Evidence for an involvement of thymidine kinase in the excision repair of ultraviolet-irradiated herpes simplex virus in human cells.

abstract：:Atmospheric pollution represents a relevant environmental hazard which has been associated with considerable excess mortality, morbidity, and increased rates of respiratory diseases in humans. To date, more than 3,000 environmental chemical compounds have been identified in the ambient atmosphere, including a variety ...

journal_title：Environmental and molecular mutagenesis

authors： Bolognesi C,Merlo F,Rabboni R,Valerio F,Abbondandolo A

更新日期：1997-01-01 00:00:00

abstract：:In vitro transcriptional signatures that predict toxicities can facilitate chemical screening. We previously developed a transcriptomic biomarker (known as TGx-28.65) for classifying agents as genotoxic (DNA damaging) and non-genotoxic in human lymphoblastoid TK6 cells. Because TK6 cells do not express cytochrome P450...

journal_title：Environmental and molecular mutagenesis

authors： Yauk CL,Buick JK,Williams A,Swartz CD,Recio L,Li HH,Fornace AJ Jr,Thomson EM,Aubrecht J

更新日期：2016-05-01 00:00:00

abstract：:Chromosome aberrations can occur by secondary mechanism(s) associated with cytotoxicity, induced by chemicals that do not attack DNA. Aberrations are formed from DNA double-strand breaks, and DSBs are known to be induced by nonmutagenic (Ames test negative) noncarcinogens at toxic levels [Storer et al. (1996): Mutat R...

journal_title：Environmental and molecular mutagenesis

authors： Hilliard CA,Armstrong MJ,Bradt CI,Hill RB,Greenwood SK,Galloway SM

更新日期：1998-01-01 00:00:00

abstract：:Our understanding of the mutation process and how it impacts target populations has deepened steadily during the hundred years since 1919. Recent advances in engineering genetically determined social traits points towards the logical culmination of this knowledge. ...

journal_title：Environmental and molecular mutagenesis

authors： Drake JW

更新日期：1994-01-01 00:00:00

abstract：:Combinations of antiretroviral drugs that include nucleoside reverse transcriptase inhibitors (NRTIs) are superior to single-agent regimens in treating or preventing HIV infection, but the potential long-term health hazards of these treatments in humans are uncertain. In earlier studies, our group found that coexposur...

journal_title：Environmental and molecular mutagenesis

authors： Meng Q,Su T,O'Neill JP,Walker VE

更新日期：2002-01-01 00:00:00

abstract：:Aldehydes are widespread environmental and industrial compounds, able to stimulate a range of adverse health effects (e.g., general toxicity, allergenic reactions, mutagenicity, and carcinogenicity). We have previously presented quantitative structure-activity relationships (QSARs) for the genotoxicity of simple and a...

journal_title：Environmental and molecular mutagenesis

authors： Benigni R,Conti L,Crebelli R,Rodomonte A,Vari' MR

更新日期：2005-12-01 00:00:00

abstract：:DNA is exposed to endogenous and environmental factors that can form stable lesions. If not repaired, these lesions can lead to transcription/replication blocking or mutagenic bypass. Our previous work has focused on 8,5'-cyclopurine 2'-deoxyribonucleosides, a unique class of oxidatively induced DNA lesions that are s...

journal_title：Environmental and molecular mutagenesis

authors： Abraham J,Brooks PJ

更新日期：2011-05-01 00:00:00

abstract：:The modulating effects of tannic acid (TA) on somatic mutation and mitotic recombination induced by methylmethanesulfonate (MMS), nitrogen mustard (HN2), and mitomycin C (MMC) were evaluated in the standard (ST) cross of the wing spot test in Drosophila melanogaster using co- and posttreatment protocols. It was shown ...

journal_title：Environmental and molecular mutagenesis

authors： Lehmann M,Graf U,Reguly ML,Rodrigues De Andrade HH

更新日期：2000-01-01 00:00:00

abstract：:Molecular analysis of proaerolysin selected glycosylphosphatidylinositol anchor (GPI-a) deficient isolates in the TK6 cell line was performed. Initial studies found that the expected X-linked PIGA mutations were rare among the spontaneous isolates but did increase modestly after ethyl methane sulfate (EMS) treatment (...

journal_title：Environmental and molecular mutagenesis

authors： Nicklas JA,Carter EW,Albertini RJ

更新日期：2015-10-01 00:00:00

abstract：:This collection of articles was inspired by the long-standing relationship between the Environmental Mutagen Society and Latin American scientists, and by the program for the 39th Environmental Mutagen Society meeting in Puerto Rico in 2008, which included a symposium featuring "South of the border" scientists. This c...

journal_title：Environmental and molecular mutagenesis

authors： Olivero OA,Larramendy M,Soloneski S,Menck CF,Matta J,Folle GA,Zamorano-Ponce E,Spivak G

更新日期：2010-10-01 00:00:00

abstract：:Identification of mutations induced by xenotoxins is a common task in the field of genetic toxicology. Mutations are often detected by clonally expanding potential mutant cells and genotyping each viable clone by Sanger sequencing. Such a "clone-by-clone" approach requires significant time and effort, and sometimes is...

journal_title：Environmental and molecular mutagenesis

authors： Revollo JR,Crabtree NM,Pearce MG,Pacheco-Martinez MM,Dobrovolsky VN

更新日期：2016-03-01 00:00:00

abstract：:Bhawalpur is a major cotton-growing area in Pakistan. Cotton picking in Pakistan is carried out by females and as a result of the intensive use of pesticides during the growing season these females are exposed to pesticide residues in the picking season. In the present study, peripheral blood was obtained from 69 cott...

journal_title：Environmental and molecular mutagenesis

authors： Ali T,Bhalli JA,Rana SM,Khan QM

更新日期：2008-06-01 00:00:00

abstract：:Urinary 1-hydroxypyrene (1-OHP), an exposure biomarker for polycyclic aromatic hydrocarbons (PAHs), was used to identify potential sources of PAH exposure for 660 Koreans who were not occupationally exposed to PAHs (65% male; 35% female; mean age, 36.5 +/- 11.1 years). In this study, 74% of subjects had detectable lev...

journal_title：Environmental and molecular mutagenesis

authors： Yang M,Kim S,Lee E,Cheong HK,Chang SS,Kang D,Choi Y,Lee SM,Jang JY

更新日期：2003-01-01 00:00:00

abstract：:Griseofulvin is an orally administered antifungal drug that affects microtubule formation in vitro and interferes with microtubule dynamics in vivo as clearly shown for mitotic cells in several cell systems. This article reports the effects of griseofulvin on in vitro maturation of porcine oocytes and subsequent effec...

journal_title：Environmental and molecular mutagenesis

authors： Miao YL,Zhang X,Zhao JG,Spate L,Zhao MT,Murphy CN,Prather RS,Sun QY,Schatten H

更新日期：2012-08-01 00:00:00

abstract：:Monohaloacetic acids (monoHAAs) are a major class of drinking water disinfection by-products (DBPs) and are cytotoxic, genotoxic, mutagenic, and teratogenic. We propose a model of toxic action based on monoHAA-mediated inhibition of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) as a target cytosolic enzyme. This mo...

journal_title：Environmental and molecular mutagenesis

authors： Dad A,Jeong CH,Pals JA,Wagner ED,Plewa MJ

更新日期：2013-10-01 00:00:00

abstract：:A mutagenesis moonshot addressing the influence of the environment on our genetic wellbeing was launched just 2 months before astronauts landed on the moon. Its impetus included the discovery that X-rays (Muller HJ. [1927]: Science 64:84-87) and chemicals (Auerbach and Robson. [1946]: Nature 157:302) were germ-cell mu...

journal_title：Environmental and molecular mutagenesis

authors： DeMarini DM

更新日期：2020-01-01 00:00:00

abstract：:Big Blue Rat-2 cells were evaluated for mutagenesis and mutational spectra (spontaneous and ethylnitrosourea [ENU]-induced). Survival, mutant frequency, population doubling time, and kinetics of mutant increase (to 120 hr) were determined. Exposures were 100, 200, 400, 600, and 1,000 micrograms ENU/ml. The spontaneous...

journal_title：Environmental and molecular mutagenesis

authors： Zimmer DM,Zhang XB,Harbach PR,Mayo JK,Aaron CS

更新日期：1996-01-01 00:00:00

abstract：:Radiation and many chemicals have been found to induce homologous genetic recombination. Experimental systems that allow the detection and characterization of recombinagens exist in organisms as diverse as bacteria, fungi, plants, insects, and mammals. Recombination plays an important role in many biological processes...

journal_title：Environmental and molecular mutagenesis

authors： Hoffmann GR

更新日期：1994-01-01 00:00:00

abstract：:The Ames Salmonella/microsomal assay was employed to test the mutagenicity of some benzamines (aniline, and o- and p-phenylenediamine) and their nitro-derivatives (p-nitroaniline, 2-nitro-p-phenylenediamine, 3- and 4-nitro-o-phenylenediamine), using strains TA98 and TA100 and their nitroreductase-deficient mutants, TA...

journal_title：Environmental and molecular mutagenesis

authors： Chung KT,Murdock CA,Zhou Y,Stevens SE Jr,Li YS,Wei CI,Fernando SY,Chou MW

更新日期：1996-01-01 00:00:00

abstract：:Polybrominated diphenyl ethers (PBDEs), which are widely used as flame retardants, are considered persistent organic pollutants. To date, the available toxicological data on PBDEs are limited and were primarily obtained by studying technical blends. The present study was undertaken to investigate the genotoxicity of t...

journal_title：Environmental and molecular mutagenesis

authors： Evandri MG,Mastrangelo S,Costa LG,Bolle P

更新日期：2003-01-01 00:00:00

abstract：:O6-alkylguanine DNA-alkyltransferase (AGT) is a widely distributed DNA repair protein that protects living organisms from endogenous and exogenous alkylation damage to DNA at the O6-position of guanine. The search of the C. elegans genome database for an AGT protein revealed the presence of a protein (cAGT-2) with som...

journal_title：Environmental and molecular mutagenesis

authors： Kanugula S,Pegg AE

更新日期：2001-01-01 00:00:00

abstract：:A collaborative international trial was conducted to evaluate the reproducibility and transferability of an in vivo mutation assay based on the enumeration of CD59-negative rat erythrocytes, a phenotype that is indicative of Pig-a gene mutation. Fourteen laboratories participated in this study, where anti-CD59-PE, SYT...

journal_title：Environmental and molecular mutagenesis

authors： Dertinger SD,Phonethepswath S,Weller P,Nicolette J,Murray J,Sonders P,Vohr HW,Shi J,Krsmanovic L,Gleason C,Custer L,Henwood A,Sweder K,Stankowski LF Jr,Roberts DJ,Giddings A,Kenny J,Lynch AM,Defrain C,Nesslany F,v

更新日期：2011-12-01 00:00:00

abstract：:2,6-Dicyano-4-nitroaniline and 2-cyano-4-nitroaniline (CNNA; 2-amino-5-nitrobenzonitrile) are potent mutagens in the Ames test, even though unsubstituted nitroanilines (NAs) are no more than weak mutagens. These compounds are putative reduction products of many commercial azo dyes, including Disperse Blue 165, Dispers...

journal_title：Environmental and molecular mutagenesis

authors： Josephy PD,Dhanoa J,Elzawy G,Heney K,Petrie L,Senis C

更新日期：2018-03-01 00:00:00

abstract：:In this study we evaluated the antigenotoxic and cytoprotective capabilities of WR-2721 [S-2-(3-aminopropylamino)-ethylphosphorothioic acid (amifostine)] in different normal tissues of BALB/c mice treated with idarubicin [4-demethoxydaunorubicin (IDA)]. The aminothiol WR-2721 is a pro-drug that requires dephosphorylat...

journal_title：Environmental and molecular mutagenesis

authors： de Campos Nebel M,Larripa I,González-Cid M

更新日期：2002-01-01 00:00:00

abstract：:Molybdenum is an essential element in plants and animals as a cofactor for enzymes. Molybdenum trioxide is used in metallurgical processes, in cosmetics as a pigment, and in contact lens solution, yet limited information is available on molybdenum genotoxicity. In the present study the micronucleus (MN) assay in human...

journal_title：Environmental and molecular mutagenesis

authors： Titenko-Holland N,Shao J,Zhang L,Xi L,Ngo H,Shang N,Smith MT

更新日期：1998-01-01 00:00:00

abstract：:Coal tar (CT) is a thick black liquid produced as a by-product of coal carbonization to produce coke or manufactured gas. It is comprised a complex mixture of polycyclic aromatic compounds, including a wide range of polycyclic aromatic hydrocarbons (PAHs), many of which are genotoxic and carcinogenic. CT is used in so...

journal_title：Environmental and molecular mutagenesis

authors： Long AS,Watson M,Arlt VM,White PA

更新日期：2016-08-01 00:00:00

abstract：:Tryptophan is metabolized through serotonin, indole, and kynurenine (KN) pathways. Uptake of an excess amount of tryptophan accompanied with vitamin B6 deficiency may result in the accumulation of higher concentrations of metabolites mainly from the KN pathways in the bladder. These metabolites could interact with nit...

journal_title：Environmental and molecular mutagenesis

authors： Chung KT,Gadupudi GS

更新日期：2011-03-01 00:00:00

abstract：:Fluorescence in situ hybridization with 7, 17, X, and Y chromosome-specific DNA probe was used to investigate the ability of Adriamycin (AM) to induce aneuploidy in interphase human lymphocytes. The reliability of the probes was tested by hybridization to metaphases and interphase nuclei of untreated normal lymphocyte...

journal_title：Environmental and molecular mutagenesis

authors： Aly MS,Othman OE,El Nahas SM

更新日期：1999-01-01 00:00:00

abstract：:The efficiency of the micronucleus test to assess radiation-induced chromosomal damage in human spermatozoa has been investigated. Micronuclei were scored in human sperm-hamster egg hybrids at the two-cell stage, after exposure of human spermatozoa to in vitro gamma-rays at doses of 0.00, 0.10, 0.25, 0.50, 1.00, 2.00,...

journal_title：Environmental and molecular mutagenesis

authors： Tusell L,Alvarez R,Caballín MR,Genescà A,Miró R,Ribas M,Egozcue J

更新日期：1995-01-01 00:00:00

abstract：:The mutagenic activity of airborne particulate matter collected in Pisa, a small nonindustrial town located in Italy, has been monitored over 1 year using the Ames Salmonella Test. Airborne particulate was collected on fibreglass filters using a Hi-Vol sampler and extracted by sonication and Soxhlet acetone extraction...

journal_title：Environmental and molecular mutagenesis

authors： Barale R,Zucconi D,Giorgelli F,Carducci AL,Tonelli M,Loprieno N

更新日期：1989-01-01 00:00:00