Changes in the repair capacity of blood cells as a biomarker for chronic low-dose exposure to ionizing radiation.

abstract：:The Big Blue mouse was used to investigate the role of cell proliferation in mutation fixation in the mouse back skin model of carcinogenesis. Phorbol 12-myristate 13 acetate (TPA) was applied to the dorsum of Big Blue mice to manipulate cell proliferation, and benzo[a]pyrene (BaP) or BaP-diolepoxide (BPDE) was applie...

journal_title：Environmental and molecular mutagenesis

authors： Miller ML,Vasunia K,Talaska G,Andringa A,de Boer J,Dixon K

更新日期：2000-01-01 00:00:00

abstract：:Ethylene oxide (EO) is a direct acting alkylating agent; in vitro and in vivo studies indicate that it is both a mutagen and a carcinogen. However, it remains unclear whether the mode of action (MOA) for cancer for EO is a mutagenic MOA, specifically via point mutation. To investigate the MOA for EO-induced mouse lung...

journal_title：Environmental and molecular mutagenesis

authors： Manjanatha MG,Shelton SD,Chen Y,Parsons BL,Myers MB,McKim KL,Gollapudi BB,Moore NP,Haber LT,Allen B,Moore MM

更新日期：2017-04-01 00:00:00

abstract：:The efficiency of the micronucleus test to assess radiation-induced chromosomal damage in human spermatozoa has been investigated. Micronuclei were scored in human sperm-hamster egg hybrids at the two-cell stage, after exposure of human spermatozoa to in vitro gamma-rays at doses of 0.00, 0.10, 0.25, 0.50, 1.00, 2.00,...

journal_title：Environmental and molecular mutagenesis

authors： Tusell L,Alvarez R,Caballín MR,Genescà A,Miró R,Ribas M,Egozcue J

更新日期：1995-01-01 00:00:00

abstract：:A wild-type strain of herpes simplex virus type 1 (HSV-1:KOS) encoding a functional thymidine kinase (tk+) and a tk- mutant strain (HSV-1:PTK3B) were used to study the role of the viral tk in the repair of UV-irradiated HSV-1 in human cells. UV survival of HSV-1:PTK3B was substantially reduced compared with that of HS...

journal_title：Environmental and molecular mutagenesis

authors： Intine RV,Rainbow AJ

更新日期：1990-01-01 00:00:00

abstract：:Experiments described herein were designed to evaluate the performance characteristics of a flow cytometry-based system that scores the incidence of peripheral blood micronucleated reticulocytes (MN-RETs). These procedures represent the continued refinement of a previously reported anti-CD71-based method (Dertinger et...

journal_title：Environmental and molecular mutagenesis

authors： Dertinger SD,Camphausen K,Macgregor JT,Bishop ME,Torous DK,Avlasevich S,Cairns S,Tometsko CR,Menard C,Muanza T,Chen Y,Miller RK,Cederbrant K,Sandelin K,Pontén I,Bolcsfoldi G

更新日期：2004-01-01 00:00:00

abstract：:The genome is programmed by the epigenome. Two of the fundamental components of the epigenome are chromatin structure and covalent modification of the DNA molecule itself by methylation. DNA methylation patterns are sculpted during development and it has been a long held belief that they remain stable after birth in s...

journal_title：Environmental and molecular mutagenesis

authors： Szyf M,McGowan P,Meaney MJ

更新日期：2008-01-01 00:00:00

abstract：:The modulation of 1,3-butadiene (BD)-induced DNA adducts by occupational exposure, glutathione S-transferase (GST) genotypes, single-strand breaks, and cytogenetic end points was studied in 15 workers and 11 controls. The exposed group consisted of 8 smokers and 7 nonsmokers, whereas the control group consisted of 7 n...

journal_title：Environmental and molecular mutagenesis

authors： Zhao C,Vodicka P,Sram RJ,Hemminki K

更新日期：2001-01-01 00:00:00

abstract：:The term "the DNA damage response" (DDR) encompasses a sophisticated array of cellular initiatives set in motion as cells are exposed to DNA-damaging events. It has been known for over half a century that all organisms have the ability to restore genomic integrity through DNA repair. More recent discoveries of signal ...

journal_title：Environmental and molecular mutagenesis

authors： Ljungman M

更新日期：2010-10-01 00:00:00

abstract：:Riddelliine (RID) is a pyrrolizidine alkaloid found in plants of the genera Crotalaria, Amsinckia, and Senecio in the United States. RID has been extensively studied in a wide variety of in vitro short-term genotoxicity tests and has yielded positive responses in most test systems; however, there are fewer data availa...

journal_title：Environmental and molecular mutagenesis

authors： Mirsalis JC,Steinmetz KL,Blazak WF,Spalding JW

更新日期：1993-01-01 00:00:00

abstract：:Amoxicillin (AMO), a drug used in the treatment of infections caused by susceptible bacteria, has been evaluated for its ability to induce genotoxicity in human peripheral blood lymphocytes. The potential genotoxic effects of AMO were investigated in vitro by the sister chromatid exchange (SCE), chromosomal aberration...

journal_title：Environmental and molecular mutagenesis

authors： Istifli ES,Topaktaş M

更新日期：2010-04-01 00:00:00

abstract：:In this study we evaluated the antigenotoxic and cytoprotective capabilities of WR-2721 [S-2-(3-aminopropylamino)-ethylphosphorothioic acid (amifostine)] in different normal tissues of BALB/c mice treated with idarubicin [4-demethoxydaunorubicin (IDA)]. The aminothiol WR-2721 is a pro-drug that requires dephosphorylat...

journal_title：Environmental and molecular mutagenesis

authors： de Campos Nebel M,Larripa I,González-Cid M

更新日期：2002-01-01 00:00:00

abstract：:Lack of cell surface glycosylphosphatidylinositol (GPI)-anchored protein(s) has been used as a reporter of Pig-a gene mutation in several model systems. As an extension of this work, our laboratory initiated development of an in vitro mutation assay based on the flow cytometric assessment of CD90.2 expression on the c...

journal_title：Environmental and molecular mutagenesis

authors： Bemis JC,Avlasevich SL,Labash C,McKinzie P,Revollo J,Dobrovolsky VN,Dertinger SD

更新日期：2018-01-01 00:00:00

abstract：:Peripheral lymphocytes from Taiwanese women (n = 35) exposed to polychlorinated aromatic hydrocarbons and from matched controls (n = 24) were assessed for the levels of sister chromatid exchanges (SCEs) after a 72-hour incubation of whole blood in the presence or absence of alpha-naphthoflavone (ANF) and for chromosom...

journal_title：Environmental and molecular mutagenesis

authors： Lundgren K,Collman GW,Wang-Wuu S,Tiernan T,Taylor M,Thompson CL,Lucier GW

更新日期：1988-01-01 00:00:00

abstract：:To what extent noncovalent chemical-DNA interactions, in particular weak nonbonded DNA intercalation, contribute to genotoxic responses in mammalian cells has not been fully elucidated. Moreover, with the exception of predominantly flat, multiple-fused-ring structures, our ability to predict intercalation ability of n...

journal_title：Environmental and molecular mutagenesis

authors： Snyder RD,Ewing DE,Hendry LB

更新日期：2004-01-01 00:00:00

abstract：:Alkylating treatments predominantly induce G: C = greater than A:T transitions, consistent with the predicted significance of the miscoding potential of the O6-alG lesion. However, the frequency and distribution of these events induced by any one compound may be diagnostic. SN1 agents that act via an alkyldiazonium ca...

journal_title：Environmental and molecular mutagenesis

authors： Horsfall MJ,Gordon AJ,Burns PA,Zielenska M,van der Vliet GM,Glickman BW

更新日期：1990-01-01 00:00:00

abstract：:Comparison of spontaneous mutation spectra derived from different transgenic constructs can provide valuable insights for interpreting the mechanisms of spontaneous mutation. In this study, spontaneous mutation frequencies and spectra of the lacI transgene are compared in the liver of C57BL/6, B6C3F1, and BC-1 mice an...

journal_title：Environmental and molecular mutagenesis

authors： Zhang S,Glickman BW,de Boer JG

更新日期：2001-01-01 00:00:00

abstract：:Monohaloacetic acids (monoHAAs) are a major class of drinking water disinfection by-products (DBPs) and are cytotoxic, genotoxic, mutagenic, and teratogenic. We propose a model of toxic action based on monoHAA-mediated inhibition of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) as a target cytosolic enzyme. This mo...

journal_title：Environmental and molecular mutagenesis

authors： Dad A,Jeong CH,Pals JA,Wagner ED,Plewa MJ

更新日期：2013-10-01 00:00:00

abstract：:Urinary 1-hydroxypyrene (1-OHP), an exposure biomarker for polycyclic aromatic hydrocarbons (PAHs), was used to identify potential sources of PAH exposure for 660 Koreans who were not occupationally exposed to PAHs (65% male; 35% female; mean age, 36.5 +/- 11.1 years). In this study, 74% of subjects had detectable lev...

journal_title：Environmental and molecular mutagenesis

authors： Yang M,Kim S,Lee E,Cheong HK,Chang SS,Kang D,Choi Y,Lee SM,Jang JY

更新日期：2003-01-01 00:00:00

abstract：:Environmental tobacco smoke (ETS) is a major source of indoor air pollution. Extractable-respirable particulate (ERP) from the ETS-contaminated indoor air (ERP-ETS) was collected from six passenger train cars and one control room. The mutagenicity of ERP-ETS was tested in the Ames/Salmonella test in the presence of ma...

journal_title：Environmental and molecular mutagenesis

authors： Zhou R,Yu G,Zhou Y,Zeng X

更新日期：1999-01-01 00:00:00

abstract：:Titanium dioxide (TiO2 ) nanomaterials (NMs) are widely used in a diversity of products including cosmetics, pharmaceuticals, food, and inks, despite uncertainties surrounding the potential health risks that they pose to humans and the environment. Previous studies on the genotoxicity of TiO2 have reported discrepant ...

journal_title：Environmental and molecular mutagenesis

authors： Louro H,Tavares A,Vital N,Costa PM,Alverca E,Zwart E,de Jong WH,Fessard V,Lavinha J,Silva MJ

更新日期：2014-07-01 00:00:00

abstract：:Identification of mutations induced by xenotoxins is a common task in the field of genetic toxicology. Mutations are often detected by clonally expanding potential mutant cells and genotyping each viable clone by Sanger sequencing. Such a "clone-by-clone" approach requires significant time and effort, and sometimes is...

journal_title：Environmental and molecular mutagenesis

authors： Revollo JR,Crabtree NM,Pearce MG,Pacheco-Martinez MM,Dobrovolsky VN

更新日期：2016-03-01 00:00:00

abstract：:A multicolor fluorescence in situ hybridization (FISH) method was developed to detect aneuploidy and diploidy in epididymal sperm of rats using DNA probes specific for chromosomes 4 and Y. Fourteen healthy young-adult rats from three strains were evaluated: inbred Fisher 344/N/ehs, outbred Sprague-Dawley, and outbred ...

journal_title：Environmental and molecular mutagenesis

authors： Lowe XR,de Stoppelaar JM,Bishop J,Cassel M,Hoebee B,Moore D 2nd,Wyrobek AJ

更新日期：1998-01-01 00:00:00

abstract：:A set of stable nitroxide free radicals that are used as spin labels have been shown to possess metal-independent superoxide dismutase-like activity. Unlike superoxide dismutase (SOD), these compounds are low molecular weight, and readily penetrate into the cell. A representative nitroxide, 4-hydroxy-2,2,6,6-tetrameth...

journal_title：Environmental and molecular mutagenesis

authors： DeGraff WG,Krishna MC,Russo A,Mitchell JB

更新日期：1992-01-01 00:00:00

abstract：:The transporter associated with antigen processing 2 (TAP2) is involved in the development of multidrug resistance and the etiology of immunological diseases. In this study, we investigated whether the expression of TAP2 can be perturbed by single nucleotide polymorphisms (SNPs) located in 3'-untranslated region (3'-U...

journal_title：Environmental and molecular mutagenesis

authors： Knox B,Wang Y,Rogers LJ,Xuan J,Yu D,Guan H,Chen J,Shi T,Ning B,Kadlubar SA

更新日期：2018-03-01 00:00:00

abstract：:Antioxidant vitamins are able to deactivate highly bioactive molecules, such as free radicals, that are generated during cellular biochemical processes. Doxorubicin (DXR) is a cancer chemotherapeutic agent that generates free radicals as a byproduct. In the present study, the Drosophila melanogaster somatic wing spot ...

journal_title：Environmental and molecular mutagenesis

authors： Costa WF,Nepomuceno JC

更新日期：2006-01-01 00:00:00

abstract：:It is estimated that 15% of all cancers are etiologically linked to viral infection. Specific cancers including adult T-cell leukemia, hepatocellular carcinoma, and uterine cervical cancer are associated with infection by human T-cell leukemia virus type I, hepatitis B virus, and high-risk human papilloma virus, respe...

journal_title：Environmental and molecular mutagenesis

authors： Gatza ML,Chandhasin C,Ducu RI,Marriott SJ

更新日期：2005-03-01 00:00:00

abstract：:Exposure to inorganic arsenic increases the risk of basal cell carcinoma (BCC). Arsenic metabolism is a susceptibility factor for arsenic toxicity, and specific haplotypes in arsenic (+3 oxidation state) methyltransferase (AS3MT) have been associated with increased urinary fractions of the most toxic arsenic metabolit...

journal_title：Environmental and molecular mutagenesis

authors： Engström KS,Vahter M,Fletcher T,Leonardi G,Goessler W,Gurzau E,Koppova K,Rudnai P,Kumar R,Broberg K

更新日期：2015-01-01 00:00:00

abstract：:Diesel exhaust (DE) is a major airborne pollutant of urban areas. It contains various polycyclic aromatic hydrocarbons (PAH) and nitrated PAHs. In this study, gpt delta mice were treated with inhalation of 1 or 3 mg m(-3) DE, or a single intratracheal instillation of diesel exhaust particles (DEP) or DEP extract. In t...

journal_title：Environmental and molecular mutagenesis

authors： Hashimoto AH,Amanuma K,Hiyoshi K,Sugawara Y,Goto S,Yanagisawa R,Takano H,Masumura K,Nohmi T,Aoki Y

更新日期：2007-10-01 00:00:00

abstract：:A quantitative structure-activity relationship (QSAR) has been formulated for 15 polycyclic aromatic nitro compounds acting on E. coli PQ37. Upon damage of DNA by these substances beta-galactosidase is induced and can be easily assayed colorimetrically, hence, this is a short-term test for mutagenicity. The QSAR (log ...

journal_title：Environmental and molecular mutagenesis

authors： Debnath AK,Hansch C

更新日期：1992-01-01 00:00:00

abstract：:Vanillin (VA) modulates the genotoxicity of chemical and physical agents in a complex manner. Previous studies indicate that VA inhibits the mutagenicity but increases the mitotic homologous recombination caused by at least some genotoxic agents. In the present study, we have evaluated the effects of VA on the repair ...

journal_title：Environmental and molecular mutagenesis

authors： Furlanetto MP,Sinigaglia M,Amaral VS,Dihl RR,de Andrade HH

更新日期：2007-01-01 00:00:00