Cytogenetic and chemical detection of human exposure to polyhalogenated aromatic hydrocarbons.

abstract：:This collection of articles was inspired by the long-standing relationship between the Environmental Mutagen Society and Latin American scientists, and by the program for the 39th Environmental Mutagen Society meeting in Puerto Rico in 2008, which included a symposium featuring "South of the border" scientists. This c...

journal_title：Environmental and molecular mutagenesis

authors： Olivero OA,Larramendy M,Soloneski S,Menck CF,Matta J,Folle GA,Zamorano-Ponce E,Spivak G

更新日期：2010-10-01 00:00:00

abstract：:Molybdenum is an essential element in plants and animals as a cofactor for enzymes. Molybdenum trioxide is used in metallurgical processes, in cosmetics as a pigment, and in contact lens solution, yet limited information is available on molybdenum genotoxicity. In the present study the micronucleus (MN) assay in human...

journal_title：Environmental and molecular mutagenesis

authors： Titenko-Holland N,Shao J,Zhang L,Xi L,Ngo H,Shang N,Smith MT

更新日期：1998-01-01 00:00:00

abstract：:Eleven mutagenic heterocyclic amines, 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]-indole (Trp-P-1), 3-amino-1-methyl-5H-pyrido[4,3]indole (Trp-P-2), 2-amino-6-methyl-dipyrido[1,2-a:3',2'-d]imidazole (Glu-P-1), 2-aminodipyrido[1,2-a:3',2'-d]imidazole (Glu-P-2), 2-amino-9H-pyrido[2,3-b]indole (A alpha C), 2-amino-3-methyl-9H-...

journal_title：Environmental and molecular mutagenesis

authors： Yoshimi N,Sugie S,Iwata H,Mori H,Williams GM

更新日期：1988-01-01 00:00:00

abstract：:A set of stable nitroxide free radicals that are used as spin labels have been shown to possess metal-independent superoxide dismutase-like activity. Unlike superoxide dismutase (SOD), these compounds are low molecular weight, and readily penetrate into the cell. A representative nitroxide, 4-hydroxy-2,2,6,6-tetrameth...

journal_title：Environmental and molecular mutagenesis

authors： DeGraff WG,Krishna MC,Russo A,Mitchell JB

更新日期：1992-01-01 00:00:00

abstract：:The mechanism of toxicity of the leukemogen benzene is not entirely known. This pilot study used RNA-sequencing (RNA-seq) technology to examine the effect of benzene exposure on gene expression in peripheral blood mononuclear cells obtained from 10 workers occupationally exposed to high levels of benzene (≥5 ppm) in a...

journal_title：Environmental and molecular mutagenesis

authors： Thomas R,McHale CM,Lan Q,Hubbard AE,Zhang L,Vermeulen R,Li G,Rappaport SM,Yin S,Rothman N,Smith MT

更新日期：2013-08-01 00:00:00

abstract：:Experimental features of a transgenic mouse mutation assay based on a lacI target transgene from Escherichia coli are considered in detail. Sources of variability in the experimental protocol that can affect the statistical nature of the observations are examined with the goal of identifying sources of excess variatio...

journal_title：Environmental and molecular mutagenesis

authors： Piegorsch WW,Lockhart AM,Margolin BH,Tindall KR,Gorelick NJ,Short JM,Carr GJ,Thompson ED,Shelby MD

更新日期：1994-01-01 00:00:00

abstract：:2,6-Dicyano-4-nitroaniline and 2-cyano-4-nitroaniline (CNNA; 2-amino-5-nitrobenzonitrile) are potent mutagens in the Ames test, even though unsubstituted nitroanilines (NAs) are no more than weak mutagens. These compounds are putative reduction products of many commercial azo dyes, including Disperse Blue 165, Dispers...

journal_title：Environmental and molecular mutagenesis

authors： Josephy PD,Dhanoa J,Elzawy G,Heney K,Petrie L,Senis C

更新日期：2018-03-01 00:00:00

abstract：:DAS (diallyl sulfide), DADS (diallyl disulfide), and DATS (diallyl trisulfide) are major oil-soluble allyl sulfides (OAS) that represent major garlic constituents. The anticarcinogenic and antimutagenic effects of these substances have been extensively studied during the last decades. Previous reports suggest that ind...

journal_title：Environmental and molecular mutagenesis

authors： Wu XJ,Hu Y,Lamy E,Mersch-Sundermann V

更新日期：2009-04-01 00:00:00

abstract：:Contamination of ground water by industrial waste poses potential health hazards for man and his environment. The improper disposal of toxic wastes could allow genotoxic chemicals to percolate into ground waters, and these contaminated ground waters may produce toxicity, including mutation and eventually cancer, in ex...

journal_title：Environmental and molecular mutagenesis

authors： Chandra S,Chauhan LK,Murthy RC,Gupta SK

更新日期：2006-06-01 00:00:00

abstract：:The genome is programmed by the epigenome. Two of the fundamental components of the epigenome are chromatin structure and covalent modification of the DNA molecule itself by methylation. DNA methylation patterns are sculpted during development and it has been a long held belief that they remain stable after birth in s...

journal_title：Environmental and molecular mutagenesis

authors： Szyf M,McGowan P,Meaney MJ

更新日期：2008-01-01 00:00:00

abstract：:311 chemicals were tested under code, for mutagenicity, in Salmonella typhimurium; 35 of the chemicals were tested more than once in the same or different laboratories. The tests were conducted using a preincubation protocol in the absence of exogenous metabolic activation, and in the presence of liver S-9 from Aroclo...

journal_title：Environmental and molecular mutagenesis

authors： Zeiger E,Anderson B,Haworth S,Lawlor T,Mortelmans K

更新日期：1992-01-01 00:00:00

abstract：:Classification of micronuclei induced by lomefloxacin, a difluorinated quinolone bactericidal agent, in mouse bone marrow was performed by fluorescence in situ hybridization using DNA probes for the centromere repeated minor satellite DNA and the telomeric hexamer repeat (5'-TTAGGG-3'). Colchicine and mitomycin C were...

journal_title：Environmental and molecular mutagenesis

authors： Attia SM

更新日期：2009-06-01 00:00:00

abstract：:A mutagenesis moonshot addressing the influence of the environment on our genetic wellbeing was launched just 2 months before astronauts landed on the moon. Its impetus included the discovery that X-rays (Muller HJ. [1927]: Science 64:84-87) and chemicals (Auerbach and Robson. [1946]: Nature 157:302) were germ-cell mu...

journal_title：Environmental and molecular mutagenesis

authors： DeMarini DM

更新日期：2020-01-01 00:00:00

abstract：:The DNA repair proteins XPD and XRCC1 are involved in the nucleotide and base excision repair of DNA lesions induced by many tobacco and environmental carcinogens. Common variant alleles at the XPD (312Asn, 751Gln) and XRCC1 (399Gln) loci have been identified and associated with increased risk for lung cancer. We ther...

journal_title：Environmental and molecular mutagenesis

authors： Hou SM,Ryk C,Kannio A,Angelini S,Fält S,Nyberg F,Husgafvel-Pursiainen K

更新日期：2003-01-01 00:00:00

abstract：:The genotoxic effects associated with automobile painting were analyzed using a panel of biomarkers. Chromosomal aberrations (CAs), sister chromatid exchange (SCE), and micronuclei were evaluated in 25 car painters (12 smokers, 13 nonsmokers) working in different automobile paint-shops in Italy and in 37 control subje...

journal_title：Environmental and molecular mutagenesis

authors： Testa A,Festa F,Ranaldi R,Giachelia M,Tirindelli D,De Marco A,Owczarek M,Guidotti M,Cozzi R

更新日期：2005-10-01 00:00:00

abstract：:Occupational exposure to coal dust causes coal workers' pneumoconiosis (CWP), which is a chronic inflammatory and fibrotic lung disease. Recently, chronic inflammation has been accepted as a crucial factor in the pathogenesis of neoplasia. The chronic inflammation provides dynamic setting for oxidative stress and form...

journal_title：Environmental and molecular mutagenesis

authors： Ulker OC,Ustundag A,Duydu Y,Yucesoy B,Karakaya A

更新日期：2008-04-01 00:00:00

abstract：:DNA damage induced by solar ultraviolet (UV) radiation plays an important role in the induction of skin cancer. Although UVA constitutes the majority of solar UV radiation, it is less damaging to DNA than UVB. The DNA damage produced by UVA radiation, however, can be augmented in the presence of a photosensitizer. We ...

journal_title：Environmental and molecular mutagenesis

authors： Toyooka T,Ibuki Y,Takabayashi F,Goto R

更新日期：2006-01-01 00:00:00

abstract：:The monoterpene indole alkaloid brachycerine from Psychotria brachyceras has been shown to be induced by UV and to have in vitro antioxidant activity, indicating a possible protective role against the secondary effects of this radiation. In this work, we have studied the antioxidant properties of brachycerine and a cr...

journal_title：Environmental and molecular mutagenesis

authors： do Nascimento NC,Fragoso V,Moura DJ,e Silva AC,Fett-Neto AG,Saffi J

更新日期：2007-12-01 00:00:00

abstract：:Understanding chemically induced changes in mutational spectra can aid in deciphering mechanisms of mutagenesis. In this paper, we propose the use of statistical methods that are based upon the mutation frequency, rather than simple mutant counts which have no relationship to the mutation frequency. These methods have...

journal_title：Environmental and molecular mutagenesis

authors： Carr GJ,Gorelick NJ

更新日期：1996-01-01 00:00:00

abstract：:The human transcriptome is complex, comprising multiple transcript types, mostly in the form of non-coding RNA (ncRNA). The majority of ncRNA is of the long form (lncRNA, ≥ 200 bp), which plays an important role in gene regulation through multiple mechanisms including epigenetics, chromatin modification, control of tr...

journal_title：Environmental and molecular mutagenesis

authors： McHale CM,Zhang L,Thomas R,Smith MT

更新日期：2013-08-01 00:00:00

abstract：:Big Blue Rat-2 cells were evaluated for mutagenesis and mutational spectra (spontaneous and ethylnitrosourea [ENU]-induced). Survival, mutant frequency, population doubling time, and kinetics of mutant increase (to 120 hr) were determined. Exposures were 100, 200, 400, 600, and 1,000 micrograms ENU/ml. The spontaneous...

journal_title：Environmental and molecular mutagenesis

authors： Zimmer DM,Zhang XB,Harbach PR,Mayo JK,Aaron CS

更新日期：1996-01-01 00:00:00

abstract：:Hypertension is often treated with diuretics, like hydrochlorothiazide (HCTZ). Previous results on the in vitro genotoxicity of HCTZ are equivocal. In the present study, we have evaluated the genotoxicity of HCTZ in cultured human lymphocytes using the Cytokinesis Blocked Micronucleus (CBMN) assay. In addition, micron...

journal_title：Environmental and molecular mutagenesis

authors： Andrianopoulos C,Stephanou G,Demopoulos NA

更新日期：2006-04-01 00:00:00

abstract：:Genomes of all living organisms are constantly threatened by endogenous and exogenous agents that challenge the chemical integrity of DNA. Most bacteria have evolved a coordinated response to DNA damage. In Escherichia coli, this inducible system is termed the SOS response. The SOS global regulatory network consists o...

journal_title：Environmental and molecular mutagenesis

authors： Maslowska KH,Makiela-Dzbenska K,Fijalkowska IJ

更新日期：2019-05-01 00:00:00

abstract：:The placenta is a readily available source of material for molecular epidemiological investigations. As such, DNA damage in this tissue can be indicative of maternal exposure to environmental pollutants such as polycyclic aromatic hydrocarbons (PAHs). Previous reports have demonstrated that (32)P-postlabeling (PPL) is...

journal_title：Environmental and molecular mutagenesis

authors： Marafie EM,Marafie I,Emery SJ,Waters R,Jones NJ

更新日期：2000-01-01 00:00:00

abstract：:An automated approach for scoring in vitro micronuclei (MN) has been described in which flow cytometric analysis is combined with compound exposure, processing, and sampling in a single 96-well plate (Bryce SM et al. [2010]: Mutat Res 703:191-199). The current report describes protocol optimization and an interlaborat...

journal_title：Environmental and molecular mutagenesis

authors： Bryce SM,Avlasevich SL,Bemis JC,Tate M,Walmsley RM,Saad F,Van Dijck K,De Boeck M,Van Goethem F,Lukamowicz-Rajska M,Elhajouji A,Dertinger SD

更新日期：2013-04-01 00:00:00

abstract：:Mitochondria are dynamic organelles that are involved in a number of diverse processes. Most often the mitochondrion is associated with energy generation, but other important processes occur in this organelle such as fatty acid synthesis and amino acid metabolism. Although mitochondria encode less than 40 genes, all o...

journal_title：Environmental and molecular mutagenesis

authors： Moore A,Golden A

更新日期：2009-10-01 00:00:00

abstract：:We describe an in vivo mutagenesis model that utilizes reverse mutation and forward mutation at the endogenous Aprt locus. Reverse mutation provides an in situ method for detecting environments or agents that cause point mutations. Forward mutation detects large chromosomal events, including mitotic recombination, chr...

journal_title：Environmental and molecular mutagenesis

authors： Stambrook PJ,Shao C,Stockelman M,Boivin G,Engle SJ,Tischfield JA

更新日期：1996-01-01 00:00:00

abstract：:We evaluated the mutagens in fumes produced by heating three different cooking oils used in Taiwan to temperatures of 100 degrees C, 200 degrees C, and 300 degrees C, and constructed models to study the efficacy of fume extractors used commonly by Taiwanese women. Particulates of volatile emissions from lard (at 200 d...

journal_title：Environmental and molecular mutagenesis

authors： Chiang TA,Wu PF,Ko YC

更新日期：1998-01-01 00:00:00

abstract：:Micronucleus (MN) expression in peripheral blood lymphocytes is well established as a standard method for monitoring chromosome damage in human populations. The first results of an analysis of pooled data from laboratories using the cytokinesis-block micronucleus (CBMN) assay and participating in the HUMN (HUman Micro...

journal_title：Environmental and molecular mutagenesis

authors： Bonassi S,Fenech M,Lando C,Lin YP,Ceppi M,Chang WP,Holland N,Kirsch-Volders M,Zeiger E,Ban S,Barale R,Bigatti MP,Bolognesi C,Jia C,Di Giorgio M,Ferguson LR,Fucic A,Lima OG,Hrelia P,Krishnaja AP,Lee TK,Migliore L

更新日期：2001-01-01 00:00:00

abstract：:The genotoxic responses of mixtures of four chlorohydroxyfuranones (CHFs), 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX), 3,4-dichloro-5-hydroxy-2(5H)-furanone (MCA), 3-chloro- 4-(chloromethyl)-5-hydroxy-2(5H)-furanone (CMCF) and 3-chloro-4-methyl-5-hydroxy-2(5H)-furanone (MCF), were compared with the geno...

journal_title：Environmental and molecular mutagenesis

authors： Mäki-Paakkanen J,Komulainen H,Kronberg L

更新日期：2004-01-01 00:00:00