Spontaneous mutation of the lacI transgene in rodents: absence of species, strain, and insertion-site influence.

abstract：:The modulating effects of tannic acid (TA) on somatic mutation and mitotic recombination induced by methylmethanesulfonate (MMS), nitrogen mustard (HN2), and mitomycin C (MMC) were evaluated in the standard (ST) cross of the wing spot test in Drosophila melanogaster using co- and posttreatment protocols. It was shown ...

journal_title：Environmental and molecular mutagenesis

authors： Lehmann M,Graf U,Reguly ML,Rodrigues De Andrade HH

更新日期：2000-01-01 00:00:00

abstract：:We describe an in vivo mutagenesis model that utilizes reverse mutation and forward mutation at the endogenous Aprt locus. Reverse mutation provides an in situ method for detecting environments or agents that cause point mutations. Forward mutation detects large chromosomal events, including mitotic recombination, chr...

journal_title：Environmental and molecular mutagenesis

authors： Stambrook PJ,Shao C,Stockelman M,Boivin G,Engle SJ,Tischfield JA

更新日期：1996-01-01 00:00:00

abstract：:Exposure to emissions from laser printers during the printing process is commonplace worldwide, both in the home and workplace environment. In the present study, cytotoxic and genotoxic effects of the emission from five low to medium-throughput laser printers were investigated with respect to the release of ozone (O(3...

journal_title：Environmental and molecular mutagenesis

authors： Tang T,Gminski R,Könczöl M,Modest C,Armbruster B,Mersch-Sundermann V

更新日期：2012-03-01 00:00:00

abstract：:Lead is a widely existing environmental pollutant with potential carcinogenicity. To investigate the association of blood lead level (B-Pb) with potential chromosomal damage and cancer, we analyzed micronucleus (MN) frequency of peripheral blood lymphocytes (PBLs) and the methylation status of six human tumor suppress...

journal_title：Environmental and molecular mutagenesis

authors： Yu LB,Tu YT,Huang JW,Zhang YN,Zheng GQ,Xu XW,Wang JW,Xiao JQ,Christiani DC,Xia ZL

更新日期：2018-07-01 00:00:00

abstract：:Molybdenum is an essential element in plants and animals as a cofactor for enzymes. Molybdenum trioxide is used in metallurgical processes, in cosmetics as a pigment, and in contact lens solution, yet limited information is available on molybdenum genotoxicity. In the present study the micronucleus (MN) assay in human...

journal_title：Environmental and molecular mutagenesis

authors： Titenko-Holland N,Shao J,Zhang L,Xi L,Ngo H,Shang N,Smith MT

更新日期：1998-01-01 00:00:00

abstract：:Genetic polymorphisms have been reported in several cytochrome P450 (CYP) genes, including CYP1B1 which metabolically activates procarcinogens present in tobacco to carcinogenic intermediates. This study used a case-control approach in North Indian population to determine associations between genetic variants in CYP1B...

journal_title：Environmental and molecular mutagenesis

authors： Katiyar T,Maurya SS,Hasan F,Singh AP,Khan AJ,Hadi R,Singh S,Bhatt MLB,Parmar D

更新日期：2017-07-01 00:00:00

abstract：:N-Hydroxymethylacrylamide (NHMA), a mouse carcinogen inactive in the Salmonella assay and mouse micronucleus (MN) assay, was tested for reproductive effects in a mouse continuous breeding study. In that study, increased embryonic deaths were observed after 13 weeks exposure of parental animals to NHMA via drinking wat...

journal_title：Environmental and molecular mutagenesis

authors： Witt KL,Hughes LA,Burka LT,McFee AF,Mathews JM,Black SL,Bishop JB

更新日期：2003-01-01 00:00:00

abstract：:Metronidazole (MTZ) is used for the treatment of many infectious diseases, including vaginal infections. While data indicate that MTZ is mutagenic and induces micronuclei in rodents, there is no information on the genotoxicity of MTZ in epithelial vaginal cells or cervical cells. In the present study, we have instille...

journal_title：Environmental and molecular mutagenesis

authors： Ornelas-Aguirre JM,Gómez-Meda BC,Zamora-Perez AL,Ramos-Ibarra ML,Batista-González CM,Zúñiga-González GM

更新日期：2006-06-01 00:00:00

abstract：:We review our studies on the role of polycyclic aromatic hydrocarbon (PAH)-DNA adducts in breast cancer. Additionally we report on analyses of the reliability of the scoring procedures used with immunohistochemical assay for PAH-DNA adducts and of potential bias arising from the use of benign breast disease (BBD) cont...

journal_title：Environmental and molecular mutagenesis

authors： Rundle A,Tang D,Hibshoosh H,Schnabel F,Kelly A,Levine R,Zhou J,Link B,Perera F

更新日期：2002-01-01 00:00:00

abstract：:To evaluate whether blood-based genotoxicity endpoints can provide temporal and dose-response data within the low-dose carcinogenic range that could contribute to carcinogenic mode of action (MoA) assessments, we evaluated the sensitivity of flow cytometry-based micronucleus and Pig-a gene mutation assays at and below...

journal_title：Environmental and molecular mutagenesis

authors： Dertinger SD,Phonethepswath S,Avlasevich SL,Torous DK,Mereness J,Cottom J,Bemis JC,Macgregor JT

更新日期：2014-05-01 00:00:00

abstract：:The endogenous X-linked PIG-A gene is involved in the synthesis of glycosyl phosphatidyl inositol (GPI) anchors that tether specific protein markers to the exterior of mammalian cell cytoplasmic membranes. Earlier studies in rodent models indicate that Pig-a mutant red blood cells (RBCs) can be induced in animals trea...

journal_title：Environmental and molecular mutagenesis

authors： Dobrovolsky VN,Elespuru RK,Bigger CA,Robison TW,Heflich RH

更新日期：2011-12-01 00:00:00

abstract：:The Benchmark Dose (BMD) method is the favored approach for quantitative dose-response analysis where uncertainty measurements are delineated between the upper (BMDU) and lower (BMDL) confidence bounds, or confidence intervals (CIs). Little has been published on the accurate interpretation of uncertainty measurements ...

journal_title：Environmental and molecular mutagenesis

authors： Wheeldon RP,Dertinger SD,Bryce SM,Bemis JC,Johnson GE

更新日期：2021-01-11 00:00:00

abstract：:AQ-13 ([N1-(7-chloro-quinolin-4yl)-3-(N3,N3-diethylamino)propylamine] dihydrochloride trihydrate) is an aminoquinoline antimalarial drug that is effective against chloroquine-resistant strains of Plasmodium falciparum. It is structurally similar to the widely used chloroquine diphosphate (CQ). We evaluated these drugs...

journal_title：Environmental and molecular mutagenesis

authors： Riccio ES,Lee PS,Winegar RA,Krogstad DJ,De D,Mirsalis JC

更新日期：2001-01-01 00:00:00

abstract：:Respirable crystalline silica has been classified as a human lung carcinogen. Ultrafine (diameter < 100 nm) silica particles may be important in carcinogenesis, although the mechanisms remain unclear. In the present study, WIL2-NS cells were incubated for 6, 24, and 48 hr with 0, 30, 60, and 120 microg/ml ultrafine cr...

journal_title：Environmental and molecular mutagenesis

authors： Wang JJ,Sanderson BJ,Wang H

更新日期：2007-03-01 00:00:00

abstract：:DNA damage induced by solar ultraviolet (UV) radiation plays an important role in the induction of skin cancer. Although UVA constitutes the majority of solar UV radiation, it is less damaging to DNA than UVB. The DNA damage produced by UVA radiation, however, can be augmented in the presence of a photosensitizer. We ...

journal_title：Environmental and molecular mutagenesis

authors： Toyooka T,Ibuki Y,Takabayashi F,Goto R

更新日期：2006-01-01 00:00:00

abstract：:Polybrominated diphenyl ethers (PBDEs), which are widely used as flame retardants, are considered persistent organic pollutants. To date, the available toxicological data on PBDEs are limited and were primarily obtained by studying technical blends. The present study was undertaken to investigate the genotoxicity of t...

journal_title：Environmental and molecular mutagenesis

authors： Evandri MG,Mastrangelo S,Costa LG,Bolle P

更新日期：2003-01-01 00:00:00

abstract：:Lack of cell surface glycosylphosphatidylinositol (GPI)-anchored protein(s) has been used as a reporter of Pig-a gene mutation in several model systems. As an extension of this work, our laboratory initiated development of an in vitro mutation assay based on the flow cytometric assessment of CD90.2 expression on the c...

journal_title：Environmental and molecular mutagenesis

authors： Bemis JC,Avlasevich SL,Labash C,McKinzie P,Revollo J,Dobrovolsky VN,Dertinger SD

更新日期：2018-01-01 00:00:00

abstract：:This laboratory has previously described a method for scoring the incidence of rodent blood Pig-a mutant phenotype erythrocytes using immunomagnetic separation in conjunction with flow cytometric analysis (In Vivo MutaFlow®). The current work extends this approach to human blood. The frequencies of CD59- and CD55-nega...

journal_title：Environmental and molecular mutagenesis

authors： Dertinger SD,Avlasevich SL,Bemis JC,Chen Y,MacGregor JT

更新日期：2015-05-01 00:00:00

abstract：:Exposure to high concentrations of hexavalent chromium [Cr(VI)] in drinking water was associated with an increased incidence of oral tumors in F344 rats in a 2-year cancer bioassay conducted by the National Toxicology Program. These tumors primarily occurred at 180 ppm Cr(VI) and appeared to originate from the gingiva...

journal_title：Environmental and molecular mutagenesis

authors： Thompson CM,Young RR,Suh M,Dinesdurage HR,Elbekai RH,Harris MA,Rohr AC,Proctor DM

更新日期：2015-08-01 00:00:00

abstract：:Quinoline is a specific and potent carcinogen to the rat and mouse liver. Studies are described here in which it was evaluated for its ability to initiate unscheduled DNA synthesis (UDS) in the rat liver in vivo. Although some individual animals showed indications of a marginal response the absence of clear group posi...

journal_title：Environmental and molecular mutagenesis

authors： Ashby J,Mohammed R,Lefevre PA,Bandara L

更新日期：1989-01-01 00:00:00

abstract：:Big Blue Rat-2 cells were evaluated for mutagenesis and mutational spectra (spontaneous and ethylnitrosourea [ENU]-induced). Survival, mutant frequency, population doubling time, and kinetics of mutant increase (to 120 hr) were determined. Exposures were 100, 200, 400, 600, and 1,000 micrograms ENU/ml. The spontaneous...

journal_title：Environmental and molecular mutagenesis

authors： Zimmer DM,Zhang XB,Harbach PR,Mayo JK,Aaron CS

更新日期：1996-01-01 00:00:00

abstract：:In order to characterize in vivo gene mutations that occur during fetal development, molecular analyses were undertaken of mutant 6-thioguanine resistant T-lymphocytes isolated from placental cord blood samples of 13 normal male newborns. These mutant T-cells were studied to define hypoxanthine-guanine phosphoribosylt...

journal_title：Environmental and molecular mutagenesis

authors： McGinniss MJ,Nicklas JA,Albertini RJ

更新日期：1989-01-01 00:00:00

abstract：:A multicolor fluorescence in situ hybridization (FISH) method was developed to detect aneuploidy and diploidy in epididymal sperm of rats using DNA probes specific for chromosomes 4 and Y. Fourteen healthy young-adult rats from three strains were evaluated: inbred Fisher 344/N/ehs, outbred Sprague-Dawley, and outbred ...

journal_title：Environmental and molecular mutagenesis

authors： Lowe XR,de Stoppelaar JM,Bishop J,Cassel M,Hoebee B,Moore D 2nd,Wyrobek AJ

更新日期：1998-01-01 00:00:00

abstract：:In industrialized countries, heart disease rates are higher among women after menopause. Recent studies indicate that consumption of phytoestorogens, e.g., isoflavones such as genistein (GE), may have potential cardiovascular health benefits; however, no studies have evaluated the effect of these agents on toxicant-in...

journal_title：Environmental and molecular mutagenesis

authors： Manjanatha MG,Shelton SD,Rhodes BS,Bishop ME,Lyn-Cook LE,Aidoo A

更新日期：2005-01-01 00:00:00

abstract：:Mitochondrial dysfunction is a global term used in the context of "unhealthy" mitochondria. In practical terms, mitochondria are extremely complex and highly adaptive in structure, chemical and enzymatic composition, subcellular distribution and functional interaction with other components of cells. Consequently, alte...

journal_title：Environmental and molecular mutagenesis

authors： Roede JR,Jones DP

更新日期：2010-06-01 00:00:00

abstract：:The types of chromosomal aberrations during the aging of Crepis capillaris (Hawksbeard; fam. Asteraceae) seeds were investigated. Seeds were stored at 22 degrees C for 2, 4, 6, and 8 years. Chromosomal aberrations were analyzed in metaphase chromosomes at the first and second mitotic cycles. A colchicine block was use...

journal_title：Environmental and molecular mutagenesis

authors： Dimitrov BD

更新日期：1994-01-01 00:00:00

abstract：:Increased telomerase expression has been implicated in the pathogenesis of lung cancer and, since the primary cause of lung cancer is smoking, an association between telomerase reactivation and tobacco smoke has been proposed. In this work an investigation has been performed to assess the relationship between tobacco ...

journal_title：Environmental and molecular mutagenesis

authors： Marcon F,Siniscalchi E,Andreoli C,Allione A,Fiorito G,Medda E,Guarrera S,Matullo G,Crebelli R

更新日期：2017-10-01 00:00:00

abstract：:Nitrous acid (NA) is often presumed to cause base substitutions in organisms with double-stranded DNA as a direct consequence of oxidative deamination of adenine and of cytosine residues. Here we summarize evidence indicating that other mechanisms are involved in the case of NA-induced G/C-->A/T transition mutations. ...

journal_title：Environmental and molecular mutagenesis

authors： Hartman Z,Henrikson EN,Hartman PE,Cebula TA

更新日期：1994-01-01 00:00:00

abstract：:The tumor suppressor breast cancer susceptibility protein 1 (BRCA1) protects our cells from genomic instability in part by facilitating the efficient repair of DNA double-strand breaks (DSBs). BRCA1 promotes the error-free repair of DSBs through homologous recombination and is also implicated in the regulation of nonh...

journal_title：Environmental and molecular mutagenesis

authors： Thompson EG,Fares H,Dixon K

更新日期：2012-01-01 00:00:00

abstract：:Coumarin (1,2-benzopyrone), a natural food constituent, prevents polycyclic aromatic hydrocarbon-induced neoplasms in rats and mice, but has not been studied with other chemical carcinogens. We examined coumarin chemoprotection against aflatoxin B1 using the 6-thioguanine resistance mutation assay in two different Chi...

journal_title：Environmental and molecular mutagenesis

authors： Goeger DE,Anderson KE,Hsie AW

更新日期：1998-01-01 00:00:00