a method to characterize putative inducible error-prone repair activities related to the PSO4 g...

journal_title：Environmental and molecular mutagenesis

authors： Severgnini A,Lillo O,Nunes E

更新日期：1991-01-01 00:00:00

abstract：:311 chemicals were tested under code, for mutagenicity, in Salmonella typhimurium; 35 of the chemicals were tested more than once in the same or different laboratories. The tests were conducted using a preincubation protocol in the absence of exogenous metabolic activation, and in the presence of liver S-9 from Aroclo...

journal_title：Environmental and molecular mutagenesis

authors： Zeiger E,Anderson B,Haworth S,Lawlor T,Mortelmans K

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Recently, high concentrations of arsenic have been documented in ground waters of Southern Assam, India. Indiscriminate smokeless tobacco consumption is a common practice in this region. Correlation between nutritional status and arsenic and smokeless tobacco-induced health effects has not been taken up in h...

journal_title：Environmental and molecular mutagenesis

authors： Das S,Langthasa P,Barhoi D,Upadhaya P,Giri S

更新日期：2018-06-01 00:00:00

abstract：:The cytotoxicity and mutagenicity of the human carcinogen, treosulphan, and its hydrolysis product, dl-1,2:3,4-diepoxybutane (DEB), were studied in Chinese hamster ovary, AS52, cells. Treosulphan (0.1-1.0 mM) is toxic and mutagenic at the gpt locus. A strong pH dependence was noted. DEB is cytotoxic and mutagenic at a...

journal_title：Environmental and molecular mutagenesis

authors： Zhu S,Zeiger E

更新日期：1993-01-01 00:00:00

abstract：:To what extent noncovalent chemical-DNA interactions, in particular weak nonbonded DNA intercalation, contribute to genotoxic responses in mammalian cells has not been fully elucidated. Moreover, with the exception of predominantly flat, multiple-fused-ring structures, our ability to predict intercalation ability of n...

journal_title：Environmental and molecular mutagenesis

authors： Snyder RD,Ewing DE,Hendry LB

更新日期：2004-01-01 00:00:00

abstract：:DNA mutations play a crucial role in the origins of cancer, and the clonal expansion of mutant cells is one of the fundamental steps in multistage carcinogenesis. In this study, we correlated tumor incidence in B6C3F1 mice during the period after exposure to N-ethyl-N-nitrosourea (ENU) with the persistence of ENU-indu...

journal_title：Environmental and molecular mutagenesis

authors： Nakayama T,Sawai T,Masuda I,Kaneko S,Yamauchi K,Blyth BJ,Shimada Y,Tachibana A,Kakinuma S

更新日期：2017-10-01 00:00:00

abstract：:Interstrand cross-links (ICLs) are among the most cytotoxic DNA lesions to cells because they prevent the two DNA strands from separating, thereby precluding replication and transcription. Even though chemotherapeutic cross-linking agents are well established in clinical use, and numerous repair proteins have been imp...

journal_title：Environmental and molecular mutagenesis

authors： Hlavin EM,Smeaton MB,Miller PS

更新日期：2010-07-01 00:00:00

abstract：:The nuclease P1 modification of the 32P-postlabeling technique was used to study the biological activity of 7H-dibenzo[c,g]carbazole (DBC) and some of its derivatives, including N-methyldibenzo[c,g]carbazole (N-MeDBC), 5,9-dimethyldibenzo[c,g]carbazole (5,9-diMeDBC), 5,9,N-trimethyldibenzo[c,g]carbazole (5,9,N-triMeDB...

journal_title：Environmental and molecular mutagenesis

authors： Gábelová A,Périn-Roussel O,Jounaidi Y,Périn F

更新日期：1997-01-01 00:00:00

abstract：:In this study, the genotoxic effects of a widely used herbicide, trifluralin, and its commercial formulation, Treflan, were evaluated using the micronucleus test in a commercially important fish species, Oreochromis niloticus (Nile Tilapia). Fish were exposed to 1, 5, and 10 microg/L doses of trifluralin and Treflan f...

journal_title：Environmental and molecular mutagenesis

authors： Könen S,Cavaş T

更新日期：2008-07-01 00:00:00

abstract：:Vanillin (VA) modulates the genotoxicity of chemical and physical agents in a complex manner. Previous studies indicate that VA inhibits the mutagenicity but increases the mitotic homologous recombination caused by at least some genotoxic agents. In the present study, we have evaluated the effects of VA on the repair ...

journal_title：Environmental and molecular mutagenesis

authors： Furlanetto MP,Sinigaglia M,Amaral VS,Dihl RR,de Andrade HH

更新日期：2007-01-01 00:00:00

abstract：:Under the exposome paradigm all nongenetic factors contributing to disease are considered to be 'environmental' including chemicals, drugs, infectious agents, and psychosocial stress. We can consider these collectively as environmental stressors. Exposomics is the comprehensive analysis of exposure to all environmenta...

journal_title：Environmental and molecular mutagenesis

authors： Smith MT,de la Rosa R,Daniels SI

更新日期：2015-12-01 00:00:00

abstract：:Molindone hydrochloride is a dihydroindolone neuroleptic with dopamine D2 and D5 receptor antagonist activity. As an integral component of its preclinical safety evaluation, molindone hydrochloride was evaluated in a series of in vitro and in vivo genetic toxicology assays. In the bacterial reverse gene mutation assay...

journal_title：Environmental and molecular mutagenesis

authors： Krishna G,Gopalakrishnan G,Goel S

更新日期：2016-05-01 00:00:00

abstract：:Malignant gliomas are heterogeneous populations of dynamically interacting cells. Genomic and transcriptional changes define this cellular hierarchy and allow certain tumor cells to co-opt metabolic machinery and adopt gene expression profiles that promote cellular reprogramming. Resultant expansion of privileged subp...

journal_title：Environmental and molecular mutagenesis

authors： Baulch JE,Geidzinski E,Tran KK,Yu L,Zhou YH,Limoli CL

更新日期：2016-06-01 00:00:00

abstract：:Chlorinated drinking water contains several chlorohydroxyfuranone (CHF) by-products whose contribution to cancer risk is not presently known. 3,4-Dichloro-5-hydroxy-2(5H)-furanone (MCA), 3-chloro-4-(chloromethyl)-5-hydroxy-2(5H)-furanone (CMCF), and 3- chloro-4-methyl-5-hydroxy-2(5H)-furanone (MCF) were studied for th...

journal_title：Environmental and molecular mutagenesis

authors： Mäki-Paakkanen J,Laaksonen M,Munter T,Kronberg L,Komulainen H

更新日期：2001-01-01 00:00:00

abstract：:The mutational spectrum for 28 X-ray induced mutations and 2 spontaneous mutations, previously determined by genetic and cytogenetic methods, consisted of 20 multilocus deficiencies (19 induced and 1 spontaneous) and 10 intragenic mutations (9 induced and 1 spontaneous). One of the X-ray induced intragenic mutations w...

journal_title：Environmental and molecular mutagenesis

authors： Mahmoud J,Fossett NG,Arbour-Reily P,McDaniel M,Tucker A,Chang SH,Lee WR

更新日期：1991-01-01 00:00:00

abstract：:To protect human and ecosystem health, it is necessary to develop sensitive assays and to identify responsive cells and species (and their life stages). In this study, the relative genotoxicity of two inorganic arsenicals: trivalent sodium arsenite (As(3+)) and pentavalent sodium arsenate (As(5+)), was evaluated in tw...

journal_title：Environmental and molecular mutagenesis

authors： Raisuddin S,Jha AN

更新日期：2004-01-01 00:00:00