Antimutagenicity of a low molecular weight superoxide dismutase mimic against oxidative mutagens.

abstract：:Ethylene oxide (EO) is a direct acting alkylating agent; in vitro and in vivo studies indicate that it is both a mutagen and a carcinogen. However, it remains unclear whether the mode of action (MOA) for cancer for EO is a mutagenic MOA, specifically via point mutation. To investigate the MOA for EO-induced mouse lung...

journal_title：Environmental and molecular mutagenesis

authors： Manjanatha MG,Shelton SD,Chen Y,Parsons BL,Myers MB,McKim KL,Gollapudi BB,Moore NP,Haber LT,Allen B,Moore MM

更新日期：2017-04-01 00:00:00

abstract：:Sickle cell anemia (SCA) is a hereditary hematological disease that is characterized by a point mutation in the beta globin S gene and has no specific treatment; hydroxyurea (HU) is the only therapeutic agent used in clinical practice. In the present study, we evaluated the deoxyribonucleic acid (DNA) damage index (DI...

journal_title：Environmental and molecular mutagenesis

authors： Maia Filho PA,Pereira JF,Almeida Filho TP,Cavalcanti BC,Sousa JC,Lemes RPG

更新日期：2019-04-01 00:00:00

abstract：:The accessibility of reactive metabolites to test cells is critical for a genotoxic response. However, sulfo-conjugates formed outside may not readily enter cells, and some metabolites formed by cytochromes P450 (CYPs) may not endure transport. This topic was addressed in the present study, using V79 cells engineered ...

journal_title：Environmental and molecular mutagenesis

authors： Zhu N,Hu K,Li Z,Chen Y,Liu Y

更新日期：2020-02-01 00:00:00

abstract：:N-Hydroxymethylacrylamide (NHMA), a mouse carcinogen inactive in the Salmonella assay and mouse micronucleus (MN) assay, was tested for reproductive effects in a mouse continuous breeding study. In that study, increased embryonic deaths were observed after 13 weeks exposure of parental animals to NHMA via drinking wat...

journal_title：Environmental and molecular mutagenesis

authors： Witt KL,Hughes LA,Burka LT,McFee AF,Mathews JM,Black SL,Bishop JB

更新日期：2003-01-01 00:00:00

abstract：:The genotoxic responses of mixtures of four chlorohydroxyfuranones (CHFs), 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX), 3,4-dichloro-5-hydroxy-2(5H)-furanone (MCA), 3-chloro- 4-(chloromethyl)-5-hydroxy-2(5H)-furanone (CMCF) and 3-chloro-4-methyl-5-hydroxy-2(5H)-furanone (MCF), were compared with the geno...

journal_title：Environmental and molecular mutagenesis

authors： Mäki-Paakkanen J,Komulainen H,Kronberg L

更新日期：2004-01-01 00:00:00

abstract：:The efficiency of the micronucleus test to assess radiation-induced chromosomal damage in human spermatozoa has been investigated. Micronuclei were scored in human sperm-hamster egg hybrids at the two-cell stage, after exposure of human spermatozoa to in vitro gamma-rays at doses of 0.00, 0.10, 0.25, 0.50, 1.00, 2.00,...

journal_title：Environmental and molecular mutagenesis

authors： Tusell L,Alvarez R,Caballín MR,Genescà A,Miró R,Ribas M,Egozcue J

更新日期：1995-01-01 00:00:00

abstract：:DNA interstrand crosslinks (ICLs) are covalent linkages between two strands of DNA, and their presence interferes with essential metabolic processes such as transcription and replication. These lesions are extremely toxic, and their repair is essential for genome stability and cell survival. In this review, we will di...

journal_title：Environmental and molecular mutagenesis

authors： Sharma S,Canman CE

更新日期：2012-12-01 00:00:00

abstract：:Coumarin (1,2-benzopyrone), a natural food constituent, prevents polycyclic aromatic hydrocarbon-induced neoplasms in rats and mice, but has not been studied with other chemical carcinogens. We examined coumarin chemoprotection against aflatoxin B1 using the 6-thioguanine resistance mutation assay in two different Chi...

journal_title：Environmental and molecular mutagenesis

authors： Goeger DE,Anderson KE,Hsie AW

更新日期：1998-01-01 00:00:00

abstract：:Structural, and numeric chromosome aberrations (CA), sister-chromatid exchange (SCE), phytohemagglutinin stimulation (LI), proliferative rate index (PRI), and UV light-induced unscheduled DNA-synthesis (UDS) were investigated in peripheral blood lymphocytes (PBL) of 48 historical controls ("Controls"); of 14 hospital ...

journal_title：Environmental and molecular mutagenesis

authors： Major J,Jakab MG,Tompa A

更新日期：1996-01-01 00:00:00

abstract：:The in vivo model Drosophila melanogaster was used here to determine the detrimental effects induced by silver nanoparticles (AgNPs) exposure. The main aim was to explore its interaction with the intestinal barrier and the genotoxic effects induced in hemocytes. The observed effects were compared with those obtained b...

journal_title：Environmental and molecular mutagenesis

authors： Alaraby M,Romero S,Hernández A,Marcos R

更新日期：2019-04-01 00:00:00

abstract：:311 chemicals were tested under code, for mutagenicity, in Salmonella typhimurium; 35 of the chemicals were tested more than once in the same or different laboratories. The tests were conducted using a preincubation protocol in the absence of exogenous metabolic activation, and in the presence of liver S-9 from Aroclo...

journal_title：Environmental and molecular mutagenesis

authors： Zeiger E,Anderson B,Haworth S,Lawlor T,Mortelmans K

更新日期：1992-01-01 00:00:00

abstract：:Radiation and many chemicals have been found to induce homologous genetic recombination. Experimental systems that allow the detection and characterization of recombinagens exist in organisms as diverse as bacteria, fungi, plants, insects, and mammals. Recombination plays an important role in many biological processes...

journal_title：Environmental and molecular mutagenesis

authors： Hoffmann GR

更新日期：1994-01-01 00:00:00

abstract：:Diesel exhaust (DE) is a major airborne pollutant of urban areas. It contains various polycyclic aromatic hydrocarbons (PAH) and nitrated PAHs. In this study, gpt delta mice were treated with inhalation of 1 or 3 mg m(-3) DE, or a single intratracheal instillation of diesel exhaust particles (DEP) or DEP extract. In t...

journal_title：Environmental and molecular mutagenesis

authors： Hashimoto AH,Amanuma K,Hiyoshi K,Sugawara Y,Goto S,Yanagisawa R,Takano H,Masumura K,Nohmi T,Aoki Y

更新日期：2007-10-01 00:00:00

abstract：:Occupational exposure to wood dust is associated with the occurrence of nasal cancer. In this study, we investigated micronuclei and nuclear changes (NCs: binucleates, karyorrhexis, karyolysis, and the "broken egg" effect) in exfoliated buccal cells of 20 workers exposed to wood dust and 20 age- and sex-matched contro...

journal_title：Environmental and molecular mutagenesis

authors： Celik A,Kanik A

更新日期：2006-12-01 00:00:00

abstract：:Benzo(a)pyrene (BaP) is a mutagenic carcinogen that is ubiquitous in our environment. To better understand the toxic effects of BaP and to explore the relationship between toxicity and toxicogenomics profiles, we assessed global mRNA and microRNA (miRNA) expression in Muta™Mouse. Adult male mice were exposed by oral g...

journal_title：Environmental and molecular mutagenesis

authors： Malik AI,Williams A,Lemieux CL,White PA,Yauk CL

更新日期：2012-01-01 00:00:00

abstract：:The modulation of 1,3-butadiene (BD)-induced DNA adducts by occupational exposure, glutathione S-transferase (GST) genotypes, single-strand breaks, and cytogenetic end points was studied in 15 workers and 11 controls. The exposed group consisted of 8 smokers and 7 nonsmokers, whereas the control group consisted of 7 n...

journal_title：Environmental and molecular mutagenesis

authors： Zhao C,Vodicka P,Sram RJ,Hemminki K

更新日期：2001-01-01 00:00:00

abstract：:Clustered damage induced by ionizing radiation--two or more oxidized bases, abasic sites, or strand breaks within a few DNA helical turns--have been postulated to be major lethal and/or mutagenic sites. Although they have recently been shown to be induced in genomic DNAs by ionizing photons and particles, little is kn...

journal_title：Environmental and molecular mutagenesis

authors： Sutherland BM,Bennett PV,Weinert E,Sidorkina O,Laval J

更新日期：2001-01-01 00:00:00

abstract：:Exposure to inorganic arsenic increases the risk of basal cell carcinoma (BCC). Arsenic metabolism is a susceptibility factor for arsenic toxicity, and specific haplotypes in arsenic (+3 oxidation state) methyltransferase (AS3MT) have been associated with increased urinary fractions of the most toxic arsenic metabolit...

journal_title：Environmental and molecular mutagenesis

authors： Engström KS,Vahter M,Fletcher T,Leonardi G,Goessler W,Gurzau E,Koppova K,Rudnai P,Kumar R,Broberg K

更新日期：2015-01-01 00:00:00

abstract：:Isothiocyanates (ITCs) are commonly found in cruciferous vegetables. A variety of biological activities have been ascribed to ITCs, such as inhibition of cytochrome P450 enzymes and induction of phase II enzymes in animal models. ITCs are also able to block cell-cycle progression and induce apoptosis in human cancer c...

journal_title：Environmental and molecular mutagenesis

authors： Fimognari C,Berti F,Cantelli-Forti G,Hrelia P

更新日期：2005-12-01 00:00:00

abstract：:DNA damage induced by solar ultraviolet (UV) radiation plays an important role in the induction of skin cancer. Although UVA constitutes the majority of solar UV radiation, it is less damaging to DNA than UVB. The DNA damage produced by UVA radiation, however, can be augmented in the presence of a photosensitizer. We ...

journal_title：Environmental and molecular mutagenesis

authors： Toyooka T,Ibuki Y,Takabayashi F,Goto R

更新日期：2006-01-01 00:00:00

abstract：:Chlorinated drinking water contains several chlorohydroxyfuranone (CHF) by-products whose contribution to cancer risk is not presently known. 3,4-Dichloro-5-hydroxy-2(5H)-furanone (MCA), 3-chloro-4-(chloromethyl)-5-hydroxy-2(5H)-furanone (CMCF), and 3- chloro-4-methyl-5-hydroxy-2(5H)-furanone (MCF) were studied for th...

journal_title：Environmental and molecular mutagenesis

authors： Mäki-Paakkanen J,Laaksonen M,Munter T,Kronberg L,Komulainen H

更新日期：2001-01-01 00:00:00

abstract：:Azidothymidine (AZT) is a nucleoside reverse transcriptase inhibitor (NRTI) that is used for reducing mother-to-child transmission of human immunodeficiency virus I. Combinations of AZT and 3'-thiacytidine (3TC) are even more effective than AZT alone. AZT, however, is a mutagen and carcinogen in rodent models and 3TC ...

journal_title：Environmental and molecular mutagenesis

authors： Dobrovolsky VN,Shaddock JG,Mittelstaedt RA,Bishop ME,Lewis SM,Lee FW,Aidoo A,Leakey JE,Dunnick JK,Heflich RH

更新日期：2007-04-01 00:00:00

abstract：:Noncovalent DNA interactions, e.g., DNA intercalation and DNA groove-binding, have not been well studied relative to covalent interactions largely due to the inability of predicting and detecting such events in intact cells. We have adapted an in vitro bleomycin amplification method for DNA intercalation for use in cu...

journal_title：Environmental and molecular mutagenesis

authors： Snyder RD,Hendry LB

更新日期：2005-03-01 00:00:00

abstract：:Halogenated acetonitriles (HANs) are known to be water disinfectant by-products. Their mutagenicity and carcinogenicity have been shown in different test systems in vivo and in vitro. They also have clastogenic properties. In this study, the ability of HAN to induce single-strand breaks on the DNA of HeLa S3 cells was...

journal_title：Environmental and molecular mutagenesis

authors： Muller-Pillet V,Joyeux M,Ambroise D,Hartemann P

更新日期：2000-01-01 00:00:00

abstract：:The monoterpene indole alkaloid brachycerine from Psychotria brachyceras has been shown to be induced by UV and to have in vitro antioxidant activity, indicating a possible protective role against the secondary effects of this radiation. In this work, we have studied the antioxidant properties of brachycerine and a cr...

journal_title：Environmental and molecular mutagenesis

authors： do Nascimento NC,Fragoso V,Moura DJ,e Silva AC,Fett-Neto AG,Saffi J

更新日期：2007-12-01 00:00:00

abstract：:Cytochrome P450 (CYP), glutathione-S-transferase (GST), and N-acetyltransferase (NAT) are crucial for metabolism and clearance of xenobiotics. This study investigated whether CYP, GST, and NAT single nucleotide polymorphisms (SNPs) are associated with colorectal cancer (CRC) in patients with Lynch syndrome. The intera...

journal_title：Environmental and molecular mutagenesis

authors： Kamiza AB,You JF,Wang WC,Tang R,Chang CY,Chien HT,Lai CH,Chiu LL,Lo TP,Hung KY,Hsiung CA,Yeh CC

更新日期：2018-01-01 00:00:00

abstract：:The Ames Salmonella/microsomal assay was employed to test the mutagenicity of some benzamines (aniline, and o- and p-phenylenediamine) and their nitro-derivatives (p-nitroaniline, 2-nitro-p-phenylenediamine, 3- and 4-nitro-o-phenylenediamine), using strains TA98 and TA100 and their nitroreductase-deficient mutants, TA...

journal_title：Environmental and molecular mutagenesis

authors： Chung KT,Murdock CA,Zhou Y,Stevens SE Jr,Li YS,Wei CI,Fernando SY,Chou MW

更新日期：1996-01-01 00:00:00

abstract：:The nuclease P1 modification of the 32P-postlabeling technique was used to study the biological activity of 7H-dibenzo[c,g]carbazole (DBC) and some of its derivatives, including N-methyldibenzo[c,g]carbazole (N-MeDBC), 5,9-dimethyldibenzo[c,g]carbazole (5,9-diMeDBC), 5,9,N-trimethyldibenzo[c,g]carbazole (5,9,N-triMeDB...

journal_title：Environmental and molecular mutagenesis

authors： Gábelová A,Périn-Roussel O,Jounaidi Y,Périn F

更新日期：1997-01-01 00:00:00

abstract：:Alkylating treatments predominantly induce G: C = greater than A:T transitions, consistent with the predicted significance of the miscoding potential of the O6-alG lesion. However, the frequency and distribution of these events induced by any one compound may be diagnostic. SN1 agents that act via an alkyldiazonium ca...

journal_title：Environmental and molecular mutagenesis

authors： Horsfall MJ,Gordon AJ,Burns PA,Zielenska M,van der Vliet GM,Glickman BW

更新日期：1990-01-01 00:00:00

abstract：:Previously, we determined that elimination of deoxycytidylate (dCMP) deaminase (DCD1) in the yeast Saccharomyces cerevisiae increases the intracellular dCTP:dTTP ratio and reduces the induction of G x C --> A x T transitions in the SUP4-o gene by ethyl methanesulfonate (EMS) and N-methyl-N'-nitro-N-nitrosoguanidine (M...

journal_title：Environmental and molecular mutagenesis

authors： Kunz BA,Henson ES,Karthikeyan R,Kuschak T,McQueen SA,Scott CA,Xiao W

更新日期：1998-01-01 00:00:00